Epb41l2

Functionⁱ

GO - Molecular functionⁱ

actin binding
Source: MGI
Inferred from sequence or structural similarityⁱ
- 11274145
PH domain binding
Source: MGI
Inferred from direct assayⁱ
- 18796539
spectrin binding
Source: MGI
Inferred from direct assayⁱ
- 18796539
structural constituent of cytoskeleton Source: GO_Central

Complete GO annotation...

GO - Biological processⁱ

actin cytoskeleton organization
Source: MGI
Inferred from sequence or structural similarityⁱ
- 11274145
actomyosin structure organization Source: GO_Central
cortical actin cytoskeleton organization Source: InterPro
regulation of cell shape
Source: MGI
Inferred from sequence or structural similarityⁱ
- 11274145

Complete GO annotation...

Keywordsⁱ

Molecular function	Actin-binding

Molecular function

Actin-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-6794361. Interactions of neurexins and neuroligins at synapses.

Reactomeⁱ

R-MMU-6794361. Interactions of neurexins and neuroligins at synapses.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Band 4.1-like protein 2 Alternative name(s): Generally expressed protein 4.1 Short name: 4.1G
Gene namesⁱ	Name:Epb41l2 Synonyms:Epb4.1l2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 10

Organism-specific databases

MGIⁱ	MGI:103009. Epb41l2.

Subcellular locationⁱ

Cytoplasm › cytoskeleton By similarity
Cell membrane By similarity

GO - Cellular componentⁱ

actin cytoskeleton
Source: MGI
Inferred from sequence or structural similarityⁱ
- 11274145
cell junction Source: MGI
COP9 signalosome Source: Ensembl
cytoplasm Source: UniProtKB-KW
cytoskeleton Source: GO_Central
extracellular exosome Source: MGI
extrinsic component of membrane Source: InterPro
focal adhesion Source: MGI
nucleoplasm Source: MGI
nucleus Source: MGI
plasma membrane Source: MGI

Complete GO annotation...

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000219398	2 – 988	Band 4.1-like protein 2Add BLAST		987

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylthreonineBy similarity	1
Modified residueⁱ	7	PhosphoserineBy similarity	1
Modified residueⁱ	38	PhosphoserineCombined sources	1
Modified residueⁱ	86	PhosphoserineCombined sources	1
Modified residueⁱ	116	PhosphoserineCombined sources	1
Modified residueⁱ	201	PhosphoserineCombined sources	1
Modified residueⁱ	379	PhosphoserineBy similarity	1
Modified residueⁱ	395	PhosphoserineCombined sources	1
Modified residueⁱ	492	PhosphoserineBy similarity	1
Modified residueⁱ	543	PhosphoserineCombined sources	1
Modified residueⁱ	555	PhosphoserineCombined sources	1
Modified residueⁱ	561	PhosphoserineCombined sources	1
Modified residueⁱ	582	PhosphoserineCombined sources	1
Modified residueⁱ	606	PhosphotyrosineCombined sources	1
Modified residueⁱ	610	PhosphoserineCombined sources	1
Modified residueⁱ	630	PhosphoserineCombined sources	1
Modified residueⁱ	698	PhosphoserineCombined sources	1
Modified residueⁱ	745	PhosphothreonineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	O70318.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O70318.
PaxDbⁱ	O70318.
PeptideAtlas More...PeptideAtlasⁱ	O70318.
PRIDEⁱ	O70318.

PTM databases

iPTMnetⁱ	O70318.
PhosphoSitePlusⁱ	O70318.
SwissPalmⁱ	O70318.

Expressionⁱ

Tissue specificityⁱ

Widely expressed.

Gene expression databases

Bgeeⁱ	ENSMUSG00000019978.
CleanExⁱ	MM_EPB4.1L2.
Genevisibleⁱ	O70318. MM.

Interactionⁱ

Subunit structureⁱ

The CTD domain interacts with FKBP2. Interacts with FCGR1A (By similarity). Interacts with TRPC4 (By similarity).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Mpp6	Q9JLB0	3	EBI-643339,EBI-771456

With

Entry

#Exp.

IntAct

Notes

Mpp6

Q9JLB0

3

EBI-643339,EBI-771456

GO - Molecular functionⁱ

actin binding
Source: MGI
Inferred from sequence or structural similarityⁱ
- 11274145
PH domain binding
Source: MGI
Inferred from direct assayⁱ
- 18796539
spectrin binding
Source: MGI
Inferred from direct assayⁱ
- 18796539

Complete GO annotation...

Protein-protein interaction databases

BioGridⁱ	199460. 4 interactors.
IntActⁱ	O70318. 6 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-4093830.
STRINGⁱ	10090.ENSMUSP00000055122.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O70318.
SMRⁱ	O70318.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	211 – 492	FERMPROSITE-ProRule annotationAdd BLAST		282

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	495 – 651	HydrophilicAdd BLAST	157
Regionⁱ	652 – 837	Spectrin--actin-bindingAdd BLAST	186
Regionⁱ	838 – 988	C-terminal (CTD)Add BLAST	151

Phylogenomic databases

eggNOGⁱ	KOG3527. Eukaryota. ENOG410Y7NQ. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118823.
HOGENOMⁱ	HOG000228841.
HOVERGENⁱ	HBG007777.
InParanoidⁱ	O70318.
KEGG Orthology (KO) More...KOⁱ	K06107.
OMAⁱ	ISEFQFA.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00IL.
TreeFamⁱ	TF351626.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd14473. FERM_B-lobe. 1 hit.
Gene3Dⁱ	1.20.80.10. 1 hit. 2.30.29.30. 1 hit.
InterProⁱ	View protein in InterPro IPR008379. Band_4.1_C. IPR019749. Band_41_domain. IPR030546. E41L2. IPR000798. Ez/rad/moesin-like. IPR014847. FERM-adjacent. IPR014352. FERM/acyl-CoA-bd_prot_3-hlx. IPR019748. FERM_central. IPR019747. FERM_CS. IPR000299. FERM_domain. IPR018979. FERM_N. IPR018980. FERM_PH-like_C. IPR011993. PH_dom-like. IPR007477. SAB_dom. IPR029071. Ubiquitin-rel_dom.
PANTHERⁱ	PTHR23280:SF32. PTHR23280:SF32. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05902. 4_1_CTD. 1 hit. PF08736. FA. 1 hit. PF09380. FERM_C. 1 hit. PF00373. FERM_M. 1 hit. PF09379. FERM_N. 1 hit. PF04382. SAB. 1 hit.
PRINTSⁱ	PR00935. BAND41. PR00661. ERMFAMILY.
SMARTⁱ	View protein in SMART SM00295. B41. 1 hit. SM01195. FA. 1 hit. SM01196. FERM_C. 1 hit.
SUPFAMⁱ	SSF47031. SSF47031. 1 hit. SSF50729. SSF50729. 1 hit. SSF54236. SSF54236. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00660. FERM_1. 1 hit. PS00661. FERM_2. 1 hit. PS50057. FERM_3. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

O70318-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTTEVGSASE VKKGSDQAGA DASKEKAKEV ENEQTPVSEP EEEKGSQPGP 
        60         70         80         90        100
PVERQSTPRL RKRGKDPSEN RGISRFIPPW LKKQRSYNLV VAKDGGDKKE 
       110        120        130        140        150
PTQADVEDQI LGKEESLPEE ESRAKGDAEE MAQRKHLEVQ VEVREAKPAL 
       160        170        180        190        200
KSSVETQPAE EVRKDKEETI QDTQEEKLEG GAAKRETKEV QTSELKAEVA 
       210        220        230        240        250
SQKATKKTKT VLAKVTLLDG TEYSCDLEKR AKGQVLFDRV CEHLNLLEKD 
       260        270        280        290        300
YFGLLFQDHP EQKNWLDPAK EIKRQLKNLP WLFTFNVKFY PPDPSQLTED 
       310        320        330        340        350
ITRYFLCLQL RQDIASGRLP CSFVTHALLG SYTLQAEHGD YDPEEYDSID 
       360        370        380        390        400
LGDFQFAPAH TKELEEKVSE LHKTHRGLSP AQADSQFLEN AKRLSMYGVD 
       410        420        430        440        450
LHHAKDSEGV DIKLGVCANG LLIYKDRLRI NRFAWPKILK ISYKRSNFYI 
       460        470        480        490        500
KVRPAELEQF ESTIGFKLPN HRAAKRLWKV CVEHHTFYRL VSPEQPPKTK 
       510        520        530        540        550
FLTLGSKFRY SGRTQAQTRE ASTLIDRPAP QFERASSKRV SRSLDGAPIG 
       560        570        580        590        600
VVDQSPPGEG SVPGPGVISY TTIQDGRRDS KSPTKATPLP AEGKKNTLRV 
       610        620        630        640        650
DGDNIYVRHS NLMLEDLDKA QEAILKHQAS ISELKRNFMA STPEPRPSEW 
       660        670        680        690        700
EKRRVTPLPF QPQASSHETL NVVEEKKRAE VGKDESVITE EMNGKEMSPG 
       710        720        730        740        750
HGPGETRKVE PVAHKDSTSL SSESSSSSSE SEEDVGEYQP HHRVTEGTIR 
       760        770        780        790        800
EEQEECDEEL EEEPGQGAKV VEREAAVPDA VPDRQAGASV LPVETEAQEH 
       810        820        830        840        850
VVAQKLPGEK GAHGGTAEQD PREEAEEDPH RVNGEVPHLD LDGLPEIICC 
       860        870        880        890        900
SEPPVVKTEM VTISDASQRT EISTKEVPIV QTETKTITYE SPQIDGGAGG 
       910        920        930        940        950
DSGVLLTAQT ITSESASTTT TTHITKTVKG GISETRIEKR IVITGDAALD 
       960        970        980 
HDQALAQAIR EAREQHPDMS VTRVVVHKET ELAEEGEE

Length:988

Mass (Da):109,940

Last modified:October 3, 2012 - v2

Checksum:ⁱD3DA78BFA14E3FBB

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	660	F → L in AAC40083 (PubMed:9531554).Curated		1
Sequence conflictⁱ	680	E → G in AAC40083 (PubMed:9531554).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF044312 mRNA. Translation: AAC40083.1. AC153547 Genomic DNA. No translation available. AC153550 Genomic DNA. No translation available. AC156274 Genomic DNA. No translation available. CH466540 Genomic DNA. Translation: EDL04798.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS23754.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001186194.1. NM_001199265.1. NP_038539.2. NM_013511.3.
UniGeneⁱ	Mm.306026.

