Epb41l2

Functionⁱ

Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase.By similarity

GO - Molecular functionⁱ

actin binding
Source: MGI
Inferred from sequence or structural similarityⁱ
- 11274145
PH domain binding
Source: MGI
Inferred from direct assayⁱ
- 18796539
spectrin binding
Source: MGI
Inferred from direct assayⁱ
- 18796539
structural constituent of cytoskeleton Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin cytoskeleton organization
Source: MGI
Inferred from sequence or structural similarityⁱ
- 11274145
actomyosin structure organization Source: GO_Central
cell cycle Source: UniProtKB-KW
cell division Source: UniProtKB-KW
cortical actin cytoskeleton organization Source: InterPro
positive regulation of protein localization to cell cortex Source: UniProtKB
regulation of cell shape
Source: MGI
Inferred from sequence or structural similarityⁱ
- 11274145

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Actin-binding
Biological process	Cell cycle, Cell division, Mitosis, Transport

Enzyme and pathway databases

Reactomeⁱ	R-MMU-6794361 Neurexins and neuroligins

Reactomeⁱ

R-MMU-6794361 Neurexins and neuroligins

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Band 4.1-like protein 2 Alternative name(s): Generally expressed protein 4.1 Short name: 4.1G
Gene namesⁱ	Name:Epb41l2 Synonyms:Epb4.1l2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 10

Organism-specific databases

MGIⁱ	MGI:103009 Epb41l2

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000219398	2 – 988	Band 4.1-like protein 2Add BLAST		987

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylthreonineBy similarity	1
Modified residueⁱ	7	PhosphoserineBy similarity	1
Modified residueⁱ	38	PhosphoserineCombined sources	1
Modified residueⁱ	86	PhosphoserineCombined sources	1
Modified residueⁱ	116	PhosphoserineCombined sources	1
Modified residueⁱ	201	PhosphoserineCombined sources	1
Modified residueⁱ	379	PhosphoserineBy similarity	1
Modified residueⁱ	395	PhosphoserineCombined sources	1
Modified residueⁱ	492	PhosphoserineBy similarity	1
Modified residueⁱ	543	PhosphoserineCombined sources	1
Modified residueⁱ	555	PhosphoserineCombined sources	1
Modified residueⁱ	561	PhosphoserineCombined sources	1
Modified residueⁱ	582	PhosphoserineCombined sources	1
Modified residueⁱ	606	PhosphotyrosineCombined sources	1
Modified residueⁱ	610	PhosphoserineCombined sources	1
Modified residueⁱ	630	PhosphoserineCombined sources	1
Modified residueⁱ	698	PhosphoserineCombined sources	1
Modified residueⁱ	745	PhosphothreonineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	O70318
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O70318
PaxDbⁱ	O70318
PeptideAtlas More...PeptideAtlasⁱ	O70318
PRIDEⁱ	O70318

PTM databases

iPTMnetⁱ	O70318
PhosphoSitePlusⁱ	O70318
SwissPalmⁱ	O70318

Expressionⁱ

Tissue specificityⁱ

Widely expressed.

Gene expression databases

Bgeeⁱ	ENSMUSG00000019978
CleanExⁱ	MM_EPB4.1L2
ExpressionAtlasⁱ	O70318 baseline and differential
Genevisibleⁱ	O70318 MM

Interactionⁱ

Subunit structureⁱ

Interacts with FCGR1A. Interacts with TRPC4 (By similarity). Interacts (via CTD domain) with FKBP2 (PubMed:9531554). Interacts with NUMA1; this interaction is negatively regulated by CDK1 during metaphase and promotes anaphase-specific localization of NUMA1 in symmetrically dividing cells (By similarity).By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Mpp6	Q9JLB0	3	EBI-643339,EBI-771456

With

Entry

#Exp.

