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Protein

Ataxin-2

Gene

Atxn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cerebellar Purkinje cell differentiation Source: MGI
  • cytoplasmic mRNA processing body assembly Source: MGI
  • homeostasis of number of cells Source: MGI
  • negative regulation of multicellular organism growth Source: MGI
  • negative regulation of receptor internalization Source: MGI
  • neuromuscular process Source: MGI
  • neuron projection morphogenesis Source: MGI
  • regulation of cytoplasmic mRNA processing body assembly Source: GO_Central
  • stress granule assembly Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ataxin-2
Alternative name(s):
Spinocerebellar ataxia type 2 protein homolog
Gene namesi
Name:Atxn2
Synonyms:Atx2, Sca2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1277223. Atxn2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12851285Ataxin-2PRO_0000064757Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei218 – 2181PhosphoserineCombined sources
Modified residuei219 – 2191PhosphoserineCombined sources
Modified residuei362 – 3621PhosphoserineBy similarity
Modified residuei435 – 4351PhosphoserineCombined sources
Modified residuei477 – 4771PhosphoserineBy similarity
Modified residuei523 – 5231PhosphoserineBy similarity
Modified residuei593 – 5931PhosphoserineCombined sources
Modified residuei611 – 6111PhosphoserineBy similarity
Modified residuei653 – 6531PhosphoserineCombined sources
Modified residuei697 – 6971PhosphoserineBy similarity
Modified residuei710 – 7101PhosphothreonineBy similarity
Modified residuei741 – 7411PhosphoserineBy similarity
Modified residuei753 – 7531PhosphoserineBy similarity
Modified residuei827 – 8271PhosphoserineCombined sources
Modified residuei828 – 8281PhosphoserineBy similarity
Modified residuei832 – 8321PhosphoserineCombined sources
Modified residuei836 – 8361PhosphoserineCombined sources
Modified residuei838 – 8381PhosphoserineCombined sources
Modified residuei859 – 8591PhosphoserineBy similarity
Modified residuei860 – 8601PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO70305.
PaxDbiO70305.
PeptideAtlasiO70305.
PRIDEiO70305.

PTM databases

iPTMnetiO70305.
PhosphoSiteiO70305.

Expressioni

Tissue specificityi

Expressed in the heart, lung, liver, kidney, skeletal muscle, spleen and intestine. Predominant expression was seen in the brain where a high level expression was found in the pyramidal cortical neurons, large brain stem neurons and cerebellar Purkinje cells. All three isoforms were found in all the tissues except skeletal muscle where only isoform 1 was found.1 Publication

Developmental stagei

Detectable at embryonic days E8-E16 and lowest expression was seen at E8.1 Publication

Gene expression databases

CleanExiMM_ATXN2.

Interactioni

Subunit structurei

Interacts with RBFOX1 (By similarity). Monomer. Can also form homodimers. Interacts with polyribosomes (By similarity). Interacts with EGFR (By similarity). Interacts with SH3GL3 (By similarity). Interacts with SH3GL2, SH3KBP1 and CBL (PubMed:18602463). Interacts with ATXN2L (By similarity).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203084. 7 interactions.
IntActiO70305. 2 interactions.
MINTiMINT-1865582.
STRINGi10090.ENSMUSP00000056715.

Structurei

3D structure databases

ProteinModelPortaliO70305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi46 – 197152Pro-richAdd
BLAST
Compositional biasi520 – 703184Pro-richAdd
BLAST
Compositional biasi808 – 84134Ser-richAdd
BLAST
Compositional biasi900 – 96162Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the ataxin-2 family.Curated

Phylogenomic databases

eggNOGiKOG2375. Eukaryota.
COG5180. LUCA.
HOGENOMiHOG000234354.
HOVERGENiHBG050623.
InParanoidiO70305.
PhylomeDBiO70305.

