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Protein

Band 4.1-like protein 2

Gene

Epb41l2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase.By similarity

GO - Molecular functioni

  • actin binding Source: MGI
  • PH domain binding Source: MGI
  • spectrin binding Source: MGI
  • structural constituent of cytoskeleton Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionActin-binding
Biological processCell cycle, Cell division, Mitosis, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6794361 Neurexins and neuroligins

Names & Taxonomyi

Protein namesi
Recommended name:
Band 4.1-like protein 2
Alternative name(s):
Generally expressed protein 4.1
Short name:
4.1G
Gene namesi
Name:Epb41l2
Synonyms:Epb4.1l2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:103009 Epb41l2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002193982 – 988Band 4.1-like protein 2Add BLAST987

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineBy similarity1
Modified residuei7PhosphoserineBy similarity1
Modified residuei38PhosphoserineCombined sources1
Modified residuei86PhosphoserineCombined sources1
Modified residuei116PhosphoserineCombined sources1
Modified residuei201PhosphoserineCombined sources1
Modified residuei379PhosphoserineBy similarity1
Modified residuei395PhosphoserineCombined sources1
Modified residuei492PhosphoserineBy similarity1
Modified residuei543PhosphoserineCombined sources1
Modified residuei555PhosphoserineCombined sources1
Modified residuei561PhosphoserineCombined sources1
Modified residuei582PhosphoserineCombined sources1
Modified residuei606PhosphotyrosineCombined sources1
Modified residuei610PhosphoserineCombined sources1
Modified residuei630PhosphoserineCombined sources1
Modified residuei698PhosphoserineCombined sources1
Modified residuei745PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO70318
MaxQBiO70318
PaxDbiO70318
PeptideAtlasiO70318
PRIDEiO70318

PTM databases

iPTMnetiO70318
PhosphoSitePlusiO70318
SwissPalmiO70318

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSMUSG00000019978
CleanExiMM_EPB4.1L2
ExpressionAtlasiO70318 baseline and differential
GenevisibleiO70318 MM

Interactioni

Subunit structurei

Interacts with FCGR1A. Interacts with TRPC4 (By similarity). Interacts (via CTD domain) with FKBP2 (PubMed:9531554). Interacts with NUMA1; this interaction is negatively regulated by CDK1 during metaphase and promotes anaphase-specific localization of NUMA1 in symmetrically dividing cells (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Mpp6Q9JLB03EBI-643339,EBI-771456

GO - Molecular functioni

  • actin binding Source: MGI
  • PH domain binding Source: MGI
  • spectrin binding Source: MGI

Protein-protein interaction databases

BioGridi199460, 5 interactors
IntActiO70318, 8 interactors
MINTiO70318
STRINGi10090.ENSMUSP00000055122

Structurei

3D structure databases

ProteinModelPortaliO70318
SMRiO70318
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini211 – 492FERMPROSITE-ProRule annotationAdd BLAST282

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni495 – 651HydrophilicAdd BLAST157
Regioni652 – 837Spectrin--actin-bindingAdd BLAST186
Regioni838 – 988C-terminal (CTD)Add BLAST151

Phylogenomic databases

eggNOGiKOG3527 Eukaryota
ENOG410Y7NQ LUCA
GeneTreeiENSGT00760000118823
HOGENOMiHOG000228841
HOVERGENiHBG007777
InParanoidiO70318
KOiK06107
OMAiISEFQFA
OrthoDBiEOG091G00IL
TreeFamiTF351626