IntAct

Notes

Mpp6

Q9JLB0

3

EBI-643339,EBI-771456

GO - Molecular functionⁱ

actin binding
Source: MGI
Inferred from sequence or structural similarityⁱ
- 11274145
PH domain binding
Source: MGI
Inferred from direct assayⁱ
- 18796539
spectrin binding
Source: MGI
Inferred from direct assayⁱ
- 18796539

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	1994605 interactors.
IntActⁱ	O70318 7 interactors.
Molecular INTeraction database More...MINTⁱ	O70318
STRINGⁱ	10090.ENSMUSP00000055122

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O70318
SMRⁱ	O70318
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	211 – 492	FERMPROSITE-ProRule annotationAdd BLAST		282

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	495 – 651	HydrophilicAdd BLAST	157
Regionⁱ	652 – 837	Spectrin--actin-bindingAdd BLAST	186
Regionⁱ	838 – 988	C-terminal (CTD)Add BLAST	151

Phylogenomic databases

eggNOGⁱ	KOG3527 Eukaryota ENOG410Y7NQ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118823
HOGENOMⁱ	HOG000228841
HOVERGENⁱ	HBG007777
InParanoidⁱ	O70318
KEGG Orthology (KO) More...KOⁱ	K06107
OMAⁱ	ISEFQFA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00IL
TreeFamⁱ	TF351626

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd14473 FERM_B-lobe, 1 hit
Gene3Dⁱ	1.20.80.101 hit 2.30.29.301 hit
InterProⁱ	View protein in InterPro IPR008379 Band_4.1_C IPR019749 Band_41_domain IPR030546 E41L2 IPR000798 Ez/rad/moesin-like IPR014847 FERM-adjacent IPR014352 FERM/acyl-CoA-bd_prot_sf IPR035963 FERM_2 IPR019748 FERM_central IPR019747 FERM_CS IPR000299 FERM_domain IPR018979 FERM_N IPR018980 FERM_PH-like_C IPR011993 PH-like_dom_sf IPR007477 SAB_dom IPR029071 Ubiquitin-like_domsf
PANTHERⁱ	PTHR23280:SF17 PTHR23280:SF17, 2 hits
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05902 4_1_CTD, 1 hit PF08736 FA, 1 hit PF09380 FERM_C, 1 hit PF00373 FERM_M, 1 hit PF09379 FERM_N, 1 hit PF04382 SAB, 1 hit
PRINTSⁱ	PR00935 BAND41 PR00661 ERMFAMILY
SMARTⁱ	View protein in SMART SM00295 B41, 1 hit SM01195 FA, 1 hit SM01196 FERM_C, 1 hit
SUPFAMⁱ	SSF47031 SSF47031, 1 hit SSF54236 SSF54236, 1 hit
PROSITEⁱ	View protein in PROSITE PS00660 FERM_1, 1 hit PS00661 FERM_2, 1 hit PS50057 FERM_3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

