Probable phospholipid-transporting ATPase IIA

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O70228 (ATP9A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 100. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Probable phospholipid-transporting ATPase IIA
EC=3.6.3.1

Alternative name(s):
ATPase class II type 9A

Gene names

Name:

Atp9a

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1047 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + H₂O + phospholipid(In) = ADP + phosphate + phospholipid(Out).
Subcellular location	Membrane; Multi-pass membrane protein By similarity.
Tissue specificity	Found in most tissues except spleen. Most abundant in brain. Also detected in fetal tissues.
Sequence similarities	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. [View classification]

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cation transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: InterPro phospholipid-translocating ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1047

1047

Probable phospholipid-transporting ATPase IIA

PRO_0000046376

Regions

Topological domain

1 – 69

Cytoplasmic Potential

Transmembrane

70 – 91

Helical; Potential

Topological domain

92 – 96

Extracellular Potential

Transmembrane

97 – 119

Helical; Potential

Topological domain

120 – 303

184

Cytoplasmic Potential

Transmembrane

304 – 325

Helical; Potential

Topological domain

326 – 332

Extracellular Potential

Transmembrane

333 – 354

Helical; Potential

Topological domain

355 – 841

487

Cytoplasmic Potential

Transmembrane

842 – 862

Helical; Potential

Topological domain

863 – 874

Extracellular Potential

Transmembrane

875 – 893

Helical; Potential

Topological domain

894 – 923

Cytoplasmic Potential

Transmembrane

924 – 942

Helical; Potential

Topological domain

943 – 949

Extracellular Potential

Transmembrane

950 – 972

Helical; Potential

Topological domain

973 – 978

Cytoplasmic Potential

Transmembrane

979 – 999

Helical; Potential

Topological domain

1000 – 1006

Extracellular Potential

Transmembrane

1007 – 1030

Helical; Potential

Topological domain

1031 – 1047

Cytoplasmic Potential

Sites

Active site

391

4-aspartylphosphate intermediate By similarity

Metal binding

785

Magnesium By similarity

Metal binding

789

Magnesium By similarity

Experimental info

Sequence conflict

R → K in AAC05245. Ref.3

Sequence conflict

129

V → I in AAC05245. Ref.3

Sequence conflict

138

V → I in AAC05245. Ref.3

Sequence conflict

227

E → K in AAF08396. Ref.1

Sequence conflict

227

E → K in AAC05245. Ref.3

Sequence conflict

243

D → N in AAF08396. Ref.1

Sequence conflict

243

D → N in AAC05245. Ref.3

Sequence conflict

278

R → K in AAC05245. Ref.3

Sequence conflict

279

E → K in AAF08396. Ref.1

Sequence conflict

279

E → K in AAC05245. Ref.3

Sequence conflict

432

Q → P in AAC05245. Ref.3

Sequence conflict

475

S → C in AAC05245. Ref.3

Sequence conflict

504 – 510

ALVQWTE → TLAGKEG in AAH21814. Ref.2

Sequence conflict

533

V → I in AAC05245. Ref.3

Sequence conflict

613

D → H in AAF08396. Ref.1

Sequence conflict

742

E → D in AAC05245. Ref.3

Sequence conflict

784

G → W in AAF08396. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

O70228 [UniParc].

Last modified May 5, 2009. Version 3.
Checksum: 5CCFAB1A83A7B966
Show »

FASTA

1,047

118,609

        10         20         30         40         50         60 
MTDSIPLQPV RHKKRVDSRP RAGCCEWLRC CGGGEPRPRT VWLGHPEKRD QRYPRNVINN 

        70         80         90        100        110        120 
QKYNFFTFLP GVLFSQFRYF FNFYFLLLAC SQFVPEMRLG ALYTYWVPLG FVLAVTIIRE 

       130        140        150        160        170        180 
AVEEIRCYVR DKEMNSQVYS RLTSRGTVKV KSSNIQVGDL ILVEKNQRVP ADMIFLRTSE 

       190        200        210        220        230        240 
KNGSCFLRTD QLDGETDWKL RLPVACTQRL PTAADLLQIR SYVYAEEPNI DIHNFLGTFT 

       250        260        270        280        290        300 
REDSDPPISE SLSIENTLWA GTVIASGTVV GVVLYTGREL RSVMNTSDPR SKIGLFDLEV 

       310        320        330        340        350        360 
NCLTKILFGA LVVVSLVMVA LQHFAGRWYL QIIRFLLLFS NIIPISLRVN LDMGKIVYSW 

       370        380        390        400        410        420 
VIRRDSKIPG TVVRSSTIPE QLGRISYLLT DKTGTLTQNE MVFKRLHLGT VAYGLDSMDE 

