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Protein

Cell death activator CIDE-B

Gene

Cideb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Activates apoptosis.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Cell death activator CIDE-B
Alternative name(s):
Cell death-inducing DFFA-like effector B
Gene namesi
Name:Cideb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1270844. Cideb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447211 – 219Cell death activator CIDE-BAdd BLAST219

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO70303.
PaxDbiO70303.
PRIDEiO70303.

PTM databases

iPTMnetiO70303.
PhosphoSitePlusiO70303.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022219.
GenevisibleiO70303. MM.

Interactioni

Subunit structurei

Inhibited by DFFB. Interacts with DFFA and DFFB (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000001497.

Structurei

3D structure databases

ProteinModelPortaliO70303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 110CIDE-NPROSITE-ProRule annotationAdd BLAST77

Sequence similaritiesi

Contains 1 CIDE-N domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IIBQ. Eukaryota.
ENOG4111N1Y. LUCA.
GeneTreeiENSGT00390000018596.
HOGENOMiHOG000029211.
HOVERGENiHBG050961.
InParanoidiO70303.
OMAiVWTSAPP.
OrthoDBiEOG091G0KVY.
PhylomeDBiO70303.
TreeFamiTF334321.

Family and domain databases

InterProiIPR003508. CIDE-N_dom.
[Graphical view]
PfamiPF02017. CIDE-N. 1 hit.
[Graphical view]
SMARTiSM00266. CAD. 1 hit.
[Graphical view]
PROSITEiPS51135. CIDE_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70303-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYLSAFNPN GLLRSVSTVS SELSRRVWNS APPPQRPFRV CDHKRTVRKG
60 70 80 90 100
LTAASLQELL DKVLETLLLR GVLTLVLEED GTAVDSEDFF QLLEDDTCLM
110 120 130 140 150
VLEQGQSWSP KSGMLSYGLG REKPKHSKDI ARITFDVYKQ NPRDLFGSLN
160 170 180 190 200
VKATFYGLYS MSCDFQGVGP KRVLRELLRW TSSLLQGLGH MLLGISSTLR
210
HVVEGADRWQ WHGQRHLHS
Length:219
Mass (Da):24,800
Last modified:March 27, 2002 - v2
Checksum:i8915FB3CC5FE7721
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti180W → G in AAC34986 (PubMed:9564035).Curated1
Sequence conflicti184L → Q in AAC34986 (PubMed:9564035).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041377 mRNA. Translation: AAC34986.1.
BC012664 mRNA. Translation: AAH12664.1.
BC046340 mRNA. Translation: AAH46340.1.
CCDSiCCDS27127.1.
RefSeqiNP_034024.2. NM_009894.3.
UniGeneiMm.466766.

Genome annotation databases

EnsembliENSMUST00000001497; ENSMUSP00000001497; ENSMUSG00000022219.
GeneIDi12684.
KEGGimmu:12684.
UCSCiuc007uap.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041377 mRNA. Translation: AAC34986.1.
BC012664 mRNA. Translation: AAH12664.1.
BC046340 mRNA. Translation: AAH46340.1.
CCDSiCCDS27127.1.
RefSeqiNP_034024.2. NM_009894.3.
UniGeneiMm.466766.

3D structure databases

ProteinModelPortaliO70303.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000001497.

PTM databases

iPTMnetiO70303.
PhosphoSitePlusiO70303.

Proteomic databases

MaxQBiO70303.
PaxDbiO70303.
PRIDEiO70303.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001497; ENSMUSP00000001497; ENSMUSG00000022219.
GeneIDi12684.
KEGGimmu:12684.
UCSCiuc007uap.2. mouse.

Organism-specific databases

CTDi27141.
MGIiMGI:1270844. Cideb.

Phylogenomic databases

eggNOGiENOG410IIBQ. Eukaryota.
ENOG4111N1Y. LUCA.
GeneTreeiENSGT00390000018596.
HOGENOMiHOG000029211.
HOVERGENiHBG050961.
InParanoidiO70303.
OMAiVWTSAPP.
OrthoDBiEOG091G0KVY.
PhylomeDBiO70303.
TreeFamiTF334321.

Miscellaneous databases

ChiTaRSiCideb. mouse.
PROiO70303.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022219.
GenevisibleiO70303. MM.

Family and domain databases

InterProiIPR003508. CIDE-N_dom.
[Graphical view]
PfamiPF02017. CIDE-N. 1 hit.
[Graphical view]
SMARTiSM00266. CAD. 1 hit.
[Graphical view]
PROSITEiPS51135. CIDE_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCIDEB_MOUSE
AccessioniPrimary (citable) accession number: O70303
Secondary accession number(s): Q91X39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: March 27, 2002
Last modified: November 30, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.