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O70199

- UGDH_RAT

UniProt

O70199 - UGDH_RAT

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Protein

UDP-glucose 6-dehydrogenase

Gene
Ugdh
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.

Catalytic activityi

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.

Enzyme regulationi

UDP-alpha-D-xylose (UDX) acts as a feedback inhibitor by activating an allosteric switch By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361NAD By similarity
Binding sitei41 – 411NAD By similarity
Binding sitei165 – 1651NAD By similarity
Active sitei276 – 2761Nucleophile By similarity
Binding sitei346 – 3461NAD By similarity
Binding sitei442 – 4421Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 166NAD By similarity
Nucleotide bindingi89 – 935NAD By similarity
Nucleotide bindingi130 – 1312NAD By similarity
Nucleotide bindingi276 – 2794NAD By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. UDP-glucose 6-dehydrogenase activity Source: RGD

GO - Biological processi

  1. UDP-glucuronate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00038; UER00491.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose 6-dehydrogenase (EC:1.1.1.22)
Short name:
UDP-Glc dehydrogenase
Short name:
UDP-GlcDH
Short name:
UDPGDH
Gene namesi
Name:Ugdh
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi621879. Ugdh.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 493493UDP-glucose 6-dehydrogenasePRO_0000074062Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei107 – 1071N6-acetyllysine By similarity
Modified residuei474 – 4741Phosphothreonine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiO70199.
PRIDEiO70199.

PTM databases

PhosphoSiteiO70199.

Expressioni

Gene expression databases

GenevestigatoriO70199.

Interactioni

Subunit structurei

Homohexamer By similarity.

Protein-protein interaction databases

MINTiMINT-4567212.
STRINGi10116.ENSRNOP00000003691.

Structurei

3D structure databases

ProteinModelPortaliO70199.
SMRiO70199. Positions 1-466.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni161 – 1655Substrate binding By similarity
Regioni220 – 2278Substrate binding By similarity
Regioni260 – 27314Substrate binding By similarityAdd
BLAST
Regioni338 – 3392Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1004.
HOGENOMiHOG000153773.
HOVERGENiHBG003512.
InParanoidiO70199.
KOiK00012.
PhylomeDBiO70199.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028356. UDPglc_DH_euk.
[Graphical view]
PANTHERiPTHR11374. PTHR11374. 1 hit.
PTHR11374:SF3. PTHR11374:SF3. 1 hit.
PfamiPF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF500133. UDPglc_DH_euk. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.

Sequencei

Sequence statusi: Complete.

O70199-1 [UniParc]FASTAAdd to Basket

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MVEIKKICCI GAGYVGGPTC SVIARMCPEI RVTVVDVNEA RINAWNSPTL    50
PIYEPGLKEV VESCRGKNLF FSTNIDDAIR EADLVFISVN TPTKTYGMGK 100
GRAADLKYIE ACARRIVQNS NGYKIVTEKS TVPVRAAESI RRIFDANTKP 150
NLNLQVLSNP EFLAEGTAIK DLKNPDRVLI GGDETPEGQR AVQALCAVYE 200
HWVPKEKILT TNTWSSELSK LAANAFLAQR ISSINSISAL CESTGADVEE 250
VATAIGMDQR IGNKFLKASV GFGGGCFQKD VLNLVYLCEA LNLPEVARYW 300
QQVIDMNDYQ RRRFASRIID SLFNTVTDKK IAILGFAFKK DTGDTRESSS 350
IYISKYLMDE GAHLHIYDPK VPREQIVVDL SHPGVSADDQ VSRLVTISKD 400
PYEACDGAHA LVICTEWDMF KELDYERIHK RMLKPAFIFD GRRVLDGLHN 450
ELQTIGFQIE TIGKKVSSKR IPYTPGEIPK FSLQDPPNKK PKV 493
Length:493
Mass (Da):54,892
Last modified:August 1, 1998 - v1
Checksum:iF435D1F9AC8307EF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB013732 mRNA. Translation: BAA28215.1.
RefSeqiNP_112615.1. NM_031325.1.
UniGeneiRn.3967.

Genome annotation databases

GeneIDi83472.
KEGGirno:83472.
UCSCiRGD:621879. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB013732 mRNA. Translation: BAA28215.1 .
RefSeqi NP_112615.1. NM_031325.1.
UniGenei Rn.3967.

3D structure databases

ProteinModelPortali O70199.
SMRi O70199. Positions 1-466.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4567212.
STRINGi 10116.ENSRNOP00000003691.

PTM databases

PhosphoSitei O70199.

Proteomic databases

PaxDbi O70199.
PRIDEi O70199.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 83472.
KEGGi rno:83472.
UCSCi RGD:621879. rat.

Organism-specific databases

CTDi 7358.
RGDi 621879. Ugdh.

Phylogenomic databases

eggNOGi COG1004.
HOGENOMi HOG000153773.
HOVERGENi HBG003512.
InParanoidi O70199.
KOi K00012.
PhylomeDBi O70199.

Enzyme and pathway databases

UniPathwayi UPA00038 ; UER00491 .

Miscellaneous databases

NextBioi 615885.
PROi O70199.

Gene expression databases

Genevestigatori O70199.

Family and domain databases

Gene3Di 3.40.50.720. 2 hits.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028356. UDPglc_DH_euk.
[Graphical view ]
PANTHERi PTHR11374. PTHR11374. 1 hit.
PTHR11374:SF3. PTHR11374:SF3. 1 hit.
Pfami PF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF500133. UDPglc_DH_euk. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTi SM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsi TIGR03026. NDP-sugDHase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "cDNA cloning of rat UDP-glucose dehydrogenase."
    Kobayashi T., Yokota H., Yuasa A.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Liver.

Entry informationi

Entry nameiUGDH_RAT
AccessioniPrimary (citable) accession number: O70199
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: April 16, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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