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Protein

Phosphoglycerate mutase 2

Gene

Pgam2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity.

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.By similarity
3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei11Tele-phosphohistidine intermediateBy similarity1
Binding sitei62SubstrateBy similarity1
Active sitei89Proton donor/acceptorBy similarity1
Binding sitei100SubstrateBy similarity1
Sitei186Transition state stabilizerBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Isomerase

Keywords - Biological processi

Glycolysis

Enzyme and pathway databases

ReactomeiR-MMU-70171. Glycolysis.
R-MMU-70263. Gluconeogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate mutase 2 (EC:5.4.2.11By similarity, EC:5.4.2.4By similarity)
Alternative name(s):
BPG-dependent PGAM 2
Muscle-specific phosphoglycerate mutase
Phosphoglycerate mutase isozyme M
Short name:
PGAM-M
Gene namesi
Name:Pgam2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1933118. Pgam2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001798301 – 253Phosphoglycerate mutase 2Add BLAST253

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3PhosphothreonineBy similarity1
Modified residuei14PhosphoserineBy similarity1
Modified residuei118PhosphoserineCombined sources1
Modified residuei121PhosphothreonineBy similarity1
Modified residuei132PhosphotyrosineBy similarity1
Modified residuei133PhosphotyrosineBy similarity1
Modified residuei135PhosphoserineBy similarity1
Modified residuei152PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO70250.
PeptideAtlasiO70250.
PRIDEiO70250.

2D gel databases

SWISS-2DPAGEO70250.

PTM databases

iPTMnetiO70250.
PhosphoSitePlusiO70250.
SwissPalmiO70250.

Expressioni

Tissue specificityi

Testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000020475.
CleanExiMM_PGAM2.
ExpressionAtlasiO70250. baseline and differential.
GenevisibleiO70250. MM.

Interactioni

Subunit structurei

Homodimer (By similarity). Interacts with ENO1 (PubMed:23446454).By similarity1 Publication

Protein-protein interaction databases

BioGridi207767. 3 interactors.
IntActiO70250. 2 interactors.
MINTiMINT-4107290.
STRINGi10090.ENSMUSP00000020768.

Structurei

3D structure databases

ProteinModelPortaliO70250.
SMRiO70250.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni10 – 17Substrate bindingBy similarity8
Regioni23 – 24Substrate bindingBy similarity2
Regioni89 – 92Substrate bindingBy similarity4
Regioni116 – 117Substrate bindingBy similarity2
Regioni187 – 188Substrate bindingBy similarity2

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi122 – 125Poly-Pro4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0235. Eukaryota.
COG0588. LUCA.
GeneTreeiENSGT00390000016700.
HOGENOMiHOG000221682.
HOVERGENiHBG027528.
InParanoidiO70250.
KOiK01834.
OMAiMSDAAIM.
OrthoDBiEOG091G0GIS.
PhylomeDBiO70250.
TreeFamiTF300007.

Family and domain databases

CDDicd07067. HP_PGM_like. 1 hit.
Gene3Di3.40.50.1240. 1 hit.
HAMAPiMF_01039. PGAM_GpmA. 1 hit.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR001345. PG/BPGM_mutase_AS.
IPR005952. Phosphogly_mut1.
[Graphical view]
PANTHERiPTHR11931. PTHR11931. 1 hit.
PfamiPF00300. His_Phos_1. 2 hits.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
TIGRFAMsiTIGR01258. pgm_1. 1 hit.
PROSITEiPS00175. PG_MUTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70250-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTHRLVMVR HGESLWNQEN RFCGWFDAEL SEKGAEEAKR GATAIKDAKI
60 70 80 90 100
EFDICYTSVL KRAIRTLWTI LDVTDQMWVP VVRTWRLNER HYGGLTGLNK
110 120 130 140 150
AETAAKHGEE QVKIWRRSFD TPPPPMDEKH NYYTSISKDR RYAGLKPEEL
160 170 180 190 200
PTCESLKDTI ARALPFWNEE IAPKIKAGQR VLIAAHGNSL RGIVKHLEGM
210 220 230 240 250
SDQAIMELNL PTGIPIVYEL DQNLKPTKPM RFLGDEETVR KAMEAVAAQG

KAK
Length:253
Mass (Da):28,827
Last modified:January 23, 2007 - v3
Checksum:i477AF9EC59A15B86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029843 mRNA. Translation: AAC13263.1.
AF317587 Genomic DNA. Translation: AAK06662.1.
BC010750 mRNA. Translation: AAH10750.1.
CCDSiCCDS24404.1.
RefSeqiNP_061358.1. NM_018870.3.
UniGeneiMm.219627.

Genome annotation databases

EnsembliENSMUST00000020768; ENSMUSP00000020768; ENSMUSG00000020475.
GeneIDi56012.
KEGGimmu:56012.
UCSCiuc007hxe.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029843 mRNA. Translation: AAC13263.1.
AF317587 Genomic DNA. Translation: AAK06662.1.
BC010750 mRNA. Translation: AAH10750.1.
CCDSiCCDS24404.1.
RefSeqiNP_061358.1. NM_018870.3.
UniGeneiMm.219627.

3D structure databases

ProteinModelPortaliO70250.
SMRiO70250.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207767. 3 interactors.
IntActiO70250. 2 interactors.
MINTiMINT-4107290.
STRINGi10090.ENSMUSP00000020768.

PTM databases

iPTMnetiO70250.
PhosphoSitePlusiO70250.
SwissPalmiO70250.

2D gel databases

SWISS-2DPAGEO70250.

Proteomic databases

PaxDbiO70250.
PeptideAtlasiO70250.
PRIDEiO70250.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020768; ENSMUSP00000020768; ENSMUSG00000020475.
GeneIDi56012.
KEGGimmu:56012.
UCSCiuc007hxe.2. mouse.

Organism-specific databases

CTDi5224.
MGIiMGI:1933118. Pgam2.

Phylogenomic databases

eggNOGiKOG0235. Eukaryota.
COG0588. LUCA.
GeneTreeiENSGT00390000016700.
HOGENOMiHOG000221682.
HOVERGENiHBG027528.
InParanoidiO70250.
KOiK01834.
OMAiMSDAAIM.
OrthoDBiEOG091G0GIS.
PhylomeDBiO70250.
TreeFamiTF300007.

Enzyme and pathway databases

ReactomeiR-MMU-70171. Glycolysis.
R-MMU-70263. Gluconeogenesis.

Miscellaneous databases

ChiTaRSiPgam2. mouse.
PROiO70250.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020475.
CleanExiMM_PGAM2.
ExpressionAtlasiO70250. baseline and differential.
GenevisibleiO70250. MM.

Family and domain databases

CDDicd07067. HP_PGM_like. 1 hit.
Gene3Di3.40.50.1240. 1 hit.
HAMAPiMF_01039. PGAM_GpmA. 1 hit.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR001345. PG/BPGM_mutase_AS.
IPR005952. Phosphogly_mut1.
[Graphical view]
PANTHERiPTHR11931. PTHR11931. 1 hit.
PfamiPF00300. His_Phos_1. 2 hits.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
TIGRFAMsiTIGR01258. pgm_1. 1 hit.
PROSITEiPS00175. PG_MUTASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPGAM2_MOUSE
AccessioniPrimary (citable) accession number: O70250
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 150 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.