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O70283 (WNT2B_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein Wnt-2b
Alternative name(s):
Protein Wnt-13
Gene names
Name:Wnt2b
Synonyms:Wnt13
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length389 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix.

Post-translational modification

Palmitoylation at Ser-241 is required for efficient binding to frizzled receptors. It is also required for subsequent palmitoylation at Cys-105. Palmitoylation is necessary for proper trafficking to cell surface By similarity.

Sequence similarities

Belongs to the Wnt family.

Ontologies

Keywords
   Biological processWnt signaling pathway
   Cellular componentExtracellular matrix
Secreted
   DomainSignal
   Molecular functionDevelopmental protein
   PTMGlycoprotein
Lipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcanonical Wnt signaling pathway

Inferred from genetic interaction PubMed 19686689. Source: MGI

cell-cell signaling

Traceable author statement PubMed 9889131. Source: MGI

chondrocyte differentiation

Inferred from electronic annotation. Source: Ensembl

forebrain regionalization

Inferred from expression pattern PubMed 15164427. Source: UniProtKB

hematopoietic stem cell proliferation

Inferred from electronic annotation. Source: Ensembl

lung induction

Inferred from genetic interaction PubMed 19686689. Source: MGI

male gonad development

Inferred from electronic annotation. Source: Ensembl

mesenchymal-epithelial cell signaling

Inferred from direct assay PubMed 11507767. Source: MGI

neuron differentiation

Inferred from Biological aspect of Ancestor. Source: RefGenome

organ morphogenesis

Traceable author statement PubMed 9889131. Source: MGI

positive regulation of branching involved in ureteric bud morphogenesis

Inferred from direct assay PubMed 11507767. Source: MGI

positive regulation of canonical Wnt signaling pathway

Inferred from electronic annotation. Source: Ensembl

signal transduction

Traceable author statement PubMed 9889131. Source: MGI

   Cellular_componentextracellular space

Inferred from Biological aspect of Ancestor. Source: RefGenome

proteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionfrizzled binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

receptor binding

Traceable author statement PubMed 9889131. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – ? Potential
Chain? – 389Protein Wnt-2bPRO_0000041414

Amino acid modifications

Lipidation1051S-palmitoyl cysteine By similarity
Lipidation2411O-palmitoyl serine; by PORCN By similarity
Glycosylation1151N-linked (GlcNAc...) Potential
Glycosylation2811N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict3131A → S in AAC25397. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O70283 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: 64F956BB9A00CEEB

FASTA38943,753
        10         20         30         40         50         60 
MLKLQGEDEA AQLAPRRARV PVPRPTAPDV SPSSARLGLA CLLLLLLLTL PARVDTSWWY 

        70         80         90        100        110        120 
IGALGARVIC DNIPGLVSRQ RQLCQRYPDI MRSVGEGARE WIRECQHQFR HHRWNCTTLD 

       130        140        150        160        170        180 
RDHTVFGRAM LRSSREAAFV YAISSAGVVH AITRACSQGE LSVCSCDPYT RGRHHDQRGD 

       190        200        210        220        230        240 
FDWGGCSDNI HYGVRFAKAF VDAKEKRLKD ARALMNLHNN RCGRTAVRRF LKLECKCHGV 

       250        260        270        280        290        300 
SGSCTLRTCW RALSDFRRTG DYLRRRYDGA VQVTATQDGA NFTAARQGYR HATRTDLVYF 

       310        320        330        340        350        360 
DNSPDYCVLD KAAGSLGTAG RVCSKTSKGT DGCEIMCCGR GYDTTRVTRV TQCECKFHWC 

       370        380 
CAVRCKECRN TVDVHTCKAP KKAEWLDQT 

« Hide

References

« Hide 'large scale' references
[1]"Structure and expression of Wnt13, a novel mouse Wnt2 related gene."
Zakin L.D.J., Mazan S., Maury M., Martin N., Guenet J.-L., Brulet P.
Mech. Dev. 73:107-116(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Urinary bladder.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[5]"The hem of the embryonic cerebral cortex is defined by the expression of multiple Wnt genes and is compromised in Gli3-deficient mice."
Grove E.A., Tole S., Limon J., Yip L., Ragsdale C.W.
Development 125:2315-2325(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 154-389.
Strain: NIH Swiss.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF070988 mRNA. Translation: AAC25397.1.
AK035653 mRNA. Translation: BAC29139.1.
CH466608 Genomic DNA. Translation: EDL07557.1.
BC119276 mRNA. Translation: AAI19277.1.
BC119278 mRNA. Translation: AAI19279.1.
AF038384 mRNA. Translation: AAC40123.1.
RefSeqNP_033546.2. NM_009520.3.
UniGeneMm.10740.

3D structure databases

ProteinModelPortalO70283.
SMRO70283. Positions 90-307.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid204573. 1 interaction.

PTM databases

PhosphoSiteO70283.

Proteomic databases

PRIDEO70283.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000029429; ENSMUSP00000029429; ENSMUSG00000027840.
GeneID22414.
KEGGmmu:22414.
UCSCuc008qut.1. mouse.

Organism-specific databases

CTD7482.
MGIMGI:1261834. Wnt2b.

Phylogenomic databases

eggNOGNOG284879.
GeneTreeENSGT00740000115400.
HOGENOMHOG000039529.
HOVERGENHBG001595.
InParanoidQ544L3.
KOK00182.
OMAPDIMQAI.
OrthoDBEOG7C8GJ8.
TreeFamTF105310.

Gene expression databases

BgeeO70283.
CleanExMM_WNT2B.
GenevestigatorO70283.

Family and domain databases

InterProIPR005817. Wnt.
IPR009140. Wnt2.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF21. PTHR12027:SF21. 1 hit.
PfamPF00110. wnt. 1 hit.
[Graphical view]
PRINTSPR01842. WNT2PROTEIN.
PR01349. WNTPROTEIN.
SMARTSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio302825.
PROO70283.
SOURCESearch...

Entry information

Entry nameWNT2B_MOUSE
AccessionPrimary (citable) accession number: O70283
Secondary accession number(s): O88530, Q544L3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot