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Protein

Glycylpeptide N-tetradecanoyltransferase 1

Gene

Nmt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. Required for normal embryogenesis.1 Publication

Catalytic activityi

Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.1 Publication

GO - Molecular functioni

  • glycylpeptide N-tetradecanoyltransferase activity Source: MGI
  • myristoyltransferase activity Source: MGI

GO - Biological processi

  • cellular ketone metabolic process Source: MGI
  • in utero embryonic development Source: MGI
  • N-terminal peptidyl-glycine N-myristoylation Source: UniProtKB
  • N-terminal protein myristoylation Source: MGI

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.3.1.97 3474
ReactomeiR-MMU-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-MMU-75108 Activation, myristolyation of BID and translocation to mitochondria

Names & Taxonomyi

Protein namesi
Recommended name:
Glycylpeptide N-tetradecanoyltransferase 1 (EC:2.3.1.971 Publication)
Alternative name(s):
Myristoyl-CoA:protein N-myristoyltransferase 1
Short name:
NMT 1
Short name:
Type I N-myristoyltransferase
Peptide N-myristoyltransferase 1
Gene namesi
Name:Nmt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:102579 Nmt1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Disruption phenotypei

Complete embryonic lethality. Embryos die between 3.5 and 7.5 dpc.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000642221 – 496Glycylpeptide N-tetradecanoyltransferase 1Add BLAST496

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei31PhosphoserineCombined sources1
Modified residuei47PhosphoserineCombined sources1
Modified residuei83PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO70310
PaxDbiO70310
PeptideAtlasiO70310
PRIDEiO70310

PTM databases

iPTMnetiO70310
PhosphoSitePlusiO70310
SwissPalmiO70310

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSMUSG00000020936
CleanExiMM_NMT1
ExpressionAtlasiO70310 baseline and differential
GenevisibleiO70310 MM

Interactioni

Protein-protein interaction databases

BioGridi201793, 1 interactor
IntActiO70310, 2 interactors
MINTiO70310
STRINGi10090.ENSMUSP00000021314

Structurei

3D structure databases

ProteinModelPortaliO70310
SMRiO70310
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni118 – 120Myristoyl-CoA bindingBy similarity3
Regioni248 – 250Myristoyl-CoA bindingBy similarity3
Regioni256 – 260Myristoyl-CoA bindingBy similarity5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi55 – 67Poly-LysAdd BLAST13

Sequence similaritiesi

Belongs to the NMT family.Curated

Phylogenomic databases

eggNOGiKOG2779 Eukaryota
COG5092 LUCA
GeneTreeiENSGT00390000017837
HOGENOMiHOG000189123
HOVERGENiHBG003404
InParanoidiO70310
KOiK00671
OMAiTIMNHPV
OrthoDBiEOG091G06JB
PhylomeDBiO70310
TreeFamiTF300701

Family and domain databases

InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR000903 MyristoylCoA_TrFase
IPR022677 MyristoylCoA_TrFase_C
IPR022678 MyristoylCoA_TrFase_CS
IPR022676 MyristoylCoA_TrFase_N
PANTHERiPTHR11377 PTHR11377, 1 hit
PfamiView protein in Pfam
PF01233 NMT, 1 hit
PF02799 NMT_C, 1 hit
PIRSFiPIRSF015892 N-myristl_transf, 1 hit
SUPFAMiSSF55729 SSF55729, 2 hits
PROSITEiView protein in PROSITE
PS00975 NMT_1, 1 hit
PS00976 NMT_2, 1 hit

Sequencei

Sequence statusi: Complete.

O70310-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADESETAVK LPAPSLPLMM EGNGNGHEHC SDCENEEDNS HNRSGLSPAN
60 70 80 90 100
DTGAKKKKKK QKKKKEKGSD MESTQDQPVK MTSLPAERIQ EIQKAIELFS
110 120 130 140 150
VGQGPAKTME EASKRSYQFW DTQPVPKLGE VVNTHGPVEP DKDNIRQEPY
160 170 180 190 200
TLPQGFTWDA LDLGDRGVLK ELYTLLNENY VEDDDNMFRF DYSPEFLLWA
210 220 230 240 250
LRPPGWLPQW HCGVRVVSSR KLVGFISAIP ANIHIYDTEK KMVEINFLCV
260 270 280 290 300
HKKLRSKRVA PVLIREITRR VHLEGIFQAV YTAGVVLPKP VGTCRYWHRS
310 320 330 340 350
LNPRKLIEVK FSHLSRNMTM QRTMKLYRLP ETPKTAGLRP MEKKDIPVVH
360 370 380 390 400
QLLSRYLKQF HLTPVMNQEE VEHWFYPQEN IIDTFVVENA NGEVTDFLSF
410 420 430 440 450
YTLPSTIMNH PTHKSLKAAY SFYNVHTQTP LLDLMSDALV LAKMKGFDVF
460 470 480 490
NALDLMENKT FLEKLKFGIG DGNLQYYLYN WKCPSMGAEK VGLVLQ
Length:496
Mass (Da):56,888
Last modified:August 1, 1998 - v1
Checksum:i61FA7B854A5CF3BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043326 mRNA Translation: AAC09296.1
BC016526 mRNA Translation: AAH16526.1
BC021635 mRNA Translation: AAH21635.1
CCDSiCCDS25511.1
RefSeqiNP_032733.1, NM_008707.3
XP_006532508.1, XM_006532445.3
UniGeneiMm.10265

Genome annotation databases

EnsembliENSMUST00000021314; ENSMUSP00000021314; ENSMUSG00000020936
GeneIDi18107
KEGGimmu:18107
UCSCiuc007ltd.1 mouse

Similar proteinsi

Entry informationi

Entry nameiNMT1_MOUSE
AccessioniPrimary (citable) accession number: O70310
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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