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O70252

- HMOX2_MOUSE

UniProt

O70252 - HMOX2_MOUSE

Protein

Heme oxygenase 2

Gene

Hmox2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.

    Catalytic activityi

    Protoheme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi44 – 441Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. heme oxygenase (decyclizing) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. heme oxidation Source: InterPro
    2. response to hypoxia Source: Ensembl
    3. response to oxidative stress Source: Ensembl

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_205755. Iron uptake and transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heme oxygenase 2 (EC:1.14.99.3)
    Short name:
    HO-2
    Gene namesi
    Name:Hmox2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:109373. Hmox2.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB-SubCell
    2. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Endoplasmic reticulum, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 315314Heme oxygenase 2PRO_0000209692Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiO70252.
    PaxDbiO70252.
    PRIDEiO70252.

    PTM databases

    PhosphoSiteiO70252.

    Expressioni

    Gene expression databases

    ArrayExpressiO70252.
    BgeeiO70252.
    CleanExiMM_HMOX2.
    GenevestigatoriO70252.

    Interactioni

    Protein-protein interaction databases

    IntActiO70252. 3 interactions.
    MINTiMINT-1847819.

    Structurei

    3D structure databases

    ProteinModelPortaliO70252.
    SMRiO70252. Positions 29-247.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati263 – 2686HRM 1
    Repeati280 – 2856HRM 2

    Sequence similaritiesi

    Belongs to the heme oxygenase family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5398.
    HOGENOMiHOG000233221.
    HOVERGENiHBG005982.
    InParanoidiO70252.
    KOiK00510.
    OMAiMDRNKDH.
    PhylomeDBiO70252.
    TreeFamiTF314786.

    Family and domain databases

    Gene3Di1.20.910.10. 1 hit.
    InterProiIPR002051. Haem_Oase.
    IPR016053. Haem_Oase-like.
    IPR016084. Haem_Oase-like_multi-hlx.
    IPR018207. Haem_oxygenase_CS.
    [Graphical view]
    PANTHERiPTHR10720. PTHR10720. 1 hit.
    PfamiPF01126. Heme_oxygenase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000343. Haem_Oase. 1 hit.
    PRINTSiPR00088. HAEMOXYGNASE.
    SUPFAMiSSF48613. SSF48613. 1 hit.
    PROSITEiPS00593. HEME_OXYGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O70252-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSEVETSEG VDESEKNSMA PEKENHTKMA DLSELLKEGT KEAHDRAENT    50
    QFVKDFLKGN IKKELFKLAT TALYFTYSAL EEEMDRNKDH PAFAPLYFPT 100
    ELHRKAALIK DMKYFFGENW EEQVKCSEAA QKYVDRIHYV GQNEPELLVA 150
    HAYTRYMGDL SGGQVLKKVA QRALKLPSTG EGTQFYLFEH VDNAQQFKQF 200
    YRARMNALDL NLKTKERIVE EANKAFEYNM QIFSELDQAG SMLARETLED 250
    GLPVHDGKGD IRKCPFYAAQ PDKGTLGGSN CPFQTTVAVL RKPSLQLILA 300
    ASVALVAGLL AWYYM 315
    Length:315
    Mass (Da):35,739
    Last modified:August 1, 1998 - v1
    Checksum:iEA382EB2C7CED6D1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti172 – 1743RAL → SSS in AAC82364. (PubMed:9795203)Curated
    Sequence conflicti172 – 1743RAL → SSS in AAC82363. (PubMed:9795203)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF029874 mRNA. Translation: AAC17981.1.
    AF054670 mRNA. Translation: AAC82364.1.
    AF054669 mRNA. Translation: AAC82363.1.
    BC002011 mRNA. Translation: AAH02011.1.
    CCDSiCCDS27924.1.
    PIRiJC5149.
    RefSeqiNP_001129538.1. NM_001136066.2.
    NP_034573.2. NM_010443.2.
    UniGeneiMm.272866.

    Genome annotation databases

    EnsembliENSMUST00000004172; ENSMUSP00000004172; ENSMUSG00000004070.
    ENSMUST00000118885; ENSMUSP00000113110; ENSMUSG00000004070.
    ENSMUST00000120232; ENSMUSP00000112397; ENSMUSG00000004070.
    GeneIDi15369.
    KEGGimmu:15369.
    UCSCiuc007yag.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF029874 mRNA. Translation: AAC17981.1 .
    AF054670 mRNA. Translation: AAC82364.1 .
    AF054669 mRNA. Translation: AAC82363.1 .
    BC002011 mRNA. Translation: AAH02011.1 .
    CCDSi CCDS27924.1.
    PIRi JC5149.
    RefSeqi NP_001129538.1. NM_001136066.2.
    NP_034573.2. NM_010443.2.
    UniGenei Mm.272866.

    3D structure databases

    ProteinModelPortali O70252.
    SMRi O70252. Positions 29-247.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O70252. 3 interactions.
    MINTi MINT-1847819.

    PTM databases

    PhosphoSitei O70252.

    Proteomic databases

    MaxQBi O70252.
    PaxDbi O70252.
    PRIDEi O70252.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000004172 ; ENSMUSP00000004172 ; ENSMUSG00000004070 .
    ENSMUST00000118885 ; ENSMUSP00000113110 ; ENSMUSG00000004070 .
    ENSMUST00000120232 ; ENSMUSP00000112397 ; ENSMUSG00000004070 .
    GeneIDi 15369.
    KEGGi mmu:15369.
    UCSCi uc007yag.2. mouse.

    Organism-specific databases

    CTDi 3163.
    MGIi MGI:109373. Hmox2.

    Phylogenomic databases

    eggNOGi COG5398.
    HOGENOMi HOG000233221.
    HOVERGENi HBG005982.
    InParanoidi O70252.
    KOi K00510.
    OMAi MDRNKDH.
    PhylomeDBi O70252.
    TreeFami TF314786.

    Enzyme and pathway databases

    Reactomei REACT_205755. Iron uptake and transport.

    Miscellaneous databases

    NextBioi 288002.
    PROi O70252.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O70252.
    Bgeei O70252.
    CleanExi MM_HMOX2.
    Genevestigatori O70252.

    Family and domain databases

    Gene3Di 1.20.910.10. 1 hit.
    InterProi IPR002051. Haem_Oase.
    IPR016053. Haem_Oase-like.
    IPR016084. Haem_Oase-like_multi-hlx.
    IPR018207. Haem_oxygenase_CS.
    [Graphical view ]
    PANTHERi PTHR10720. PTHR10720. 1 hit.
    Pfami PF01126. Heme_oxygenase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000343. Haem_Oase. 1 hit.
    PRINTSi PR00088. HAEMOXYGNASE.
    SUPFAMi SSF48613. SSF48613. 1 hit.
    PROSITEi PS00593. HEME_OXYGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of mouse heme oxygenase-2."
      Mount D.B.
      Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: CD-1.
    2. "The identification and expression of heme oxygenase-2 alternative transcripts in the mouse."
      Gibbs L., Willis D., Morgan M.J.
      Gene 221:171-177(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiHMOX2_MOUSE
    AccessioniPrimary (citable) accession number: O70252
    Secondary accession number(s): O70626
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3