       430        440        450        460        470        480 
VQSHIFSIYT QQSQDPPAQK GPTVTTKVRR TMSSRVHEAV KAIALCHNVT PVYESNGVTD 

       490        500        510        520        530        540 
QAEAEKQFED SCRVYQASSP DEVALVQWTE SVGLTLVGRD QSSMQLRTPG DQVLNLTILQ 

       550        560        570        580        590        600 
VFPFTYESKR MGIIVRDEST GEITFYMKGA DVVMAGIVQY NDWLEEECGN MAREGLRVLV 

       610        620        630        640        650        660 
VAKKSLTEEQ YQDFEARYVQ AKLSVHDRSL KVATVIESLE MEMELLCLTG VEDQLQADVR 

       670        680        690        700        710        720 
PTLETLRNAG IKVWMLTGDK LETATCTAKN AHLVTRNQDI HVFRLVTNRG EAHLELNAFR 

       730        740        750        760        770        780 
RKHDCALVIS GDSLEVCLKY YEYEFMELAC QCPAVVCCRC APTQKAQIVR LLQERTGKLT 

       790        800        810        820        830        840 
CAVGDGGNDV SMIQESDCGV GVEGKEGKQA SLAADFSITQ FKHLGRLLMV HGRNSYKRSA 

       850        860        870        880        890        900 
ALSQFVIHRS LCISTMQAVF SSVFYFASVP LYQGFLIIGY STIYTMFPVF SLVLDKDVKS 

       910        920        930        940        950        960 
EVAMLYPELY KDLLKGRPLS YKTFLIWVLI SIYQGSTIMY GALLLFESEF VHIVAISFTS 

       970        980        990       1000       1010       1020 
LILTELLMVA LTIQTWHWLM TVAELLSLAC YIASLVFLHE FIDVYFIATL SFLWKVSVIT 

      1030       1040 
LVSCLPLYVL KYLRRRFSPP SYSKLTS

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Differential expression of putative transbilayer amphipath transporters." Halleck M.S., Lawler J.F. Jr., Blackshaw S., Gao L., Nagarajan P., Hacker C., Pyle S., Newman J.T., Nakanishi Y., Ando H., Weinstock D., Williamson P.L., Schlegel R.A. Physiol. Genomics 1:139-150(1999) [PubMed: 11015572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Multiple members of a third subfamily of P-type ATPases identified by genomic sequences and ESTs." Halleck M.S., Pradhan D., Blackman C.F., Berkes C., Williamson P.L., Schlegel R.A. Genome Res. 8:354-361(1998) [PubMed: 9548971] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 28-1047.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF152243 mRNA. Translation: AAF08396.1. BC021814 mRNA. Translation: AAH21814.1. BC006949 mRNA. Translation: AAH06949.1. AF011336 mRNA. Translation: AAC05245.1.
IPI	IPI00116394.
PIR	T42229.
RefSeq	NP_056546.2. NM_015731.3.
UniGene	Mm.330819.
3D structure databases
ProteinModelPortal	O70228.
SMR	O70228. Positions 757-820.
ModBase	Search...
Protein-protein interaction databases
STRING	O70228.
Proteomic databases
PRIDE	O70228.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000029060; ENSMUSP00000029060; ENSMUSG00000027546.
GeneID	11981.
KEGG	mmu:11981.
Organism-specific databases
CTD	10079.
MGI	MGI:1330826. Atp9a.
Phylogenomic databases
HOVERGEN	HBG050617.
InParanoid	O70228.
Gene expression databases
ArrayExpress	O70228.
Bgee	O70228.
CleanEx	MM_ATP9A.
Genevestigator	O70228.
GermOnline	ENSMUSG00000027546. Mus musculus.
Family and domain databases
InterPro	IPR023306. ATPase_cation_domN. IPR008250. ATPase_P-typ_ATPase-assoc-dom. IPR023300. ATPase_P-typ_cyto_domA. IPR023299. ATPase_P-typ_cyto_domN. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR006539. ATPase_P-typ_Plipid-transl. IPR023214. HAD-like_dom. [Graphical view]
Gene3D	G3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 2 hits. G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 1 hit. G3DSA:3.40.50.1000. HAD-like_dom. 2 hits.
KO	K01530.
Pfam	PF00122. E1-E2_ATPase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE.
SUPFAM	SSF81660. ATPase_cation_domN. 1 hit. SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01652. ATPase-Plipid. 1 hit. TIGR01494. ATPase_P-type. 2 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

ATP9A_MOUSE

Accession

Primary (citable) accession number: O70228
Secondary accession number(s): Q8VDI5, Q922L9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 5, 2009
Last modified:	December 14, 2011
This is version 100 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents