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Protein

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma

Gene

Pik3c2g

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis (By similarity).By similarity1 Publication

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Chemotaxis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.137. 5301.
2.7.1.154. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma (EC:2.7.1.154)
Short name:
PI3K-C2-gamma
Short name:
PtdIns-3-kinase C2 subunit gamma
Alternative name(s):
Phosphoinositide 3-kinase-C2-gamma
Gene namesi
Name:Pik3c2g
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620231. Pik3c2g.

Subcellular locationi

GO - Cellular componenti

  • Golgi apparatus Source: RGD
  • nuclear envelope Source: RGD
  • phosphatidylinositol 3-kinase complex Source: GO_Central
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15051505Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gammaPRO_0000088801Add
BLAST

Proteomic databases

PaxDbiO70173.
PRIDEiO70173.

Expressioni

Tissue specificityi

Predominantly expressed in normal liver. High levels also found in regenerating liver. Very low levels found in heart and testis.1 Publication

Developmental stagei

Higher levels of expression found in adult liver than in fetal liver.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043855.

Structurei

3D structure databases

ProteinModelPortaliO70173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini278 – 37093PI3K-RBDPROSITE-ProRule annotationAdd
BLAST
Domaini540 – 688149C2 PI3K-typePROSITE-ProRule annotationAdd
BLAST
Domaini703 – 879177PIK helicalPROSITE-ProRule annotationAdd
BLAST
Domaini976 – 1240265PI3K/PI4KPROSITE-ProRule annotationAdd
BLAST
Domaini1259 – 1371113PXPROSITE-ProRule annotationAdd
BLAST
Domaini1402 – 149998C2Add
BLAST

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotation
Contains 1 C2 domain.Curated
Contains 1 C2 PI3K-type domain.PROSITE-ProRule annotation
Contains 1 PI3K-RBD domain.PROSITE-ProRule annotation
Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation
Contains 1 PIK helical domain.PROSITE-ProRule annotation
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0905. Eukaryota.
COG5032. LUCA.
HOGENOMiHOG000168239.
HOVERGENiHBG053398.
InParanoidiO70173.
KOiK00923.
PhylomeDBiO70173.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 2 hits.
3.30.1520.10. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR001683. Phox.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 2 hits.
PfamiPF00168. C2. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
PF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 2 hits.
SM00142. PI3K_C2. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
SM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 2 hits.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
PS50195. PX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70173-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYNWQTEPN RAEPQEGGHD HQQCHHADQH LSSRQVRLGF DQLVEELSNK
60 70 80 90 100
TPLPEDEKEG TCFVPDTPNL DSKWQSIYGP HPRHFNEFTS QSPHFSQLPF
110 120 130 140 150
GKASAIGFNP AVLPAHQFIH EGASWRNPTR KYHGGEDPRF SALTPSSTGL
160 170 180 190 200
DKCHQQGQSG TEHCNYYVEP ENNVPHHYSP YSMDSIPDSE EKGSGDADLV
210 220 230 240 250
EPSLVFSKDS FLPRASENMS VESTEPIGCP LEIVEAPQGS NKSLASFCNN
260 270 280 290 300
VTKIRGLYHA SDTNSNSGKI WAITTAYPSR LFADTQFRVK ISTDNSAQLL
310 320 330 340 350
LLKPPANYLV KDLIAEILLL CANEQLSPKE YLLSICGSEE FLQTDHCLGS
360 370 380 390 400
HKIFQKSKSV IQLHLQRSRD TPGKLSRKRD DDRSRVHLNQ LLEFTHIWKI
410 420 430 440 450
SRQCLSTVMK SYNLHVEHLL KTQEDVEEKP LSSMFSCGRH PPQPHGNDII
460 470 480 490 500
EDVRNICSVL GCIETKQVSD AVKELTLILQ RPSQNFHQNS ETSKKGFIEN
510 520 530 540 550
VTSELSRSLH QLVDVYCSSF CTDFRPARAP GGVSRDHAGL HSHLSFTVCS
560 570 580 590 600
LHNVPETWAH SYKAFSFSCW LTYAGKKLCQ VKSCRSLPVT KSFSFSVNWN
610 620 630 640 650
EIINFPLEIK SLPRESMLVI KLFGIDSATH SANLLAWTCL PLFPKEKSPL
660 670 680 690 700
GSRLLSMTLQ SEPPIEMMAP GVWDGSQPTP LTLQIDFPAA TWEYVKPETE
710 720 730 740 750
ENRTDHQEPP RECLKHIARL SQKQPPLLLS VEKRRYLWFY RFYCNNENSS
760 770 780 790 800
LPLVLGSAPG WDEGTVSEMH AVLRRWTFSH PLEALGLLTS RFPDQDIREV
810 820 830 840 850
AVQQLDNFLT DELLDCLPQL VQAVKFEWSL ESPLVELLLH RSLQSIRVAH
860 870 880 890 900
RLFWLLRDAQ GEDYFKSWYQ ELLAALQFCA GEALIEELSK EQKLVKLLGD
910 920 930 940 950
IGEKVKSAGD AQRKDVLKKE IGSLEEFFKD IKTCHLPLNP ALCVKGIDRD
960 970 980 990 1000
ACSYFTSNAL PLKITFINAN PMGKNISVIF KAGDDLRQDM LVLQIIQVMD
1010 1020 1030 1040 1050
NVWLQEGLDM QMIIYGCLAT GKAQGFIEMV PDAVTLAKIH LHSGLIGPLK
1060 1070 1080 1090 1100
ENTIKKWFSQ HNHLKEDYEK ALRNFFYSCA GWCVVTFILG VCDRHNDNIM
1110 1120 1130 1140 1150
LTKSGHMFHI DFGKFLGHAQ TFGGIKRDRA PFIFTSEMEY FITEGGKNTQ
1160 1170 1180 1190 1200
HFQDFVELCC RAYNIVRKHS QLLLSLLEMM LHAGLPELRG IEDLKYVHDN
1210 1220 1230 1240 1250
LRPQDTDLEA TSHFTTKIKQ SLECFPVKLN NLIHTLAQMP AFSLARPAPQ
1260 1270 1280 1290 1300
TPPQECCVLN KTRTIQRVTI LGFSKTHSNL YLIEVTRSDN RKNLAKKSFE
1310 1320 1330 1340 1350
QFYRLHSQIQ KQFPLLTLPE FPHWWHLPFT DSHHERIRDL SHYVEQVLHG
1360 1370 1380 1390 1400
SYEVANSDCV LSFFLSEHIQ QTLEDSPFVD PGDHSPDKSP QVQLLMTYED
1410 1420 1430 1440 1450
TKLTILVKHL KNIHLPDGSA PSAHVEIYLL PHPSEVRRKK TKCVPKCTDP
1460 1470 1480 1490 1500
TYNEIVVYDD VSGLQGHVLM LIVKSKTVFV GAVNIQLCSV PLNEEKWYPL

