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O70324

- MOT8_MOUSE

UniProt

O70324 - MOT8_MOUSE

Protein

Monocarboxylate transporter 8

Gene

Slc16a2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr By similarity.By similarity

    GO - Molecular functioni

    1. symporter activity Source: UniProtKB-KW

    Keywords - Biological processi

    Symport, Transport

    Protein family/group databases

    TCDBi2.A.1.13.3. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Monocarboxylate transporter 8
    Short name:
    MCT 8
    Alternative name(s):
    Solute carrier family 16 member 2
    X-linked PEST-containing transporter
    Gene namesi
    Name:Slc16a2
    Synonyms:Mct8, Xpct
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1203732. Slc16a2.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 545544Monocarboxylate transporter 8PRO_0000211402Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiO70324.
    PaxDbiO70324.
    PRIDEiO70324.

    PTM databases

    PhosphoSiteiO70324.

    Expressioni

    Tissue specificityi

    Highly expressed in liver and kidney.

    Gene expression databases

    ArrayExpressiO70324.
    BgeeiO70324.
    GenevestigatoriO70324.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliO70324.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 102101CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini124 – 14926ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini171 – 1777CytoplasmicSequence Analysis
    Topological domaini199 – 2068ExtracellularSequence Analysis
    Topological domaini228 – 2358CytoplasmicSequence Analysis
    Topological domaini257 – 2648ExtracellularSequence Analysis
    Topological domaini286 – 32843CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini350 – 36213ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini384 – 3929CytoplasmicSequence Analysis
    Topological domaini414 – 4152ExtracellularSequence Analysis
    Topological domaini437 – 45317CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini475 – 4839ExtracellularSequence Analysis
    Topological domaini505 – 54541CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei103 – 12321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei150 – 17021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei178 – 19821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei207 – 22721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei236 – 25621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei265 – 28521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei329 – 34921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei363 – 38321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei393 – 41321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei416 – 43621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei454 – 47421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei484 – 50421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati29 – 50221Add
    BLAST
    Repeati51 – 72222Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni29 – 72442 X 22 AA approximate tandem repeatsAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG321880.
    HOGENOMiHOG000046644.
    HOVERGENiHBG006387.
    InParanoidiO70324.
    KOiK08231.
    OMAiIKQTWVL.
    OrthoDBiEOG7KWSH8.
    PhylomeDBiO70324.
    TreeFamiTF313792.

    Family and domain databases

    InterProiIPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view]
    PfamiPF07690. MFS_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O70324-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALPSPASEE AEGPCQEANQ EYQEPVCSPV PEPEPEPEPE PEPDPEPVPV    50
    PPPEPQPEPE PQPLPDPAPL PELGFEAEPV QEPEPTPTVE TRGTARGFQP 100
    PEGGFGWIVV FAATWCNGSI FGIHNSVGIL YSMLLEEEKE KNRQVEFQAA 150
    WVGALAMGMI FFCSPIVSIF TDRLGCRITA TTGAAVAFIG LHTSSFTSSL 200
    SLRYFTYGIL FGCGCSFAFQ PSLVILGHYF QRRLGLANGV VSAGSSIFSM 250
    SFPFLIKMLG DKIKLAQTFQ VLSTFMFVLT LLSLTYRPLL PSSQDTPSKR 300
    GAHTLRQRFL VQFRKYFNMR VFRQRTYRIW AFGIAAAALG YFVPYVHLMK 350
    YVEDKFKEIK ETWVLLVCIG ATSGLGRLVS GHISDSIPGL KKIYLQVLSF 400
    LLLGLMSMMI PLCRDFGGLI VVCLFLGLCD GFFITIMAPI AFELVGPMQA 450
    SQAIGYLLGM MALPMIAGPP IAGLLRNCFG DYHVAFYFAG VPPIIGAVIL 500
    FFVPLMHQRM FKKEQRDSSK DKMLSHDPDP NGELLPGSPT PEEPI 545
    Length:545
    Mass (Da):60,025
    Last modified:September 5, 2006 - v2
    Checksum:iACCC7EC6B902A6DE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti62 – 621Q → QPLPDPAPLPELGFEAEPEP Q(PubMed:9545634)Curated
    Sequence conflicti227 – 2271G → D in AAC40078. (PubMed:9545634)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF045692 mRNA. Translation: AAC40078.1.
    AJ421478 Genomic DNA. Translation: CAD33931.1.
    BC080678 mRNA. Translation: AAH80678.1.
    CCDSiCCDS30330.1.
    RefSeqiNP_033223.2. NM_009197.2.
    UniGeneiMm.388973.

    Genome annotation databases

    EnsembliENSMUST00000042664; ENSMUSP00000037629; ENSMUSG00000033965.
    GeneIDi20502.
    KEGGimmu:20502.
    UCSCiuc009tzy.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF045692 mRNA. Translation: AAC40078.1 .
    AJ421478 Genomic DNA. Translation: CAD33931.1 .
    BC080678 mRNA. Translation: AAH80678.1 .
    CCDSi CCDS30330.1.
    RefSeqi NP_033223.2. NM_009197.2.
    UniGenei Mm.388973.

    3D structure databases

    ProteinModelPortali O70324.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    TCDBi 2.A.1.13.3. the major facilitator superfamily (mfs).

    PTM databases

    PhosphoSitei O70324.

    Proteomic databases

    MaxQBi O70324.
    PaxDbi O70324.
    PRIDEi O70324.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000042664 ; ENSMUSP00000037629 ; ENSMUSG00000033965 .
    GeneIDi 20502.
    KEGGi mmu:20502.
    UCSCi uc009tzy.1. mouse.

    Organism-specific databases

    CTDi 6567.
    MGIi MGI:1203732. Slc16a2.

    Phylogenomic databases

    eggNOGi NOG321880.
    HOGENOMi HOG000046644.
    HOVERGENi HBG006387.
    InParanoidi O70324.
    KOi K08231.
    OMAi IKQTWVL.
    OrthoDBi EOG7KWSH8.
    PhylomeDBi O70324.
    TreeFami TF313792.

    Miscellaneous databases

    ChiTaRSi SLC16A2. mouse.
    NextBioi 298675.
    PROi O70324.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O70324.
    Bgeei O70324.
    Genevestigatori O70324.

    Family and domain databases

    InterProi IPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view ]
    Pfami PF07690. MFS_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and localization of the murine Xpct gene: evidence for complex rearrangements during the evolution of the region around the Xist gene."
      Debrand E., Heard E., Avner P.
      Genomics 48:296-303(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Liver.
    2. "Comparative sequence analysis of the X-inactivation center region in mouse, human and bovine."
      Chureau C., Prissette M., Bourdet A., Barbe V., Cattolico L., Jones L., Eggen A., Avner P., Duret L.
      Genome Res. 12:894-908(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Olfactory epithelium.

    Entry informationi

    Entry nameiMOT8_MOUSE
    AccessioniPrimary (citable) accession number: O70324
    Secondary accession number(s): Q8K3S9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3