Family and domain databases

InterProiIPR009818. Ataxin-2_C.
IPR033093. ATXN2.
IPR010920. LSM_dom.
IPR009604. LsmAD_domain.
IPR025852. SM_dom_ATX.
[Graphical view]
PANTHERiPTHR12854:SF11. PTHR12854:SF11. 1 hit.
PfamiPF06741. LsmAD. 1 hit.
PF07145. PAM2. 1 hit.
PF14438. SM-ATX. 1 hit.
[Graphical view]
SMARTiSM01272. LsmAD. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O70305-1) [UniParc]FASTAAdd to basket
Also known as: Type I

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRSSTAAVQR PAAGDPEPRR PAGWAARRSL PRTARRGGRG GAVAYPSAGP
60 70 80 90 100
PPRGPGAPPR GPRSPPCASD CFGSNGHGAS RPGSRRLLGV CGPPRPFVVV
110 120 130 140 150
LLALAPAATP ARACPPGVRA SPPRSGVSSS ARPAPGCPRP ACEPVYGPLT
160 170 180 190 200
MSLKPQPQPP APATGRKPGG GLLSSPGAAP ASAAVTSASV VPAPAAPVAS
210 220 230 240 250
SSAAAGGGRP GLGRGRNSSK GLPQPTISFD GIYANVRMVH ILTSVVGSKC
260 270 280 290 300
EVQVKNGGIY EGVFKTYSPK CDLVLDAAHE KSTESSSGPK REEIMESVLF
310 320 330 340 350
KCSDFVVVQF KDTDSSYARR DAFTDSALSA KVNGEHKEKD LEPWDAGELT
360 370 380 390 400
ASEELELEND VSNGWDPNDM FRYNEENYGV VSTYDSSLSS YTVPLERDNS
410 420 430 440 450
EEFLKREARA NQLAEEIESS AQYKARVALE NDDRSEEEKY TAVQRNCSDR
460 470 480 490 500
EGHGPNTRDN KYIPPGQRNR EVLSWGSGRQ SSPRMGQPGP GSMPSRAASH
510 520 530 540 550
TSDFNPNAGS DQRVVNGGVP WPSPCPSHSS RPPSRYQSGP NSLPPRAATH
560 570 580 590 600
TRPPSRPPSR PSRPPSHPSA HGSPAPVSTM PKRMSSEGPP RMSPKAQRHP
610 620 630 640 650
RNHRVSAGRG SMSSGLEFVS HNPPSEAAAP PVARTSPAGG TWSSVVSGVP
660 670 680 690 700
RLSPKTHRPR SPRQSSIGNS PSGPVLASPQ AGIIPAEAVS MPVPAASPTP
710 720 730 740 750
ASPASNRALT PSIEAKDSRL QDQRQNSPAG SKENVKASET SPSFSKADNK
760 770 780 790 800
GMSPVVSEHR KQIDDLKKFK NDFRLQPSST SESMDQLLSK NREGEKSRDL
810 820 830 840 850
IKDKTEASAK DSFIDSSSSS SNCTSGSSKT NSPSISPSML SNAEHKRGPE
860 870 880 890 900
VTSQGVQTSS PACKQEKDDR EEKKDTTEQV RKSTLNPNAK EFNPRSFSQP
910 920 930 940 950
KPSTTPTSPR PQAQPSPSMV GHQQPAPVYT QPVCFAPNMM YPVPVSPGVQ
960 970 980 990 1000
PLYPIPMTPM PVNQAKTYRA GKVPNMPQQR QDQHHQSTMM HPASAAGPPI
1010 1020 1030 1040 1050
VATPPAYSTQ YVAYSPQQFP NQPLVQHVPH YQSQHPHVYS PVIQGNARMM
1060 1070 1080 1090 1100
APPAHAQPGL VSSSAAQFGA HEQTHAMYAC PKLPYNKETS PSFYFAISTG
1110 1120 1130 1140 1150
SLAQQYAHPN AALHPHTPHP QPSATPTGQQ QSQHGGSHPA PSPVQHHQHQ
1160 1170 1180 1190 1200
AAQALHLASP QQQSAIYHAG LAPTPPSMTP ASNTQSPQSS FPAAQQTVFT
1210 1220 1230 1240 1250
IHPSHVQPAY TTPPHMAHVP QAHVQSGMVP SHPTAHAPMM LMTTQPPGPK
1260 1270 1280
AALAQSALQP IPVSTTAHFP YMTHPSVQAH HQQQL
Length:1,285
Mass (Da):136,485
Last modified:August 1, 1998 - v1
Checksum:i2C72EF68A79F3793
GO
Isoform 2 (identifier: O70305-2) [UniParc]FASTAAdd to basket
Also known as: Type II

