ID STX7_RAT Reviewed; 261 AA. AC O70257; Q5U337; DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-2007, sequence version 4. DT 16-NOV-2011, entry version 95. DE RecName: Full=Syntaxin-7; GN Name=Stx7; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION. RC TISSUE=Brain; RX MEDLINE=98079071; PubMed=9417091; DOI=10.1074/jbc.273.1.375; RA Wong S.H., Xu Y., Zhang T., Hong W.; RT "Syntaxin 7, a novel syntaxin member associated with the early RT endosomal compartment."; RL J. Biol. Chem. 273:375-380(1998). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA], AND SNARE COMPLEX CHARACTERIZATION. RX MEDLINE=20553225; PubMed=11101518; DOI=10.1093/emboj/19.23.6453; RA Antonin W., Holroyd C., Fasshauer D., Pabst S., RA Fischer von Mollard G., Jahn R.; RT "A SNARE complex mediating fusion of late endosomes defines conserved RT properties of SNARE structure and function."; RL EMBO J. 19:6453-6464(2000). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Heart; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP SNARE COMPLEX CHARACTERIZATION. RX PubMed=15133481; DOI=10.1038/sj.embor.7400150; RA Pryor P.R., Mullock B.M., Bright N.A., Lindsay M.R., Gray S.R., RA Richardson S.C.W., Stewart A., James D.E., Piper R.C., Luzio J.P.; RT "Combinatorial SNARE complexes with VAMP7 or VAMP8 define different RT late endocytic fusion events."; RL EMBO Rep. 5:590-595(2004). CC -!- FUNCTION: May be involved in protein trafficking from the plasma CC membrane to the early endosome (EE) as well as in homotypic fusion CC of endocytic organelles. Mediates the endocytic trafficking from CC early endosomes to late endosomes and lysosomes (By similarity). CC -!- SUBUNIT: Interacts with STX8. Forms a SNARE complex with VTI1B, CC STX8 and VAMP8 which functions in the homotypic fusion of late CC endosomes. Component of the SNARE complex composed of STX7, STX8, CC VAMP7 and VTI1B that is required for heterotypic fusion of late CC endosomes with lysosomes in liver cells. Interacts with VPS11, CC VPS16 and VPS18. Found in a complex with VAMP8 and VTI1B in the CC liver. Part of the SNARE core complex containing VAMP8, STX8 and CC VTI1B (By similarity). Interacts with VPS33A. CC -!- SUBCELLULAR LOCATION: Early endosome membrane; Single-pass type IV CC membrane protein (By similarity). CC -!- TISSUE SPECIFICITY: Detected in all tissues tested. Highest CC expression is found in kidney followed by lung, spleen, heart and CC brain. Lower expression, in skeletal muscle, liver and testis. CC -!- SIMILARITY: Belongs to the syntaxin family. CC -!- SIMILARITY: Contains 1 t-SNARE coiled-coil homology domain. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF031430; AAC17131.1; -; mRNA. DR EMBL; BC085737; AAH85737.1; -; mRNA. DR IPI; IPI00196648; -. DR RefSeq; NP_068641.2; NM_021869.2. DR UniGene; Rn.1993; -. DR ProteinModelPortal; O70257; -. DR SMR; O70257; 169-227. DR IntAct; O70257; 1. DR STRING; O70257; -. DR PhosphoSite; O70257; -. DR PRIDE; O70257; -. DR Ensembl; ENSRNOT00000021318; ENSRNOP00000021318; ENSRNOG00000015670. DR GeneID; 60466; -. DR KEGG; rno:60466; -. DR NMPDR; fig|10116.3.peg.252; -. DR UCSC; NM_021869; rat. DR CTD; 8417; -. DR RGD; 619747; Stx7. DR eggNOG; roNOG10770; -. DR GeneTree; ENSGT00450000040239; -. DR HOVERGEN; HBG053083; -. DR InParanoid; O70257; -. DR OMA; EQGDMID; -. DR OrthoDB; EOG41NTN3; -. DR PhylomeDB; O70257; -. DR NextBio; 612234; -. DR ArrayExpress; O70257; -. DR Genevestigator; O70257; -. DR GermOnline; ENSRNOG00000015670; Rattus norvegicus. DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0031902; C:late endosome membrane; IDA:RGD. DR GO; GO:0005765; C:lysosomal membrane; IDA:RGD. DR GO; GO:0031201; C:SNARE complex; IDA:UniProtKB. DR GO; GO:0032403; F:protein complex binding; IDA:RGD. DR GO; GO:0005484; F:SNAP receptor activity; IEA:InterPro. DR GO; GO:0000149; F:SNARE binding; IPI:RGD. DR GO; GO:0008333; P:endosome to lysosome transport; IDA:RGD. DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro. DR GO; GO:0016079; P:synaptic vesicle exocytosis; TAS:RGD. DR GO; GO:0006906; P:vesicle fusion; IDA:RGD. DR InterPro; IPR006012; Syntaxin/epimorphin_CS. DR InterPro; IPR006011; Syntaxin_N. DR InterPro; IPR010989; t-SNARE. DR InterPro; IPR000727; T_SNARE_dom. DR KO; K08488; -. DR Pfam; PF05739; SNARE; 1. DR Pfam; PF00804; Syntaxin; 1. DR SMART; SM00503; SynN; 1. DR SMART; SM00397; t_SNARE; 1. DR SUPFAM; SSF47661; t-snare; 1. DR PROSITE; PS00914; SYNTAXIN; 1. DR PROSITE; PS50192; T_SNARE; 1. PE 1: Evidence at protein level; KW Acetylation; Coiled coil; Complete proteome; Endosome; Membrane; KW Phosphoprotein; Reference proteome; Transmembrane; KW Transmembrane helix. FT INIT_MET 1 1 Removed (By similarity). FT CHAIN 2 261 Syntaxin-7. FT /FTId=PRO_0000210216. FT TOPO_DOM 2 238 Cytoplasmic (Potential). FT TRANSMEM 239 259 Helical; Anchor for type IV membrane FT protein; (Potential). FT TOPO_DOM 260 261 Vesicular (Potential). FT DOMAIN 165 227 t-SNARE coiled-coil homology. FT COILED 47 68 Potential. FT MOD_RES 2 2 N-acetylserine (By similarity). FT MOD_RES 3 3 Phosphotyrosine (By similarity). FT MOD_RES 79 79 Phosphothreonine (By similarity). FT MOD_RES 125 125 Phosphoserine (By similarity). FT MOD_RES 126 126 Phosphoserine (By similarity). FT MOD_RES 129 129 Phosphoserine (By similarity). FT MOD_RES 205 205 Phosphoserine (By similarity). FT CONFLICT 139 139 E -> A (in Ref. 1; AAC17131). SQ SEQUENCE 261 AA; 29851 MW; 42D23BA7EC5F5F09 CRC64; MSYTPGIGGD PAQLAQRISS NIQKITQCSA EIQRTLNQLG TPQDTPELRQ QLQQEQQYTN QLAKETDKYI KEFGFLPTTP SEQRQRKIQK DRLVAEFTTA LTNFQKVQRQ AAEREKEFVA RVRASSRVSG GFPEDSSKEK NFVSWESQTQ PQVQVQDEEI TEDDLRLIHE RESSIRQLEA DIMDINEIFK DLGMMIHEQG DVIDSIEANV ESAEVHVQQA NQQLSRAANY QRKSRKTLCI IILILVVGIV IIFFIVWGLK G //