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Protein

Forkhead box protein Q1

Gene

Foxq1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in hair follicle differentiation.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi115 – 21096Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • hair follicle morphogenesis Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein Q1
Alternative name(s):
HFH-1l
HNF-3/forkhead-like protein 1
Short name:
HFH-1
Hepatocyte nuclear factor 3 forkhead homolog 1
Gene namesi
Name:Foxq1
Synonyms:Hfh1, Hfh1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1298228. Foxq1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in Foxq1 are the cause of the satin (sa) phenotype and results in a silky coat with high sheen arising from structurally abnormal medulla cells and defects in differentiation of the hair shaft.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 400400Forkhead box protein Q1PRO_0000091891Add
BLAST

Proteomic databases

PaxDbiO70220.
PRIDEiO70220.

PTM databases

PhosphoSiteiO70220.

Expressioni

Tissue specificityi

Expressed in kidney and stomach. Expression in the outer medulla of the kidney and the transitional epithelium. Expressed in the hair follicle medulla.2 Publications

Gene expression databases

BgeeiO70220.
CleanExiMM_FOXQ1.
GenevisibleiO70220. MM.

Interactioni

Protein-protein interaction databases

BioGridi200287. 2 interactions.
STRINGi10090.ENSMUSP00000036952.

Structurei

3D structure databases

ProteinModelPortaliO70220.
SMRiO70220. Positions 120-194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00800000124014.
HOGENOMiHOG000112634.
HOVERGENiHBG051658.
InParanoidiO70220.
KOiK09410.
OMAiPAKPFRG.
OrthoDBiEOG708W0T.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70220-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLEVFVPRA AHGDKMGSDL EGAGSSDVPS PLSAAGDDSL GSDGDCAANS
60 70 80 90 100
PAAGSGAGDL EGGGGERNSS GGPSAQDGPE ATDDSRTQAS AAGPCAGGVG
110 120 130 140 150
GGEGARSKPY TRRPKPPYSY IALIAMAIRD SAGGRLTLAE INEYLMGKFP
160 170 180 190 200
FFRGSYTGWR NSVRHNLSLN DCFVKVLRDP SRPWGKDNYW MLNPNSEYTF
210 220 230 240 250
ADGVFRRRRK RLSHRTTVSA SGLRPEEAPP GPAGTPQPAP AARSSPIARS
260 270 280 290 300
PARQEERSSP ASKFSSSFAI DSILSKPFRS RRDGDSALGV QLPWGAAPCP
310 320 330 340 350
PLRAYPALLP AAPGGALLPL CAYGASEPTL LASRGTEVQP AAPLLLAPLS
360 370 380 390 400
TAAPAKPFRG PETAGAAHLY CPLRLPTALQ AAAACGPGPH LSYPVETLLA
Length:400
Mass (Da):41,368
Last modified:July 27, 2011 - v3
Checksum:iF286AEEF81D4759B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti238 – 2381P → A in AAC12973 (PubMed:9726250).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF010405 Genomic DNA. Translation: AAC12973.2.
AF154426 Genomic DNA. Translation: AAF74524.1.
AK147202 mRNA. Translation: BAE27760.1.
AL589738 Genomic DNA. Translation: CAC60398.1.
CH466561 Genomic DNA. Translation: EDL32371.1.
BC047155 mRNA. Translation: AAH47155.1.
CCDSiCCDS26423.1.
RefSeqiNP_032265.3. NM_008239.4.
UniGeneiMm.44235.

Genome annotation databases

EnsembliENSMUST00000042118; ENSMUSP00000036952; ENSMUSG00000038415.
GeneIDi15220.
KEGGimmu:15220.
UCSCiuc007pzj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF010405 Genomic DNA. Translation: AAC12973.2.
AF154426 Genomic DNA. Translation: AAF74524.1.
AK147202 mRNA. Translation: BAE27760.1.
AL589738 Genomic DNA. Translation: CAC60398.1.
CH466561 Genomic DNA. Translation: EDL32371.1.
BC047155 mRNA. Translation: AAH47155.1.
CCDSiCCDS26423.1.
RefSeqiNP_032265.3. NM_008239.4.
UniGeneiMm.44235.

3D structure databases

ProteinModelPortaliO70220.
SMRiO70220. Positions 120-194.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200287. 2 interactions.
STRINGi10090.ENSMUSP00000036952.

PTM databases

PhosphoSiteiO70220.

Proteomic databases

PaxDbiO70220.
PRIDEiO70220.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042118; ENSMUSP00000036952; ENSMUSG00000038415.
GeneIDi15220.
KEGGimmu:15220.
UCSCiuc007pzj.2. mouse.

Organism-specific databases

CTDi94234.
MGIiMGI:1298228. Foxq1.

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00800000124014.
HOGENOMiHOG000112634.
HOVERGENiHBG051658.
InParanoidiO70220.
KOiK09410.
OMAiPAKPFRG.
OrthoDBiEOG708W0T.
TreeFamiTF316127.

Miscellaneous databases

NextBioi287803.
PROiO70220.
SOURCEiSearch...

Gene expression databases

BgeeiO70220.
CleanExiMM_FOXQ1.
GenevisibleiO70220. MM.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse HNF-3/fork head homolog-1-like gene: structure, chromosomal location, and expression in adult and embryonic kidney."
    Frank S., Zoll B.
    DNA Cell Biol. 17:679-688(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    Strain: 129.
    Tissue: Kidney.
  2. Pasche B., Bieller A., Zoll B.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "The winged helix/forkhead transcription factor Foxq1 regulates differentiation of hair in satin mice."
    Hong H.-K., Noveroske J.K., Headon D.J., Liu T., Sy M.S., Justice M.J., Chakravarti A.
    Genesis 29:163-171(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DISEASE.
    Strain: 129.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  6. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3.
    Tissue: Mammary tumor.
  8. "Evidence that the satin hair mutant gene Foxq1 is among multiple and functionally diverse regulatory targets for Hoxc13 during hair follicle differentiation."
    Potter C.S., Peterson R.L., Barth J.L., Pruett N.D., Jacobs D.F., Kern M.J., Argraves W.S., Sundberg J.P., Awgulewitsch A.
    J. Biol. Chem. 281:29245-29255(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiFOXQ1_MOUSE
AccessioniPrimary (citable) accession number: O70220
Secondary accession number(s): Q9JJ18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: July 27, 2011
Last modified: May 11, 2016
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.