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Protein

Elongation factor 1-beta

Gene

Eef1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.By similarity

GO - Molecular functioni

  • translation elongation factor activity Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

ReactomeiR-MMU-156842. Eukaryotic Translation Elongation.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor 1-beta
Short name:
EF-1-beta
Gene namesi
Name:Eef1b
Synonyms:Eef1b2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1929520. Eef1b2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • endoplasmic reticulum Source: Ensembl
  • eukaryotic translation elongation factor 1 complex Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 225224Elongation factor 1-betaPRO_0000155022Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei7 – 71N6-acetyllysineBy similarity
Modified residuei42 – 421PhosphoserineBy similarity
Modified residuei83 – 831PhosphoserineCombined sources
Modified residuei88 – 881PhosphothreonineCombined sources
Modified residuei106 – 1061PhosphoserineCombined sources
Modified residuei174 – 1741PhosphoserineBy similarity

Post-translational modificationi

Phosphorylation affects the GDP/GTP exchange rate.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO70251.
MaxQBiO70251.
PaxDbiO70251.
PeptideAtlasiO70251.
PRIDEiO70251.
TopDownProteomicsiO70251.

PTM databases

iPTMnetiO70251.
PhosphoSiteiO70251.
SwissPalmiO70251.

Expressioni

Gene expression databases

BgeeiENSMUSG00000025967.
CleanExiMM_EEF1B2.
ExpressionAtlasiO70251. baseline and differential.
GenevisibleiO70251. MM.

Interactioni

Subunit structurei

EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.By similarity

Protein-protein interaction databases

BioGridi207744. 5 interactions.
DIPiDIP-32121N.
IntActiO70251. 5 interactions.
MINTiMINT-1847466.
STRINGi10090.ENSMUSP00000116492.

Structurei

3D structure databases

ProteinModelPortaliO70251.
SMRiO70251. Positions 9-69, 97-225.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 9089GST C-terminalAdd
BLAST

Sequence similaritiesi

Belongs to the EF-1-beta/EF-1-delta family.Curated
Contains 1 GST C-terminal domain.Curated

Phylogenomic databases

eggNOGiKOG1668. Eukaryota.
COG2092. LUCA.
GeneTreeiENSGT00390000011747.
HOGENOMiHOG000207273.
HOVERGENiHBG000787.
InParanoidiO70251.
KOiK03232.
OMAiMAVAFYD.
OrthoDBiEOG091G0P0Z.
PhylomeDBiO70251.
TreeFamiTF313134.

Family and domain databases

CDDicd00292. EF1B. 1 hit.
Gene3Di1.20.1050.10. 1 hit.
3.30.70.60. 1 hit.
InterProiIPR018940. EF-1_beta_acid_region_euk.
IPR014038. EF1B_bsu/dsu_GNE.
IPR010987. Glutathione-S-Trfase_C-like.
IPR014717. Transl_elong_EF1B/ribosomal_S6.
IPR001326. Transl_elong_EF1B_B/D_CS.
[Graphical view]
PfamiPF10587. EF-1_beta_acid. 1 hit.
PF00736. EF1_GNE. 1 hit.
[Graphical view]
SMARTiSM01182. EF-1_beta_acid. 1 hit.
SM00888. EF1_GNE. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF54984. SSF54984. 1 hit.
PROSITEiPS00824. EF1BD_1. 1 hit.
PS00825. EF1BD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70251-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFGDLKTPA GLQVLNDYLA DKSYIEGYVP SQADVAVFEA VSGPPPADLC
60 70 80 90 100
HALRWYNHIK SYEKEKASLP GVKKSLGKYG PSSVEDTTGS GAADAKDDDD
110 120 130 140 150
IDLFGSDDEE ESEEAKKLRE ERLAQYESKK AKKPAVVAKS SILLDVKPWD
160 170 180 190 200
DETDMTKLEE CVRSIQADGL VWGSSKLVPV GYGIKKLQIQ CVVEDDKVGT
210 220
DMLEEQITAF EDYVQSMDVA AFNKI
Length:225
Mass (Da):24,694
Last modified:January 23, 2007 - v5
Checksum:i6E497150AD88F887
GO

Sequence cautioni

The sequence AAH39635 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti113 – 1131E → G in BAB28447 (PubMed:16141072).Curated
Sequence conflicti116 – 1161K → E in AAC13264 (Ref. 1) Curated
Sequence conflicti136 – 1361V → I in AAC13264 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029844 mRNA. Translation: AAC13264.2.
AK012756 mRNA. Translation: BAB28447.1.
AK027911 mRNA. Translation: BAC25661.1.
AK168191 mRNA. Translation: BAE40151.1.
AL645950 Genomic DNA. Translation: CAI24121.1.
BC003899 mRNA. Translation: AAH03899.1.
BC023139 mRNA. Translation: AAH23139.1.
BC039635 mRNA. Translation: AAH39635.1. Different initiation.
CCDSiCCDS14997.1.
PIRiPC7074.
RefSeqiNP_061266.2. NM_018796.3.
UniGeneiMm.2718.

Genome annotation databases

EnsembliENSMUST00000129339; ENSMUSP00000116492; ENSMUSG00000025967.
GeneIDi55949.
KEGGimmu:55949.
UCSCiuc007bfz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029844 mRNA. Translation: AAC13264.2.
AK012756 mRNA. Translation: BAB28447.1.
AK027911 mRNA. Translation: BAC25661.1.
AK168191 mRNA. Translation: BAE40151.1.
AL645950 Genomic DNA. Translation: CAI24121.1.
BC003899 mRNA. Translation: AAH03899.1.
BC023139 mRNA. Translation: AAH23139.1.
BC039635 mRNA. Translation: AAH39635.1. Different initiation.
CCDSiCCDS14997.1.
PIRiPC7074.
RefSeqiNP_061266.2. NM_018796.3.
UniGeneiMm.2718.

3D structure databases

ProteinModelPortaliO70251.
SMRiO70251. Positions 9-69, 97-225.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207744. 5 interactions.
DIPiDIP-32121N.
IntActiO70251. 5 interactions.
MINTiMINT-1847466.
STRINGi10090.ENSMUSP00000116492.

PTM databases

iPTMnetiO70251.
PhosphoSiteiO70251.
SwissPalmiO70251.

Proteomic databases

EPDiO70251.
MaxQBiO70251.
PaxDbiO70251.
PeptideAtlasiO70251.
PRIDEiO70251.
TopDownProteomicsiO70251.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000129339; ENSMUSP00000116492; ENSMUSG00000025967.
GeneIDi55949.
KEGGimmu:55949.
UCSCiuc007bfz.2. mouse.

Organism-specific databases

CTDi1933.
MGIiMGI:1929520. Eef1b2.

Phylogenomic databases

eggNOGiKOG1668. Eukaryota.
COG2092. LUCA.
GeneTreeiENSGT00390000011747.
HOGENOMiHOG000207273.
HOVERGENiHBG000787.
InParanoidiO70251.
KOiK03232.
OMAiMAVAFYD.
OrthoDBiEOG091G0P0Z.
PhylomeDBiO70251.
TreeFamiTF313134.

Enzyme and pathway databases

ReactomeiR-MMU-156842. Eukaryotic Translation Elongation.

Miscellaneous databases

ChiTaRSiEef1b2. mouse.
PROiO70251.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025967.
CleanExiMM_EEF1B2.
ExpressionAtlasiO70251. baseline and differential.
GenevisibleiO70251. MM.

Family and domain databases

CDDicd00292. EF1B. 1 hit.
Gene3Di1.20.1050.10. 1 hit.
3.30.70.60. 1 hit.
InterProiIPR018940. EF-1_beta_acid_region_euk.
IPR014038. EF1B_bsu/dsu_GNE.
IPR010987. Glutathione-S-Trfase_C-like.
IPR014717. Transl_elong_EF1B/ribosomal_S6.
IPR001326. Transl_elong_EF1B_B/D_CS.
[Graphical view]
PfamiPF10587. EF-1_beta_acid. 1 hit.
PF00736. EF1_GNE. 1 hit.
[Graphical view]
SMARTiSM01182. EF-1_beta_acid. 1 hit.
SM00888. EF1_GNE. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF54984. SSF54984. 1 hit.
PROSITEiPS00824. EF1BD_1. 1 hit.
PS00825. EF1BD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEF1B_MOUSE
AccessioniPrimary (citable) accession number: O70251
Secondary accession number(s): Q3THP5
, Q5SUH1, Q8CHS1, Q99L22, Q9CZD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 139 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.