Syntaxin-7 - Rattus norvegicus (Rat)

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O70257 (STX7_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 95. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Syntaxin-7

Gene names

Name:

Stx7

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes By similarity.
Subunit structure	Interacts with STX8. Forms a SNARE complex with VTI1B, STX8 and VAMP8 which functions in the homotypic fusion of late endosomes. Component of the SNARE complex composed of STX7, STX8, VAMP7 and VTI1B that is required for heterotypic fusion of late endosomes with lysosomes in liver cells. Interacts with VPS11, VPS16 and VPS18. Found in a complex with VAMP8 and VTI1B in the liver. Part of the SNARE core complex containing VAMP8, STX8 and VTI1B By similarity. Interacts with VPS33A.
Subcellular location	Early endosome membrane; Single-pass type IV membrane protein By similarity.
Tissue specificity	Detected in all tissues tested. Highest expression is found in kidney followed by lung, spleen, heart and brain. Lower expression, in skeletal muscle, liver and testis.
Sequence similarities	Belongs to the syntaxin family. Contains 1 t-SNARE coiled-coil homology domain.

Ontologies

Keywords
Cellular component	Endosome Membrane
Domain	Coiled coil Transmembrane Transmembrane helix
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	endosome to lysosome transport Inferred from direct assay Ref.4. Source: RGD intracellular protein transport Inferred from electronic annotation. Source: InterPro synaptic vesicle exocytosis Traceable author statement. Source: RGD vesicle fusion Inferred from direct assay Ref.4. Source: RGD
Cellular component	SNARE complex Inferred from direct assay Ref.4. Source: UniProtKB early endosome membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW late endosome membrane Inferred from direct assay Ref.4. Source: RGD lysosomal membrane Inferred from direct assay Ref.4. Source: RGD
Molecular function	SNAP receptor activity Inferred from electronic annotation. Source: InterPro SNARE binding Inferred from physical interaction Ref.4. Source: RGD protein complex binding Inferred from direct assay. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed By similarity

Chain

2 – 261

260

Syntaxin-7

PRO_0000210216

Regions

Topological domain

2 – 238

237

Cytoplasmic Potential

Transmembrane

239 – 259

Helical; Anchor for type IV membrane protein; Potential

Topological domain

260 – 261

Vesicular Potential

Domain

165 – 227

t-SNARE coiled-coil homology

Coiled coil

47 – 68

Potential

Amino acid modifications

Modified residue

N-acetylserine By similarity

Modified residue

Phosphotyrosine By similarity

Modified residue

Phosphothreonine By similarity

Modified residue

125

Phosphoserine By similarity

Modified residue

126

Phosphoserine By similarity

Modified residue

129

Phosphoserine By similarity

Modified residue

205

Phosphoserine By similarity

Experimental info

Sequence conflict

139

E → A in AAC17131. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

O70257 [UniParc].

Last modified May 1, 2007. Version 4.
Checksum: 42D23BA7EC5F5F09
Show »

FASTA

261

29,851

        10         20         30         40         50         60 
MSYTPGIGGD PAQLAQRISS NIQKITQCSA EIQRTLNQLG TPQDTPELRQ QLQQEQQYTN 

        70         80         90        100        110        120 
QLAKETDKYI KEFGFLPTTP SEQRQRKIQK DRLVAEFTTA LTNFQKVQRQ AAEREKEFVA 

       130        140        150        160        170        180 
RVRASSRVSG GFPEDSSKEK NFVSWESQTQ PQVQVQDEEI TEDDLRLIHE RESSIRQLEA 

       190        200        210        220        230        240 
DIMDINEIFK DLGMMIHEQG DVIDSIEANV ESAEVHVQQA NQQLSRAANY QRKSRKTLCI 

       250        260 
IILILVVGIV IIFFIVWGLK G

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Syntaxin 7, a novel syntaxin member associated with the early endosomal compartment." Wong S.H., Xu Y., Zhang T., Hong W. J. Biol. Chem. 273:375-380(1998) [PubMed: 9417091] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION. Tissue: Brain.
[2]	"A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function." Antonin W., Holroyd C., Fasshauer D., Pabst S., Fischer von Mollard G., Jahn R. EMBO J. 19:6453-6464(2000) [PubMed: 11101518] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SNARE COMPLEX CHARACTERIZATION.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart.
[4]	"Combinatorial SNARE complexes with VAMP7 or VAMP8 define different late endocytic fusion events." Pryor P.R., Mullock B.M., Bright N.A., Lindsay M.R., Gray S.R., Richardson S.C.W., Stewart A., James D.E., Piper R.C., Luzio J.P. EMBO Rep. 5:590-595(2004) [PubMed: 15133481] [Abstract] Cited for: SNARE COMPLEX CHARACTERIZATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF031430 mRNA. Translation: AAC17131.1. BC085737 mRNA. Translation: AAH85737.1.
IPI	IPI00196648.
RefSeq	NP_068641.2. NM_021869.2.
UniGene	Rn.1993.
3D structure databases
ProteinModelPortal	O70257.
SMR	O70257. Positions 169-227.
ModBase	Search...
Protein-protein interaction databases
IntAct	O70257. 1 interaction.
STRING	O70257.
PTM databases
PhosphoSite	O70257.
Proteomic databases
PRIDE	O70257.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000021318; ENSRNOP00000021318; ENSRNOG00000015670.
GeneID	60466.
KEGG	rno:60466.
NMPDR	fig\|10116.3.peg.252.
UCSC	NM_021869. rat.
Organism-specific databases
CTD	8417.
RGD	619747. Stx7.
Phylogenomic databases
eggNOG	roNOG10770.
GeneTree	ENSGT00450000040239.
HOVERGEN	HBG053083.
InParanoid	O70257.
OMA	EQGDMID.
OrthoDB	EOG41NTN3.
PhylomeDB	O70257.
Gene expression databases
ArrayExpress	O70257.
Genevestigator	O70257.
GermOnline	ENSRNOG00000015670. Rattus norvegicus.
Family and domain databases
InterPro	IPR006012. Syntaxin/epimorphin_CS. IPR006011. Syntaxin_N. IPR010989. t-SNARE. IPR000727. T_SNARE_dom. [Graphical view]
KO	K08488.
Pfam	PF05739. SNARE. 1 hit. PF00804. Syntaxin. 1 hit. [Graphical view]
SMART	SM00503. SynN. 1 hit. SM00397. t_SNARE. 1 hit. [Graphical view]
SUPFAM	SSF47661. t-snare. 1 hit.
PROSITE	PS00914. SYNTAXIN. 1 hit. PS50192. T_SNARE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	612234.

Entry information

Entry name

STX7_RAT

Accession

Primary (citable) accession number: O70257
Secondary accession number(s): Q5U337

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2007
Last modified:	November 16, 2011
This is version 95 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents