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Protein

Myelin protein zero-like protein 2

Gene

Mpzl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates homophilic cell-cell adhesion.

GO - Biological processi

  • cell-cell adhesion Source: MGI
  • T cell differentiation in thymus Source: MGI

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin protein zero-like protein 2
Alternative name(s):
Epithelial V-like antigen 1
Gene namesi
Name:Mpzl2
Synonyms:Eva, Eva1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1289160 Mpzl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 154ExtracellularSequence analysisAdd BLAST128
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Topological domaini176 – 215CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001475727 – 215Myelin protein zero-like protein 2Add BLAST189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi39N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi47 ↔ 123PROSITE-ProRule annotation
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO70255
PRIDEiO70255

PTM databases

iPTMnetiO70255
PhosphoSitePlusiO70255

Expressioni

Tissue specificityi

Expressed in liver and gut, skin, and testis but not in thymocytes, lymphocytes, macrophage or dendritic cells or cell lines.

Gene expression databases

CleanExiMM_MPZL2

Interactioni

Protein-protein interaction databases

IntActiO70255, 1 interactor
STRINGi10090.ENSMUSP00000034600

Structurei

3D structure databases

ProteinModelPortaliO70255
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 141Ig-like V-typeAdd BLAST115

Sequence similaritiesi

Belongs to the myelin P0 protein family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IU94 Eukaryota
ENOG410YKVV LUCA
HOGENOMiHOG000232144
HOVERGENiHBG107197
InParanoidiO70255
PhylomeDBiO70255

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR029863 MPZL2
IPR000920 Myelin_P0-rel
PANTHERiPTHR13869 PTHR13869, 1 hit
PTHR13869:SF21 PTHR13869:SF21, 1 hit
PfamiView protein in Pfam
PF07686 V-set, 1 hit
PRINTSiPR00213 MYELINP0
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70255-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYGKSPALVL PLLLSLQLTA LCPTEAVEIY TSGALEAVNG TDVRLKCTFS
60 70 80 90 100
SFAPVGDALT VTWNFRPRDG GREQFVFYYH MDPFRPMSGR FKDRVVWDGN
110 120 130 140 150
PERYDVSILL WKLQFDDNGT YTCQVKNPPD VDGLVGTIRL SVVHTVPFSE
160 170 180 190 200
IYFLAVAIGS ACALMIIVVI VVVLFQHFRK KRWADRADKA EGTKSKEEEK
210
LNQGNKVSVF VEDTD
Length:215
Mass (Da):24,162
Last modified:August 1, 1998 - v1
Checksum:iF6E5E36787CE69D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030454 mRNA Translation: AAC40128.1
CCDSiCCDS23126.1
UniGeneiMm.33240

Similar proteinsi

Entry informationi

Entry nameiMPZL2_MOUSE
AccessioniPrimary (citable) accession number: O70255
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: August 1, 1998
Last modified: April 25, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health