Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Myelin protein zero-like protein 2

Gene

Mpzl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mediates homophilic cell-cell adhesion.

GO - Biological processi

  • single organismal cell-cell adhesion Source: MGI
  • T cell differentiation in thymus Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin protein zero-like protein 2
Alternative name(s):
Epithelial V-like antigen 1
Gene namesi
Name:Mpzl2
Synonyms:Eva, Eva1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1289160. Mpzl2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 154128ExtracellularSequence analysisAdd
BLAST
Transmembranei155 – 17521HelicalSequence analysisAdd
BLAST
Topological domaini176 – 21540CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 215189Myelin protein zero-like protein 2PRO_0000014757Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi39 – 391N-linked (GlcNAc...)1 Publication
Disulfide bondi47 ↔ 123PROSITE-ProRule annotation
Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO70255.
PRIDEiO70255.

PTM databases

iPTMnetiO70255.
PhosphoSiteiO70255.

Expressioni

Tissue specificityi

Expressed in liver and gut, skin, and testis but not in thymocytes, lymphocytes, macrophage or dendritic cells or cell lines.

Gene expression databases

CleanExiMM_MPZL2.

Interactioni

Protein-protein interaction databases

IntActiO70255. 1 interaction.
STRINGi10090.ENSMUSP00000034600.

Structurei

3D structure databases

ProteinModelPortaliO70255.
SMRiO70255. Positions 27-146.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 141115Ig-like V-typeAdd
BLAST

Sequence similaritiesi

Belongs to the myelin P0 protein family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IU94. Eukaryota.
ENOG410YKVV. LUCA.
HOGENOMiHOG000232144.
HOVERGENiHBG107197.
InParanoidiO70255.
PhylomeDBiO70255.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR029863. MPZL2.
IPR000920. Myelin_P0-rel.
[Graphical view]
PANTHERiPTHR13869. PTHR13869. 1 hit.
PTHR13869:SF21. PTHR13869:SF21. 1 hit.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR00213. MYELINP0.
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70255-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYGKSPALVL PLLLSLQLTA LCPTEAVEIY TSGALEAVNG TDVRLKCTFS
60 70 80 90 100
SFAPVGDALT VTWNFRPRDG GREQFVFYYH MDPFRPMSGR FKDRVVWDGN
110 120 130 140 150
PERYDVSILL WKLQFDDNGT YTCQVKNPPD VDGLVGTIRL SVVHTVPFSE
160 170 180 190 200
IYFLAVAIGS ACALMIIVVI VVVLFQHFRK KRWADRADKA EGTKSKEEEK
210
LNQGNKVSVF VEDTD
Length:215
Mass (Da):24,162
Last modified:August 1, 1998 - v1
Checksum:iF6E5E36787CE69D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030454 mRNA. Translation: AAC40128.1.
CCDSiCCDS23126.1.
UniGeneiMm.33240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030454 mRNA. Translation: AAC40128.1.
CCDSiCCDS23126.1.
UniGeneiMm.33240.

3D structure databases

ProteinModelPortaliO70255.
SMRiO70255. Positions 27-146.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO70255. 1 interaction.
STRINGi10090.ENSMUSP00000034600.

PTM databases

iPTMnetiO70255.
PhosphoSiteiO70255.

Proteomic databases

PaxDbiO70255.
PRIDEiO70255.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1289160. Mpzl2.

Phylogenomic databases

eggNOGiENOG410IU94. Eukaryota.
ENOG410YKVV. LUCA.
HOGENOMiHOG000232144.
HOVERGENiHBG107197.
InParanoidiO70255.
PhylomeDBiO70255.

Miscellaneous databases

PROiO70255.
SOURCEiSearch...

Gene expression databases

CleanExiMM_MPZL2.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR029863. MPZL2.
IPR000920. Myelin_P0-rel.
[Graphical view]
PANTHERiPTHR13869. PTHR13869. 1 hit.
PTHR13869:SF21. PTHR13869:SF21. 1 hit.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR00213. MYELINP0.
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMPZL2_MOUSE
AccessioniPrimary (citable) accession number: O70255
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: August 1, 1998
Last modified: May 11, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.