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Protein

Protein tyrosine phosphatase type IVA 2

Gene

Ptp4a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Enzyme regulationi

Inhibited by sodium orthovanadate and pentamidine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei69Proton donorBy similarity1
Active sitei101Phosphocysteine intermediateBy similarity1
Binding sitei107SubstrateBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiR-MMU-8873719. RAB geranylgeranylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein tyrosine phosphatase type IVA 2 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase 4a2
Protein-tyrosine phosphatase of regenerating liver 2
Short name:
PRL-2
Gene namesi
Name:Ptp4a2
Synonyms:Prl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1277117. Ptp4a2.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi164 – 167Missing : Locates in the nucleus. 1 Publication4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000947861 – 164Protein tyrosine phosphatase type IVA 2Add BLAST164
PropeptideiPRO_0000396732165 – 167Removed in mature formCurated3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 101By similarity
Modified residuei164Cysteine methyl esterCurated1
Lipidationi164S-farnesyl cysteine1 Publication1

Post-translational modificationi

Farnesylated. Farnesylation is required for membrane targeting and for interaction with RABGGTB (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiO70274.
MaxQBiO70274.
PaxDbiO70274.
PeptideAtlasiO70274.
PRIDEiO70274.

PTM databases

iPTMnetiO70274.
PhosphoSitePlusiO70274.

Expressioni

Tissue specificityi

Expressed in skeletal muscle, and at lower levels in liver, lung, heart, kidney, brain, testis and spleen.1 Publication

Gene expression databases

BgeeiENSMUSG00000028788.
CleanExiMM_PTP4A2.
GenevisibleiO70274. MM.

Interactioni

Subunit structurei

In contrast to PTP4A1 and PTP4A3, does not interact with tubulin. Interacts with RABGGTB (By similarity).By similarity

Protein-protein interaction databases

BioGridi202474. 1 interactor.
IntActiO70274. 1 interactor.
MINTiMINT-4105284.
STRINGi10090.ENSMUSP00000030578.

Structurei

Secondary structure

1167
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 11Combined sources5
Beta strandi14 – 18Combined sources5
Helixi27 – 37Combined sources11
Beta strandi39 – 46Combined sources8
Helixi53 – 56Combined sources4
Turni57 – 59Combined sources3
Beta strandi61 – 64Combined sources4
Helixi75 – 91Combined sources17
Beta strandi96 – 100Combined sources5
Beta strandi102 – 106Combined sources5
Helixi107 – 118Combined sources12
Helixi123 – 133Combined sources11
Helixi140 – 148Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5K24X-ray3.10A/B1-163[»]
ProteinModelPortaliO70274.
SMRiO70274.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini79 – 145Tyrosine-protein phosphataseAdd BLAST67

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni102 – 107Phosphate bindingBy similarity6

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2836. Eukaryota.
ENOG4111I7J. LUCA.
GeneTreeiENSGT00390000009788.
HOGENOMiHOG000231265.
HOVERGENiHBG071295.
InParanoidiO70274.
KOiK18041.
OMAiAPIEKEG.
OrthoDBiEOG091G0MYM.
PhylomeDBiO70274.
TreeFamiTF313384.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiView protein in InterPro
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
PfamiView protein in Pfam
PF00102. Y_phosphatase. 1 hit.
SMARTiView protein in SMART
SM00404. PTPc_motif. 1 hit.
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiView protein in PROSITE
PS50056. TYR_PHOSPHATASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70274-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRPAPVEIS YENMRFLITH NPTNATLNKF TEELKKYGVT TLVRVCDATY
60 70 80 90 100
DKAPVEKEGI HVLDWPFDDG APPPNQIVDD WLNLLKTKFR EEPGCCVAVH
110 120 130 140 150
CVAGLGRAPV LVALALIECG MKYEDAVQFI RQKRRGAFNS KQLLYLEKYR
160
PKMRLRFRDT NGHCCVQ
Length:167
Mass (Da):19,127
Last modified:August 1, 1998 - v1
Checksum:iE97B88BF87B87943
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035644 mRNA. Translation: AAC15874.1.
AK033092 mRNA. Translation: BAC28149.1.
AK045093 mRNA. Translation: BAC32217.1.
AK155895 mRNA. Translation: BAE33489.1.
BC086794 mRNA. Translation: AAH86794.1.
BC087551 mRNA. Translation: AAH87551.1.
CCDSiCCDS18704.1.
PIRiJC5981.
RefSeqiNP_001158217.1. NM_001164745.1.
NP_033000.1. NM_008974.4.
XP_017175534.1. XM_017320045.1.
UniGeneiMm.193688.

Genome annotation databases

EnsembliENSMUST00000030578; ENSMUSP00000030578; ENSMUSG00000028788.
ENSMUST00000165853; ENSMUSP00000125901; ENSMUSG00000028788.
GeneIDi19244.
KEGGimmu:19244.
UCSCiuc008uyf.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTP4A2_MOUSE
AccessioniPrimary (citable) accession number: O70274
Secondary accession number(s): Q3U1K7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: August 1, 1998
Last modified: May 10, 2017
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families