Reviewed,
UniProtKB/Swiss-Prot O70325 (GPX41_MOUSE)
Last modified
November 25, 2008.
Version 83.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Phospholipid hydroperoxide glutathione peroxidase, mitochondrial Short name=PHGPx EC=1.11.1.12 Alternative name(s): GPX-4 | ||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 197 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage. |
| Catalytic activity | 2 glutathione + a lipid hydroperoxide = glutathione disulfide + lipid + 2 H(2)O. |
| Subcellular location | |
| Tissue specificity | Present primarily in testis. |
| Sequence similarities | Belongs to the glutathione peroxidase family. |
Ontologies
Alternative products
| This entry describes 3 isoforms produced by alternative splicing and alternative initiation. [Align] [Select] | ||||||
| Isoform Mitochondrial (identifier: O70325-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform Nuclear (identifier: Q91XR9-1) The sequence of this isoform can be found in the external entry Q91XR9-1. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly. | ||||||
| Isoform Cytoplasmic (identifier: O70325-2) The sequence of this isoform differs from the canonical sequence as follows: 1-27: Missing. | ||||||
| Notes: Produced by alternative initiation at Met-28 of isoform Mitochondrial. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – ? | Mitochondrion Potential | |||||||
| Chain | ? – 197 | Phospholipid hydroperoxide glutathione peroxidase, mitochondrial | PRO_0000013069 | ||||||
Sites | |||||||||
| Active site | 73 | 1 | |||||||
Amino acid modifications | |||||||||
| Non-standard residue | 73 | 1 | Selenocysteine | ||||||
Natural variations | |||||||||
| Alternative sequence | 1 – 27 | 27 | Missing in isoform Cytoplasmic. | VSP_018743 | |||||
Experimental info | |||||||||
| Sequence conflict | 39 | 1 | R → A in BAA22780. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning and sequencing of the cDNA encoding a phospholipid hydroperoxide glutathione peroxidase." Nam S.-Y., Nakamuta N., Kurohmaru M., Hayashi Y. Gene 198:245-249(1997) [PubMed: 9370288] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: CD-1. Tissue: Testis. |
| [2] | "Cloning of the mouse phospholipid hydroperoxide glutathione peroxidase gene." Borchert A., Schnurr K., Thiele B.J., Kuehn H. FEBS Lett. 446:223-227(1999) [PubMed: 10100845] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: C57BL/6N. |
| [3] | "Murine phospholipid hydroperoxide glutathione peroxidase: cDNA sequence, tissue expression, and mapping." Knopp E.A., Arndt T.L., Eng K.L., Caldwell M., LeBoeuf R.C., Deeb S.S., O'Brien K.D. Mamm. Genome 10:601-605(1999) [PubMed: 10341094] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Strain: BALB/c and C57BL/6J. Tissue: Myocardium and Testis. |
| [4] | "Early embryonic lethality caused by targeted disruption of the mouse PHGPx gene." Imai H., Hirao F., Sakamoto T., Sekine K., Mizukura Y., Saito M., Kitamoto T., Hayasaka M., Hanaoka K., Nakagawa Y. Biochem. Biophys. Res. Commun. 305:278-286(2003) [PubMed: 12745070] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/SvJ. Tissue: Liver. |
| [5] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Testis. |
| [6] | "The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults." Yant L.J., Ran Q., Rao L., Van Remmen H., Shibatani T., Belter J.G., Motta L., Richardson A., Prolla T.A. Free Radic. Biol. Med. 34:496-502(2003) [PubMed: 12566075] [Abstract] Cited for: FUNCTION. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| D87896 mRNA. Translation: BAA22780.1. AJ012104 Genomic DNA. Translation: CAB42657.2. AF045768 mRNA. Translation: AAC15832.1. AF045769 mRNA. Translation: AAC15833.1. AF044056 Genomic DNA. Translation: AAC14560.1. AB030643 Genomic DNA. Translation: BAC06507.1. AB030643 Genomic DNA. Translation: BAC06508.1. AB030728 Genomic DNA. Translation: BAC06511.1. AK006441 mRNA. Translation: BAC55251.1. | |
| RefSeq | NP_032188.3. |
| UniGene | Mm.359573 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1GP1 based on UniProtKB P00435. |
| SMR | O70325. Positions 36-197. |
| ModBase | Search... |
Protein family/group databases | |
| PeroxiBase | 3714. MmGPx04-a. 3867. MmGPx04-c. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000075706. Mus musculus. [Contig view] |
| GeneID | 625249. |
Organism-specific databases | |
| MGI | MGI:104767. Gpx4. |
Phylogenomic databases | |
| HOGENOM | O70325. |
| HOVERGEN | O70325. |
Gene expression databases | |
| CleanEx | MM_GPX4. |
| GermOnline | ENSMUSG00000065948. Mus musculus. |
Family and domain databases | |
| InterPro | IPR000889. Glut_peroxidase. IPR012335. Thioredoxin_fold. [Graphical view] |
| Gene3D | G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit. |
| PANTHER | PTHR11592. Glut_peroxidase. 1 hit. |
| Pfam | PF00255. GSHPx. 1 hit. [Graphical view] |
| PIRSF | PIRSF000303. Glutathion_perox. 1 hit. |
| PRINTS | PR01011. GLUTPROXDASE. |
| PROSITE | PS00460. GLUTATHIONE_PEROXID_1. 1 hit. PS00763. GLUTATHIONE_PEROXID_2. 1 hit. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 418158. |
| SOURCE | Search... |
Entry information
| Entry name | GPX41_MOUSE | ||||||||
| Accession | Primary (citable) accession number: O70325 Secondary accession number(s): O35560, Q9JK35 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

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