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Protein

Cell death activator CIDE-B

Gene

Cideb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Activates apoptosis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Cell death activator CIDE-B
Alternative name(s):
Cell death-inducing DFFA-like effector B
Gene namesi
Name:Cideb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1270844. Cideb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 219219Cell death activator CIDE-BPRO_0000144721Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei18 – 181PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO70303.
MaxQBiO70303.
PaxDbiO70303.
PRIDEiO70303.

PTM databases

iPTMnetiO70303.
PhosphoSiteiO70303.

Expressioni

Gene expression databases

BgeeiO70303.
GenevisibleiO70303. MM.

Interactioni

Subunit structurei

Inhibited by DFFB. Interacts with DFFA and DFFB (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000001497.

Structurei

3D structure databases

ProteinModelPortaliO70303.
SMRiO70303. Positions 1-115.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 11077CIDE-NPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CIDE-N domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IIBQ. Eukaryota.
ENOG4111N1Y. LUCA.
GeneTreeiENSGT00390000018596.
HOGENOMiHOG000029211.
HOVERGENiHBG050961.
InParanoidiO70303.
OMAiVWTSAPP.
OrthoDBiEOG78WKSV.
PhylomeDBiO70303.
TreeFamiTF334321.

Family and domain databases

InterProiIPR003508. CIDE-N_dom.
[Graphical view]
PfamiPF02017. CIDE-N. 1 hit.
[Graphical view]
SMARTiSM00266. CAD. 1 hit.
[Graphical view]
PROSITEiPS51135. CIDE_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70303-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYLSAFNPN GLLRSVSTVS SELSRRVWNS APPPQRPFRV CDHKRTVRKG
60 70 80 90 100
LTAASLQELL DKVLETLLLR GVLTLVLEED GTAVDSEDFF QLLEDDTCLM
110 120 130 140 150
VLEQGQSWSP KSGMLSYGLG REKPKHSKDI ARITFDVYKQ NPRDLFGSLN
160 170 180 190 200
VKATFYGLYS MSCDFQGVGP KRVLRELLRW TSSLLQGLGH MLLGISSTLR
210
HVVEGADRWQ WHGQRHLHS
Length:219
Mass (Da):24,800
Last modified:March 27, 2002 - v2
Checksum:i8915FB3CC5FE7721
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti180 – 1801W → G in AAC34986 (PubMed:9564035).Curated
Sequence conflicti184 – 1841L → Q in AAC34986 (PubMed:9564035).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041377 mRNA. Translation: AAC34986.1.
BC012664 mRNA. Translation: AAH12664.1.
BC046340 mRNA. Translation: AAH46340.1.
CCDSiCCDS27127.1.
RefSeqiNP_034024.2. NM_009894.3.
UniGeneiMm.466766.

Genome annotation databases

EnsembliENSMUST00000001497; ENSMUSP00000001497; ENSMUSG00000022219.
GeneIDi12684.
KEGGimmu:12684.
UCSCiuc007uap.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041377 mRNA. Translation: AAC34986.1.
BC012664 mRNA. Translation: AAH12664.1.
BC046340 mRNA. Translation: AAH46340.1.
CCDSiCCDS27127.1.
RefSeqiNP_034024.2. NM_009894.3.
UniGeneiMm.466766.

3D structure databases

ProteinModelPortaliO70303.
SMRiO70303. Positions 1-115.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000001497.

PTM databases

iPTMnetiO70303.
PhosphoSiteiO70303.

Proteomic databases

EPDiO70303.
MaxQBiO70303.
PaxDbiO70303.
PRIDEiO70303.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001497; ENSMUSP00000001497; ENSMUSG00000022219.
GeneIDi12684.
KEGGimmu:12684.
UCSCiuc007uap.2. mouse.

Organism-specific databases

CTDi27141.
MGIiMGI:1270844. Cideb.

Phylogenomic databases

eggNOGiENOG410IIBQ. Eukaryota.
ENOG4111N1Y. LUCA.
GeneTreeiENSGT00390000018596.
HOGENOMiHOG000029211.
HOVERGENiHBG050961.
InParanoidiO70303.
OMAiVWTSAPP.
OrthoDBiEOG78WKSV.
PhylomeDBiO70303.
TreeFamiTF334321.

Miscellaneous databases

ChiTaRSiCideb. mouse.
NextBioi281932.
PROiO70303.
SOURCEiSearch...

Gene expression databases

BgeeiO70303.
GenevisibleiO70303. MM.

Family and domain databases

InterProiIPR003508. CIDE-N_dom.
[Graphical view]
PfamiPF02017. CIDE-N. 1 hit.
[Graphical view]
SMARTiSM00266. CAD. 1 hit.
[Graphical view]
PROSITEiPS51135. CIDE_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor."
    Inohara N., Koseki T., Chen S., Wu X., Nunez G.
    EMBO J. 17:2526-2533(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-18, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCIDEB_MOUSE
AccessioniPrimary (citable) accession number: O70303
Secondary accession number(s): Q91X39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: March 27, 2002
Last modified: May 11, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.