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Protein

Sodium-dependent multivitamin transporter

Gene

Slc5a6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transports pantothenate, biotin and lipoate in the presence of sodium.

GO - Molecular functioni

  • sodium-dependent multivitamin transmembrane transporter activity Source: RGD

GO - Biological processi

  • biotin transport Source: RGD
  • pantothenate transmembrane transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Biotin, Sodium

Enzyme and pathway databases

ReactomeiR-RNO-196780. Biotin transport and metabolism.
R-RNO-199220. Vitamin B5 (pantothenate) metabolism.
R-RNO-425397. Transport of vitamins, nucleosides, and related molecules.

Protein family/group databases

TCDBi2.A.21.5.2. the solute:sodium symporter (sss) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent multivitamin transporter
Short name:
Na(+)-dependent multivitamin transporter
Alternative name(s):
Solute carrier family 5 member 6
Gene namesi
Name:Slc5a6
Synonyms:Smvt
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi69648. Slc5a6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei23 – 4321HelicalSequence analysisAdd
BLAST
Transmembranei65 – 8521HelicalSequence analysisAdd
BLAST
Transmembranei100 – 12021HelicalSequence analysisAdd
BLAST
Transmembranei142 – 16221HelicalSequence analysisAdd
BLAST
Transmembranei175 – 19521HelicalSequence analysisAdd
BLAST
Transmembranei207 – 22721HelicalSequence analysisAdd
BLAST
Transmembranei255 – 27521HelicalSequence analysisAdd
BLAST
Transmembranei295 – 31521HelicalSequence analysisAdd
BLAST
Transmembranei350 – 37021HelicalSequence analysisAdd
BLAST
Transmembranei403 – 42321HelicalSequence analysisAdd
BLAST
Transmembranei427 – 44721HelicalSequence analysisAdd
BLAST
Transmembranei455 – 47521HelicalSequence analysisAdd
BLAST
Transmembranei526 – 54621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • brush border membrane Source: RGD
  • integral component of plasma membrane Source: GO_Central
  • vesicle membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2176793.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 634634Sodium-dependent multivitamin transporterPRO_0000105389Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi488 – 4881N-linked (GlcNAc...)Sequence analysis
Glycosylationi497 – 4971N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO70247.
PRIDEiO70247.

PTM databases

PhosphoSiteiO70247.

Expressioni

Gene expression databases

ExpressionAtlasiO70247. differential.
GenevisibleiO70247. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009042.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2349. Eukaryota.
COG0591. LUCA.
GeneTreeiENSGT00760000118955.
HOGENOMiHOG000261662.
HOVERGENiHBG057280.
InParanoidiO70247.
KOiK14386.
OMAiLIMFLGQ.
OrthoDBiEOG70PBX7.
PhylomeDBiO70247.
TreeFamiTF316728.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 2 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70247-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVASTAAPS YTTSDTNRVI STFSVVDYVV FGLLLVLSLV IGLYHACRGW
60 70 80 90 100
GRHTVGELLM ADRKMGCLPV ALSLLATFQS AVAILGGPAE IYRFGTQYWF
110 120 130 140 150
LGCSYFLGLL IPAHIFIPVF YRLHLTSAYE YLELRFNKAV RICGTVTFIF
160 170 180 190 200
QMVVYMGVAL YAPSLALNAV TGFDLWLSVL ALGIVCNIYT ALGGLKAVIW
210 220 230 240 250
TDVFQTLIMF LGQLVVIIVG AAKVGGLGHV WAVASQHGLI SGIELDPDPF
260 270 280 290 300
VRHTFWTLAF GGVFMMLSLY GVNQAQVQRY LSSHSEKAAV LSCYAVFPCQ
310 320 330 340 350
QVALCMSCLI GLVMFAYYKK YSMSPQQEQA APDQLVLYFV MDLLKDMPGL
360 370 380 390 400
PGLFVACLFS GSLSTISSAF NSLATVTMED LIQPWFPQLT ETRAIMLSRS
410 420 430 440 450
LAFAYGLVCL GMAYVSSHLG SVLQAALSIF GMVGGPLLGL FCLGMFFPCA
460 470 480 490 500
NPLGAIVGLL TGLTMAFWIG IGSIVSRMSS AAASPPLNGS SSFLPSNLTV
510 520 530 540 550
ATVTTLMPST LSKPTGLQQF YSLSYLWYSA HNSTTVIAVG LIVSLLTGGM
560 570 580 590 600
RGRSLNPGTI YPVLPKLLAL LPLSCQKRLC WRSHNQDIPV VTNLFPEKMG
610 620 630
NGALQDSRDK ERMAEDGLVH QPCSPTYIVQ ETSL
Length:634
Mass (Da):68,642
Last modified:August 1, 1998 - v1
Checksum:i902F60978831BEFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026554 mRNA. Translation: AAC12270.1.
AF081205 mRNA. Translation: AAC64061.1.
AF081204 mRNA. Translation: AAC64060.1.
RefSeqiNP_570102.1. NM_130746.1.
UniGeneiRn.11105.

Genome annotation databases

EnsembliENSRNOT00000081167; ENSRNOP00000071291; ENSRNOG00000057628.
ENSRNOT00000082623; ENSRNOP00000075361; ENSRNOG00000057628.
GeneIDi170551.
KEGGirno:170551.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026554 mRNA. Translation: AAC12270.1.
AF081205 mRNA. Translation: AAC64061.1.
AF081204 mRNA. Translation: AAC64060.1.
RefSeqiNP_570102.1. NM_130746.1.
UniGeneiRn.11105.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009042.

Chemistry

ChEMBLiCHEMBL2176793.

Protein family/group databases

TCDBi2.A.21.5.2. the solute:sodium symporter (sss) family.

PTM databases

PhosphoSiteiO70247.

Proteomic databases

PaxDbiO70247.
PRIDEiO70247.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000081167; ENSRNOP00000071291; ENSRNOG00000057628.
ENSRNOT00000082623; ENSRNOP00000075361; ENSRNOG00000057628.
GeneIDi170551.
KEGGirno:170551.

Organism-specific databases

CTDi8884.
RGDi69648. Slc5a6.

Phylogenomic databases

eggNOGiKOG2349. Eukaryota.
COG0591. LUCA.
GeneTreeiENSGT00760000118955.
HOGENOMiHOG000261662.
HOVERGENiHBG057280.
InParanoidiO70247.
KOiK14386.
OMAiLIMFLGQ.
OrthoDBiEOG70PBX7.
PhylomeDBiO70247.
TreeFamiTF316728.

Enzyme and pathway databases

ReactomeiR-RNO-196780. Biotin transport and metabolism.
R-RNO-199220. Vitamin B5 (pantothenate) metabolism.
R-RNO-425397. Transport of vitamins, nucleosides, and related molecules.

Miscellaneous databases

PROiO70247.

Gene expression databases

ExpressionAtlasiO70247. differential.
GenevisibleiO70247. RN.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 2 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate."
    Prasad P.D., Wang H., Kekuda R., Fujita T., Fei Y.-J., Devoe L.D., Leibach F.H., Ganapathy V.
    J. Biol. Chem. 273:7501-7506(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. "Cloning and characterization of rat kidney sodium dependent multivitamin transporter."
    Kumar C.K., Chatterjee N.S., Rubin S.A., Said H.M.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney and Small intestine.

Entry informationi

Entry nameiSC5A6_RAT
AccessioniPrimary (citable) accession number: O70247
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: August 1, 1998
Last modified: July 6, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.