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O70169 (PRS39_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inactive serine protease 39
Alternative name(s):
Inactive testicular serine protease 1
Gene names
Name:Prss39
Synonyms:Tesp1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play an important role in the sperm/egg interaction; released during the acrosome reaction. Ref.1

Subcellular location

Cytoplasmic vesiclesecretory vesicleacrosome. Secreted Ref.1.

Tissue specificity

Expressed in testis. More specifically, abundantly expressed in the haploid round spermatid. Ref.1

Miscellaneous

There appears to be no human ortholog of this protein.

Sequence similarities

Belongs to the peptidase S1 family.

Contains 1 peptidase S1 domain.

Caution

In contrast to other members of the family, lacks the conserved Asp at position 158, which is replaced by an Asn residue, suggesting it is inactive.

Ontologies

Keywords
   Cellular componentCytoplasmic vesicle
Secreted
   DomainSignal
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentacrosomal vesicle

Inferred from electronic annotation. Source: UniProtKB-SubCell

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3131 Potential
Chain32 – 367336Inactive serine protease 39
PRO_0000344981

Regions

Domain68 – 312245Peptidase S1

Amino acid modifications

Disulfide bond93 ↔ 109 By similarity
Disulfide bond192 ↔ 269 By similarity
Disulfide bond225 ↔ 248 By similarity
Disulfide bond259 ↔ 287 By similarity

Sequences

Sequence LengthMass (Da)Tools
O70169 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 029833E3253CF954

FASTA36740,766
        10         20         30         40         50         60 
MWGSRAQQSG PDRGGACLLA AFLLCFSLLH AQDYTPSQTP PPTSNTSLKP RGRVQKELCG 

        70         80         90        100        110        120 
KTKFQGKIYG GQIAKAERWP WQASLIFRGR HICGAVLIDK TWLLSAAHCF QRSLTPSDYR 

       130        140        150        160        170        180 
ILLGYNQLSN PSNYSRQMTV NKVILHEDYS KLSRLEKNIV LIQLHHPVIY STHIFPACVP 

       190        200        210        220        230        240 
DGTTKVSPNN LCWISGWGML SADKFLQAPF PLLDAEVSLI DEEECTTFFQ TPEVSITEYD 

       250        260        270        280        290        300 
VIKDDVLCAG DLTNQKSSCR GDSGGPLVCF LNSFWYVVGL ANWNGACLEP IHSPNIFTKV 

       310        320        330        340        350        360 
SYFSDWIKQK KANTPAADVS SAPLEEMASS LRGWGNYSAG ITLKPRISTT LLSSQALLLQ 


SIWLRIL 

« Hide

References

« Hide 'large scale' references
[1]"Two novel testicular serine proteases, TESP1 and TESP2, are present in the mouse sperm acrosome."
Kohno N., Yamagata K., Yamada S., Kashiwabara S., Sakai Y., Baba T.
Biochem. Biophys. Res. Commun. 245:658-665(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
Tissue: Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC049616 mRNA. Translation: AAH49616.2.
BC115665 mRNA. Translation: AAI15666.1.
BC115666 mRNA. Translation: AAI15667.1.
AB008910 mRNA. Translation: BAA26132.1.
CCDSCCDS14868.1.
PIRJE0104.
RefSeqNP_033381.1. NM_009355.2.
UniGeneMm.10725.

3D structure databases

ProteinModelPortalO70169.
SMRO70169. Positions 68-312.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000027299.

Protein family/group databases

MEROPSS01.985.

Proteomic databases

PRIDEO70169.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000027299; ENSMUSP00000027299; ENSMUSG00000026125.
GeneID21755.
KEGGmmu:21755.
UCSCuc007aov.1. mouse.

Organism-specific databases

CTD21755.
MGIMGI:1270856. Prss39.

Phylogenomic databases

eggNOGCOG5640.
GeneTreeENSGT00750000117431.
HOGENOMHOG000154548.
HOVERGENHBG108561.
InParanoidO70169.
OMATERQTIR.
OrthoDBEOG7G4QFP.
PhylomeDBO70169.
TreeFamTF351692.

Gene expression databases

BgeeO70169.
GenevestigatorO70169.

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio301063.
PROO70169.
SOURCESearch...

Entry information

Entry namePRS39_MOUSE
AccessionPrimary (citable) accession number: O70169
Secondary accession number(s): Q80YD5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: August 1, 1998
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot