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O70249

- OGG1_RAT

UniProt

O70249 - OGG1_RAT

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Protein

N-glycosylase/DNA lyase

Gene

Ogg1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.

Catalytic activityi

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei149 – 1491DNABy similarity
Binding sitei154 – 1541DNABy similarity
Binding sitei204 – 2041DNABy similarity
Active sitei249 – 2491Schiff-base intermediate with DNABy similarity
Binding sitei266 – 26618-oxoguanine; via carbonyl oxygenBy similarity
Binding sitei268 – 26818-oxoguanineBy similarity
Binding sitei270 – 2701DNABy similarity
Binding sitei287 – 2871DNABy similarity
Binding sitei315 – 31518-oxoguanineBy similarity
Binding sitei319 – 31918-oxoguanineBy similarity

GO - Molecular functioni

  1. 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity Source: Ensembl
  2. damaged DNA binding Source: RGD
  3. DNA N-glycosylase activity Source: RGD
  4. oxidized purine nucleobase lesion DNA N-glycosylase activity Source: RGD

GO - Biological processi

  1. acute inflammatory response Source: RGD
  2. aging Source: RGD
  3. base-excision repair Source: RGD
  4. cellular response to cadmium ion Source: RGD
  5. DNA catabolic process, endonucleolytic Source: GOC
  6. negative regulation of apoptotic process Source: RGD
  7. nucleotide-excision repair Source: InterPro
  8. regulation of protein import into nucleus, translocation Source: UniProtKB
  9. regulation of transcription, DNA-templated Source: UniProtKB
  10. response to drug Source: RGD
  11. response to estradiol Source: RGD
  12. response to ethanol Source: RGD
  13. response to folic acid Source: RGD
  14. response to light stimulus Source: RGD
  15. response to oxidative stress Source: UniProtKB
  16. response to radiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase, Lyase

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
N-glycosylase/DNA lyase
Including the following 2 domains:
8-oxoguanine DNA glycosylase (EC:3.2.2.-)
DNA-(apurinic or apyrimidinic site) lyase (EC:4.2.99.18)
Short name:
AP lyase
Gene namesi
Name:Ogg1
Synonyms:Mmh, Ogh1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi621168. Ogg1.

Subcellular locationi

Nucleusnucleoplasm By similarity. Nucleus speckle By similarity. Nucleus matrix By similarity
Note: Together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells.By similarity

GO - Cellular componenti

  1. mitochondrion Source: RGD
  2. nuclear matrix Source: UniProtKB
  3. nuclear speck Source: UniProtKB
  4. nucleoplasm Source: UniProtKB
  5. nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 345345N-glycosylase/DNA lyasePRO_0000058593Add
BLAST

Proteomic databases

PRIDEiO70249.

PTM databases

PhosphoSiteiO70249.

Expressioni

Gene expression databases

ExpressionAtlasiO70249. baseline.
GenevestigatoriO70249.

Structurei

3D structure databases

ProteinModelPortaliO70249.
SMRiO70249. Positions 13-323.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type-1 OGG1 family.Curated

Phylogenomic databases

eggNOGiCOG0122.
HOGENOMiHOG000180756.
HOVERGENiHBG001047.
InParanoidiO70249.
KOiK03660.
PhylomeDBiO70249.

Family and domain databases

Gene3Di1.10.1670.10. 1 hit.
1.10.340.30. 1 hit.
InterProiIPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
IPR023170. HTH_base_excis_C.
IPR004577. Ogg.
IPR012904. OGG_N.
[Graphical view]
PfamiPF00730. HhH-GPD. 1 hit.
PF07934. OGG_N. 1 hit.
[Graphical view]
SMARTiSM00478. ENDO3c. 1 hit.
[Graphical view]
SUPFAMiSSF48150. SSF48150. 1 hit.
TIGRFAMsiTIGR00588. ogg. 1 hit.

Sequencei

Sequence statusi: Complete.

O70249-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLFSSSLSSS MRHRTLTSSP ALWASIPCPR SELRLDLVLA SGQSFRWREQ
60 70 80 90 100
SPAHWSGVLA DQVWTLTQTE DQLYCTVYRG DKGQVGRPTL EELETLHKYF
110 120 130 140 150
QLDVSLTQLY SHWASVDSHF QSVAQKFQGV RLLRQDPTEC LFSFICSSNN
160 170 180 190 200
NIARITGMVE RLCQAFGPRL VQLDDVTYHG FPNLHALAGP EVETHLRKLG
210 220 230 240 250
LGYRARYVCA SAKAILEEQG GPAWLQQLRV ASYEEAHKAL CTLPGVGTKV
260 270 280 290 300
ADCICLMALD KPQAVPVDIH VWQIAHRDYG WQPKTSQTKG PSPLANKELG
310 320 330 340
NFFRNLWGPY AGWAQAVLFS ADLRQQNLSR EPPAKRKKGS KKTEG
Length:345
Mass (Da):38,711
Last modified:August 1, 1998 - v1
Checksum:iB7FDF8C782644C41
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF029690 mRNA. Translation: AAC77525.1.
RefSeqiNP_110497.1. NM_030870.1.
UniGeneiRn.22623.

Genome annotation databases

GeneIDi81528.
KEGGirno:81528.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF029690 mRNA. Translation: AAC77525.1 .
RefSeqi NP_110497.1. NM_030870.1.
UniGenei Rn.22623.

3D structure databases

ProteinModelPortali O70249.
SMRi O70249. Positions 13-323.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei O70249.

Proteomic databases

PRIDEi O70249.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 81528.
KEGGi rno:81528.

Organism-specific databases

CTDi 4968.
RGDi 621168. Ogg1.

Phylogenomic databases

eggNOGi COG0122.
HOGENOMi HOG000180756.
HOVERGENi HBG001047.
InParanoidi O70249.
KOi K03660.
PhylomeDBi O70249.

Miscellaneous databases

NextBioi 615069.
PROi O70249.

Gene expression databases

ExpressionAtlasi O70249. baseline.
Genevestigatori O70249.

Family and domain databases

Gene3Di 1.10.1670.10. 1 hit.
1.10.340.30. 1 hit.
InterProi IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
IPR023170. HTH_base_excis_C.
IPR004577. Ogg.
IPR012904. OGG_N.
[Graphical view ]
Pfami PF00730. HhH-GPD. 1 hit.
PF07934. OGG_N. 1 hit.
[Graphical view ]
SMARTi SM00478. ENDO3c. 1 hit.
[Graphical view ]
SUPFAMi SSF48150. SSF48150. 1 hit.
TIGRFAMsi TIGR00588. ogg. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Rat 7,8-dihydro-8-oxoguanine DNA glycosylase: substrate specificity, kinetics and cleavagemechanism at an apurinic site."
    Prieto Alamo M.J., Jurado J., Francastel E., Laval F.
    Nucleic Acids Res. 26:5199-5202(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hepatoma.

Entry informationi

Entry nameiOGG1_RAT
AccessioniPrimary (citable) accession number: O70249
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3