The sequence of this isoform differs from the canonical sequence as follows:
     519-588: Missing.

Show »
Length:1,215
Mass (Da):129,067
Checksum:iCAEC4D66129F7C88
GO
Isoform 3 (identifier: O70305-3) [UniParc]FASTAAdd to basket
Also known as: Type III

The sequence of this isoform differs from the canonical sequence as follows:
     519-588: Missing.
     589-649: Missing.

Show »
Length:1,154
Mass (Da):122,798
Checksum:iEC3D2183836928E7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti145 – 1462VY → HE in AAB19202 (PubMed:8896555).Curated
Sequence conflicti528 – 5281H → P in AAB19202 (PubMed:8896555).Curated
Sequence conflicti550 – 5501H → P in AAB19202 (PubMed:8896555).Curated
Sequence conflicti554 – 56310PSRPPSRPSR → RAEFLQPGDP in AAB19202 (PubMed:8896555).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei519 – 58870Missing in isoform 2 and isoform 3. 1 PublicationVSP_011583Add
BLAST
Alternative sequencei589 – 64961Missing in isoform 3. 1 PublicationVSP_011584Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041472 mRNA. Translation: AAC09275.1.
U70670 mRNA. Translation: AAB19202.1.
PIRiT14171.
RefSeqiNP_033151.2. NM_009125.2.
UniGeneiMm.260900.

Genome annotation databases

GeneIDi20239.
KEGGimmu:20239.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041472 mRNA. Translation: AAC09275.1.
U70670 mRNA. Translation: AAB19202.1.
PIRiT14171.
RefSeqiNP_033151.2. NM_009125.2.
UniGeneiMm.260900.

3D structure databases

ProteinModelPortaliO70305.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203084. 7 interactions.
IntActiO70305. 2 interactions.
MINTiMINT-1865582.
STRINGi10090.ENSMUSP00000056715.

PTM databases

iPTMnetiO70305.
PhosphoSiteiO70305.

Proteomic databases

MaxQBiO70305.
PaxDbiO70305.
PeptideAtlasiO70305.
PRIDEiO70305.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi20239.
KEGGimmu:20239.

Organism-specific databases

CTDi6311.
MGIiMGI:1277223. Atxn2.

Phylogenomic databases

eggNOGiKOG2375. Eukaryota.
COG5180. LUCA.
HOGENOMiHOG000234354.
HOVERGENiHBG050623.
InParanoidiO70305.
PhylomeDBiO70305.

Miscellaneous databases

ChiTaRSiAtxn2. mouse.
PROiO70305.
SOURCEiSearch...

Gene expression databases

CleanExiMM_ATXN2.

Family and domain databases

InterProiIPR009818. Ataxin-2_C.
IPR033093. ATXN2.
IPR010920. LSM_dom.
IPR009604. LsmAD_domain.
IPR025852. SM_dom_ATX.
[Graphical view]
PANTHERiPTHR12854:SF11. PTHR12854:SF11. 1 hit.
PfamiPF06741. LsmAD. 1 hit.
PF07145. PAM2. 1 hit.
PF14438. SM-ATX. 1 hit.
[Graphical view]
SMARTiSM01272. LsmAD. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiATX2_MOUSE
AccessioniPrimary (citable) accession number: O70305
Secondary accession number(s): P97421
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.