GNSII
Length:1,505
Mass (Da):170,975
Last modified:August 1, 1998 - v1
Checksum:i5ED4C2239968C4B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009636 mRNA. Translation: BAA25634.1.
RefSeqiNP_446375.1. NM_053923.1.
UniGeneiRn.14870.

Genome annotation databases

GeneIDi116720.
KEGGirno:116720.
UCSCiRGD:620231. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009636 mRNA. Translation: BAA25634.1.
RefSeqiNP_446375.1. NM_053923.1.
UniGeneiRn.14870.

3D structure databases

ProteinModelPortaliO70173.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043855.

Proteomic databases

PaxDbiO70173.
PRIDEiO70173.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi116720.
KEGGirno:116720.
UCSCiRGD:620231. rat.

Organism-specific databases

CTDi5288.
RGDi620231. Pik3c2g.

Phylogenomic databases

eggNOGiKOG0905. Eukaryota.
COG5032. LUCA.
HOGENOMiHOG000168239.
HOVERGENiHBG053398.
InParanoidiO70173.
KOiK00923.
PhylomeDBiO70173.

Enzyme and pathway databases

BRENDAi2.7.1.137. 5301.
2.7.1.154. 5301.

Miscellaneous databases

PROiO70173.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 2 hits.
3.30.1520.10. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR001683. Phox.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 2 hits.
PfamiPF00168. C2. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
PF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 2 hits.
SM00142. PI3K_C2. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
SM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 2 hits.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
PS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A novel class II phosphoinositide 3-kinase predominantly expressed in the liver and its enhanced expression during liver regeneration."
    Ono F., Nakagawa T., Saito S., Owada Y., Sakagami H., Goto K., Suzuki M., Matsuno S., Kondo H.
    J. Biol. Chem. 273:7731-7736(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Regenerating liver.

Entry informationi

Entry nameiP3C2G_RAT
AccessioniPrimary (citable) accession number: O70173
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 1, 1998
Last modified: July 6, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.