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Protein

Homeobox protein HMX1

Gene

Hmx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

DNA-binding protein that binds to the 5'-CAAG-3' core sequence. May function as a transcriptional repressor. Seems to act as a transcriptional antagonist of NKX2-5. May play an important role in the development of craniofacial structures such as the eye and ear.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi191 – 250HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
  • sequence-specific DNA binding Source: MGI
  • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding Source: NTNU_SB

GO - Biological processi

  • multicellular organism development Source: UniProtKB-KW
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein HMX1
Alternative name(s):
Homeobox protein H6
Gene namesi
Name:Hmx1
Synonyms:H6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:107178. Hmx1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002784541 – 332Homeobox protein HMX1Add BLAST332

Proteomic databases

PaxDbiO70218.
PRIDEiO70218.

PTM databases

iPTMnetiO70218.
PhosphoSitePlusiO70218.

Expressioni

Tissue specificityi

Expressed in neural crest-derived tissues, including, nerve ganglia and cranial mesenchyme.1 Publication

Developmental stagei

On 9.5 dpc expressed in the trigeminal (V) ganglion. On 10.5-11 dpc, expressed in the eye, second branchial arch and the dorsal root ganglion. On 11.5-12 dpc, expressed in the lens and neural epithelium of the eye. On 14-16 dpc, expressed in the sympathetic ganglon and dorso-lateral mesenchyme near the developing ear.1 Publication

Gene expression databases

BgeeiENSMUSG00000067438.
CleanExiMM_HMX1.
ExpressionAtlasiO70218. baseline and differential.
GenevisibleiO70218. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084958.

Structurei

3D structure databases

ProteinModelPortaliO70218.
SMRiO70218.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi251 – 261HMX family specific domain 1Add BLAST11
Motifi264 – 277HMX family specific domain 2Add BLAST14

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi43 – 47Poly-Glu5
Compositional biasi48 – 51Poly-Asp4
Compositional biasi173 – 182Poly-Ala10
Compositional biasi261 – 300Pro-richAdd BLAST40

Sequence similaritiesi

Belongs to the HMX homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0485. Eukaryota.
ENOG4111R8D. LUCA.
GeneTreeiENSGT00860000133665.
HOGENOMiHOG000231923.
HOVERGENiHBG031610.
InParanoidiO70218.
KOiK09349.
OMAiCGGATRW.
OrthoDBiEOG091G0RNV.
PhylomeDBiO70218.
TreeFamiTF320562.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70218-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDELTEPGR ATPARASSFL IENLLAAEAK GAGRSTQGDG VREEEEEDDD
60 70 80 90 100
DPEDEDPEQA RRRLQRRRQQ RAGSGPGGEA RARALGLGPR PPPGPGPPFA
110 120 130 140 150
LGCGGTTRWY PRVHGGYGGG LSPDTSDRDS PETGEEMGRA ESAWPRCPGP
160 170 180 190 200
GTVPREVTTQ GPATGGEEAA ELAEAPAVAA AATGEARGGR RKKTRTVFSR
210 220 230 240 250
SQVFQLESTF DLKRYLSSAE RAGLAASLQL TETQVKIWFQ NRRNKWKRQL
260 270 280 290 300
AAELEAASLS PPGAQRLVRV PVLYHESPPA AAGPALPFPL APPAPAPPPP
310 320 330
LLGFSGALAY PLAAFPAAAS VPFLRAQMPG LV
Length:332
Mass (Da):35,054
Last modified:August 1, 1998 - v1
Checksum:i5D1A9F8439ABF310
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009614 Genomic DNA. Translation: AAC24193.1.
AF009367 mRNA. Translation: AAC24324.1.
CCDSiCCDS19228.1.
RefSeqiNP_034575.1. NM_010445.2.
UniGeneiMm.358606.

Genome annotation databases

EnsembliENSMUST00000087674; ENSMUSP00000084958; ENSMUSG00000067438.
GeneIDi15371.
KEGGimmu:15371.
UCSCiuc008xds.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009614 Genomic DNA. Translation: AAC24193.1.
AF009367 mRNA. Translation: AAC24324.1.
CCDSiCCDS19228.1.
RefSeqiNP_034575.1. NM_010445.2.
UniGeneiMm.358606.

3D structure databases

ProteinModelPortaliO70218.
SMRiO70218.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084958.

PTM databases

iPTMnetiO70218.
PhosphoSitePlusiO70218.

Proteomic databases

PaxDbiO70218.
PRIDEiO70218.

Protocols and materials databases

DNASUi15371.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000087674; ENSMUSP00000084958; ENSMUSG00000067438.
GeneIDi15371.
KEGGimmu:15371.
UCSCiuc008xds.1. mouse.

Organism-specific databases

CTDi3166.
MGIiMGI:107178. Hmx1.

Phylogenomic databases

eggNOGiKOG0485. Eukaryota.
ENOG4111R8D. LUCA.
GeneTreeiENSGT00860000133665.
HOGENOMiHOG000231923.
HOVERGENiHBG031610.
InParanoidiO70218.
KOiK09349.
OMAiCGGATRW.
OrthoDBiEOG091G0RNV.
PhylomeDBiO70218.
TreeFamiTF320562.

Miscellaneous databases

PROiO70218.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000067438.
CleanExiMM_HMX1.
ExpressionAtlasiO70218. baseline and differential.
GenevisibleiO70218. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHMX1_MOUSE
AccessioniPrimary (citable) accession number: O70218
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.