SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O70176

- PACA_MOUSE

UniProt

O70176 - PACA_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Pituitary adenylate cyclase-activating polypeptide
Gene
Adcyap1, Pacap
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway By similarity.

GO - Molecular functioni

  1. neuropeptide hormone activity Source: UniProtKB
  2. peptide hormone receptor binding Source: UniProtKB
  3. pituitary adenylate cyclase activating polypeptide activity Source: BHF-UCL
  4. receptor signaling protein activity Source: MGI
Complete GO annotation...

GO - Biological processi

  1. ATP metabolic process Source: Ensembl
  2. activation of adenylate cyclase activity Source: MGI
  3. behavioral fear response Source: Ensembl
  4. cAMP-mediated signaling Source: UniProtKB
  5. cellular response to glucocorticoid stimulus Source: Ensembl
  6. histamine secretion Source: Ensembl
  7. negative regulation of Rho GTPase activity Source: Ensembl
  8. negative regulation of acute inflammatory response to antigenic stimulus Source: Ensembl
  9. negative regulation of acute inflammatory response to non-antigenic stimulus Source: Ensembl
  10. negative regulation of cell cycle Source: MGI
  11. negative regulation of glial cell proliferation Source: Ensembl
  12. negative regulation of muscle cell apoptotic process Source: Ensembl
  13. negative regulation of potassium ion transport Source: Ensembl
  14. neuron projection development Source: UniProtKB
  15. neuropeptide signaling pathway Source: UniProtKB
  16. ovarian follicle development Source: Ensembl
  17. pituitary gland development Source: Ensembl
  18. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  19. positive regulation of Rap GTPase activity Source: UniProtKB
  20. positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway Source: BHF-UCL
  21. positive regulation of cell proliferation Source: Ensembl
  22. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  23. positive regulation of gene expression Source: MGI
  24. positive regulation of growth hormone secretion Source: Ensembl
  25. positive regulation of interleukin-6 production Source: Ensembl
  26. positive regulation of neuron projection development Source: Ensembl
  27. positive regulation of protein kinase activity Source: UniProtKB
  28. positive regulation of somatostatin secretion Source: Ensembl
  29. positive regulation of synaptic transmission, glutamatergic Source: Ensembl
  30. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  31. positive regulation of vasodilation Source: Ensembl
  32. regulation of G-protein coupled receptor protein signaling pathway Source: UniProtKB
  33. regulation of oligodendrocyte progenitor proliferation Source: Ensembl
  34. regulation of postsynaptic membrane potential Source: Ensembl
  35. regulation of protein localization Source: BHF-UCL
  36. response to ethanol Source: Ensembl
  37. response to starvation Source: Ensembl
  38. sensory perception of pain Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Keywords - Biological processi

Neurogenesis

Enzyme and pathway databases

ReactomeiREACT_209347. NGF-independant TRKA activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Pituitary adenylate cyclase-activating polypeptide
Short name:
PACAP
Cleaved into the following 3 chains:
Alternative name(s):
PRP-48
Pituitary adenylate cyclase-activating polypeptide 27
Short name:
PACAP-27
Short name:
PACAP27
Pituitary adenylate cyclase-activating polypeptide 38
Short name:
PACAP-38
Short name:
PACAP38
Gene namesi
Name:Adcyap1
Synonyms:Pacap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:105094. Adcyap1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. terminal bouton Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed prediction
Add
BLAST
Propeptidei25 – 7854
PRO_0000011491Add
BLAST
Peptidei81 – 12848PACAP-related peptide
PRO_0000011492Add
BLAST
Peptidei131 – 16838Pituitary adenylate cyclase-activating polypeptide 38
PRO_0000011493Add
BLAST
Peptidei131 – 15727Pituitary adenylate cyclase-activating polypeptide 27
PRO_0000011494Add
BLAST
Propeptidei172 – 1754
PRO_0000011495

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei157 – 1571Leucine amide By similarity
Modified residuei168 – 1681Lysine amide By similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PRIDEiO70176.

PTM databases

PhosphoSiteiO70176.

Expressioni

Gene expression databases

ArrayExpressiO70176.
BgeeiO70176.
CleanExiMM_ADCYAP1.
GenevestigatoriO70176.

