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Protein

Pituitary adenylate cyclase-activating polypeptide

Gene

Adcyap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Keywords - Biological processi

Neurogenesis

Enzyme and pathway databases

ReactomeiREACT_277487. NGF-independant TRKA activation.
REACT_313192. G alpha (s) signalling events.
REACT_339920. Glucagon-type ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Pituitary adenylate cyclase-activating polypeptide
Short name:
PACAP
Cleaved into the following 3 chains:
Alternative name(s):
PRP-48
Pituitary adenylate cyclase-activating polypeptide 27
Short name:
PACAP-27
Short name:
PACAP27
Pituitary adenylate cyclase-activating polypeptide 38
Short name:
PACAP-38
Short name:
PACAP38
Gene namesi
Name:Adcyap1
Synonyms:Pacap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:105094. Adcyap1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Propeptidei25 – 7854PRO_0000011491Add
BLAST
Peptidei81 – 12848PACAP-related peptidePRO_0000011492Add
BLAST
Peptidei131 – 16838Pituitary adenylate cyclase-activating polypeptide 38PRO_0000011493Add
BLAST
Peptidei131 – 15727Pituitary adenylate cyclase-activating polypeptide 27PRO_0000011494Add
BLAST
Propeptidei172 – 1754PRO_0000011495

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei157 – 1571Leucine amideBy similarity
Modified residuei168 – 1681Lysine amideBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PRIDEiO70176.

PTM databases

PhosphoSiteiO70176.

Expressioni

Gene expression databases

BgeeiO70176.
CleanExiMM_ADCYAP1.
ExpressionAtlasiO70176. baseline and differential.
GenevisibleiO70176. MM.

Interactioni

Subunit structurei

Interacts with ADCYAP1R1 (via N-terminal extracellular domain).By similarity

Protein-protein interaction databases

BioGridi197979. 1 interaction.
MINTiMINT-1512367.
STRINGi10090.ENSMUSP00000067057.

Structurei

3D structure databases

ProteinModelPortaliO70176.
SMRiO70176. Positions 84-109, 131-168.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni149 – 1579Important for receptor bindingBy similarity

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG39235.
HOGENOMiHOG000253943.
HOVERGENiHBG018069.
InParanoidiO70176.
KOiK05262.
OMAiADGIFNK.
OrthoDBiEOG7M6D8P.
PhylomeDBiO70176.
TreeFamiTF332804.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
[Graphical view]
PfamiPF00123. Hormone_2. 2 hits.
[Graphical view]
PRINTSiPR00275. GLUCAGON.
SMARTiSM00070. GLUCA. 2 hits.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70176-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMCSGARLA LLVYGIIMHS SVSCSPAAGL SFPGIRPEDE AYDQDGNPLQ
60 70 80 90 100
DFYDWDPPGV GSPASALRDA YALYYPADRR DVAHEILNEA YRKVLDQLSA
110 120 130 140 150
RKYLQSVVAR GAGENLGGSA VDDPAPLTKR HSDGIFTDSY SRYRKQMAVK
160 170
KYLAAVLGKR YKQRVKNKGR RIAYL
Length:175
Mass (Da):19,381
Last modified:August 1, 1998 - v1
Checksum:iD0E2007DB0C6E8C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010149 Genomic DNA. Translation: BAA28355.1.
BC057344 mRNA. Translation: AAH57344.1.
CCDSiCCDS29029.1.
RefSeqiNP_033755.1. NM_009625.2.
UniGeneiMm.3407.

Genome annotation databases

EnsembliENSMUST00000064775; ENSMUSP00000067057; ENSMUSG00000024256.
GeneIDi11516.
KEGGimmu:11516.
UCSCiuc008dwi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010149 Genomic DNA. Translation: BAA28355.1.
BC057344 mRNA. Translation: AAH57344.1.
CCDSiCCDS29029.1.
RefSeqiNP_033755.1. NM_009625.2.
UniGeneiMm.3407.

3D structure databases

ProteinModelPortaliO70176.
SMRiO70176. Positions 84-109, 131-168.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi197979. 1 interaction.
MINTiMINT-1512367.
STRINGi10090.ENSMUSP00000067057.

PTM databases

PhosphoSiteiO70176.

Proteomic databases

PRIDEiO70176.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064775; ENSMUSP00000067057; ENSMUSG00000024256.
GeneIDi11516.
KEGGimmu:11516.
UCSCiuc008dwi.1. mouse.

Organism-specific databases

CTDi116.
MGIiMGI:105094. Adcyap1.

Phylogenomic databases

eggNOGiNOG39235.
HOGENOMiHOG000253943.
HOVERGENiHBG018069.
InParanoidiO70176.
KOiK05262.
OMAiADGIFNK.
OrthoDBiEOG7M6D8P.
PhylomeDBiO70176.
TreeFamiTF332804.

Enzyme and pathway databases

ReactomeiREACT_277487. NGF-independant TRKA activation.
REACT_313192. G alpha (s) signalling events.
REACT_339920. Glucagon-type ligand receptors.

Miscellaneous databases

NextBioi278934.
PROiO70176.
SOURCEiSearch...

Gene expression databases

BgeeiO70176.
CleanExiMM_ADCYAP1.
ExpressionAtlasiO70176. baseline and differential.
GenevisibleiO70176. MM.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
[Graphical view]
PfamiPF00123. Hormone_2. 2 hits.
[Graphical view]
PRINTSiPR00275. GLUCAGON.
SMARTiSM00070. GLUCA. 2 hits.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of the mouse pituitary adenylate cyclase-activating polypeptide (PACAP) gene."
    Yamamoto K., Hashimoto H., Hagihara N., Nishino A., Fujita T., Matsuda T., Baba A.
    Gene 211:63-69(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiPACA_MOUSE
AccessioniPrimary (citable) accession number: O70176
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 1, 1998
Last modified: June 24, 2015
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.