Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O70283

- WNT2B_MOUSE

UniProt

O70283 - WNT2B_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protein Wnt-2b

Gene

Wnt2b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).By similarity

GO - Molecular functioni

  1. frizzled binding Source: RefGenome
  2. receptor binding Source: MGI

GO - Biological processi

  1. canonical Wnt signaling pathway Source: MGI
  2. cell-cell signaling Source: MGI
  3. cellular response to starvation Source: MGI
  4. chondrocyte differentiation Source: Ensembl
  5. forebrain regionalization Source: UniProtKB
  6. hematopoietic stem cell proliferation Source: Ensembl
  7. lung induction Source: MGI
  8. male gonad development Source: Ensembl
  9. mesenchymal-epithelial cell signaling Source: MGI
  10. neuron differentiation Source: RefGenome
  11. organ morphogenesis Source: MGI
  12. positive regulation of branching involved in ureteric bud morphogenesis Source: MGI
  13. positive regulation of canonical Wnt signaling pathway Source: Ensembl
  14. signal transduction Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_213918. WNT ligand biogenesis and trafficking.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-2b
Alternative name(s):
Protein Wnt-13
Gene namesi
Name:Wnt2b
Synonyms:Wnt13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1261834. Wnt2b.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: RefGenome
  2. proteinaceous extracellular matrix Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 389Protein Wnt-2bPRO_0000041414
Signal peptidei1 – ?Sequence Analysis

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi105 ↔ 116By similarity
Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi156 ↔ 164By similarity
Disulfide bondi166 ↔ 186By similarity
Disulfide bondi235 ↔ 249By similarity
Disulfide bondi237 ↔ 244By similarity
Lipidationi241 – 2411O-palmitoyl serine; by PORCNBy similarity
Glycosylationi281 – 2811N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi323 ↔ 338By similarity
Disulfide bondi353 ↔ 368By similarity
Disulfide bondi355 ↔ 365By similarity
Disulfide bondi360 ↔ 361By similarity

Post-translational modificationi

Palmitoylation at Ser-241 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiO70283.

PTM databases

PhosphoSiteiO70283.

Expressioni

Gene expression databases

BgeeiO70283.
CleanExiMM_WNT2B.
GenevestigatoriO70283.

Interactioni

Protein-protein interaction databases

BioGridi204573. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliO70283.
SMRiO70283. Positions 90-307.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG284879.
GeneTreeiENSGT00760000118943.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiO70283.
KOiK00182.
OMAiDYCVMDK.
OrthoDBiEOG7C8GJ8.
TreeFamiTF105310.

Family and domain databases

InterProiIPR005817. Wnt.
IPR009140. Wnt2.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01842. WNT2PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70283 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKLQGEDEA AQLAPRRARV PVPRPTAPDV SPSSARLGLA CLLLLLLLTL
60 70 80 90 100
PARVDTSWWY IGALGARVIC DNIPGLVSRQ RQLCQRYPDI MRSVGEGARE
110 120 130 140 150
WIRECQHQFR HHRWNCTTLD RDHTVFGRAM LRSSREAAFV YAISSAGVVH
160 170 180 190 200
AITRACSQGE LSVCSCDPYT RGRHHDQRGD FDWGGCSDNI HYGVRFAKAF
210 220 230 240 250
VDAKEKRLKD ARALMNLHNN RCGRTAVRRF LKLECKCHGV SGSCTLRTCW
260 270 280 290 300
RALSDFRRTG DYLRRRYDGA VQVTATQDGA NFTAARQGYR HATRTDLVYF
310 320 330 340 350
DNSPDYCVLD KAAGSLGTAG RVCSKTSKGT DGCEIMCCGR GYDTTRVTRV
360 370 380
TQCECKFHWC CAVRCKECRN TVDVHTCKAP KKAEWLDQT
Length:389
Mass (Da):43,753
Last modified:July 27, 2011 - v3
Checksum:i64F956BB9A00CEEB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti313 – 3131A → S in AAC25397. (PubMed:9545553)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF070988 mRNA. Translation: AAC25397.1.
AK035653 mRNA. Translation: BAC29139.1.
CH466608 Genomic DNA. Translation: EDL07557.1.
BC119276 mRNA. Translation: AAI19277.1.
BC119278 mRNA. Translation: AAI19279.1.
AF038384 mRNA. Translation: AAC40123.1.
CCDSiCCDS17706.1.
RefSeqiNP_033546.2. NM_009520.3.
UniGeneiMm.10740.

Genome annotation databases

EnsembliENSMUST00000029429; ENSMUSP00000029429; ENSMUSG00000027840.
GeneIDi22414.
KEGGimmu:22414.
UCSCiuc008qut.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF070988 mRNA. Translation: AAC25397.1 .
AK035653 mRNA. Translation: BAC29139.1 .
CH466608 Genomic DNA. Translation: EDL07557.1 .
BC119276 mRNA. Translation: AAI19277.1 .
BC119278 mRNA. Translation: AAI19279.1 .
AF038384 mRNA. Translation: AAC40123.1 .
CCDSi CCDS17706.1.
RefSeqi NP_033546.2. NM_009520.3.
UniGenei Mm.10740.

3D structure databases

ProteinModelPortali O70283.
SMRi O70283. Positions 90-307.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204573. 1 interaction.

PTM databases

PhosphoSitei O70283.

Proteomic databases

PRIDEi O70283.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029429 ; ENSMUSP00000029429 ; ENSMUSG00000027840 .
GeneIDi 22414.
KEGGi mmu:22414.
UCSCi uc008qut.1. mouse.

Organism-specific databases

CTDi 7482.
MGIi MGI:1261834. Wnt2b.

Phylogenomic databases

eggNOGi NOG284879.
GeneTreei ENSGT00760000118943.
HOGENOMi HOG000039529.
HOVERGENi HBG001595.
InParanoidi O70283.
KOi K00182.
OMAi DYCVMDK.
OrthoDBi EOG7C8GJ8.
TreeFami TF105310.

Enzyme and pathway databases

Reactomei REACT_213918. WNT ligand biogenesis and trafficking.

Miscellaneous databases

NextBioi 302825.
PROi O70283.
SOURCEi Search...

Gene expression databases

Bgeei O70283.
CleanExi MM_WNT2B.
Genevestigatori O70283.

Family and domain databases

InterProi IPR005817. Wnt.
IPR009140. Wnt2.
IPR018161. Wnt_CS.
[Graphical view ]
PANTHERi PTHR12027. PTHR12027. 1 hit.
Pfami PF00110. wnt. 1 hit.
[Graphical view ]
PRINTSi PR01842. WNT2PROTEIN.
PR01349. WNTPROTEIN.
SMARTi SM00097. WNT1. 1 hit.
[Graphical view ]
PROSITEi PS00246. WNT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and expression of Wnt13, a novel mouse Wnt2 related gene."
    Zakin L.D.J., Mazan S., Maury M., Martin N., Guenet J.-L., Brulet P.
    Mech. Dev. 73:107-116(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Urinary bladder.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "The hem of the embryonic cerebral cortex is defined by the expression of multiple Wnt genes and is compromised in Gli3-deficient mice."
    Grove E.A., Tole S., Limon J., Yip L., Ragsdale C.W.
    Development 125:2315-2325(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 154-389.
    Strain: NIH Swiss.

Entry informationi

Entry nameiWNT2B_MOUSE
AccessioniPrimary (citable) accession number: O70283
Secondary accession number(s): O88530, Q544L3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3