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O70169

- PRS39_MOUSE

UniProt

O70169 - PRS39_MOUSE

Protein

Inactive serine protease 39

Gene

Prss39

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    May play an important role in the sperm/egg interaction; released during the acrosome reaction.1 Publication

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    Protein family/group databases

    MEROPSiS01.985.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inactive serine protease 39
    Alternative name(s):
    Inactive testicular serine protease 1
    Gene namesi
    Name:Prss39
    Synonyms:Tesp1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1270856. Prss39.

    Subcellular locationi

    Cytoplasmic vesiclesecretory vesicleacrosome 1 Publication. Secreted 1 Publication

    GO - Cellular componenti

    1. acrosomal vesicle Source: UniProtKB-SubCell
    2. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3131Sequence AnalysisAdd
    BLAST
    Chaini32 – 367336Inactive serine protease 39PRO_0000344981Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi93 ↔ 109PROSITE-ProRule annotation
    Disulfide bondi192 ↔ 269PROSITE-ProRule annotation
    Disulfide bondi225 ↔ 248PROSITE-ProRule annotation
    Disulfide bondi259 ↔ 287PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiO70169.

    Expressioni

    Tissue specificityi

    Expressed in testis. More specifically, abundantly expressed in the haploid round spermatid.1 Publication

    Gene expression databases

    BgeeiO70169.
    GenevestigatoriO70169.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000027299.

    Structurei

    3D structure databases

    ProteinModelPortaliO70169.
    SMRiO70169. Positions 68-312.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini68 – 312245Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    GeneTreeiENSGT00750000117431.
    HOGENOMiHOG000154548.
    HOVERGENiHBG108561.
    InParanoidiO70169.
    OMAiTERQTIR.
    OrthoDBiEOG7G4QFP.
    PhylomeDBiO70169.
    TreeFamiTF351692.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O70169-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWGSRAQQSG PDRGGACLLA AFLLCFSLLH AQDYTPSQTP PPTSNTSLKP    50
    RGRVQKELCG KTKFQGKIYG GQIAKAERWP WQASLIFRGR HICGAVLIDK 100
    TWLLSAAHCF QRSLTPSDYR ILLGYNQLSN PSNYSRQMTV NKVILHEDYS 150
    KLSRLEKNIV LIQLHHPVIY STHIFPACVP DGTTKVSPNN LCWISGWGML 200
    SADKFLQAPF PLLDAEVSLI DEEECTTFFQ TPEVSITEYD VIKDDVLCAG 250
    DLTNQKSSCR GDSGGPLVCF LNSFWYVVGL ANWNGACLEP IHSPNIFTKV 300
    SYFSDWIKQK KANTPAADVS SAPLEEMASS LRGWGNYSAG ITLKPRISTT 350
    LLSSQALLLQ SIWLRIL 367
    Length:367
    Mass (Da):40,766
    Last modified:August 1, 1998 - v1
    Checksum:i029833E3253CF954
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC049616 mRNA. Translation: AAH49616.2.
    BC115665 mRNA. Translation: AAI15666.1.
    BC115666 mRNA. Translation: AAI15667.1.
    AB008910 mRNA. Translation: BAA26132.1.
    CCDSiCCDS14868.1.
    PIRiJE0104.
    RefSeqiNP_033381.1. NM_009355.2.
    UniGeneiMm.10725.

    Genome annotation databases

    EnsembliENSMUST00000027299; ENSMUSP00000027299; ENSMUSG00000026125.
    GeneIDi21755.
    KEGGimmu:21755.
    UCSCiuc007aov.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC049616 mRNA. Translation: AAH49616.2 .
    BC115665 mRNA. Translation: AAI15666.1 .
    BC115666 mRNA. Translation: AAI15667.1 .
    AB008910 mRNA. Translation: BAA26132.1 .
    CCDSi CCDS14868.1.
    PIRi JE0104.
    RefSeqi NP_033381.1. NM_009355.2.
    UniGenei Mm.10725.

    3D structure databases

    ProteinModelPortali O70169.
    SMRi O70169. Positions 68-312.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000027299.

    Protein family/group databases

    MEROPSi S01.985.

    Proteomic databases

    PRIDEi O70169.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027299 ; ENSMUSP00000027299 ; ENSMUSG00000026125 .
    GeneIDi 21755.
    KEGGi mmu:21755.
    UCSCi uc007aov.1. mouse.

    Organism-specific databases

    CTDi 21755.
    MGIi MGI:1270856. Prss39.

    Phylogenomic databases

    eggNOGi COG5640.
    GeneTreei ENSGT00750000117431.
    HOGENOMi HOG000154548.
    HOVERGENi HBG108561.
    InParanoidi O70169.
    OMAi TERQTIR.
    OrthoDBi EOG7G4QFP.
    PhylomeDBi O70169.
    TreeFami TF351692.

    Miscellaneous databases

    NextBioi 301063.
    PROi O70169.
    SOURCEi Search...

    Gene expression databases

    Bgeei O70169.
    Genevestigatori O70169.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Two novel testicular serine proteases, TESP1 and TESP2, are present in the mouse sperm acrosome."
      Kohno N., Yamagata K., Yamada S., Kashiwabara S., Sakai Y., Baba T.
      Biochem. Biophys. Res. Commun. 245:658-665(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
      Tissue: Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiPRS39_MOUSE
    AccessioniPrimary (citable) accession number: O70169
    Secondary accession number(s): Q80YD5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 22, 2008
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    There appears to be no human ortholog of this protein.

    Caution

    In contrast to other members of the family, lacks the conserved Asp at position 158, which is replaced by an Asn residue, suggesting it is inactive.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3