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O70252

- HMOX2_MOUSE

UniProt

O70252 - HMOX2_MOUSE

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Protein

Heme oxygenase 2

Gene

Hmox2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.

Catalytic activityi

Protoheme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi44 – 441Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. heme oxygenase (decyclizing) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. heme oxidation Source: InterPro
  2. response to hypoxia Source: Ensembl
  3. response to oxidative stress Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_205755. Iron uptake and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Heme oxygenase 2 (EC:1.14.99.3)
Short name:
HO-2
Gene namesi
Name:Hmox2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:109373. Hmox2.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 315314Heme oxygenase 2PRO_0000209692Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiO70252.
PaxDbiO70252.
PRIDEiO70252.

PTM databases

PhosphoSiteiO70252.

Expressioni

Gene expression databases

BgeeiO70252.
CleanExiMM_HMOX2.
ExpressionAtlasiO70252. baseline and differential.
GenevestigatoriO70252.

Interactioni

Protein-protein interaction databases

IntActiO70252. 3 interactions.
MINTiMINT-1847819.

Structurei

3D structure databases

ProteinModelPortaliO70252.
SMRiO70252. Positions 29-247.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati263 – 2686HRM 1
Repeati280 – 2856HRM 2

Sequence similaritiesi

Belongs to the heme oxygenase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5398.
HOGENOMiHOG000233221.
HOVERGENiHBG005982.
InParanoidiO70252.
KOiK00510.
OMAiMDRNKDH.
PhylomeDBiO70252.
TreeFamiTF314786.

Family and domain databases

Gene3Di1.20.910.10. 1 hit.
InterProiIPR002051. Haem_Oase.
IPR016053. Haem_Oase-like.
IPR016084. Haem_Oase-like_multi-hlx.
IPR018207. Haem_oxygenase_CS.
[Graphical view]
PANTHERiPTHR10720. PTHR10720. 1 hit.
PfamiPF01126. Heme_oxygenase. 1 hit.
[Graphical view]
PIRSFiPIRSF000343. Haem_Oase. 1 hit.
PRINTSiPR00088. HAEMOXYGNASE.
SUPFAMiSSF48613. SSF48613. 1 hit.
PROSITEiPS00593. HEME_OXYGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70252-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSEVETSEG VDESEKNSMA PEKENHTKMA DLSELLKEGT KEAHDRAENT
60 70 80 90 100
QFVKDFLKGN IKKELFKLAT TALYFTYSAL EEEMDRNKDH PAFAPLYFPT
110 120 130 140 150
ELHRKAALIK DMKYFFGENW EEQVKCSEAA QKYVDRIHYV GQNEPELLVA
160 170 180 190 200
HAYTRYMGDL SGGQVLKKVA QRALKLPSTG EGTQFYLFEH VDNAQQFKQF
210 220 230 240 250
YRARMNALDL NLKTKERIVE EANKAFEYNM QIFSELDQAG SMLARETLED
260 270 280 290 300
GLPVHDGKGD IRKCPFYAAQ PDKGTLGGSN CPFQTTVAVL RKPSLQLILA
310
ASVALVAGLL AWYYM
Length:315
Mass (Da):35,739
Last modified:August 1, 1998 - v1
Checksum:iEA382EB2C7CED6D1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti172 – 1743RAL → SSS in AAC82364. (PubMed:9795203)Curated
Sequence conflicti172 – 1743RAL → SSS in AAC82363. (PubMed:9795203)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF029874 mRNA. Translation: AAC17981.1.
AF054670 mRNA. Translation: AAC82364.1.
AF054669 mRNA. Translation: AAC82363.1.
BC002011 mRNA. Translation: AAH02011.1.
CCDSiCCDS27924.1.
PIRiJC5149.
RefSeqiNP_001129538.1. NM_001136066.2.
NP_034573.2. NM_010443.2.
UniGeneiMm.272866.

Genome annotation databases

EnsembliENSMUST00000004172; ENSMUSP00000004172; ENSMUSG00000004070.
ENSMUST00000118885; ENSMUSP00000113110; ENSMUSG00000004070.
ENSMUST00000120232; ENSMUSP00000112397; ENSMUSG00000004070.
GeneIDi15369.
KEGGimmu:15369.
UCSCiuc007yag.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF029874 mRNA. Translation: AAC17981.1 .
AF054670 mRNA. Translation: AAC82364.1 .
AF054669 mRNA. Translation: AAC82363.1 .
BC002011 mRNA. Translation: AAH02011.1 .
CCDSi CCDS27924.1.
PIRi JC5149.
RefSeqi NP_001129538.1. NM_001136066.2.
NP_034573.2. NM_010443.2.
UniGenei Mm.272866.

3D structure databases

ProteinModelPortali O70252.
SMRi O70252. Positions 29-247.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O70252. 3 interactions.
MINTi MINT-1847819.

PTM databases

PhosphoSitei O70252.

Proteomic databases

MaxQBi O70252.
PaxDbi O70252.
PRIDEi O70252.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000004172 ; ENSMUSP00000004172 ; ENSMUSG00000004070 .
ENSMUST00000118885 ; ENSMUSP00000113110 ; ENSMUSG00000004070 .
ENSMUST00000120232 ; ENSMUSP00000112397 ; ENSMUSG00000004070 .
GeneIDi 15369.
KEGGi mmu:15369.
UCSCi uc007yag.2. mouse.

Organism-specific databases

CTDi 3163.
MGIi MGI:109373. Hmox2.

Phylogenomic databases

eggNOGi COG5398.
HOGENOMi HOG000233221.
HOVERGENi HBG005982.
InParanoidi O70252.
KOi K00510.
OMAi MDRNKDH.
PhylomeDBi O70252.
TreeFami TF314786.

Enzyme and pathway databases

Reactomei REACT_205755. Iron uptake and transport.

Miscellaneous databases

NextBioi 288002.
PROi O70252.
SOURCEi Search...

Gene expression databases

Bgeei O70252.
CleanExi MM_HMOX2.
ExpressionAtlasi O70252. baseline and differential.
Genevestigatori O70252.

Family and domain databases

Gene3Di 1.20.910.10. 1 hit.
InterProi IPR002051. Haem_Oase.
IPR016053. Haem_Oase-like.
IPR016084. Haem_Oase-like_multi-hlx.
IPR018207. Haem_oxygenase_CS.
[Graphical view ]
PANTHERi PTHR10720. PTHR10720. 1 hit.
Pfami PF01126. Heme_oxygenase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000343. Haem_Oase. 1 hit.
PRINTSi PR00088. HAEMOXYGNASE.
SUPFAMi SSF48613. SSF48613. 1 hit.
PROSITEi PS00593. HEME_OXYGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of mouse heme oxygenase-2."
    Mount D.B.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD-1.
  2. "The identification and expression of heme oxygenase-2 alternative transcripts in the mouse."
    Gibbs L., Willis D., Morgan M.J.
    Gene 221:171-177(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.

Entry informationi

Entry nameiHMOX2_MOUSE
AccessioniPrimary (citable) accession number: O70252
Secondary accession number(s): O70626
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3