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Protein

Inactive serine protease 39

Gene

Prss39

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play an important role in the sperm/egg interaction; released during the acrosome reaction.1 Publication

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Protein family/group databases

MEROPSiS01.985.

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive serine protease 39
Alternative name(s):
Inactive testicular serine protease 1
Gene namesi
Name:Prss39
Synonyms:Tesp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1270856. Prss39.

Subcellular locationi

Cytoplasmic vesiclesecretory vesicleacrosome 1 Publication. Secreted 1 Publication

GO - Cellular componenti

  1. acrosomal vesicle Source: UniProtKB-SubCell
  2. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence AnalysisAdd
BLAST
Chaini32 – 367336Inactive serine protease 39PRO_0000344981Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi93 ↔ 109PROSITE-ProRule annotation
Disulfide bondi192 ↔ 269PROSITE-ProRule annotation
Disulfide bondi225 ↔ 248PROSITE-ProRule annotation
Disulfide bondi259 ↔ 287PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiO70169.

Expressioni

Tissue specificityi

Expressed in testis. More specifically, abundantly expressed in the haploid round spermatid.1 Publication

Gene expression databases

BgeeiO70169.
GenevestigatoriO70169.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027299.

Structurei

3D structure databases

ProteinModelPortaliO70169.
SMRiO70169. Positions 68-312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 312245Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00760000118810.
HOGENOMiHOG000154548.
HOVERGENiHBG108561.
InParanoidiO70169.
OMAiKSHEPSD.
OrthoDBiEOG7G4QFP.
PhylomeDBiO70169.
TreeFamiTF351692.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70169-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWGSRAQQSG PDRGGACLLA AFLLCFSLLH AQDYTPSQTP PPTSNTSLKP
60 70 80 90 100
RGRVQKELCG KTKFQGKIYG GQIAKAERWP WQASLIFRGR HICGAVLIDK
110 120 130 140 150
TWLLSAAHCF QRSLTPSDYR ILLGYNQLSN PSNYSRQMTV NKVILHEDYS
160 170 180 190 200
KLSRLEKNIV LIQLHHPVIY STHIFPACVP DGTTKVSPNN LCWISGWGML
210 220 230 240 250
SADKFLQAPF PLLDAEVSLI DEEECTTFFQ TPEVSITEYD VIKDDVLCAG
260 270 280 290 300
DLTNQKSSCR GDSGGPLVCF LNSFWYVVGL ANWNGACLEP IHSPNIFTKV
310 320 330 340 350
SYFSDWIKQK KANTPAADVS SAPLEEMASS LRGWGNYSAG ITLKPRISTT
360
LLSSQALLLQ SIWLRIL
Length:367
Mass (Da):40,766
Last modified:August 1, 1998 - v1
Checksum:i029833E3253CF954
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC049616 mRNA. Translation: AAH49616.2.
BC115665 mRNA. Translation: AAI15666.1.
BC115666 mRNA. Translation: AAI15667.1.
AB008910 mRNA. Translation: BAA26132.1.
CCDSiCCDS14868.1.
PIRiJE0104.
RefSeqiNP_033381.1. NM_009355.2.
UniGeneiMm.10725.

Genome annotation databases

EnsembliENSMUST00000027299; ENSMUSP00000027299; ENSMUSG00000026125.
GeneIDi21755.
KEGGimmu:21755.
UCSCiuc007aov.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC049616 mRNA. Translation: AAH49616.2.
BC115665 mRNA. Translation: AAI15666.1.
BC115666 mRNA. Translation: AAI15667.1.
AB008910 mRNA. Translation: BAA26132.1.
CCDSiCCDS14868.1.
PIRiJE0104.
RefSeqiNP_033381.1. NM_009355.2.
UniGeneiMm.10725.

3D structure databases

ProteinModelPortaliO70169.
SMRiO70169. Positions 68-312.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027299.

Protein family/group databases

MEROPSiS01.985.

Proteomic databases

PRIDEiO70169.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027299; ENSMUSP00000027299; ENSMUSG00000026125.
GeneIDi21755.
KEGGimmu:21755.
UCSCiuc007aov.1. mouse.

Organism-specific databases

CTDi21755.
MGIiMGI:1270856. Prss39.

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00760000118810.
HOGENOMiHOG000154548.
HOVERGENiHBG108561.
InParanoidiO70169.
OMAiKSHEPSD.
OrthoDBiEOG7G4QFP.
PhylomeDBiO70169.
TreeFamiTF351692.

Miscellaneous databases

NextBioi301063.
PROiO70169.
SOURCEiSearch...

Gene expression databases

BgeeiO70169.
GenevestigatoriO70169.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Two novel testicular serine proteases, TESP1 and TESP2, are present in the mouse sperm acrosome."
    Kohno N., Yamagata K., Yamada S., Kashiwabara S., Sakai Y., Baba T.
    Biochem. Biophys. Res. Commun. 245:658-665(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiPRS39_MOUSE
AccessioniPrimary (citable) accession number: O70169
Secondary accession number(s): Q80YD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: August 1, 1998
Last modified: January 7, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There appears to be no human ortholog of this protein.

Caution

In contrast to other members of the family, lacks the conserved Asp at position 158, which is replaced by an Asn residue, suggesting it is inactive.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.