UniProtKB - O70318 (E41L2_MOUSE)
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Protein
Band 4.1-like protein 2
Gene
Epb41l2
Organism
Mus musculus (Mouse)
Status
Functioni
Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase.By similarity
GO - Molecular functioni
- actin binding Source: MGI
- PH domain binding Source: MGI
- spectrin binding Source: MGI
- structural constituent of cytoskeleton Source: GO_Central
GO - Biological processi
- actin cytoskeleton organization Source: MGI
- actomyosin structure organization Source: GO_Central
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
- cortical actin cytoskeleton organization Source: InterPro
- positive regulation of protein localization to cell cortex Source: UniProtKB
- regulation of cell shape Source: MGI
Keywordsi
Molecular function | Actin-binding |
Biological process | Cell cycle, Cell division, Mitosis, Transport |
Enzyme and pathway databases
Reactomei | R-MMU-6794361 Neurexins and neuroligins |
Names & Taxonomyi
Protein namesi | Recommended name: Band 4.1-like protein 2Alternative name(s): Generally expressed protein 4.1 Short name: 4.1G |
Gene namesi | Name:Epb41l2 Synonyms:Epb4.1l2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:103009 Epb41l2 |
Subcellular locationi
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Cytoskeleton, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000219398 | 2 – 988 | Band 4.1-like protein 2Add BLAST | 987 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylthreonineBy similarity | 1 | |
Modified residuei | 7 | PhosphoserineBy similarity | 1 | |
Modified residuei | 38 | PhosphoserineCombined sources | 1 | |
Modified residuei | 86 | PhosphoserineCombined sources | 1 | |
Modified residuei | 116 | PhosphoserineCombined sources | 1 | |
Modified residuei | 201 | PhosphoserineCombined sources | 1 | |
Modified residuei | 379 | PhosphoserineBy similarity | 1 | |
Modified residuei | 395 | PhosphoserineCombined sources | 1 | |
Modified residuei | 492 | PhosphoserineBy similarity | 1 | |
Modified residuei | 543 | PhosphoserineCombined sources | 1 | |
Modified residuei | 555 | PhosphoserineCombined sources | 1 | |
Modified residuei | 561 | PhosphoserineCombined sources | 1 | |
Modified residuei | 582 | PhosphoserineCombined sources | 1 | |
Modified residuei | 606 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 610 | PhosphoserineCombined sources | 1 | |
Modified residuei | 630 | PhosphoserineCombined sources | 1 | |
Modified residuei | 698 | PhosphoserineCombined sources | 1 | |
Modified residuei | 745 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | O70318 |
MaxQBi | O70318 |
PaxDbi | O70318 |
PeptideAtlasi | O70318 |
PRIDEi | O70318 |
PTM databases
iPTMneti | O70318 |
PhosphoSitePlusi | O70318 |
SwissPalmi | O70318 |
Expressioni
Tissue specificityi
Widely expressed.
Gene expression databases
Bgeei | ENSMUSG00000019978 |
CleanExi | MM_EPB4.1L2 |
ExpressionAtlasi | O70318 baseline and differential |
Genevisiblei | O70318 MM |
Interactioni
Subunit structurei
Interacts with FCGR1A. Interacts with TRPC4 (By similarity). Interacts (via CTD domain) with FKBP2 (PubMed:9531554). Interacts with NUMA1; this interaction is negatively regulated by CDK1 during metaphase and promotes anaphase-specific localization of NUMA1 in symmetrically dividing cells (By similarity).By similarity1 Publication
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
Mpp6 | Q9JLB0 | 3 | EBI-643339,EBI-771456 |
GO - Molecular functioni
- actin binding Source: MGI
- PH domain binding Source: MGI
- spectrin binding Source: MGI
Protein-protein interaction databases
BioGridi | 1994605 interactors. |
IntActi | O70318 7 interactors. |
MINTi | O70318 |
STRINGi | 10090.ENSMUSP00000055122 |
Structurei
3D structure databases
ProteinModelPortali | O70318 |
SMRi | O70318 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 211 – 492 | FERMPROSITE-ProRule annotationAdd BLAST | 282 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 495 – 651 | HydrophilicAdd BLAST | 157 | |
Regioni | 652 – 837 | Spectrin--actin-bindingAdd BLAST | 186 | |
Regioni | 838 – 988 | C-terminal (CTD)Add BLAST | 151 |
Phylogenomic databases
eggNOGi | KOG3527 Eukaryota ENOG410Y7NQ LUCA |
GeneTreei | ENSGT00760000118823 |
HOGENOMi | HOG000228841 |
HOVERGENi | HBG007777 |
InParanoidi | O70318 |
KOi | K06107 |
OMAi | ISEFQFA |
OrthoDBi | EOG091G00IL |
TreeFami | TF351626 |
Family and domain databases
CDDi | cd14473 FERM_B-lobe, 1 hit |
Gene3Di | 1.20.80.101 hit 2.30.29.301 hit |
InterProi | View protein in InterPro IPR008379 Band_4.1_C IPR019749 Band_41_domain IPR030546 E41L2 IPR000798 Ez/rad/moesin-like IPR014847 FERM-adjacent IPR014352 FERM/acyl-CoA-bd_prot_sf IPR035963 FERM_2 IPR019748 FERM_central IPR019747 FERM_CS IPR000299 FERM_domain IPR018979 FERM_N IPR018980 FERM_PH-like_C IPR011993 PH-like_dom_sf IPR007477 SAB_dom IPR029071 Ubiquitin-like_domsf |
PANTHERi | PTHR23280:SF17 PTHR23280:SF17, 2 hits |
Pfami | View protein in Pfam PF05902 4_1_CTD, 1 hit PF08736 FA, 1 hit PF09380 FERM_C, 1 hit PF00373 FERM_M, 1 hit PF09379 FERM_N, 1 hit PF04382 SAB, 1 hit |
PRINTSi | PR00935 BAND41 PR00661 ERMFAMILY |
SMARTi | View protein in SMART SM00295 B41, 1 hit SM01195 FA, 1 hit SM01196 FERM_C, 1 hit |
SUPFAMi | SSF47031 SSF47031, 1 hit SSF54236 SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS00660 FERM_1, 1 hit PS00661 FERM_2, 1 hit PS50057 FERM_3, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
O70318-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTTEVGSASE VKKGSDQAGA DASKEKAKEV ENEQTPVSEP EEEKGSQPGP
60 70 80 90 100
PVERQSTPRL RKRGKDPSEN RGISRFIPPW LKKQRSYNLV VAKDGGDKKE
110 120 130 140 150
PTQADVEDQI LGKEESLPEE ESRAKGDAEE MAQRKHLEVQ VEVREAKPAL
160 170 180 190 200
KSSVETQPAE EVRKDKEETI QDTQEEKLEG GAAKRETKEV QTSELKAEVA
210 220 230 240 250
SQKATKKTKT VLAKVTLLDG TEYSCDLEKR AKGQVLFDRV CEHLNLLEKD
260 270 280 290 300
YFGLLFQDHP EQKNWLDPAK EIKRQLKNLP WLFTFNVKFY PPDPSQLTED
310 320 330 340 350
ITRYFLCLQL RQDIASGRLP CSFVTHALLG SYTLQAEHGD YDPEEYDSID
360 370 380 390 400
LGDFQFAPAH TKELEEKVSE LHKTHRGLSP AQADSQFLEN AKRLSMYGVD
410 420 430 440 450
LHHAKDSEGV DIKLGVCANG LLIYKDRLRI NRFAWPKILK ISYKRSNFYI
460 470 480 490 500
KVRPAELEQF ESTIGFKLPN HRAAKRLWKV CVEHHTFYRL VSPEQPPKTK
510 520 530 540 550
FLTLGSKFRY SGRTQAQTRE ASTLIDRPAP QFERASSKRV SRSLDGAPIG
560 570 580 590 600
VVDQSPPGEG SVPGPGVISY TTIQDGRRDS KSPTKATPLP AEGKKNTLRV
610 620 630 640 650
DGDNIYVRHS NLMLEDLDKA QEAILKHQAS ISELKRNFMA STPEPRPSEW
660 670 680 690 700
EKRRVTPLPF QPQASSHETL NVVEEKKRAE VGKDESVITE EMNGKEMSPG
710 720 730 740 750
HGPGETRKVE PVAHKDSTSL SSESSSSSSE SEEDVGEYQP HHRVTEGTIR
760 770 780 790 800
EEQEECDEEL EEEPGQGAKV VEREAAVPDA VPDRQAGASV LPVETEAQEH
810 820 830 840 850
VVAQKLPGEK GAHGGTAEQD PREEAEEDPH RVNGEVPHLD LDGLPEIICC
860 870 880 890 900
SEPPVVKTEM VTISDASQRT EISTKEVPIV QTETKTITYE SPQIDGGAGG
910 920 930 940 950
DSGVLLTAQT ITSESASTTT TTHITKTVKG GISETRIEKR IVITGDAALD
960 970 980
HDQALAQAIR EAREQHPDMS VTRVVVHKET ELAEEGEE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 660 | F → L in AAC40083 (PubMed:9531554).Curated | 1 | |
Sequence conflicti | 680 | E → G in AAC40083 (PubMed:9531554).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF044312 mRNA Translation: AAC40083.1 AC153547 Genomic DNA No translation available. AC153550 Genomic DNA No translation available. AC156274 Genomic DNA No translation available. CH466540 Genomic DNA Translation: EDL04798.1 |
CCDSi | CCDS23754.1 |
RefSeqi | NP_001186194.1, NM_001199265.1 NP_038539.2, NM_013511.3 |
UniGenei | Mm.306026 |
Genome annotation databases
Ensembli | ENSMUST00000053748; ENSMUSP00000055122; ENSMUSG00000019978 ENSMUST00000092645; ENSMUSP00000090314; ENSMUSG00000019978 |
GeneIDi | 13822 |
KEGGi | mmu:13822 |
UCSCi | uc007erk.2 mouse |
Similar proteinsi
Entry informationi
Entry namei | E41L2_MOUSE | |
Accessioni | O70318Primary (citable) accession number: O70318 Secondary accession number(s): G3X9B8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 5, 2001 |
Last sequence update: | October 3, 2012 | |
Last modified: | March 28, 2018 | |
This is version 152 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |