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UniProtKB - O70318 (E41L2_MOUSE)

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Protein

Band 4.1-like protein 2

Gene

Epb41l2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase.By similarity

GO - Molecular functioni

  • actin binding Source: MGI
  • PH domain binding Source: MGI
  • spectrin binding Source: MGI
  • structural constituent of cytoskeleton Source: GO_Central
Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionActin-binding
Biological processCell cycle, Cell division, Mitosis, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6794361. Interactions of neurexins and neuroligins at synapses.

Names & Taxonomyi

Protein namesi
Recommended name:
Band 4.1-like protein 2
Alternative name(s):
Generally expressed protein 4.1
Short name:
4.1G
Gene namesi
Name:Epb41l2
Synonyms:Epb4.1l2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:103009. Epb41l2.

Subcellular locationi

  • Cytoplasm › cytoskeleton By similarity
  • Cytoplasm › cell cortex By similarity
  • Cell membrane By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002193982 – 988Band 4.1-like protein 2Add BLAST987

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineBy similarity1
Modified residuei7PhosphoserineBy similarity1
Modified residuei38PhosphoserineCombined sources1
Modified residuei86PhosphoserineCombined sources1
Modified residuei116PhosphoserineCombined sources1
Modified residuei201PhosphoserineCombined sources1
Modified residuei379PhosphoserineBy similarity1
Modified residuei395PhosphoserineCombined sources1
Modified residuei492PhosphoserineBy similarity1
Modified residuei543PhosphoserineCombined sources1
Modified residuei555PhosphoserineCombined sources1
Modified residuei561PhosphoserineCombined sources1
Modified residuei582PhosphoserineCombined sources1
Modified residuei606PhosphotyrosineCombined sources1
Modified residuei610PhosphoserineCombined sources1
Modified residuei630PhosphoserineCombined sources1
Modified residuei698PhosphoserineCombined sources1
Modified residuei745PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO70318.
MaxQBiO70318.
PaxDbiO70318.
PeptideAtlasiO70318.
PRIDEiO70318.

PTM databases

iPTMnetiO70318.
PhosphoSitePlusiO70318.
SwissPalmiO70318.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSMUSG00000019978.
CleanExiMM_EPB4.1L2.
ExpressionAtlasiO70318. baseline and differential.
GenevisibleiO70318. MM.

Interactioni

Subunit structurei

Interacts with FCGR1A. Interacts with TRPC4 (By similarity). Interacts (via CTD domain) with FKBP2 (PubMed:9531554). Interacts with NUMA1; this interaction is negatively regulated by CDK1 during metaphase and promotes anaphase-specific localization of NUMA1 in symmetrically dividing cells (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Mpp6Q9JLB03EBI-643339,EBI-771456

GO - Molecular functioni

  • actin binding Source: MGI
  • PH domain binding Source: MGI
  • spectrin binding Source: MGI
Complete GO annotation...

Protein-protein interaction databases

BioGridi199460. 4 interactors.
IntActiO70318. 6 interactors.
MINTiMINT-4093830.
STRINGi10090.ENSMUSP00000055122.

Structurei

3D structure databases

ProteinModelPortaliO70318.
SMRiO70318.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini211 – 492FERMPROSITE-ProRule annotationAdd BLAST282

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni495 – 651HydrophilicAdd BLAST157
Regioni652 – 837Spectrin--actin-bindingAdd BLAST186
Regioni838 – 988C-terminal (CTD)Add BLAST151

Phylogenomic databases

eggNOGiKOG3527. Eukaryota.
ENOG410Y7NQ. LUCA.
GeneTreeiENSGT00760000118823.
HOGENOMiHOG000228841.
HOVERGENiHBG007777.
InParanoidiO70318.
KOiK06107.
OMAiISEFQFA.
OrthoDBiEOG091G00IL.
TreeFamiTF351626.