Interactioni

Subunit structurei

Interacts with ADCYAP1R1 (via N-terminal extracellular domain) By similarity.

Protein-protein interaction databases

BioGridi197979. 1 interaction.
MINTiMINT-1512367.

Structurei

3D structure databases

ProteinModelPortaliO70176.
SMRiO70176. Positions 131-168.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni149 – 1579Important for receptor binding By similarity

Sequence similaritiesi

Belongs to the glucagon family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG39235.
HOGENOMiHOG000253943.
HOVERGENiHBG018069.
InParanoidiO70176.
KOiK05262.
OMAiPPEKRHA.
OrthoDBiEOG7M6D8P.
PhylomeDBiO70176.
TreeFamiTF332804.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
[Graphical view]
PfamiPF00123. Hormone_2. 2 hits.
[Graphical view]
PRINTSiPR00275. GLUCAGON.
SMARTiSM00070. GLUCA. 2 hits.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70176-1 [UniParc]FASTAAdd to Basket

« Hide

MTMCSGARLA LLVYGIIMHS SVSCSPAAGL SFPGIRPEDE AYDQDGNPLQ    50
DFYDWDPPGV GSPASALRDA YALYYPADRR DVAHEILNEA YRKVLDQLSA 100
RKYLQSVVAR GAGENLGGSA VDDPAPLTKR HSDGIFTDSY SRYRKQMAVK 150
KYLAAVLGKR YKQRVKNKGR RIAYL 175
Length:175
Mass (Da):19,381
Last modified:August 1, 1998 - v1
Checksum:iD0E2007DB0C6E8C2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB010149 Genomic DNA. Translation: BAA28355.1.
BC057344 mRNA. Translation: AAH57344.1.
CCDSiCCDS29029.1.
RefSeqiNP_033755.1. NM_009625.2.
UniGeneiMm.3407.

Genome annotation databases

EnsembliENSMUST00000064775; ENSMUSP00000067057; ENSMUSG00000024256.
GeneIDi11516.
KEGGimmu:11516.
UCSCiuc008dwi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB010149 Genomic DNA. Translation: BAA28355.1 .
BC057344 mRNA. Translation: AAH57344.1 .
CCDSi CCDS29029.1.
RefSeqi NP_033755.1. NM_009625.2.
UniGenei Mm.3407.

3D structure databases

ProteinModelPortali O70176.
SMRi O70176. Positions 131-168.
ModBasei Search...

Protein-protein interaction databases

BioGridi 197979. 1 interaction.
MINTi MINT-1512367.

PTM databases

PhosphoSitei O70176.

Proteomic databases

PRIDEi O70176.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000064775 ; ENSMUSP00000067057 ; ENSMUSG00000024256 .
GeneIDi 11516.
KEGGi mmu:11516.
UCSCi uc008dwi.1. mouse.

Organism-specific databases

CTDi 116.
MGIi MGI:105094. Adcyap1.

Phylogenomic databases

eggNOGi NOG39235.
HOGENOMi HOG000253943.
HOVERGENi HBG018069.
InParanoidi O70176.
KOi K05262.
OMAi PPEKRHA.
OrthoDBi EOG7M6D8P.
PhylomeDBi O70176.
TreeFami TF332804.

Enzyme and pathway databases

Reactomei REACT_209347. NGF-independant TRKA activation.

Miscellaneous databases

NextBioi 278934.
PROi O70176.
SOURCEi Search...

Gene expression databases

ArrayExpressi O70176.
Bgeei O70176.
CleanExi MM_ADCYAP1.
Genevestigatori O70176.

Family and domain databases

InterProi IPR000532. Glucagon_GIP_secretin_VIP.
[Graphical view ]
Pfami PF00123. Hormone_2. 2 hits.
[Graphical view ]
PRINTSi PR00275. GLUCAGON.
SMARTi SM00070. GLUCA. 2 hits.
[Graphical view ]
PROSITEi PS00260. GLUCAGON. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of the mouse pituitary adenylate cyclase-activating polypeptide (PACAP) gene."
    Yamamoto K., Hashimoto H., Hagihara N., Nishino A., Fujita T., Matsuda T., Baba A.
    Gene 211:63-69(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiPACA_MOUSE
AccessioniPrimary (citable) accession number: O70176
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 1, 1998
Last modified: September 3, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi