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O70324

- MOT8_MOUSE

UniProt

O70324 - MOT8_MOUSE

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Protein

Monocarboxylate transporter 8

Gene

Slc16a2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr (By similarity).By similarity

GO - Molecular functioni

  1. symporter activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Protein family/group databases

TCDBi2.A.1.13.3. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 8
Short name:
MCT 8
Alternative name(s):
Solute carrier family 16 member 2
X-linked PEST-containing transporter
Gene namesi
Name:Slc16a2
Synonyms:Mct8, Xpct
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1203732. Slc16a2.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 102101CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei103 – 12321HelicalSequence AnalysisAdd
BLAST
Topological domaini124 – 14926ExtracellularSequence AnalysisAdd
BLAST
Transmembranei150 – 17021HelicalSequence AnalysisAdd
BLAST
Topological domaini171 – 1777CytoplasmicSequence Analysis
Transmembranei178 – 19821HelicalSequence AnalysisAdd
BLAST
Topological domaini199 – 2068ExtracellularSequence Analysis
Transmembranei207 – 22721HelicalSequence AnalysisAdd
BLAST
Topological domaini228 – 2358CytoplasmicSequence Analysis
Transmembranei236 – 25621HelicalSequence AnalysisAdd
BLAST
Topological domaini257 – 2648ExtracellularSequence Analysis
Transmembranei265 – 28521HelicalSequence AnalysisAdd
BLAST
Topological domaini286 – 32843CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei329 – 34921HelicalSequence AnalysisAdd
BLAST
Topological domaini350 – 36213ExtracellularSequence AnalysisAdd
BLAST
Transmembranei363 – 38321HelicalSequence AnalysisAdd
BLAST
Topological domaini384 – 3929CytoplasmicSequence Analysis
Transmembranei393 – 41321HelicalSequence AnalysisAdd
BLAST
Topological domaini414 – 4152ExtracellularSequence Analysis
Transmembranei416 – 43621HelicalSequence AnalysisAdd
BLAST
Topological domaini437 – 45317CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei454 – 47421HelicalSequence AnalysisAdd
BLAST
Topological domaini475 – 4839ExtracellularSequence Analysis
Transmembranei484 – 50421HelicalSequence AnalysisAdd
BLAST
Topological domaini505 – 54541CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 545544Monocarboxylate transporter 8PRO_0000211402Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiO70324.
PaxDbiO70324.
PRIDEiO70324.

PTM databases

PhosphoSiteiO70324.

Expressioni

Tissue specificityi

Highly expressed in liver and kidney.

