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Protein

Forkhead box protein Q1

Gene

Foxq1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in hair follicle differentiation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi115 – 210Fork-headPROSITE-ProRule annotationAdd BLAST96

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: GO_Central
  • hair follicle morphogenesis Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: NTNU_SB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein Q1
Alternative name(s):
HFH-1l
HNF-3/forkhead-like protein 1
Short name:
HFH-1
Hepatocyte nuclear factor 3 forkhead homolog 1
Gene namesi
Name:Foxq1
Synonyms:Hfh1, Hfh1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1298228 Foxq1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in Foxq1 are the cause of the satin (sa) phenotype and results in a silky coat with high sheen arising from structurally abnormal medulla cells and defects in differentiation of the hair shaft.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918911 – 400Forkhead box protein Q1Add BLAST400

Proteomic databases

PaxDbiO70220
PRIDEiO70220

PTM databases

iPTMnetiO70220
PhosphoSitePlusiO70220

Expressioni

Tissue specificityi

Expressed in kidney and stomach. Expression in the outer medulla of the kidney and the transitional epithelium. Expressed in the hair follicle medulla.2 Publications

Gene expression databases

BgeeiENSMUSG00000038415
CleanExiMM_FOXQ1
GenevisibleiO70220 MM

Interactioni

Protein-protein interaction databases

BioGridi200287, 2 interactors
STRINGi10090.ENSMUSP00000036952

Structurei

3D structure databases

ProteinModelPortaliO70220
SMRiO70220
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00900000140781
HOGENOMiHOG000112634
HOVERGENiHBG051658
InParanoidiO70220
KOiK09410
OMAiAYGMGEP
OrthoDBiEOG091G0LMU
TreeFamiTF316127

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequencei

Sequence statusi: Complete.

O70220-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLEVFVPRA AHGDKMGSDL EGAGSSDVPS PLSAAGDDSL GSDGDCAANS
60 70 80 90 100
PAAGSGAGDL EGGGGERNSS GGPSAQDGPE ATDDSRTQAS AAGPCAGGVG
110 120 130 140 150
GGEGARSKPY TRRPKPPYSY IALIAMAIRD SAGGRLTLAE INEYLMGKFP
160 170 180 190 200
FFRGSYTGWR NSVRHNLSLN DCFVKVLRDP SRPWGKDNYW MLNPNSEYTF
210 220 230 240 250
ADGVFRRRRK RLSHRTTVSA SGLRPEEAPP GPAGTPQPAP AARSSPIARS
260 270 280 290 300
PARQEERSSP ASKFSSSFAI DSILSKPFRS RRDGDSALGV QLPWGAAPCP
310 320 330 340 350
PLRAYPALLP AAPGGALLPL CAYGASEPTL LASRGTEVQP AAPLLLAPLS
360 370 380 390 400
TAAPAKPFRG PETAGAAHLY CPLRLPTALQ AAAACGPGPH LSYPVETLLA
Length:400
Mass (Da):41,368
Last modified:July 27, 2011 - v3
Checksum:iF286AEEF81D4759B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti238P → A in AAC12973 (PubMed:9726250).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF010405 Genomic DNA Translation: AAC12973.2
AF154426 Genomic DNA Translation: AAF74524.1
AK147202 mRNA Translation: BAE27760.1
AL589738 Genomic DNA Translation: CAC60398.1
CH466561 Genomic DNA Translation: EDL32371.1
BC047155 mRNA Translation: AAH47155.1
CCDSiCCDS26423.1
RefSeqiNP_032265.3, NM_008239.4
UniGeneiMm.44235

Genome annotation databases

EnsembliENSMUST00000042118; ENSMUSP00000036952; ENSMUSG00000038415
GeneIDi15220
KEGGimmu:15220
UCSCiuc007pzj.2 mouse

Similar proteinsi

Entry informationi

Entry nameiFOXQ1_MOUSE
AccessioniPrimary (citable) accession number: O70220
Secondary accession number(s): Q9JJ18
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 135 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health