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O70252 (HMOX2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Heme oxygenase 2
Short name=HO-2
EC=1.14.99.3
Gene names
Name:Hmox2
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.

Catalytic activity

Heme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O.

Subcellular location

Microsome. Endoplasmic reticulum.

Sequence similarities

Belongs to the heme oxygenase family.

Contains 2 HRM (heme regulatory motif) repeats.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Microsome
   DomainRepeat
   LigandHeme
Iron
Metal-binding
   Molecular functionOxidoreductase
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processheme oxidation

Inferred from electronic annotation. Source: InterPro

   Cellular componentendoplasmic reticulum

Inferred from electronic annotation. Source: UniProtKB-SubCell

microsome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionheme oxygenase (decyclizing) activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 315314Heme oxygenase 2
PRO_0000209692

Regions

Repeat263 – 2686HRM 1
Repeat280 – 2856HRM 2

Sites

Metal binding441Iron (heme axial ligand) By similarity

Amino acid modifications

Modified residue21N-acetylserine By similarity

Experimental info

Sequence conflict172 – 1743RAL → SSS in AAC82364. Ref.2
Sequence conflict172 – 1743RAL → SSS in AAC82363. Ref.2

Sequences

Sequence LengthMass (Da)Tools
O70252 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: EA382EB2C7CED6D1

FASTA31535,739
        10         20         30         40         50         60 
MSSEVETSEG VDESEKNSMA PEKENHTKMA DLSELLKEGT KEAHDRAENT QFVKDFLKGN 

        70         80         90        100        110        120 
IKKELFKLAT TALYFTYSAL EEEMDRNKDH PAFAPLYFPT ELHRKAALIK DMKYFFGENW 

       130        140        150        160        170        180 
EEQVKCSEAA QKYVDRIHYV GQNEPELLVA HAYTRYMGDL SGGQVLKKVA QRALKLPSTG 

       190        200        210        220        230        240 
EGTQFYLFEH VDNAQQFKQF YRARMNALDL NLKTKERIVE EANKAFEYNM QIFSELDQAG 

       250        260        270        280        290        300 
SMLARETLED GLPVHDGKGD IRKCPFYAAQ PDKGTLGGSN CPFQTTVAVL RKPSLQLILA 

       310 
ASVALVAGLL AWYYM

« Hide

References

« Hide 'large scale' references
[1]"Sequence of mouse heme oxygenase-2."
Mount D.B.
Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: CD-1.
[2]"The identification and expression of heme oxygenase-2 alternative transcripts in the mouse."
Gibbs L., Willis D., Morgan M.J.
Gene 221:171-177(1998) [PubMed: 9795203] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF029874 mRNA. Translation: AAC17981.1.
AF054670 mRNA. Translation: AAC82364.1.
AF054669 mRNA. Translation: AAC82363.1.
BC002011 mRNA. Translation: AAH02011.1.
IPIIPI00309322.
PIRJC5149.
RefSeqNP_001129538.1. NM_001136066.2.
NP_034573.2. NM_010443.2.
UniGeneMm.272866.

3D structure databases

ProteinModelPortalO70252.
SMRO70252. Positions 29-247.
ModBaseSearch...

Protein-protein interaction databases

STRINGO70252.

PTM databases

PhosphoSiteO70252.

Proteomic databases

PRIDEO70252.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000004172; ENSMUSP00000004172; ENSMUSG00000004070.
ENSMUST00000118885; ENSMUSP00000113110; ENSMUSG00000004070.
ENSMUST00000120232; ENSMUSP00000112397; ENSMUSG00000004070.
GeneID15369.
KEGGmmu:15369.

Organism-specific databases

CTD3163.
MGIMGI:109373. Hmox2.

Phylogenomic databases

eggNOGroNOG10441.
HOGENOMHBG431019.
HOVERGENHBG005982.
InParanoidO70252.
OMAREGTKKS.
OrthoDBEOG4RNB8T.
PhylomeDBO70252.

Gene expression databases

ArrayExpressO70252.
BgeeO70252.
CleanExMM_HMOX2.
GenevestigatorO70252.
GermOnlineENSMUSG00000004070. Mus musculus.

Family and domain databases

InterProIPR002051. Haem_Oase.
IPR016053. Haem_Oase-like.
IPR016084. Haem_Oase-like_multi-hlx.
IPR018207. Haem_oxygenase_CS.
[Graphical view]
Gene3DG3DSA:1.20.910.10. Haem_Oase-like_multi-hlx. 1 hit.
KOK00510.
PANTHERPTHR10720. Haem_Oase. 1 hit.
PfamPF01126. Heme_oxygenase. 1 hit.
[Graphical view]
PIRSFPIRSF000343. Haem_Oase. 1 hit.
PRINTSPR00088. HAEMOXYGNASE.
SUPFAMSSF48613. Heme_oxygenase. 1 hit.
PROSITEPS00593. HEME_OXYGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288002.
SOURCESearch...

Entry information

Entry nameHMOX2_MOUSE
AccessionPrimary (citable) accession number: O70252
Secondary accession number(s): O70626
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: November 16, 2011
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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