O70318-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTTEVGSASE VKKGSDQAGA DASKEKAKEV ENEQTPVSEP EEEKGSQPGP 
        60         70         80         90        100
PVERQSTPRL RKRGKDPSEN RGISRFIPPW LKKQRSYNLV VAKDGGDKKE 
       110        120        130        140        150
PTQADVEDQI LGKEESLPEE ESRAKGDAEE MAQRKHLEVQ VEVREAKPAL 
       160        170        180        190        200
KSSVETQPAE EVRKDKEETI QDTQEEKLEG GAAKRETKEV QTSELKAEVA 
       210        220        230        240        250
SQKATKKTKT VLAKVTLLDG TEYSCDLEKR AKGQVLFDRV CEHLNLLEKD 
       260        270        280        290        300
YFGLLFQDHP EQKNWLDPAK EIKRQLKNLP WLFTFNVKFY PPDPSQLTED 
       310        320        330        340        350
ITRYFLCLQL RQDIASGRLP CSFVTHALLG SYTLQAEHGD YDPEEYDSID 
       360        370        380        390        400
LGDFQFAPAH TKELEEKVSE LHKTHRGLSP AQADSQFLEN AKRLSMYGVD 
       410        420        430        440        450
LHHAKDSEGV DIKLGVCANG LLIYKDRLRI NRFAWPKILK ISYKRSNFYI 
       460        470        480        490        500
KVRPAELEQF ESTIGFKLPN HRAAKRLWKV CVEHHTFYRL VSPEQPPKTK 
       510        520        530        540        550
FLTLGSKFRY SGRTQAQTRE ASTLIDRPAP QFERASSKRV SRSLDGAPIG 
       560        570        580        590        600
VVDQSPPGEG SVPGPGVISY TTIQDGRRDS KSPTKATPLP AEGKKNTLRV 
       610        620        630        640        650
DGDNIYVRHS NLMLEDLDKA QEAILKHQAS ISELKRNFMA STPEPRPSEW 
       660        670        680        690        700
EKRRVTPLPF QPQASSHETL NVVEEKKRAE VGKDESVITE EMNGKEMSPG 
       710        720        730        740        750
HGPGETRKVE PVAHKDSTSL SSESSSSSSE SEEDVGEYQP HHRVTEGTIR 
       760        770        780        790        800
EEQEECDEEL EEEPGQGAKV VEREAAVPDA VPDRQAGASV LPVETEAQEH 
       810        820        830        840        850
VVAQKLPGEK GAHGGTAEQD PREEAEEDPH RVNGEVPHLD LDGLPEIICC 
       860        870        880        890        900
SEPPVVKTEM VTISDASQRT EISTKEVPIV QTETKTITYE SPQIDGGAGG 
       910        920        930        940        950
DSGVLLTAQT ITSESASTTT TTHITKTVKG GISETRIEKR IVITGDAALD 
       960        970        980 
HDQALAQAIR EAREQHPDMS VTRVVVHKET ELAEEGEE

Length:988

Mass (Da):109,940

Last modified:October 3, 2012 - v2

Checksum:ⁱD3DA78BFA14E3FBB

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	660	F → L in AAC40083 (PubMed:9531554).Curated		1
Sequence conflictⁱ	680	E → G in AAC40083 (PubMed:9531554).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF044312 mRNA Translation: AAC40083.1 AC153547 Genomic DNA No translation available. AC153550 Genomic DNA No translation available. AC156274 Genomic DNA No translation available. CH466540 Genomic DNA Translation: EDL04798.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS23754.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001186194.1, NM_001199265.1 NP_038539.2, NM_013511.3
UniGeneⁱ	Mm.306026

Genome annotation databases

Ensemblⁱ	ENSMUST00000053748; ENSMUSP00000055122; ENSMUSG00000019978 ENSMUST00000092645; ENSMUSP00000090314; ENSMUSG00000019978
GeneIDⁱ	13822
KEGGⁱ	mmu:13822
UCSC genome browser More...UCSCⁱ	uc007erk.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
O70318	UPI0000353E61 D3ZM69 UPI0003D771F4 Q3UNQ6 B6ZHD0 Q80UE3	Mus musculus (Mouse) Rattus norvegicus (Rat)	988	UniRef90_O70318	Cluster: Band 4.1-like protein 2	7

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
O70318	O43491 UPI00048E408C UPI0004D0538B UPI000B545ECE G7MQD7 G7P362 H9F9A7 G3QZL4 A0A2J8PT92 H2QTQ8 +503	Homo sapiens (Human) Oryctolagus cuniculus (Rabbit) Galeopterus variegatus (Malayan flying lemur) (Cynocephalus variegatus) Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus) Macaca mulatta (Rhesus macaque) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Gorilla gorilla gorilla (Western lowland gorilla) Pan troglodytes (Chimpanzee) Cebus capucinus imitator Mandrillus leucophaeus (Drill) (Papio leucophaeus) And more	1,005	UniRef50_O43491	Cluster: Band 4.1-like protein 2	514

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF044312 mRNA Translation: AAC40083.1 AC153547 Genomic DNA No translation available. AC153550 Genomic DNA No translation available. AC156274 Genomic DNA No translation available. CH466540 Genomic DNA Translation: EDL04798.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS23754.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001186194.1, NM_001199265.1 NP_038539.2, NM_013511.3
UniGeneⁱ	Mm.306026

3D structure databases

ProteinModelPortalⁱ	O70318
SMRⁱ	O70318
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	1994605 interactors.
IntActⁱ	O70318 7 interactors.
Molecular INTeraction database More...MINTⁱ	O70318
STRINGⁱ	10090.ENSMUSP00000055122

PTM databases

iPTMnetⁱ	O70318
PhosphoSitePlusⁱ	O70318
SwissPalmⁱ	O70318

Proteomic databases

EPDⁱ	O70318
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O70318
PaxDbⁱ	O70318
PeptideAtlas More...PeptideAtlasⁱ	O70318
PRIDEⁱ	O70318

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000053748; ENSMUSP00000055122; ENSMUSG00000019978 ENSMUST00000092645; ENSMUSP00000090314; ENSMUSG00000019978
GeneIDⁱ	13822
KEGGⁱ	mmu:13822
UCSC genome browser More...UCSCⁱ	uc007erk.2 mouse

Organism-specific databases

CTDⁱ	2037
MGIⁱ	MGI:103009 Epb41l2

Phylogenomic databases

eggNOGⁱ	KOG3527 Eukaryota ENOG410Y7NQ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118823
HOGENOMⁱ	HOG000228841
HOVERGENⁱ	HBG007777
InParanoidⁱ	O70318
KEGG Orthology (KO) More...KOⁱ	K06107
OMAⁱ	ISEFQFA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00IL
TreeFamⁱ	TF351626

Enzyme and pathway databases

Reactomeⁱ	R-MMU-6794361 Neurexins and neuroligins

Reactomeⁱ

R-MMU-6794361 Neurexins and neuroligins

Miscellaneous databases

ChiTaRSⁱ	Epb41l2 mouse
Protein Ontology More...PROⁱ	PR:O70318
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000019978
CleanExⁱ	MM_EPB4.1L2
ExpressionAtlasⁱ	O70318 baseline and differential
Genevisibleⁱ	O70318 MM

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd14473 FERM_B-lobe, 1 hit
Gene3Dⁱ	1.20.80.101 hit 2.30.29.301 hit
InterProⁱ	View protein in InterPro IPR008379 Band_4.1_C IPR019749 Band_41_domain IPR030546 E41L2 IPR000798 Ez/rad/moesin-like IPR014847 FERM-adjacent IPR014352 FERM/acyl-CoA-bd_prot_sf IPR035963 FERM_2 IPR019748 FERM_central IPR019747 FERM_CS IPR000299 FERM_domain IPR018979 FERM_N IPR018980 FERM_PH-like_C IPR011993 PH-like_dom_sf IPR007477 SAB_dom IPR029071 Ubiquitin-like_domsf
PANTHERⁱ	PTHR23280:SF17 PTHR23280:SF17, 2 hits
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05902 4_1_CTD, 1 hit PF08736 FA, 1 hit PF09380 FERM_C, 1 hit PF00373 FERM_M, 1 hit PF09379 FERM_N, 1 hit PF04382 SAB, 1 hit
PRINTSⁱ	PR00935 BAND41 PR00661 ERMFAMILY
SMARTⁱ	View protein in SMART SM00295 B41, 1 hit SM01195 FA, 1 hit SM01196 FERM_C, 1 hit
SUPFAMⁱ	SSF47031 SSF47031, 1 hit SSF54236 SSF54236, 1 hit
PROSITEⁱ	View protein in PROSITE PS00660 FERM_1, 1 hit PS00661 FERM_2, 1 hit PS50057 FERM_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	E41L2_MOUSE
Accessionⁱ	O70318Primary (citable) accession number: O70318 Secondary accession number(s): G3X9B8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 5, 2001
	Last sequence update:	October 3, 2012
	Last modified:	March 28, 2018
	This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O70318 (E41L2_MOUSE)

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Band 4.1-like protein 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Cytoskeleton

Other locations

Cytoskeleton

Nucleus

Plasma Membrane

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