Family and domain databases

CDDicd14473. FERM_B-lobe. 1 hit.
Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiView protein in InterPro
IPR008379. Band_4.1_C.
IPR019749. Band_41_domain.
IPR030546. E41L2.
IPR000798. Ez/rad/moesin-like.
IPR014847. FERM-adjacent.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_dom-like.
IPR007477. SAB_dom.
IPR029071. Ubiquitin-rel_dom.
PANTHERiPTHR23280:SF32. PTHR23280:SF32. 1 hit.
PfamiView protein in Pfam
PF05902. 4_1_CTD. 1 hit.
PF08736. FA. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF04382. SAB. 1 hit.
PRINTSiPR00935. BAND41.
PR00661. ERMFAMILY.
SMARTiView protein in SMART
SM00295. B41. 1 hit.
SM01195. FA. 1 hit.
SM01196. FERM_C. 1 hit.
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiView protein in PROSITE
PS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70318-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTEVGSASE VKKGSDQAGA DASKEKAKEV ENEQTPVSEP EEEKGSQPGP 
        60         70         80         90        100
PVERQSTPRL RKRGKDPSEN RGISRFIPPW LKKQRSYNLV VAKDGGDKKE 
       110        120        130        140        150
PTQADVEDQI LGKEESLPEE ESRAKGDAEE MAQRKHLEVQ VEVREAKPAL 
       160        170        180        190        200
KSSVETQPAE EVRKDKEETI QDTQEEKLEG GAAKRETKEV QTSELKAEVA 
       210        220        230        240        250
SQKATKKTKT VLAKVTLLDG TEYSCDLEKR AKGQVLFDRV CEHLNLLEKD 
       260        270        280        290        300
YFGLLFQDHP EQKNWLDPAK EIKRQLKNLP WLFTFNVKFY PPDPSQLTED 
       310        320        330        340        350
ITRYFLCLQL RQDIASGRLP CSFVTHALLG SYTLQAEHGD YDPEEYDSID 
       360        370        380        390        400
LGDFQFAPAH TKELEEKVSE LHKTHRGLSP AQADSQFLEN AKRLSMYGVD 
       410        420        430        440        450
LHHAKDSEGV DIKLGVCANG LLIYKDRLRI NRFAWPKILK ISYKRSNFYI 
       460        470        480        490        500
KVRPAELEQF ESTIGFKLPN HRAAKRLWKV CVEHHTFYRL VSPEQPPKTK 
       510        520        530        540        550
FLTLGSKFRY SGRTQAQTRE ASTLIDRPAP QFERASSKRV SRSLDGAPIG 
       560        570        580        590        600
VVDQSPPGEG SVPGPGVISY TTIQDGRRDS KSPTKATPLP AEGKKNTLRV 
       610        620        630        640        650
DGDNIYVRHS NLMLEDLDKA QEAILKHQAS ISELKRNFMA STPEPRPSEW 
       660        670        680        690        700
EKRRVTPLPF QPQASSHETL NVVEEKKRAE VGKDESVITE EMNGKEMSPG 
       710        720        730        740        750
HGPGETRKVE PVAHKDSTSL SSESSSSSSE SEEDVGEYQP HHRVTEGTIR 
       760        770        780        790        800
EEQEECDEEL EEEPGQGAKV VEREAAVPDA VPDRQAGASV LPVETEAQEH 
       810        820        830        840        850
VVAQKLPGEK GAHGGTAEQD PREEAEEDPH RVNGEVPHLD LDGLPEIICC 
       860        870        880        890        900
SEPPVVKTEM VTISDASQRT EISTKEVPIV QTETKTITYE SPQIDGGAGG 
       910        920        930        940        950
DSGVLLTAQT ITSESASTTT TTHITKTVKG GISETRIEKR IVITGDAALD 
       960        970        980 
HDQALAQAIR EAREQHPDMS VTRVVVHKET ELAEEGEE
Length:988
Mass (Da):109,940
Last modified:October 3, 2012 - v2
Checksum:iD3DA78BFA14E3FBB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti660F → L in AAC40083 (PubMed:9531554).Curated1
Sequence conflicti680E → G in AAC40083 (PubMed:9531554).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044312 mRNA. Translation: AAC40083.1.
AC153547 Genomic DNA. No translation available.
AC153550 Genomic DNA. No translation available.
AC156274 Genomic DNA. No translation available.
CH466540 Genomic DNA. Translation: EDL04798.1.
CCDSiCCDS23754.1.
RefSeqiNP_001186194.1. NM_001199265.1.
NP_038539.2. NM_013511.3.
UniGeneiMm.306026.

Genome annotation databases

EnsembliENSMUST00000053748; ENSMUSP00000055122; ENSMUSG00000019978.
ENSMUST00000092645; ENSMUSP00000090314; ENSMUSG00000019978.
GeneIDi13822.
KEGGimmu:13822.
UCSCiuc007erk.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiE41L2_MOUSE
AccessioniPrimary (citable) accession number: O70318
Secondary accession number(s): G3X9B8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: October 3, 2012
Last modified: July 5, 2017
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot