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Protein

PDZ and LIM domain protein 3

Gene

Pdlim3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the organization of actin filament arrays within muscle cells.By similarity

GO - Molecular functioni

  • cytoskeletal protein binding Source: MGI
  • structural constituent of muscle Source: MGI
  • zinc ion binding Source: InterPro

GO - Biological processi

  • actin filament organization Source: MGI
  • heart development Source: MGI
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
PDZ and LIM domain protein 3
Alternative name(s):
Actinin-associated LIM protein
Alpha-actinin-2-associated LIM protein
Gene namesi
Name:Pdlim3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1859274. Pdlim3.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: MGI
  • Z disc Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316PDZ and LIM domain protein 3PRO_0000075868Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei18 – 181PhosphoserineBy similarity
Modified residuei93 – 931PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO70209.
PaxDbiO70209.
PRIDEiO70209.

2D gel databases

REPRODUCTION-2DPAGEIPI00116347.

PTM databases

iPTMnetiO70209.
PhosphoSiteiO70209.

Expressioni

Developmental stagei

At E15 highly expressed in skeletal muscle and heart.1 Publication

Gene expression databases

BgeeiO70209.
CleanExiMM_PDLIM3.
GenevisibleiO70209. MM.

Interactioni

Subunit structurei

Interacts with ACTN2.By similarity

GO - Molecular functioni

  • cytoskeletal protein binding Source: MGI

Protein-protein interaction databases

IntActiO70209. 1 interaction.
MINTiMINT-4105265.
STRINGi10090.ENSMUSP00000034053.

Structurei

Secondary structure

1
316
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 116Combined sources
Beta strandi18 – 203Combined sources
Turni21 – 244Combined sources
Beta strandi25 – 284Combined sources
Beta strandi34 – 363Combined sources
Helixi39 – 413Combined sources
Beta strandi48 – 525Combined sources
Helixi62 – 698Combined sources
Beta strandi74 – 774Combined sources
Turni84 – 874Combined sources
Turni247 – 2493Combined sources
Beta strandi258 – 2625Combined sources
Turni267 – 2693Combined sources
Beta strandi273 – 2753Combined sources
Turni279 – 2813Combined sources
Beta strandi285 – 2873Combined sources
Beta strandi290 – 2923Combined sources
Helixi294 – 3007Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1V5LNMR-A4-93[»]
1X64NMR-A226-301[»]
ProteinModelPortaliO70209.
SMRiO70209. Positions 4-93, 221-304.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO70209.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8484PDZPROSITE-ProRule annotationAdd
BLAST
Domaini244 – 30360LIM zinc-bindingPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 LIM zinc-binding domain.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain

Phylogenomic databases

eggNOGiKOG1703. Eukaryota.
ENOG410XRD4. LUCA.
GeneTreeiENSGT00590000082980.
HOGENOMiHOG000290704.
HOVERGENiHBG061371.
InParanoidiO70209.
OMAiMRPPEGH.
OrthoDBiEOG77DJ69.
PhylomeDBiO70209.
TreeFamiTF106408.

Family and domain databases

Gene3Di2.10.110.10. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR031847. DUF4749.
IPR001478. PDZ.
IPR006643. ZASP.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF15936. DUF4749. 1 hit.
PF00412. LIM. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00132. LIM. 1 hit.
SM00228. PDZ. 1 hit.
SM00735. ZM. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70209-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQNVVLPGP APWGFRLSGG IDFNQPLVIT RITPGSKAAA ANLCPGDVIL
60 70 80 90 100
AIDGFGTESM THADAQDRIK AASYQLCLKI DRAETRLWSP QVSEDGKAHP
110 120 130 140 150
FKINLEAEPQ EFKPIGTAHN RRAQPFVAAA NIDDKRQVVS ASYNSPIGLY
160 170 180 190 200
STSNIQDALH GQLRGLIPGS LQNEPTASVP PQSDVYRMLH DNRDDPAAPR
210 220 230 240 250
QSGSFRVLQD LVNDGPDDRP AGTRSVRAPV TKVHGGAGSA QRMPLCDKCG
260 270 280 290 300
SGIVGAVVKA RDKYRHPECF VCADCNLNLK QKGYFFVEGE LYCETHARAR
310
TRPPEGYDTV TLYPKA
Length:316
Mass (Da):34,300
Last modified:August 1, 1998 - v1
Checksum:iE59916D0BC430B6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF002283 mRNA. Translation: AAC16673.1.
AK078421 mRNA. Translation: BAC37266.1.
BC070418 mRNA. Translation: AAH70418.1.
CCDSiCCDS22281.1.
RefSeqiNP_058078.1. NM_016798.3.
UniGeneiMm.282900.

Genome annotation databases

EnsembliENSMUST00000034053; ENSMUSP00000034053; ENSMUSG00000031636.
GeneIDi53318.
KEGGimmu:53318.
UCSCiuc009lpl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF002283 mRNA. Translation: AAC16673.1.
AK078421 mRNA. Translation: BAC37266.1.
BC070418 mRNA. Translation: AAH70418.1.
CCDSiCCDS22281.1.
RefSeqiNP_058078.1. NM_016798.3.
UniGeneiMm.282900.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1V5LNMR-A4-93[»]
1X64NMR-A226-301[»]
ProteinModelPortaliO70209.
SMRiO70209. Positions 4-93, 221-304.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO70209. 1 interaction.
MINTiMINT-4105265.
STRINGi10090.ENSMUSP00000034053.

PTM databases

iPTMnetiO70209.
PhosphoSiteiO70209.

2D gel databases

REPRODUCTION-2DPAGEIPI00116347.

Proteomic databases

MaxQBiO70209.
PaxDbiO70209.
PRIDEiO70209.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034053; ENSMUSP00000034053; ENSMUSG00000031636.
GeneIDi53318.
KEGGimmu:53318.
UCSCiuc009lpl.1. mouse.

Organism-specific databases

CTDi27295.
MGIiMGI:1859274. Pdlim3.

Phylogenomic databases

eggNOGiKOG1703. Eukaryota.
ENOG410XRD4. LUCA.
GeneTreeiENSGT00590000082980.
HOGENOMiHOG000290704.
HOVERGENiHBG061371.
InParanoidiO70209.
OMAiMRPPEGH.
OrthoDBiEOG77DJ69.
PhylomeDBiO70209.
TreeFamiTF106408.

Miscellaneous databases

EvolutionaryTraceiO70209.
PROiO70209.
SOURCEiSearch...

Gene expression databases

BgeeiO70209.
CleanExiMM_PDLIM3.
GenevisibleiO70209. MM.

Family and domain databases

Gene3Di2.10.110.10. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR031847. DUF4749.
IPR001478. PDZ.
IPR006643. ZASP.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF15936. DUF4749. 1 hit.
PF00412. LIM. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00132. LIM. 1 hit.
SM00228. PDZ. 1 hit.
SM00735. ZM. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Actinin-associated LIM protein: identification of a domain interaction between PDZ and spectrin-like repeat motifs."
    Xia H., Winokur S.T., Kuo W.-L., Altherr M.R., Bredt D.S.
    J. Cell Biol. 139:507-515(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
    Tissue: Skeletal muscle.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Wolffian duct.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Heart, Lung and Testis.
  5. "Solution structure of PDZ and LIM domains of mouse alpha-actinin-2 associated LIM protein."
    RIKEN structural genomics initiative (RSGI)
    Submitted (MAY-2004) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 4-93 AND 226-301 IN COMPLEX WITH ZINC IONS.

Entry informationi

Entry nameiPDLI3_MOUSE
AccessioniPrimary (citable) accession number: O70209
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: August 1, 1998
Last modified: June 8, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.