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O70273

- EHF_MOUSE

UniProt

O70273 - EHF_MOUSE

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Protein

ETS homologous factor

Gene
Ehf
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes, and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter By similarity.By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi207 – 28983ETSAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. sequence-specific DNA binding Source: InterPro
  3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome
  4. sequence-specific DNA binding transcription factor activity Source: UniProtKB

GO - Biological processi

  1. cell differentiation Source: RefGenome
  2. epithelial cell differentiation Source: UniProtKB
  3. positive regulation of transcription, DNA-templated Source: UniProtKB
  4. regulation of transcription from RNA polymerase II promoter Source: RefGenome
  5. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ETS homologous factor
Alternative name(s):
ETS domain-containing transcription factor
Gene namesi
Name:Ehf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1270840. Ehf.

Subcellular locationi

Nucleus By similarity By similarity

GO - Cellular componenti

  1. nucleus Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 300300ETS homologous factorPRO_0000257970Add
BLAST

Proteomic databases

MaxQBiO70273.
PRIDEiO70273.

PTM databases

PhosphoSiteiO70273.

Expressioni

Tissue specificityi

Highly expressed in kidney and lung, weakly in skeletal muscle, heart, and liver, and not detected in brain, spleen or testis.1 Publication

Gene expression databases

ArrayExpressiO70273.
BgeeiO70273.
CleanExiMM_EHF.
GenevestigatoriO70273.

Interactioni

Protein-protein interaction databases

BioGridi199409. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliO70273.
SMRiO70273. Positions 40-111, 206-299.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 11587PNTAdd
BLAST

Domaini

The PNT domain acts as a transcriptional activator.1 Publication

Sequence similaritiesi

Belongs to the ETS family.

Phylogenomic databases

eggNOGiNOG307806.
GeneTreeiENSGT00750000117299.
HOGENOMiHOG000232188.
HOVERGENiHBG074143.
InParanoidiO70273.
KOiK17102.
OMAiVMNLNPG.
OrthoDBiEOG7M0NRR.
PhylomeDBiO70273.
TreeFamiTF318679.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: O70273-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MILEGSGVMN LNPANNLLHQ QPAWTDSYPT CNVSSGFFGS QWHEIHPQYW    50
TKYQVWEWLQ HLLDTNQLDA SCIPFQEFDI SGEHLCSMSL QEFTRAAGSA 100
GQLLYSNLQH LKWNGQCSSD LFQSAHNVIV KTEQTDPSIM NTWKEENYLY 150
DPSYGSTVDL LDSKTFCRAQ ISMTTSSHLP VAESPDMKKE QDHPVKSHTK 200
KHNPRGTHLW EFIRDILLSP DKNPGLIKWE DRSEGIFRFL KSEAVAQLWG 250
KKKNNSSMTY EKLSRAMRYY YKREILERVD GRRLVYKFGK NARGWRENEN 300
Length:300
Mass (Da):34,903
Last modified:August 1, 1998 - v1
Checksum:i91D9477EFB874747
GO
Isoform 21 Publication (identifier: O70273-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-93: Missing.

Note: No experimental confirmation available.

Show »
Length:285
Mass (Da):33,225
Checksum:i91398C527C65955F
GO
Isoform 31 Publication (identifier: O70273-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     200-211: KKHNPRGTHLWE → YFIIELLLSESR
     212-300: Missing.

Note: No experimental confirmation available.

Show »
Length:211
Mass (Da):24,139
Checksum:i54F8846761D533CD
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei79 – 9315Missing in isoform 2. 1 PublicationVSP_052191Add
BLAST
Alternative sequencei200 – 21112KKHNP…THLWE → YFIIELLLSESR in isoform 3. 1 PublicationVSP_052192Add
BLAST
Alternative sequencei212 – 30089Missing in isoform 3. 1 PublicationVSP_052193Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF035527 mRNA. Translation: AAC40119.1.
BC005520 mRNA. Translation: AAH05520.1.
BC006789 mRNA. Translation: AAH06789.1.
BC008249 mRNA. Translation: AAH08249.1.
CCDSiCCDS16475.1. [O70273-1]
PIRiJW0048.
RefSeqiNP_031940.1. NM_007914.3. [O70273-1]
XP_006498760.1. XM_006498697.1. [O70273-1]
XP_006498761.1. XM_006498698.1. [O70273-1]
XP_006498762.1. XM_006498699.1. [O70273-1]
XP_006498763.1. XM_006498700.1. [O70273-1]
XP_006498764.1. XM_006498701.1. [O70273-1]
XP_006498765.1. XM_006498702.1. [O70273-1]
XP_006500821.1. XM_006500758.1. [O70273-1]
XP_006500822.1. XM_006500759.1. [O70273-1]
XP_006500823.1. XM_006500760.1. [O70273-1]
XP_006500824.1. XM_006500761.1. [O70273-1]
XP_006500825.1. XM_006500762.1. [O70273-1]
XP_006500826.1. XM_006500763.1. [O70273-1]
UniGeneiMm.10724.