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR008379 Band_4.1_C
IPR019749 Band_41_domain
IPR030546 E41L2
IPR000798 Ez/rad/moesin-like
IPR014847 FERM-adjacent
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR011993 PH-like_dom_sf
IPR007477 SAB_dom
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR23280:SF17 PTHR23280:SF17, 2 hits
PfamiView protein in Pfam
PF05902 4_1_CTD, 1 hit
PF08736 FA, 1 hit
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PF04382 SAB, 1 hit
PRINTSiPR00935 BAND41
PR00661 ERMFAMILY
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01195 FA, 1 hit
SM01196 FERM_C, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00660 FERM_1, 1 hit
PS00661 FERM_2, 1 hit
PS50057 FERM_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70318-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTEVGSASE VKKGSDQAGA DASKEKAKEV ENEQTPVSEP EEEKGSQPGP
60 70 80 90 100
PVERQSTPRL RKRGKDPSEN RGISRFIPPW LKKQRSYNLV VAKDGGDKKE
110 120 130 140 150
PTQADVEDQI LGKEESLPEE ESRAKGDAEE MAQRKHLEVQ VEVREAKPAL
160 170 180 190 200
KSSVETQPAE EVRKDKEETI QDTQEEKLEG GAAKRETKEV QTSELKAEVA
210 220 230 240 250
SQKATKKTKT VLAKVTLLDG TEYSCDLEKR AKGQVLFDRV CEHLNLLEKD
260 270 280 290 300
YFGLLFQDHP EQKNWLDPAK EIKRQLKNLP WLFTFNVKFY PPDPSQLTED
310 320 330 340 350
ITRYFLCLQL RQDIASGRLP CSFVTHALLG SYTLQAEHGD YDPEEYDSID
360 370 380 390 400
LGDFQFAPAH TKELEEKVSE LHKTHRGLSP AQADSQFLEN AKRLSMYGVD
410 420 430 440 450
LHHAKDSEGV DIKLGVCANG LLIYKDRLRI NRFAWPKILK ISYKRSNFYI
460 470 480 490 500
KVRPAELEQF ESTIGFKLPN HRAAKRLWKV CVEHHTFYRL VSPEQPPKTK
510 520 530 540 550
FLTLGSKFRY SGRTQAQTRE ASTLIDRPAP QFERASSKRV SRSLDGAPIG
560 570 580 590 600
VVDQSPPGEG SVPGPGVISY TTIQDGRRDS KSPTKATPLP AEGKKNTLRV
610 620 630 640 650
DGDNIYVRHS NLMLEDLDKA QEAILKHQAS ISELKRNFMA STPEPRPSEW
660 670 680 690 700
EKRRVTPLPF QPQASSHETL NVVEEKKRAE VGKDESVITE EMNGKEMSPG
710 720 730 740 750
HGPGETRKVE PVAHKDSTSL SSESSSSSSE SEEDVGEYQP HHRVTEGTIR
760 770 780 790 800
EEQEECDEEL EEEPGQGAKV VEREAAVPDA VPDRQAGASV LPVETEAQEH
810 820 830 840 850
VVAQKLPGEK GAHGGTAEQD PREEAEEDPH RVNGEVPHLD LDGLPEIICC
860 870 880 890 900
SEPPVVKTEM VTISDASQRT EISTKEVPIV QTETKTITYE SPQIDGGAGG
910 920 930 940 950
DSGVLLTAQT ITSESASTTT TTHITKTVKG GISETRIEKR IVITGDAALD
960 970 980
HDQALAQAIR EAREQHPDMS VTRVVVHKET ELAEEGEE
Length:988
Mass (Da):109,940
Last modified:October 3, 2012 - v2
Checksum:iD3DA78BFA14E3FBB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti660F → L in AAC40083 (PubMed:9531554).Curated1
Sequence conflicti680E → G in AAC40083 (PubMed:9531554).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044312 mRNA Translation: AAC40083.1
AC153547 Genomic DNA No translation available.
AC153550 Genomic DNA No translation available.
AC156274 Genomic DNA No translation available.
CH466540 Genomic DNA Translation: EDL04798.1
CCDSiCCDS23754.1
RefSeqiNP_001186194.1, NM_001199265.1
NP_038539.2, NM_013511.3
UniGeneiMm.306026

Genome annotation databases

EnsembliENSMUST00000053748; ENSMUSP00000055122; ENSMUSG00000019978
ENSMUST00000092645; ENSMUSP00000090314; ENSMUSG00000019978
GeneIDi13822
KEGGimmu:13822
UCSCiuc007erk.2 mouse

Similar proteinsi

Entry informationi

Entry nameiE41L2_MOUSE
AccessioniPrimary (citable) accession number: O70318
Secondary accession number(s): G3X9B8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: October 3, 2012
Last modified: May 23, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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