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Protein

Cysteine-rich PDZ-binding protein

Gene

Cript

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich PDZ-binding protein
Alternative name(s):
Cysteine-rich interactor of PDZ three
Short name:
Cysteine-rich interactor of PDZ3
Gene namesi
Name:Cript
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1929655. Cript.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 101101Cysteine-rich PDZ-binding proteinPRO_0000314564Add
BLAST

Proteomic databases

EPDiO70333.
MaxQBiO70333.
PaxDbiO70333.
PRIDEiO70333.

PTM databases

PhosphoSiteiO70333.

Expressioni

Gene expression databases

BgeeiO70333.
CleanExiMM_CRIPT.
ExpressionAtlasiO70333. baseline and differential.
GenevisibleiO70333. MM.

Interactioni

Subunit structurei

Interacts with TUBB1. Interacts strongly with the PDZ3 domain of members of the DLG4 family. Associates with microtubules (By similarity). Interacts with DLG4.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiO70333. 1 interaction.
MINTiMINT-1605557.
STRINGi10090.ENSMUSP00000024959.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni95 – 1017Sufficient for interaction with DLG4
Regioni98 – 1014PDZ3-binding

Sequence similaritiesi

Belongs to the CRIPT family.Curated

Phylogenomic databases

eggNOGiKOG3476. Eukaryota.
ENOG4111RAI. LUCA.
GeneTreeiENSGT00390000002260.
HOGENOMiHOG000242625.
HOVERGENiHBG097641.
InParanoidiO70333.
OrthoDBiEOG75B87J.
PhylomeDBiO70333.
TreeFamiTF300144.

Family and domain databases

InterProiIPR019367. PDZ-binding_CRIPT.
[Graphical view]
PfamiPF10235. Cript. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70333-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVCEKCEKKL GRVITPDTWK DGARNTTESG GRKLNENKAL TSKKARFDPY
60 70 80 90 100
GKNKFSTCRI CKSSVHQPGS HYCQGCAYKK GICAMCGKKV LDTKNYKQTS

V
Length:101
Mass (Da):11,271
Last modified:August 1, 1998 - v1
Checksum:i161D694AC81BFDCB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti86 – 861C → Y in BAB23596 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151637 mRNA. Translation: AAD38045.1.
AK004828 mRNA. Translation: BAB23596.1.
AK008523 mRNA. Translation: BAB25719.1.
AK029409 mRNA. Translation: BAC26438.1.
BC002258 mRNA. Translation: AAH02258.1.
BC023013 mRNA. Translation: AAH23013.1.
CCDSiCCDS29012.1.
RefSeqiNP_064320.1. NM_019936.3.
UniGeneiMm.109329.

Genome annotation databases

EnsembliENSMUST00000024959; ENSMUSP00000024959; ENSMUSG00000024146.
GeneIDi56724.
KEGGimmu:56724.
UCSCiuc008duo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151637 mRNA. Translation: AAD38045.1.
AK004828 mRNA. Translation: BAB23596.1.
AK008523 mRNA. Translation: BAB25719.1.
AK029409 mRNA. Translation: BAC26438.1.
BC002258 mRNA. Translation: AAH02258.1.
BC023013 mRNA. Translation: AAH23013.1.
CCDSiCCDS29012.1.
RefSeqiNP_064320.1. NM_019936.3.
UniGeneiMm.109329.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO70333. 1 interaction.
MINTiMINT-1605557.
STRINGi10090.ENSMUSP00000024959.

PTM databases

PhosphoSiteiO70333.

Proteomic databases

EPDiO70333.
MaxQBiO70333.
PaxDbiO70333.
PRIDEiO70333.

Protocols and materials databases

DNASUi56724.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024959; ENSMUSP00000024959; ENSMUSG00000024146.
GeneIDi56724.
KEGGimmu:56724.
UCSCiuc008duo.2. mouse.

Organism-specific databases

CTDi9419.
MGIiMGI:1929655. Cript.

Phylogenomic databases

eggNOGiKOG3476. Eukaryota.
ENOG4111RAI. LUCA.
GeneTreeiENSGT00390000002260.
HOGENOMiHOG000242625.
HOVERGENiHBG097641.
InParanoidiO70333.
OrthoDBiEOG75B87J.
PhylomeDBiO70333.
TreeFamiTF300144.

Miscellaneous databases

NextBioi313202.
PROiO70333.
SOURCEiSearch...

Gene expression databases

BgeeiO70333.
CleanExiMM_CRIPT.
ExpressionAtlasiO70333. baseline and differential.
GenevisibleiO70333. MM.

Family and domain databases

InterProiIPR019367. PDZ-binding_CRIPT.
[Graphical view]
PfamiPF10235. Cript. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of mouse testicular CRIPT."
    Sebire K.L., de Kretser D.M., O'Bryan M.K.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
    Tissue: Testis.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head, Lung and Small intestine.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II and FVB/N-3.
    Tissue: Mammary tumor.
  4. "A thermodynamic ligand binding study of the third PDZ domain (PDZ3) from the mammalian neuronal protein PSD-95."
    Saro D., Li T., Rupasinghe C., Paredes A., Caspers N., Spaller M.R.
    Biochemistry 46:6340-6352(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DLG4.

Entry informationi

Entry nameiCRIPT_MOUSE
AccessioniPrimary (citable) accession number: O70333
Secondary accession number(s): Q99LR6, Q9DBP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 1, 1998
Last modified: March 16, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.