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Protein

Persephin

Gene

Pspn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons.

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiR-RNO-5673001. RAF/MAP kinase cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Persephin
Short name:
PSP
Gene namesi
Name:Pspn
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi3432. Pspn.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 156135PersephinPRO_0000034016Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi66 ↔ 124By similarity
Disulfide bondi93 ↔ 152By similarity
Disulfide bondi97 ↔ 154By similarity
Disulfide bondi123 – 123InterchainBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO70301.

Expressioni

Tissue specificityi

Cochlea. Expressed at low levels in substantia nigra.1 Publication

Gene expression databases

BgeeiENSRNOG00000049171.
GenevisibleiO70301. RN.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065156.

Structurei

3D structure databases

ProteinModelPortaliO70301.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family. GDNF subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J061. Eukaryota.
ENOG4111Y7H. LUCA.
GeneTreeiENSGT00520000055559.
HOVERGENiHBG008316.
InParanoidiO70301.
OMAiAPAGPCQ.
OrthoDBiEOG091G0NJT.
PhylomeDBiO70301.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
[Graphical view]
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70301-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGRLRILF LLLLSLHLGL GWVLDLQEAP AADELSSGKM AETGRTWKPH
60 70 80 90 100
QGNNNVRLPR ALPGLCRLWS LTLPVAELGL GYASEEKIIF RYCAGSCPQE
110 120 130 140 150
VRTQHSLVLA RLRGQGRAHG RPCCQPTSYA DVTFLDDHHH WQQLPQLSAA

ACGCGG
Length:156
Mass (Da):17,063
Last modified:August 1, 1998 - v1
Checksum:i9631941CC69B00B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040961 mRNA. Translation: AAC40058.1.
AJ005169 Genomic DNA. Translation: CAA06410.1.
RefSeqiNP_037146.1. NM_013014.1.
UniGeneiRn.44349.

Genome annotation databases

EnsembliENSRNOT00000071188; ENSRNOP00000065156; ENSRNOG00000049171.
GeneIDi25525.
KEGGirno:25525.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040961 mRNA. Translation: AAC40058.1.
AJ005169 Genomic DNA. Translation: CAA06410.1.
RefSeqiNP_037146.1. NM_013014.1.
UniGeneiRn.44349.

3D structure databases

ProteinModelPortaliO70301.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065156.

Proteomic databases

PaxDbiO70301.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000071188; ENSRNOP00000065156; ENSRNOG00000049171.
GeneIDi25525.
KEGGirno:25525.

Organism-specific databases

CTDi5623.
RGDi3432. Pspn.

Phylogenomic databases

eggNOGiENOG410J061. Eukaryota.
ENOG4111Y7H. LUCA.
GeneTreeiENSGT00520000055559.
HOVERGENiHBG008316.
InParanoidiO70301.
OMAiAPAGPCQ.
OrthoDBiEOG091G0NJT.
PhylomeDBiO70301.

Enzyme and pathway databases

ReactomeiR-RNO-5673001. RAF/MAP kinase cascade.

Miscellaneous databases

PROiO70301.

Gene expression databases

BgeeiENSRNOG00000049171.
GenevisibleiO70301. RN.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
[Graphical view]
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSPN_RAT
AccessioniPrimary (citable) accession number: O70301
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.