Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O70176

- PACA_MOUSE

UniProt

O70176 - PACA_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Pituitary adenylate cyclase-activating polypeptide

Gene

Adcyap1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (By similarity).By similarity

GO - Molecular functioni

  1. neuropeptide hormone activity Source: UniProtKB
  2. peptide hormone receptor binding Source: UniProtKB
  3. pituitary adenylate cyclase activating polypeptide activity Source: BHF-UCL
  4. receptor signaling protein activity Source: MGI

GO - Biological processi

  1. activation of adenylate cyclase activity Source: MGI
  2. ATP metabolic process Source: Ensembl
  3. behavioral fear response Source: Ensembl
  4. cAMP-mediated signaling Source: UniProtKB
  5. cellular response to glucocorticoid stimulus Source: Ensembl
  6. histamine secretion Source: Ensembl
  7. negative regulation of acute inflammatory response to antigenic stimulus Source: Ensembl
  8. negative regulation of acute inflammatory response to non-antigenic stimulus Source: Ensembl
  9. negative regulation of cell cycle Source: MGI
  10. negative regulation of glial cell proliferation Source: Ensembl
  11. negative regulation of muscle cell apoptotic process Source: Ensembl
  12. negative regulation of potassium ion transport Source: Ensembl
  13. negative regulation of Rho GTPase activity Source: Ensembl
  14. neuron projection development Source: UniProtKB
  15. neuropeptide signaling pathway Source: UniProtKB
  16. ovarian follicle development Source: Ensembl
  17. pituitary gland development Source: Ensembl
  18. positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway Source: BHF-UCL
  19. positive regulation of cell proliferation Source: Ensembl
  20. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  21. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  22. positive regulation of gene expression Source: MGI
  23. positive regulation of growth hormone secretion Source: Ensembl
  24. positive regulation of interleukin-6 production Source: Ensembl
  25. positive regulation of neuron projection development Source: Ensembl
  26. positive regulation of protein kinase activity Source: UniProtKB
  27. positive regulation of Rap GTPase activity Source: UniProtKB
  28. positive regulation of somatostatin secretion Source: Ensembl
  29. positive regulation of synaptic transmission, glutamatergic Source: Ensembl
  30. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  31. positive regulation of vasodilation Source: Ensembl
  32. regulation of G-protein coupled receptor protein signaling pathway Source: UniProtKB
  33. regulation of oligodendrocyte progenitor proliferation Source: Ensembl
  34. regulation of postsynaptic membrane potential Source: Ensembl
  35. regulation of protein localization Source: BHF-UCL
  36. response to ethanol Source: Ensembl
  37. response to starvation Source: Ensembl
  38. sensory perception of pain Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Keywords - Biological processi

Neurogenesis

Enzyme and pathway databases

ReactomeiREACT_209347. NGF-independant TRKA activation.
REACT_231304. Glucagon-type ligand receptors.
REACT_242871. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Pituitary adenylate cyclase-activating polypeptide
Short name:
PACAP
Cleaved into the following 3 chains:
Alternative name(s):
PRP-48
Pituitary adenylate cyclase-activating polypeptide 27
Short name:
PACAP-27
Short name:
PACAP27
Pituitary adenylate cyclase-activating polypeptide 38
Short name:
PACAP-38
Short name:
PACAP38
Gene namesi
Name:Adcyap1
Synonyms:Pacap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:105094. Adcyap1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. terminal bouton Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Propeptidei25 – 7854PRO_0000011491Add
BLAST
Peptidei81 – 12848PACAP-related peptidePRO_0000011492Add
BLAST
Peptidei131 – 16838Pituitary adenylate cyclase-activating polypeptide 38PRO_0000011493Add
BLAST
Peptidei131 – 15727Pituitary adenylate cyclase-activating polypeptide 27PRO_0000011494Add
BLAST
Propeptidei172 – 1754PRO_0000011495

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei157 – 1571Leucine amideBy similarity
Modified residuei168 – 1681Lysine amideBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PRIDEiO70176.

PTM databases

PhosphoSiteiO70176.

Expressioni

Gene expression databases

BgeeiO70176.
CleanExiMM_ADCYAP1.
ExpressionAtlasiO70176. baseline and differential.
GenevestigatoriO70176.

Interactioni

Subunit structurei

Interacts with ADCYAP1R1 (via N-terminal extracellular domain).By similarity

Protein-protein interaction databases

BioGridi197979. 1 interaction.
MINTiMINT-1512367.

Structurei

3D structure databases

ProteinModelPortaliO70176.
SMRiO70176. Positions 131-168.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni149 – 1579Important for receptor bindingBy similarity

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG39235.
HOGENOMiHOG000253943.
HOVERGENiHBG018069.
InParanoidiO70176.
KOiK05262.
OMAiPPEKRHA.
OrthoDBiEOG7M6D8P.
PhylomeDBiO70176.
TreeFamiTF332804.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
[Graphical view]
PfamiPF00123. Hormone_2. 2 hits.
[Graphical view]
PRINTSiPR00275. GLUCAGON.
SMARTiSM00070. GLUCA. 2 hits.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70176-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTMCSGARLA LLVYGIIMHS SVSCSPAAGL SFPGIRPEDE AYDQDGNPLQ
60 70 80 90 100
DFYDWDPPGV GSPASALRDA YALYYPADRR DVAHEILNEA YRKVLDQLSA
110 120 130 140 150
RKYLQSVVAR GAGENLGGSA VDDPAPLTKR HSDGIFTDSY SRYRKQMAVK
160 170
KYLAAVLGKR YKQRVKNKGR RIAYL
Length:175
Mass (Da):19,381
Last modified:August 1, 1998 - v1
Checksum:iD0E2007DB0C6E8C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010149 Genomic DNA. Translation: BAA28355.1.
BC057344 mRNA. Translation: AAH57344.1.
CCDSiCCDS29029.1.
RefSeqiNP_033755.1. NM_009625.2.
UniGeneiMm.3407.

Genome annotation databases

EnsembliENSMUST00000064775; ENSMUSP00000067057; ENSMUSG00000024256.
GeneIDi11516.
KEGGimmu:11516.
UCSCiuc008dwi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010149 Genomic DNA. Translation: BAA28355.1 .
BC057344 mRNA. Translation: AAH57344.1 .
CCDSi CCDS29029.1.
RefSeqi NP_033755.1. NM_009625.2.
UniGenei Mm.3407.

3D structure databases

ProteinModelPortali O70176.
SMRi O70176. Positions 131-168.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 197979. 1 interaction.
MINTi MINT-1512367.

PTM databases

PhosphoSitei O70176.

Proteomic databases

PRIDEi O70176.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000064775 ; ENSMUSP00000067057 ; ENSMUSG00000024256 .
GeneIDi 11516.
KEGGi mmu:11516.
UCSCi uc008dwi.1. mouse.

Organism-specific databases

CTDi 116.
MGIi MGI:105094. Adcyap1.

Phylogenomic databases

eggNOGi NOG39235.
HOGENOMi HOG000253943.
HOVERGENi HBG018069.
InParanoidi O70176.
KOi K05262.
OMAi PPEKRHA.
OrthoDBi EOG7M6D8P.
PhylomeDBi O70176.
TreeFami TF332804.

Enzyme and pathway databases

Reactomei REACT_209347. NGF-independant TRKA activation.
REACT_231304. Glucagon-type ligand receptors.
REACT_242871. G alpha (s) signalling events.

Miscellaneous databases

NextBioi 278934.
PROi O70176.
SOURCEi Search...

Gene expression databases

Bgeei O70176.
CleanExi MM_ADCYAP1.
ExpressionAtlasi O70176. baseline and differential.
Genevestigatori O70176.

Family and domain databases

InterProi IPR000532. Glucagon_GIP_secretin_VIP.
[Graphical view ]
Pfami PF00123. Hormone_2. 2 hits.
[Graphical view ]
PRINTSi PR00275. GLUCAGON.
SMARTi SM00070. GLUCA. 2 hits.
[Graphical view ]
PROSITEi PS00260. GLUCAGON. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of the mouse pituitary adenylate cyclase-activating polypeptide (PACAP) gene."
    Yamamoto K., Hashimoto H., Hagihara N., Nishino A., Fujita T., Matsuda T., Baba A.
    Gene 211:63-69(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiPACA_MOUSE
AccessioniPrimary (citable) accession number: O70176
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 1, 1998
Last modified: November 26, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3