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Protein

Syntaxin-7

Gene

Stx7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes (By similarity).By similarity

GO - Molecular functioni

  • protein complex binding Source: RGD
  • SNAP receptor activity Source: FlyBase
  • SNARE binding Source: RGD

GO - Biological processi

  • endosome to lysosome transport Source: RGD
  • intracellular protein transport Source: GO_Central
  • synaptic vesicle exocytosis Source: RGD
  • vesicle docking Source: GO_Central
  • vesicle fusion Source: RGD
  • vesicle-mediated transport Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-7
Gene namesi
Name:Stx7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi619747. Stx7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 238237CytoplasmicSequence analysisAdd
BLAST
Transmembranei239 – 25921Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST
Topological domaini260 – 2612VesicularSequence analysis

GO - Cellular componenti

  • cytosol Source: GOC
  • early endosome membrane Source: UniProtKB-SubCell
  • endosome Source: RGD
  • integral component of membrane Source: GO_Central
  • late endosome membrane Source: RGD
  • lysosomal membrane Source: RGD
  • SNARE complex Source: UniProtKB
  • terminal bouton Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 261260Syntaxin-7PRO_0000210216Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei4 – 41PhosphothreonineBy similarity
Modified residuei79 – 791PhosphothreonineBy similarity
Modified residuei125 – 1251PhosphoserineBy similarity
Modified residuei126 – 1261PhosphoserineBy similarity
Modified residuei129 – 1291PhosphoserineBy similarity
Modified residuei205 – 2051PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiO70257.
PRIDEiO70257.

PTM databases

iPTMnetiO70257.
PhosphoSiteiO70257.
SwissPalmiO70257.

Expressioni

Tissue specificityi

Detected in all tissues tested. Highest expression is found in kidney followed by lung, spleen, heart and brain. Lower expression, in skeletal muscle, liver and testis.

Gene expression databases

ExpressionAtlasiO70257. baseline and differential.
GenevisibleiO70257. RN.

Interactioni

Subunit structurei

Interacts with VPS11, VPS16 and VPS18. Interacts with VPS33A (By similarity). Forms a SNARE complex with VTI1B, STX8 and VAMP8 which functions in the homotypic fusion of late endosomes. Component of the SNARE complex composed of STX7, STX8, VAMP7 and VTI1B that is required for heterotypic fusion of late endosomes with lysosomes.By similarity

GO - Molecular functioni

  • protein complex binding Source: RGD
  • SNAP receptor activity Source: FlyBase
  • SNARE binding Source: RGD

Protein-protein interaction databases

BioGridi248851. 2 interactions.
DIPiDIP-37411N.
IntActiO70257. 2 interactions.
STRINGi10116.ENSRNOP00000021318.

Structurei

3D structure databases

ProteinModelPortaliO70257.
SMRiO70257. Positions 169-227.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini165 – 22763t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili47 – 6822Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0811. Eukaryota.
COG5325. LUCA.
GeneTreeiENSGT00450000040239.
HOGENOMiHOG000188453.
HOVERGENiHBG053083.
InParanoidiO70257.
KOiK08488.
OMAiCISSNIQ.
OrthoDBiEOG7B31PS.
PhylomeDBiO70257.
TreeFamiTF315607.

Family and domain databases

InterProiIPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70257-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYTPGIGGD PAQLAQRISS NIQKITQCSA EIQRTLNQLG TPQDTPELRQ
60 70 80 90 100
QLQQEQQYTN QLAKETDKYI KEFGFLPTTP SEQRQRKIQK DRLVAEFTTA
110 120 130 140 150
LTNFQKVQRQ AAEREKEFVA RVRASSRVSG GFPEDSSKEK NFVSWESQTQ
160 170 180 190 200
PQVQVQDEEI TEDDLRLIHE RESSIRQLEA DIMDINEIFK DLGMMIHEQG
210 220 230 240 250
DVIDSIEANV ESAEVHVQQA NQQLSRAANY QRKSRKTLCI IILILVVGIV
260
IIFFIVWGLK G
Length:261
Mass (Da):29,851
Last modified:May 1, 2007 - v4
Checksum:i42D23BA7EC5F5F09
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti139 – 1391E → A in AAC17131 (PubMed:9417091).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031430 mRNA. Translation: AAC17131.1.
BC085737 mRNA. Translation: AAH85737.1.
RefSeqiNP_068641.2. NM_021869.2.
XP_006227753.1. XM_006227691.2.
XP_008756848.1. XM_008758626.1.
UniGeneiRn.1993.

Genome annotation databases

EnsembliENSRNOT00000021318; ENSRNOP00000021318; ENSRNOG00000015670.
GeneIDi60466.
KEGGirno:60466.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031430 mRNA. Translation: AAC17131.1.
BC085737 mRNA. Translation: AAH85737.1.
RefSeqiNP_068641.2. NM_021869.2.
XP_006227753.1. XM_006227691.2.
XP_008756848.1. XM_008758626.1.
UniGeneiRn.1993.

3D structure databases

ProteinModelPortaliO70257.
SMRiO70257. Positions 169-227.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248851. 2 interactions.
DIPiDIP-37411N.
IntActiO70257. 2 interactions.
STRINGi10116.ENSRNOP00000021318.

PTM databases

iPTMnetiO70257.
PhosphoSiteiO70257.
SwissPalmiO70257.

Proteomic databases

PaxDbiO70257.
PRIDEiO70257.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021318; ENSRNOP00000021318; ENSRNOG00000015670.
GeneIDi60466.
KEGGirno:60466.

Organism-specific databases

CTDi8417.
RGDi619747. Stx7.

Phylogenomic databases

eggNOGiKOG0811. Eukaryota.
COG5325. LUCA.
GeneTreeiENSGT00450000040239.
HOGENOMiHOG000188453.
HOVERGENiHBG053083.
InParanoidiO70257.
KOiK08488.
OMAiCISSNIQ.
OrthoDBiEOG7B31PS.
PhylomeDBiO70257.
TreeFamiTF315607.

Miscellaneous databases

PROiO70257.

Gene expression databases

ExpressionAtlasiO70257. baseline and differential.
GenevisibleiO70257. RN.

Family and domain databases

InterProiIPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Syntaxin 7, a novel syntaxin member associated with the early endosomal compartment."
    Wong S.H., Xu Y., Zhang T., Hong W.
    J. Biol. Chem. 273:375-380(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    Tissue: Brain.
  2. "A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function."
    Antonin W., Holroyd C., Fasshauer D., Pabst S., Fischer von Mollard G., Jahn R.
    EMBO J. 19:6453-6464(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SNARE COMPLEX CHARACTERIZATION.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  4. "Combinatorial SNARE complexes with VAMP7 or VAMP8 define different late endocytic fusion events."
    Pryor P.R., Mullock B.M., Bright N.A., Lindsay M.R., Gray S.R., Richardson S.C.W., Stewart A., James D.E., Piper R.C., Luzio J.P.
    EMBO Rep. 5:590-595(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SNARE COMPLEX CHARACTERIZATION.

Entry informationi

Entry nameiSTX7_RAT
AccessioniPrimary (citable) accession number: O70257
Secondary accession number(s): Q5U337
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2007
Last modified: July 6, 2016
This is version 134 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.