Gene expression databases

BgeeiO70324.
ExpressionAtlasiO70324. baseline and differential.
GenevestigatoriO70324.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO70324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati29 – 50221Add
BLAST
Repeati51 – 72222Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni29 – 72442 X 22 AA approximate tandem repeatsAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG321880.
HOGENOMiHOG000046644.
HOVERGENiHBG006387.
InParanoidiO70324.
KOiK08231.
OMAiIKQTWVL.
OrthoDBiEOG7KWSH8.
PhylomeDBiO70324.
TreeFamiTF313792.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70324-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALPSPASEE AEGPCQEANQ EYQEPVCSPV PEPEPEPEPE PEPDPEPVPV
60 70 80 90 100
PPPEPQPEPE PQPLPDPAPL PELGFEAEPV QEPEPTPTVE TRGTARGFQP
110 120 130 140 150
PEGGFGWIVV FAATWCNGSI FGIHNSVGIL YSMLLEEEKE KNRQVEFQAA
160 170 180 190 200
WVGALAMGMI FFCSPIVSIF TDRLGCRITA TTGAAVAFIG LHTSSFTSSL
210 220 230 240 250
SLRYFTYGIL FGCGCSFAFQ PSLVILGHYF QRRLGLANGV VSAGSSIFSM
260 270 280 290 300
SFPFLIKMLG DKIKLAQTFQ VLSTFMFVLT LLSLTYRPLL PSSQDTPSKR
310 320 330 340 350
GAHTLRQRFL VQFRKYFNMR VFRQRTYRIW AFGIAAAALG YFVPYVHLMK
360 370 380 390 400
YVEDKFKEIK ETWVLLVCIG ATSGLGRLVS GHISDSIPGL KKIYLQVLSF
410 420 430 440 450
LLLGLMSMMI PLCRDFGGLI VVCLFLGLCD GFFITIMAPI AFELVGPMQA
460 470 480 490 500
SQAIGYLLGM MALPMIAGPP IAGLLRNCFG DYHVAFYFAG VPPIIGAVIL
510 520 530 540
FFVPLMHQRM FKKEQRDSSK DKMLSHDPDP NGELLPGSPT PEEPI
Length:545
Mass (Da):60,025
Last modified:September 5, 2006 - v2
Checksum:iACCC7EC6B902A6DE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti62 – 621Q → QPLPDPAPLPELGFEAEPEP Q(PubMed:9545634)Curated
Sequence conflicti227 – 2271G → D in AAC40078. (PubMed:9545634)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045692 mRNA. Translation: AAC40078.1.
AJ421478 Genomic DNA. Translation: CAD33931.1.
BC080678 mRNA. Translation: AAH80678.1.
CCDSiCCDS30330.1.
RefSeqiNP_033223.2. NM_009197.2.
UniGeneiMm.388973.

Genome annotation databases

EnsembliENSMUST00000042664; ENSMUSP00000037629; ENSMUSG00000033965.
GeneIDi20502.
KEGGimmu:20502.
UCSCiuc009tzy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045692 mRNA. Translation: AAC40078.1 .
AJ421478 Genomic DNA. Translation: CAD33931.1 .
BC080678 mRNA. Translation: AAH80678.1 .
CCDSi CCDS30330.1.
RefSeqi NP_033223.2. NM_009197.2.
UniGenei Mm.388973.

3D structure databases

ProteinModelPortali O70324.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

TCDBi 2.A.1.13.3. the major facilitator superfamily (mfs).

PTM databases

PhosphoSitei O70324.

Proteomic databases

MaxQBi O70324.
PaxDbi O70324.
PRIDEi O70324.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000042664 ; ENSMUSP00000037629 ; ENSMUSG00000033965 .
GeneIDi 20502.
KEGGi mmu:20502.
UCSCi uc009tzy.1. mouse.

Organism-specific databases

CTDi 6567.
MGIi MGI:1203732. Slc16a2.

Phylogenomic databases

eggNOGi NOG321880.
HOGENOMi HOG000046644.
HOVERGENi HBG006387.
InParanoidi O70324.
KOi K08231.
OMAi IKQTWVL.
OrthoDBi EOG7KWSH8.
PhylomeDBi O70324.
TreeFami TF313792.

Miscellaneous databases

ChiTaRSi Slc16a2. mouse.
NextBioi 298675.
PROi O70324.
SOURCEi Search...

Gene expression databases

Bgeei O70324.
ExpressionAtlasi O70324. baseline and differential.
Genevestigatori O70324.

Family and domain databases

InterProi IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view ]
Pfami PF07690. MFS_1. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and localization of the murine Xpct gene: evidence for complex rearrangements during the evolution of the region around the Xist gene."
    Debrand E., Heard E., Avner P.
    Genomics 48:296-303(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Liver.
  2. "Comparative sequence analysis of the X-inactivation center region in mouse, human and bovine."
    Chureau C., Prissette M., Bourdet A., Barbe V., Cattolico L., Jones L., Eggen A., Avner P., Duret L.
    Genome Res. 12:894-908(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiMOT8_MOUSE
AccessioniPrimary (citable) accession number: O70324
Secondary accession number(s): Q8K3S9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: September 5, 2006
Last modified: November 26, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3