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Protein

Pituitary adenylate cyclase-activating polypeptide

Gene

Adcyap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells (By similarity). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (By similarity). In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (PubMed:23913443).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone
Biological processNeurogenesis

Enzyme and pathway databases

ReactomeiR-MMU-418555 G alpha (s) signalling events
R-MMU-420092 Glucagon-type ligand receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Pituitary adenylate cyclase-activating polypeptide
Short name:
PACAP
Cleaved into the following 3 chains:
Alternative name(s):
PRP-48
Pituitary adenylate cyclase-activating polypeptide 27
Short name:
PACAP-27
Short name:
PACAP27
Pituitary adenylate cyclase-activating polypeptide 38
Short name:
PACAP-38
Short name:
PACAP38
Gene namesi
Name:Adcyap1
Synonyms:Pacap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:105094 Adcyap1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
PropeptideiPRO_000001149125 – 78Add BLAST54
PeptideiPRO_000001149281 – 128PACAP-related peptideAdd BLAST48
PeptideiPRO_0000011493131 – 168Pituitary adenylate cyclase-activating polypeptide 38Add BLAST38
PeptideiPRO_0000011494131 – 157Pituitary adenylate cyclase-activating polypeptide 27Add BLAST27
PropeptideiPRO_0000011495172 – 1754

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei157Leucine amideBy similarity1
Modified residuei168Lysine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiO70176
PRIDEiO70176

PTM databases

PhosphoSitePlusiO70176

Expressioni

Gene expression databases

BgeeiENSMUSG00000024256
CleanExiMM_ADCYAP1
ExpressionAtlasiO70176 baseline and differential
GenevisibleiO70176 MM

Interactioni

Subunit structurei

Interacts with ADCYAP1R1 (via N-terminal extracellular domain).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi197979, 1 interactor
STRINGi10090.ENSMUSP00000067057

Structurei

3D structure databases

ProteinModelPortaliO70176
SMRiO70176
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni149 – 157Important for receptor bindingBy similarity9

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWIZ Eukaryota
ENOG4111FZG LUCA
GeneTreeiENSGT00530000063592
HOGENOMiHOG000253943
HOVERGENiHBG018069
InParanoidiO70176
KOiK05262
OMAiRYRQRIR
OrthoDBiEOG091G0J1P
PhylomeDBiO70176
TreeFamiTF332804

Family and domain databases

InterProiView protein in InterPro
IPR000532 Glucagon_GIP_secretin_VIP
PfamiView protein in Pfam
PF00123 Hormone_2, 2 hits
PRINTSiPR00275 GLUCAGON
SMARTiView protein in SMART
SM00070 GLUCA, 2 hits
PROSITEiView protein in PROSITE
PS00260 GLUCAGON, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70176-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMCSGARLA LLVYGIIMHS SVSCSPAAGL SFPGIRPEDE AYDQDGNPLQ
60 70 80 90 100
DFYDWDPPGV GSPASALRDA YALYYPADRR DVAHEILNEA YRKVLDQLSA
110 120 130 140 150
RKYLQSVVAR GAGENLGGSA VDDPAPLTKR HSDGIFTDSY SRYRKQMAVK
160 170
KYLAAVLGKR YKQRVKNKGR RIAYL
Length:175
Mass (Da):19,381
Last modified:August 1, 1998 - v1
Checksum:iD0E2007DB0C6E8C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010149 Genomic DNA Translation: BAA28355.1
BC057344 mRNA Translation: AAH57344.1
CCDSiCCDS29029.1
RefSeqiNP_001302432.1, NM_001315503.1
NP_001302433.1, NM_001315504.1
NP_033755.1, NM_009625.3
UniGeneiMm.3407

Genome annotation databases

EnsembliENSMUST00000064775; ENSMUSP00000067057; ENSMUSG00000024256
GeneIDi11516
KEGGimmu:11516
UCSCiuc008dwi.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPACA_MOUSE
AccessioniPrimary (citable) accession number: O70176
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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