Genome annotation databases

EnsembliENSMUST00000090475; ENSMUSP00000087961; ENSMUSG00000012350. [O70273-1]
ENSMUST00000111174; ENSMUSP00000106805; ENSMUSG00000012350. [O70273-1]
GeneIDi13661.
KEGGimmu:13661.
UCSCiuc008lio.1. mouse. [O70273-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF035527 mRNA. Translation: AAC40119.1 .
BC005520 mRNA. Translation: AAH05520.1 .
BC006789 mRNA. Translation: AAH06789.1 .
BC008249 mRNA. Translation: AAH08249.1 .
CCDSi CCDS16475.1. [O70273-1 ]
PIRi JW0048.
RefSeqi NP_031940.1. NM_007914.3. [O70273-1 ]
XP_006498760.1. XM_006498697.1. [O70273-1 ]
XP_006498761.1. XM_006498698.1. [O70273-1 ]
XP_006498762.1. XM_006498699.1. [O70273-1 ]
XP_006498763.1. XM_006498700.1. [O70273-1 ]
XP_006498764.1. XM_006498701.1. [O70273-1 ]
XP_006498765.1. XM_006498702.1. [O70273-1 ]
XP_006500821.1. XM_006500758.1. [O70273-1 ]
XP_006500822.1. XM_006500759.1. [O70273-1 ]
XP_006500823.1. XM_006500760.1. [O70273-1 ]
XP_006500824.1. XM_006500761.1. [O70273-1 ]
XP_006500825.1. XM_006500762.1. [O70273-1 ]
XP_006500826.1. XM_006500763.1. [O70273-1 ]
UniGenei Mm.10724.

3D structure databases

ProteinModelPortali O70273.
SMRi O70273. Positions 40-111, 206-299.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199409. 1 interaction.

PTM databases

PhosphoSitei O70273.

Proteomic databases

MaxQBi O70273.
PRIDEi O70273.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000090475 ; ENSMUSP00000087961 ; ENSMUSG00000012350 . [O70273-1 ]
ENSMUST00000111174 ; ENSMUSP00000106805 ; ENSMUSG00000012350 . [O70273-1 ]
GeneIDi 13661.
KEGGi mmu:13661.
UCSCi uc008lio.1. mouse. [O70273-1 ]

Organism-specific databases

CTDi 26298.
MGIi MGI:1270840. Ehf.

Phylogenomic databases

eggNOGi NOG307806.
GeneTreei ENSGT00750000117299.
HOGENOMi HOG000232188.
HOVERGENi HBG074143.
InParanoidi O70273.
KOi K17102.
OMAi VMNLNPG.
OrthoDBi EOG7M0NRR.
PhylomeDBi O70273.
TreeFami TF318679.

Miscellaneous databases

NextBioi 284404.
PROi O70273.
SOURCEi Search...

Gene expression databases

ArrayExpressi O70273.
Bgeei O70273.
CleanExi MM_EHF.
Genevestigatori O70273.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProi IPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view ]
PRINTSi PR00454. ETSDOMAIN.
SMARTi SM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view ]
SUPFAMi SSF47769. SSF47769. 1 hit.
PROSITEi PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and expression of Ehf, a new member of the ets transcription factor/oncoprotein gene family."
    Bochert M.A., Kleinbaum L.A., Sun L.-Y., Burton F.H.
    Biochem. Biophys. Res. Commun. 246:176-181(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Pituitary.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 222-300 (ISOFORMS 1/2).
    Strain: Czech II and FVB/N.
    Tissue: Mammary gland.
  3. "Determination of the consensus DNA-binding sequence and a transcriptional activation domain for ESE-2."
    Choi Y.S., Sinha S.
    Biochem. J. 398:497-507(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: DOMAIN.

Entry informationi

Entry nameiEHF_MOUSE
AccessioniPrimary (citable) accession number: O70273
Secondary accession number(s): Q922E8, Q922T6, Q99K12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: August 1, 1998
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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