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Protein

Pituitary adenylate cyclase-activating polypeptide

Gene

Adcyap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Keywords - Biological processi

Neurogenesis

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.
R-MMU-420092. Glucagon-type ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Pituitary adenylate cyclase-activating polypeptide
Short name:
PACAP
Cleaved into the following 3 chains:
Alternative name(s):
PRP-48
Pituitary adenylate cyclase-activating polypeptide 27
Short name:
PACAP-27
Short name:
PACAP27
Pituitary adenylate cyclase-activating polypeptide 38
Short name:
PACAP-38
Short name:
PACAP38
Gene namesi
Name:Adcyap1
Synonyms:Pacap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:105094. Adcyap1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
PropeptideiPRO_000001149125 – 78Add BLAST54
PeptideiPRO_000001149281 – 128PACAP-related peptideAdd BLAST48
PeptideiPRO_0000011493131 – 168Pituitary adenylate cyclase-activating polypeptide 38Add BLAST38
PeptideiPRO_0000011494131 – 157Pituitary adenylate cyclase-activating polypeptide 27Add BLAST27
PropeptideiPRO_0000011495172 – 1754

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei157Leucine amideBy similarity1
Modified residuei168Lysine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiO70176.
PRIDEiO70176.

PTM databases

PhosphoSitePlusiO70176.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024256.
CleanExiMM_ADCYAP1.
ExpressionAtlasiO70176. baseline and differential.
GenevisibleiO70176. MM.

Interactioni

Subunit structurei

Interacts with ADCYAP1R1 (via N-terminal extracellular domain).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi197979. 1 interactor.
MINTiMINT-1512367.
STRINGi10090.ENSMUSP00000067057.

Structurei

3D structure databases

ProteinModelPortaliO70176.
SMRiO70176.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni149 – 157Important for receptor bindingBy similarity9

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWIZ. Eukaryota.
ENOG4111FZG. LUCA.
GeneTreeiENSGT00530000063592.
HOGENOMiHOG000253943.
HOVERGENiHBG018069.
InParanoidiO70176.
KOiK05262.
OMAiRYRQRIR.
OrthoDBiEOG091G0J1P.
PhylomeDBiO70176.
TreeFamiTF332804.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
[Graphical view]
PfamiPF00123. Hormone_2. 2 hits.
[Graphical view]
PRINTSiPR00275. GLUCAGON.
SMARTiSM00070. GLUCA. 2 hits.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70176-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMCSGARLA LLVYGIIMHS SVSCSPAAGL SFPGIRPEDE AYDQDGNPLQ
60 70 80 90 100
DFYDWDPPGV GSPASALRDA YALYYPADRR DVAHEILNEA YRKVLDQLSA
110 120 130 140 150
RKYLQSVVAR GAGENLGGSA VDDPAPLTKR HSDGIFTDSY SRYRKQMAVK
160 170
KYLAAVLGKR YKQRVKNKGR RIAYL
Length:175
Mass (Da):19,381
Last modified:August 1, 1998 - v1
Checksum:iD0E2007DB0C6E8C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010149 Genomic DNA. Translation: BAA28355.1.
BC057344 mRNA. Translation: AAH57344.1.
CCDSiCCDS29029.1.
RefSeqiNP_001302432.1. NM_001315503.1.
NP_001302433.1. NM_001315504.1.
NP_033755.1. NM_009625.3.
UniGeneiMm.3407.

Genome annotation databases

EnsembliENSMUST00000064775; ENSMUSP00000067057; ENSMUSG00000024256.
GeneIDi11516.
KEGGimmu:11516.
UCSCiuc008dwi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010149 Genomic DNA. Translation: BAA28355.1.
BC057344 mRNA. Translation: AAH57344.1.
CCDSiCCDS29029.1.
RefSeqiNP_001302432.1. NM_001315503.1.
NP_001302433.1. NM_001315504.1.
NP_033755.1. NM_009625.3.
UniGeneiMm.3407.

3D structure databases

ProteinModelPortaliO70176.
SMRiO70176.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi197979. 1 interactor.
MINTiMINT-1512367.
STRINGi10090.ENSMUSP00000067057.

PTM databases

PhosphoSitePlusiO70176.

Proteomic databases

PaxDbiO70176.
PRIDEiO70176.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064775; ENSMUSP00000067057; ENSMUSG00000024256.
GeneIDi11516.
KEGGimmu:11516.
UCSCiuc008dwi.1. mouse.

Organism-specific databases

CTDi116.
MGIiMGI:105094. Adcyap1.

Phylogenomic databases

eggNOGiENOG410IWIZ. Eukaryota.
ENOG4111FZG. LUCA.
GeneTreeiENSGT00530000063592.
HOGENOMiHOG000253943.
HOVERGENiHBG018069.
InParanoidiO70176.
KOiK05262.
OMAiRYRQRIR.
OrthoDBiEOG091G0J1P.
PhylomeDBiO70176.
TreeFamiTF332804.

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.
R-MMU-420092. Glucagon-type ligand receptors.

Miscellaneous databases

PROiO70176.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024256.
CleanExiMM_ADCYAP1.
ExpressionAtlasiO70176. baseline and differential.
GenevisibleiO70176. MM.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
[Graphical view]
PfamiPF00123. Hormone_2. 2 hits.
[Graphical view]
PRINTSiPR00275. GLUCAGON.
SMARTiSM00070. GLUCA. 2 hits.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPACA_MOUSE
AccessioniPrimary (citable) accession number: O70176
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.