Genome annotation databases

Ensemblⁱ	ENSMUST00000053748; ENSMUSP00000055122; ENSMUSG00000019978. ENSMUST00000092645; ENSMUSP00000090314; ENSMUSG00000019978.
GeneIDⁱ	13822.
KEGGⁱ	mmu:13822.
UCSC genome browser More...UCSCⁱ	uc007erk.2. mouse.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF044312 mRNA. Translation: AAC40083.1. AC153547 Genomic DNA. No translation available. AC153550 Genomic DNA. No translation available. AC156274 Genomic DNA. No translation available. CH466540 Genomic DNA. Translation: EDL04798.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS23754.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001186194.1. NM_001199265.1. NP_038539.2. NM_013511.3.
UniGeneⁱ	Mm.306026.

3D structure databases

ProteinModelPortalⁱ	O70318.
SMRⁱ	O70318.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	199460. 4 interactors.
IntActⁱ	O70318. 6 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-4093830.
STRINGⁱ	10090.ENSMUSP00000055122.

PTM databases

iPTMnetⁱ	O70318.
PhosphoSitePlusⁱ	O70318.
SwissPalmⁱ	O70318.

Proteomic databases

EPDⁱ	O70318.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O70318.
PaxDbⁱ	O70318.
PeptideAtlas More...PeptideAtlasⁱ	O70318.
PRIDEⁱ	O70318.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000053748; ENSMUSP00000055122; ENSMUSG00000019978. ENSMUST00000092645; ENSMUSP00000090314; ENSMUSG00000019978.
GeneIDⁱ	13822.
KEGGⁱ	mmu:13822.
UCSC genome browser More...UCSCⁱ	uc007erk.2. mouse.

Organism-specific databases

CTDⁱ	2037.
MGIⁱ	MGI:103009. Epb41l2.

Phylogenomic databases

eggNOGⁱ	KOG3527. Eukaryota. ENOG410Y7NQ. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118823.
HOGENOMⁱ	HOG000228841.
HOVERGENⁱ	HBG007777.
InParanoidⁱ	O70318.
KEGG Orthology (KO) More...KOⁱ	K06107.
OMAⁱ	ISEFQFA.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00IL.
TreeFamⁱ	TF351626.

Enzyme and pathway databases

Reactomeⁱ	R-MMU-6794361. Interactions of neurexins and neuroligins at synapses.

Reactomeⁱ

R-MMU-6794361. Interactions of neurexins and neuroligins at synapses.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:O70318.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000019978.
CleanExⁱ	MM_EPB4.1L2.
Genevisibleⁱ	O70318. MM.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd14473. FERM_B-lobe. 1 hit.
Gene3Dⁱ	1.20.80.10. 1 hit. 2.30.29.30. 1 hit.
InterProⁱ	View protein in InterPro IPR008379. Band_4.1_C. IPR019749. Band_41_domain. IPR030546. E41L2. IPR000798. Ez/rad/moesin-like. IPR014847. FERM-adjacent. IPR014352. FERM/acyl-CoA-bd_prot_3-hlx. IPR019748. FERM_central. IPR019747. FERM_CS. IPR000299. FERM_domain. IPR018979. FERM_N. IPR018980. FERM_PH-like_C. IPR011993. PH_dom-like. IPR007477. SAB_dom. IPR029071. Ubiquitin-rel_dom.
PANTHERⁱ	PTHR23280:SF32. PTHR23280:SF32. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05902. 4_1_CTD. 1 hit. PF08736. FA. 1 hit. PF09380. FERM_C. 1 hit. PF00373. FERM_M. 1 hit. PF09379. FERM_N. 1 hit. PF04382. SAB. 1 hit.
PRINTSⁱ	PR00935. BAND41. PR00661. ERMFAMILY.
SMARTⁱ	View protein in SMART SM00295. B41. 1 hit. SM01195. FA. 1 hit. SM01196. FERM_C. 1 hit.
SUPFAMⁱ	SSF47031. SSF47031. 1 hit. SSF50729. SSF50729. 1 hit. SSF54236. SSF54236. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00660. FERM_1. 1 hit. PS00661. FERM_2. 1 hit. PS50057. FERM_3. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	E41L2_MOUSE
Accessionⁱ	O70318Primary (citable) accession number: O70318 Secondary accession number(s): G3X9B8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 5, 2001
	Last sequence update:	October 3, 2012
	Last modified:	June 7, 2017
	This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O70318 (E41L2_MOUSE)

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Band 4.1-like protein 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