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Protein

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma

Gene

Pik3c2g

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis (By similarity).By similarity1 Publication

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processChemotaxis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.137 5301
2.7.1.154 5301

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma (EC:2.7.1.154)
Short name:
PI3K-C2-gamma
Short name:
PtdIns-3-kinase C2 subunit gamma
Alternative name(s):
Phosphoinositide 3-kinase-C2-gamma
Gene namesi
Name:Pik3c2g
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620231 Pik3c2g

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000888011 – 1505Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gammaAdd BLAST1505

Proteomic databases

PaxDbiO70173
PRIDEiO70173

PTM databases

PhosphoSitePlusiO70173

Expressioni

Tissue specificityi

Predominantly expressed in normal liver. High levels also found in regenerating liver. Very low levels found in heart and testis.1 Publication

Developmental stagei

Higher levels of expression found in adult liver than in fetal liver.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043855

Structurei

3D structure databases

ProteinModelPortaliO70173
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini278 – 370PI3K-RBDPROSITE-ProRule annotationAdd BLAST93
Domaini540 – 688C2 PI3K-typePROSITE-ProRule annotationAdd BLAST149
Domaini703 – 879PIK helicalPROSITE-ProRule annotationAdd BLAST177
Domaini976 – 1240PI3K/PI4KPROSITE-ProRule annotationAdd BLAST265
Domaini1259 – 1371PXPROSITE-ProRule annotationAdd BLAST113
Domaini1402 – 1499C2Add BLAST98

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0905 Eukaryota
COG5032 LUCA
HOGENOMiHOG000168239
HOVERGENiHBG053398
InParanoidiO70173
KOiK00923
PhylomeDBiO70173

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
2.60.40.150, 2 hits
3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011009 Kinase-like_dom_sf
IPR001683 Phox
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR002420 PI3K_C2_dom
IPR000341 PI3K_Ras-bd_dom
IPR015433 PI_Kinase
IPR001263 PInositide-3_kin_accessory_dom
IPR036871 PX_dom_sf
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR10048 PTHR10048, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF00454 PI3_PI4_kinase, 1 hit
PF00792 PI3K_C2, 1 hit
PF00794 PI3K_rbd, 1 hit
PF00613 PI3Ka, 1 hit
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00239 C2, 2 hits
SM00142 PI3K_C2, 1 hit
SM00145 PI3Ka, 1 hit
SM00146 PI3Kc, 1 hit
SM00312 PX, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF54236 SSF54236, 1 hit
SSF56112 SSF56112, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51547 PI3K_C2, 1 hit
PS51546 PI3K_RBD, 1 hit
PS51545 PIK_HELICAL, 1 hit
PS50195 PX, 1 hit

Sequencei

Sequence statusi: Complete.

O70173-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYNWQTEPN RAEPQEGGHD HQQCHHADQH LSSRQVRLGF DQLVEELSNK
60 70 80 90 100
TPLPEDEKEG TCFVPDTPNL DSKWQSIYGP HPRHFNEFTS QSPHFSQLPF
110 120 130 140 150
GKASAIGFNP AVLPAHQFIH EGASWRNPTR KYHGGEDPRF SALTPSSTGL
160 170 180 190 200
DKCHQQGQSG TEHCNYYVEP ENNVPHHYSP YSMDSIPDSE EKGSGDADLV
210 220 230 240 250
EPSLVFSKDS FLPRASENMS VESTEPIGCP LEIVEAPQGS NKSLASFCNN
260 270 280 290 300
VTKIRGLYHA SDTNSNSGKI WAITTAYPSR LFADTQFRVK ISTDNSAQLL
310 320 330 340 350
LLKPPANYLV KDLIAEILLL CANEQLSPKE YLLSICGSEE FLQTDHCLGS
360 370 380 390 400
HKIFQKSKSV IQLHLQRSRD TPGKLSRKRD DDRSRVHLNQ LLEFTHIWKI
410 420 430 440 450
SRQCLSTVMK SYNLHVEHLL KTQEDVEEKP LSSMFSCGRH PPQPHGNDII
460 470 480 490 500
EDVRNICSVL GCIETKQVSD AVKELTLILQ RPSQNFHQNS ETSKKGFIEN
510 520 530 540 550
VTSELSRSLH QLVDVYCSSF CTDFRPARAP GGVSRDHAGL HSHLSFTVCS
560 570 580 590 600
LHNVPETWAH SYKAFSFSCW LTYAGKKLCQ VKSCRSLPVT KSFSFSVNWN
610 620 630 640 650
EIINFPLEIK SLPRESMLVI KLFGIDSATH SANLLAWTCL PLFPKEKSPL
660 670 680 690 700
GSRLLSMTLQ SEPPIEMMAP GVWDGSQPTP LTLQIDFPAA TWEYVKPETE
710 720 730 740 750
ENRTDHQEPP RECLKHIARL SQKQPPLLLS VEKRRYLWFY RFYCNNENSS
760 770 780 790 800
LPLVLGSAPG WDEGTVSEMH AVLRRWTFSH PLEALGLLTS RFPDQDIREV
810 820 830 840 850
AVQQLDNFLT DELLDCLPQL VQAVKFEWSL ESPLVELLLH RSLQSIRVAH
860 870 880 890 900
RLFWLLRDAQ GEDYFKSWYQ ELLAALQFCA GEALIEELSK EQKLVKLLGD
910 920 930 940 950
IGEKVKSAGD AQRKDVLKKE IGSLEEFFKD IKTCHLPLNP ALCVKGIDRD
960 970 980 990 1000
ACSYFTSNAL PLKITFINAN PMGKNISVIF KAGDDLRQDM LVLQIIQVMD
1010 1020 1030 1040 1050
NVWLQEGLDM QMIIYGCLAT GKAQGFIEMV PDAVTLAKIH LHSGLIGPLK
1060 1070 1080 1090 1100
ENTIKKWFSQ HNHLKEDYEK ALRNFFYSCA GWCVVTFILG VCDRHNDNIM
1110 1120 1130 1140 1150
LTKSGHMFHI DFGKFLGHAQ TFGGIKRDRA PFIFTSEMEY FITEGGKNTQ
1160 1170 1180 1190 1200
HFQDFVELCC RAYNIVRKHS QLLLSLLEMM LHAGLPELRG IEDLKYVHDN
1210 1220 1230 1240 1250
LRPQDTDLEA TSHFTTKIKQ SLECFPVKLN NLIHTLAQMP AFSLARPAPQ
1260 1270 1280 1290 1300
TPPQECCVLN KTRTIQRVTI LGFSKTHSNL YLIEVTRSDN RKNLAKKSFE
1310 1320 1330 1340 1350
QFYRLHSQIQ KQFPLLTLPE FPHWWHLPFT DSHHERIRDL SHYVEQVLHG
1360 1370 1380 1390 1400
SYEVANSDCV LSFFLSEHIQ QTLEDSPFVD PGDHSPDKSP QVQLLMTYED
1410 1420 1430 1440 1450
TKLTILVKHL KNIHLPDGSA PSAHVEIYLL PHPSEVRRKK TKCVPKCTDP
1460 1470 1480 1490 1500
TYNEIVVYDD VSGLQGHVLM LIVKSKTVFV GAVNIQLCSV PLNEEKWYPL

GNSII
Length:1,505
Mass (Da):170,975
Last modified:August 1, 1998 - v1
Checksum:i5ED4C2239968C4B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009636 mRNA Translation: BAA25634.1
RefSeqiNP_446375.1, NM_053923.1
UniGeneiRn.14870

Genome annotation databases

GeneIDi116720
KEGGirno:116720
UCSCiRGD:620231 rat

Similar proteinsi

Entry informationi

Entry nameiP3C2G_RAT
AccessioniPrimary (citable) accession number: O70173
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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