Reviewed, UniProtKB/Swiss-Prot O70252 (HMOX2_MOUSE)

Names and origin

Protein names

Recommended name:
    Heme oxygenase 2
      Short name=HO-2
    EC=1.14.99.3

Gene names

Name:

Hmox2

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	315 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.
Catalytic activity	Heme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O.
Subcellular location	Microsome. Endoplasmic reticulum.
Sequence similarities	Belongs to the heme oxygenase family. Contains 2 HRM (heme regulatory motif) repeats.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Microsome
Domain	Repeat
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	heme oxidation Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	heme oxygenase (decyclizing) activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 315	315	Heme oxygenase 2		PRO_0000209692
Regions
	Repeat	263 – 268	6	HRM 1
	Repeat	280 – 285	6	HRM 2
Sites
	Metal binding	44	1	Iron (heme axial ligand) By similarity
Experimental info
	Sequence conflict	172 – 174	3	RAL → SSS in AAC82364. Ref.2
	Sequence conflict	172 – 174	3	RAL → SSS in AAC82363. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	O70252-1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: EA382EB2C7CED6D1	FASTA	315	35,739
	10 20 30 40 50 60 MSSEVETSEG VDESEKNSMA PEKENHTKMA DLSELLKEGT KEAHDRAENT QFVKDFLKGN 70 80 90 100 110 120 IKKELFKLAT TALYFTYSAL EEEMDRNKDH PAFAPLYFPT ELHRKAALIK DMKYFFGENW 130 140 150 160 170 180 EEQVKCSEAA QKYVDRIHYV GQNEPELLVA HAYTRYMGDL SGGQVLKKVA QRALKLPSTG 190 200 210 220 230 240 EGTQFYLFEH VDNAQQFKQF YRARMNALDL NLKTKERIVE EANKAFEYNM QIFSELDQAG 250 260 270 280 290 300 SMLARETLED GLPVHDGKGD IRKCPFYAAQ PDKGTLGGSN CPFQTTVAVL RKPSLQLILA 310 ASVALVAGLL AWYYM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence of mouse heme oxygenase-2." Mount D.B. Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: CD-1.
[2]	"The identification and expression of heme oxygenase-2 alternative transcripts in the mouse." Gibbs L., Willis D., Morgan M.J. Gene 221:171-177(1998) [PubMed: 9795203] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Mammary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF029874 mRNA. Translation: AAC17981.1. AF054670 mRNA. Translation: AAC82364.1. AF054669 mRNA. Translation: AAC82363.1. BC002011 mRNA. Translation: AAH02011.1.
IPI	IPI00309322.
PIR	JC5149.
RefSeq	NP_001129538.1. NP_034573.2.
UniGene	Mm.272866
3D structure databases
HSSP	HSSP built from PDB template 1IVJ based on UniProtKB P06762.
ModBase	Search...
Proteomic databases
PRIDE	O70252.
Genome annotation databases
Ensembl	ENSMUSG00000004070. Mus musculus. [Contig view]
GeneID	15369.
KEGG	mmu:15369.
Organism-specific databases
MGI	MGI:109373. Hmox2.
Phylogenomic databases
HOGENOM	O70252.
HOVERGEN	O70252.
OMA	O70252. REGTKKS.
Enzyme and pathway databases
BRENDA	1.14.99.3. 244.
Gene expression databases
Bgee	O70252.
CleanEx	MM_HMOX2.
GermOnline	ENSMUSG00000004070. Mus musculus.
Family and domain databases
InterPro	IPR002051. Haem_Oase. IPR016053. Haem_Oase-like. IPR016084. Haem_Oase-like_multi-hlx. IPR018207. Haem_oxygenase_CS. [Graphical view]
Gene3D	G3DSA:1.20.910.10. Haem_Oase-like_multi-hlx. 1 hit.
PANTHER	PTHR10720. Haem_Oase. 1 hit.
Pfam	PF01126. Heme_oxygenase. 1 hit. [Graphical view]
PIRSF	PIRSF000343. Haem_Oase. 1 hit.
PRINTS	PR00088. HAEMOXYGNASE.
PROSITE	PS00593. HEME_OXYGENASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	288002.
SOURCE	Search...

Entry information

Entry name

HMOX2_MOUSE

Accession

Primary (citable) accession number: O70252
Secondary accession number(s): O70626

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	August 1, 1998
Last modified:	June 16, 2009
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)