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Protein

Glycylpeptide N-tetradecanoyltransferase 1

Gene

Nmt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. Required for normal embryogenesis.1 Publication

Catalytic activityi

Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.1 Publication

GO - Molecular functioni

  • glycylpeptide N-tetradecanoyltransferase activity Source: MGI
  • myristoyltransferase activity Source: MGI

GO - Biological processi

  • cellular ketone metabolic process Source: MGI
  • in utero embryonic development Source: MGI
  • N-terminal peptidyl-glycine N-myristoylation Source: UniProtKB
  • N-terminal protein myristoylation Source: MGI

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.3.1.97. 3474.
ReactomeiR-MMU-2514859. Inactivation, recovery and regulation of the phototransduction cascade.
R-MMU-75108. Activation, myristolyation of BID and translocation to mitochondria.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycylpeptide N-tetradecanoyltransferase 1 (EC:2.3.1.971 Publication)
Alternative name(s):
Myristoyl-CoA:protein N-myristoyltransferase 1
Short name:
NMT 1
Short name:
Type I N-myristoyltransferase
Peptide N-myristoyltransferase 1
Gene namesi
Name:Nmt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:102579. Nmt1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Disruption phenotypei

Complete embryonic lethality. Embryos die between 3.5 and 7.5 dpc.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000642221 – 496Glycylpeptide N-tetradecanoyltransferase 1Add BLAST496

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei31PhosphoserineCombined sources1
Modified residuei47PhosphoserineCombined sources1
Modified residuei83PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO70310.
PaxDbiO70310.
PeptideAtlasiO70310.
PRIDEiO70310.

PTM databases

iPTMnetiO70310.
PhosphoSitePlusiO70310.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSMUSG00000020936.
CleanExiMM_NMT1.
ExpressionAtlasiO70310. baseline and differential.
GenevisibleiO70310. MM.

Interactioni

Protein-protein interaction databases

BioGridi201793. 1 interactor.
IntActiO70310. 2 interactors.
MINTiO70310.
STRINGi10090.ENSMUSP00000021314.

Structurei

3D structure databases

ProteinModelPortaliO70310.
SMRiO70310.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni118 – 120Myristoyl-CoA bindingBy similarity3
Regioni248 – 250Myristoyl-CoA bindingBy similarity3
Regioni256 – 260Myristoyl-CoA bindingBy similarity5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi55 – 67Poly-LysAdd BLAST13

Sequence similaritiesi

Belongs to the NMT family.Curated

Phylogenomic databases

eggNOGiKOG2779. Eukaryota.
COG5092. LUCA.
GeneTreeiENSGT00390000017837.
HOGENOMiHOG000189123.
HOVERGENiHBG003404.
InParanoidiO70310.
KOiK00671.
OMAiTIMNHPV.
OrthoDBiEOG091G06JB.
PhylomeDBiO70310.
TreeFamiTF300701.

Family and domain databases

InterProiView protein in InterPro
IPR016181. Acyl_CoA_acyltransferase.
IPR000903. MyristoylCoA_TrFase.
IPR022677. MyristoylCoA_TrFase_C.
IPR022678. MyristoylCoA_TrFase_CS.
IPR022676. MyristoylCoA_TrFase_N.
PANTHERiPTHR11377. PTHR11377. 1 hit.
PfamiView protein in Pfam
PF01233. NMT. 1 hit.
PF02799. NMT_C. 1 hit.
PIRSFiPIRSF015892. N-myristl_transf. 1 hit.
SUPFAMiSSF55729. SSF55729. 2 hits.
PROSITEiView protein in PROSITE
PS00975. NMT_1. 1 hit.
PS00976. NMT_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O70310-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADESETAVK LPAPSLPLMM EGNGNGHEHC SDCENEEDNS HNRSGLSPAN
60 70 80 90 100
DTGAKKKKKK QKKKKEKGSD MESTQDQPVK MTSLPAERIQ EIQKAIELFS
110 120 130 140 150
VGQGPAKTME EASKRSYQFW DTQPVPKLGE VVNTHGPVEP DKDNIRQEPY
160 170 180 190 200
TLPQGFTWDA LDLGDRGVLK ELYTLLNENY VEDDDNMFRF DYSPEFLLWA
210 220 230 240 250
LRPPGWLPQW HCGVRVVSSR KLVGFISAIP ANIHIYDTEK KMVEINFLCV
260 270 280 290 300
HKKLRSKRVA PVLIREITRR VHLEGIFQAV YTAGVVLPKP VGTCRYWHRS
310 320 330 340 350
LNPRKLIEVK FSHLSRNMTM QRTMKLYRLP ETPKTAGLRP MEKKDIPVVH
360 370 380 390 400
QLLSRYLKQF HLTPVMNQEE VEHWFYPQEN IIDTFVVENA NGEVTDFLSF
410 420 430 440 450
YTLPSTIMNH PTHKSLKAAY SFYNVHTQTP LLDLMSDALV LAKMKGFDVF
460 470 480 490
NALDLMENKT FLEKLKFGIG DGNLQYYLYN WKCPSMGAEK VGLVLQ
Length:496
Mass (Da):56,888
Last modified:August 1, 1998 - v1
Checksum:i61FA7B854A5CF3BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043326 mRNA. Translation: AAC09296.1.
BC016526 mRNA. Translation: AAH16526.1.
BC021635 mRNA. Translation: AAH21635.1.
CCDSiCCDS25511.1.
RefSeqiNP_032733.1. NM_008707.3.
XP_006532508.1. XM_006532445.3.
UniGeneiMm.10265.

Genome annotation databases

EnsembliENSMUST00000021314; ENSMUSP00000021314; ENSMUSG00000020936.
GeneIDi18107.
KEGGimmu:18107.
UCSCiuc007ltd.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiNMT1_MOUSE
AccessioniPrimary (citable) accession number: O70310
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: February 28, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome