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O70169

- PRS39_MOUSE

UniProt

O70169 - PRS39_MOUSE

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Protein

Inactive serine protease 39

Gene
Prss39, Tesp1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May play an important role in the sperm/egg interaction; released during the acrosome reaction.1 Publication

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Protein family/group databases

MEROPSiS01.985.

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive serine protease 39
Alternative name(s):
Inactive testicular serine protease 1
Gene namesi
Name:Prss39
Synonyms:Tesp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1270856. Prss39.

Subcellular locationi

Cytoplasmic vesiclesecretory vesicleacrosome. Secreted 1 Publication

GO - Cellular componenti

  1. acrosomal vesicle Source: UniProtKB-SubCell
  2. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131 Reviewed predictionAdd
BLAST
Chaini32 – 367336Inactive serine protease 39PRO_0000344981Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi93 ↔ 109 By similarity
Disulfide bondi192 ↔ 269 By similarity
Disulfide bondi225 ↔ 248 By similarity
Disulfide bondi259 ↔ 287 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiO70169.

Expressioni

Tissue specificityi

Expressed in testis. More specifically, abundantly expressed in the haploid round spermatid.1 Publication

Gene expression databases

BgeeiO70169.
GenevestigatoriO70169.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027299.

Structurei

3D structure databases

ProteinModelPortaliO70169.
SMRiO70169. Positions 68-312.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 312245Peptidase S1Add
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00750000117431.
HOGENOMiHOG000154548.
HOVERGENiHBG108561.
InParanoidiO70169.
OMAiTERQTIR.
OrthoDBiEOG7G4QFP.
PhylomeDBiO70169.
TreeFamiTF351692.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70169-1 [UniParc]FASTAAdd to Basket

« Hide

MWGSRAQQSG PDRGGACLLA AFLLCFSLLH AQDYTPSQTP PPTSNTSLKP    50
RGRVQKELCG KTKFQGKIYG GQIAKAERWP WQASLIFRGR HICGAVLIDK 100
TWLLSAAHCF QRSLTPSDYR ILLGYNQLSN PSNYSRQMTV NKVILHEDYS 150
KLSRLEKNIV LIQLHHPVIY STHIFPACVP DGTTKVSPNN LCWISGWGML 200
SADKFLQAPF PLLDAEVSLI DEEECTTFFQ TPEVSITEYD VIKDDVLCAG 250
DLTNQKSSCR GDSGGPLVCF LNSFWYVVGL ANWNGACLEP IHSPNIFTKV 300
SYFSDWIKQK KANTPAADVS SAPLEEMASS LRGWGNYSAG ITLKPRISTT 350
LLSSQALLLQ SIWLRIL 367
Length:367
Mass (Da):40,766
Last modified:August 1, 1998 - v1
Checksum:i029833E3253CF954
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC049616 mRNA. Translation: AAH49616.2.
BC115665 mRNA. Translation: AAI15666.1.
BC115666 mRNA. Translation: AAI15667.1.
AB008910 mRNA. Translation: BAA26132.1.
CCDSiCCDS14868.1.
PIRiJE0104.
RefSeqiNP_033381.1. NM_009355.2.
UniGeneiMm.10725.

Genome annotation databases

EnsembliENSMUST00000027299; ENSMUSP00000027299; ENSMUSG00000026125.
GeneIDi21755.
KEGGimmu:21755.
UCSCiuc007aov.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC049616 mRNA. Translation: AAH49616.2 .
BC115665 mRNA. Translation: AAI15666.1 .
BC115666 mRNA. Translation: AAI15667.1 .
AB008910 mRNA. Translation: BAA26132.1 .
CCDSi CCDS14868.1.
PIRi JE0104.
RefSeqi NP_033381.1. NM_009355.2.
UniGenei Mm.10725.

3D structure databases

ProteinModelPortali O70169.
SMRi O70169. Positions 68-312.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000027299.

Protein family/group databases

MEROPSi S01.985.

Proteomic databases

PRIDEi O70169.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027299 ; ENSMUSP00000027299 ; ENSMUSG00000026125 .
GeneIDi 21755.
KEGGi mmu:21755.
UCSCi uc007aov.1. mouse.

Organism-specific databases

CTDi 21755.
MGIi MGI:1270856. Prss39.

Phylogenomic databases

eggNOGi COG5640.
GeneTreei ENSGT00750000117431.
HOGENOMi HOG000154548.
HOVERGENi HBG108561.
InParanoidi O70169.
OMAi TERQTIR.
OrthoDBi EOG7G4QFP.
PhylomeDBi O70169.
TreeFami TF351692.

Miscellaneous databases

NextBioi 301063.
PROi O70169.
SOURCEi Search...

Gene expression databases

Bgeei O70169.
Genevestigatori O70169.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Two novel testicular serine proteases, TESP1 and TESP2, are present in the mouse sperm acrosome."
    Kohno N., Yamagata K., Yamada S., Kashiwabara S., Sakai Y., Baba T.
    Biochem. Biophys. Res. Commun. 245:658-665(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiPRS39_MOUSE
AccessioniPrimary (citable) accession number: O70169
Secondary accession number(s): Q80YD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: August 1, 1998
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There appears to be no human ortholog of this protein.

Caution

In contrast to other members of the family, lacks the conserved Asp at position 158, which is replaced by an Asn residue, suggesting it is inactive.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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