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O70283

- WNT2B_MOUSE

UniProt

O70283 - WNT2B_MOUSE

Protein

Protein Wnt-2b

Gene

Wnt2b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.By similarity

    GO - Molecular functioni

    1. frizzled binding Source: RefGenome
    2. protein binding Source: MGI
    3. receptor binding Source: MGI

    GO - Biological processi

    1. canonical Wnt signaling pathway Source: MGI
    2. cell-cell signaling Source: MGI
    3. cellular response to starvation Source: MGI
    4. chondrocyte differentiation Source: Ensembl
    5. forebrain regionalization Source: UniProtKB
    6. hematopoietic stem cell proliferation Source: Ensembl
    7. lung induction Source: MGI
    8. male gonad development Source: Ensembl
    9. mesenchymal-epithelial cell signaling Source: MGI
    10. neuron differentiation Source: RefGenome
    11. organ morphogenesis Source: MGI
    12. positive regulation of branching involved in ureteric bud morphogenesis Source: MGI
    13. positive regulation of canonical Wnt signaling pathway Source: Ensembl
    14. signal transduction Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_213918. WNT ligand biogenesis and trafficking.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Wnt-2b
    Alternative name(s):
    Protein Wnt-13
    Gene namesi
    Name:Wnt2b
    Synonyms:Wnt13
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1261834. Wnt2b.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: RefGenome
    2. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 389Protein Wnt-2bPRO_0000041414
    Signal peptidei1 – ?Sequence Analysis

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi105 ↔ 116By similarity
    Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi156 ↔ 164By similarity
    Disulfide bondi166 ↔ 186By similarity
    Disulfide bondi235 ↔ 249By similarity
    Disulfide bondi237 ↔ 244By similarity
    Lipidationi241 – 2411O-palmitoyl serine; by PORCNBy similarity
    Glycosylationi281 – 2811N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi323 ↔ 338By similarity
    Disulfide bondi353 ↔ 368By similarity
    Disulfide bondi355 ↔ 365By similarity
    Disulfide bondi360 ↔ 361By similarity

    Post-translational modificationi

    Palmitoylation at Ser-241 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiO70283.

    PTM databases

    PhosphoSiteiO70283.

    Expressioni

    Gene expression databases

    BgeeiO70283.
    CleanExiMM_WNT2B.
    GenevestigatoriO70283.

    Interactioni

    Protein-protein interaction databases

    BioGridi204573. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliO70283.
    SMRiO70283. Positions 90-307.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Wnt family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG284879.
    GeneTreeiENSGT00740000115400.
    HOGENOMiHOG000039529.
    HOVERGENiHBG001595.
    InParanoidiQ544L3.
    KOiK00182.
    OMAiDYCVMDK.
    OrthoDBiEOG7C8GJ8.
    TreeFamiTF105310.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR009140. Wnt2.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01842. WNT2PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O70283-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKLQGEDEA AQLAPRRARV PVPRPTAPDV SPSSARLGLA CLLLLLLLTL    50
    PARVDTSWWY IGALGARVIC DNIPGLVSRQ RQLCQRYPDI MRSVGEGARE 100
    WIRECQHQFR HHRWNCTTLD RDHTVFGRAM LRSSREAAFV YAISSAGVVH 150
    AITRACSQGE LSVCSCDPYT RGRHHDQRGD FDWGGCSDNI HYGVRFAKAF 200
    VDAKEKRLKD ARALMNLHNN RCGRTAVRRF LKLECKCHGV SGSCTLRTCW 250
    RALSDFRRTG DYLRRRYDGA VQVTATQDGA NFTAARQGYR HATRTDLVYF 300
    DNSPDYCVLD KAAGSLGTAG RVCSKTSKGT DGCEIMCCGR GYDTTRVTRV 350
    TQCECKFHWC CAVRCKECRN TVDVHTCKAP KKAEWLDQT 389
    Length:389
    Mass (Da):43,753
    Last modified:July 27, 2011 - v3
    Checksum:i64F956BB9A00CEEB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti313 – 3131A → S in AAC25397. (PubMed:9545553)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF070988 mRNA. Translation: AAC25397.1.
    AK035653 mRNA. Translation: BAC29139.1.
    CH466608 Genomic DNA. Translation: EDL07557.1.
    BC119276 mRNA. Translation: AAI19277.1.
    BC119278 mRNA. Translation: AAI19279.1.
    AF038384 mRNA. Translation: AAC40123.1.
    CCDSiCCDS17706.1.
    RefSeqiNP_033546.2. NM_009520.3.
    UniGeneiMm.10740.

    Genome annotation databases

    EnsembliENSMUST00000029429; ENSMUSP00000029429; ENSMUSG00000027840.
    GeneIDi22414.
    KEGGimmu:22414.
    UCSCiuc008qut.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF070988 mRNA. Translation: AAC25397.1 .
    AK035653 mRNA. Translation: BAC29139.1 .
    CH466608 Genomic DNA. Translation: EDL07557.1 .
    BC119276 mRNA. Translation: AAI19277.1 .
    BC119278 mRNA. Translation: AAI19279.1 .
    AF038384 mRNA. Translation: AAC40123.1 .
    CCDSi CCDS17706.1.
    RefSeqi NP_033546.2. NM_009520.3.
    UniGenei Mm.10740.

    3D structure databases

    ProteinModelPortali O70283.
    SMRi O70283. Positions 90-307.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204573. 1 interaction.

    PTM databases

    PhosphoSitei O70283.

    Proteomic databases

    PRIDEi O70283.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029429 ; ENSMUSP00000029429 ; ENSMUSG00000027840 .
    GeneIDi 22414.
    KEGGi mmu:22414.
    UCSCi uc008qut.1. mouse.

    Organism-specific databases

    CTDi 7482.
    MGIi MGI:1261834. Wnt2b.

    Phylogenomic databases

    eggNOGi NOG284879.
    GeneTreei ENSGT00740000115400.
    HOGENOMi HOG000039529.
    HOVERGENi HBG001595.
    InParanoidi Q544L3.
    KOi K00182.
    OMAi DYCVMDK.
    OrthoDBi EOG7C8GJ8.
    TreeFami TF105310.

    Enzyme and pathway databases

    Reactomei REACT_213918. WNT ligand biogenesis and trafficking.

    Miscellaneous databases

    NextBioi 302825.
    PROi O70283.
    SOURCEi Search...

    Gene expression databases

    Bgeei O70283.
    CleanExi MM_WNT2B.
    Genevestigatori O70283.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR009140. Wnt2.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01842. WNT2PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and expression of Wnt13, a novel mouse Wnt2 related gene."
      Zakin L.D.J., Mazan S., Maury M., Martin N., Guenet J.-L., Brulet P.
      Mech. Dev. 73:107-116(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Urinary bladder.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. "The hem of the embryonic cerebral cortex is defined by the expression of multiple Wnt genes and is compromised in Gli3-deficient mice."
      Grove E.A., Tole S., Limon J., Yip L., Ragsdale C.W.
      Development 125:2315-2325(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 154-389.
      Strain: NIH Swiss.

    Entry informationi

    Entry nameiWNT2B_MOUSE
    AccessioniPrimary (citable) accession number: O70283
    Secondary accession number(s): O88530, Q544L3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 111 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3