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Protein

Glycylpeptide N-tetradecanoyltransferase 2

Gene

Nmt2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.By similarity

Catalytic activityi

Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.By similarity

GO - Molecular functioni

GO - Biological processi

  • N-terminal peptidyl-glycine N-myristoylation Source: UniProtKB
  • N-terminal protein myristoylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.3.1.97. 3474.
ReactomeiR-MMU-2514859. Inactivation, recovery and regulation of the phototransduction cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycylpeptide N-tetradecanoyltransferase 2 (EC:2.3.1.97By similarity)
Alternative name(s):
Myristoyl-CoA:protein N-myristoyltransferase 2
Short name:
NMT 2
Peptide N-myristoyltransferase 2
Type II N-myristoyltransferase
Gene namesi
Name:Nmt2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1202298. Nmt2.

Subcellular locationi

  • Cytoplasm By similarity
  • Membrane By similarity; Peripheral membrane protein By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 529529Glycylpeptide N-tetradecanoyltransferase 2PRO_0000064227Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei38 – 381PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO70311.
PaxDbiO70311.
PRIDEiO70311.

PTM databases

PhosphoSiteiO70311.

Expressioni

Gene expression databases

BgeeiO70311.
CleanExiMM_NMT2.
ExpressionAtlasiO70311. baseline and differential.
GenevisibleiO70311. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080600.

Structurei

3D structure databases

ProteinModelPortaliO70311.
SMRiO70311. Positions 142-529.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni151 – 1533Myristoyl-CoA bindingBy similarity
Regioni281 – 2833Myristoyl-CoA bindingBy similarity
Regioni289 – 2935Myristoyl-CoA bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi46 – 5611Poly-LysAdd
BLAST

Sequence similaritiesi

Belongs to the NMT family.Curated

Phylogenomic databases

eggNOGiKOG2779. Eukaryota.
COG5092. LUCA.
HOGENOMiHOG000189123.
HOVERGENiHBG003404.
InParanoidiO70311.
KOiK00671.
OMAiSARNVQM.
OrthoDBiEOG76DTS3.
PhylomeDBiO70311.
TreeFamiTF300701.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000903. MyristoylCoA_TrFase.
IPR022677. MyristoylCoA_TrFase_C.
IPR022678. MyristoylCoA_TrFase_CS.
IPR022676. MyristoylCoA_TrFase_N.
[Graphical view]
PANTHERiPTHR11377. PTHR11377. 2 hits.
PfamiPF01233. NMT. 1 hit.
PF02799. NMT_C. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 2 hits.
PROSITEiPS00975. NMT_1. 1 hit.
PS00976. NMT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70311-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEDSESAAS QQSLELDDQD TCGIDGDNEE ETEHAKGSPG GDLGAKKKKK
60 70 80 90 100
KQKRKKEKPN SGGTKSDSAS DSQEIKIQQS SKHNAIWQQI SAGAAMGGDT
110 120 130 140 150
MEGEWIDLRM YHKNPTIPIQ KLQDIQRAME LLSACQGPAR NIDEATKRRY
160 170 180 190 200
QFWDTQPVPK LNEVITSHGA IEPDKDNIRQ EPYSLPQGFM WDTLDLSNAE
210 220 230 240 250
VLKELYTLLN ENYVEDDDNM FRFDYSPEFL LWALRPPGWL LQWHCGVRVS
260 270 280 290 300
SNKKLVGFIS AIPANIRIYD SVKRMVEINF LCVHKKLRSK RVAPVLIREI
310 320 330 340 350
TRRVNLEGIF QAVYTAGVVL PKPVATCRYW HRSLNPRKLV EVKFSHLSRN
360 370 380 390 400
MTLQRTMKLY RLPDVTKTSG LRPMEPKDIK AVRELINIYL KQFHLAPVMD
410 420 430 440 450
DAEVAHWFLP REHIIDTFVV ENPSGKLTDF LSFYTLPSTV MHHPAHKSLK
460 470 480 490 500
AAYSFYNIHT ETPLLDLMND ALIIAKLKGF DVFNALDLME NKTFLEKLKF
510 520
GIGDGNLQYY LYNWRCPGTD SEKVGLVLQ
Length:529
Mass (Da):60,484
Last modified:August 1, 1998 - v1
Checksum:i7D5C93D9159F315C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043327 mRNA. Translation: AAC09297.1.
CCDSiCCDS15644.1.
RefSeqiNP_032734.1. NM_008708.2.
UniGeneiMm.392918.
Mm.65021.

Genome annotation databases

EnsembliENSMUST00000081932; ENSMUSP00000080600; ENSMUSG00000026643.
GeneIDi18108.
KEGGimmu:18108.
UCSCiuc008idq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043327 mRNA. Translation: AAC09297.1.
CCDSiCCDS15644.1.
RefSeqiNP_032734.1. NM_008708.2.
UniGeneiMm.392918.
Mm.65021.

3D structure databases

ProteinModelPortaliO70311.
SMRiO70311. Positions 142-529.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080600.

PTM databases

PhosphoSiteiO70311.

Proteomic databases

EPDiO70311.
PaxDbiO70311.
PRIDEiO70311.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000081932; ENSMUSP00000080600; ENSMUSG00000026643.
GeneIDi18108.
KEGGimmu:18108.
UCSCiuc008idq.2. mouse.

Organism-specific databases

CTDi9397.
MGIiMGI:1202298. Nmt2.

Phylogenomic databases

eggNOGiKOG2779. Eukaryota.
COG5092. LUCA.
HOGENOMiHOG000189123.
HOVERGENiHBG003404.
InParanoidiO70311.
KOiK00671.
OMAiSARNVQM.
OrthoDBiEOG76DTS3.
PhylomeDBiO70311.
TreeFamiTF300701.

Enzyme and pathway databases

BRENDAi2.3.1.97. 3474.
ReactomeiR-MMU-2514859. Inactivation, recovery and regulation of the phototransduction cascade.

Miscellaneous databases

NextBioi293297.
PROiO70311.
SOURCEiSearch...

Gene expression databases

BgeeiO70311.
CleanExiMM_NMT2.
ExpressionAtlasiO70311. baseline and differential.
GenevisibleiO70311. MM.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000903. MyristoylCoA_TrFase.
IPR022677. MyristoylCoA_TrFase_C.
IPR022678. MyristoylCoA_TrFase_CS.
IPR022676. MyristoylCoA_TrFase_N.
[Graphical view]
PANTHERiPTHR11377. PTHR11377. 2 hits.
PfamiPF01233. NMT. 1 hit.
PF02799. NMT_C. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 2 hits.
PROSITEiPS00975. NMT_1. 1 hit.
PS00976. NMT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A second mammalian N-myristoyltransferase."
    Giang D.K., Cravatt B.F.
    J. Biol. Chem. 273:6595-6598(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain and Testis.

Entry informationi

Entry nameiNMT2_MOUSE
AccessioniPrimary (citable) accession number: O70311
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: May 11, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.