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O70167

- P3C2G_MOUSE

UniProt

O70167 - P3C2G_MOUSE

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Protein

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma

Gene

Pik3c2g

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis.2 Publications

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate.

GO - Molecular functioni

  1. 1-phosphatidylinositol-3-kinase activity Source: RefGenome
  2. 1-phosphatidylinositol-4-phosphate 3-kinase activity Source: RefGenome
  3. ATP binding Source: UniProtKB-KW
  4. phosphatidylinositol binding Source: InterPro

GO - Biological processi

  1. chemotaxis Source: UniProtKB
  2. phosphatidylinositol-3-phosphate biosynthetic process Source: GOC
  3. phosphatidylinositol-mediated signaling Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Chemotaxis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.137. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma (EC:2.7.1.154)
Short name:
PI3K-C2-gamma
Short name:
PtdIns-3-kinase C2 subunit gamma
Alternative name(s):
Phosphoinositide 3-kinase-C2-gamma
Gene namesi
Name:Pik3c2g
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1203730. Pik3c2g.

Subcellular locationi

Membrane 1 Publication; Peripheral membrane protein 1 Publication

GO - Cellular componenti

  1. phosphatidylinositol 3-kinase complex Source: RefGenome
  2. plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15061506Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gammaPRO_0000088800Add
BLAST

Proteomic databases

PaxDbiO70167.
PRIDEiO70167.

PTM databases

PhosphoSiteiO70167.

Expressioni

Tissue specificityi

Expressed predominantly in liver. Also found in kidney, lung and lymphoid tissue. Down-regulated in BeF3 cells expressing the BCR-ABL oncogene p185.2 Publications

Gene expression databases

GenevestigatoriO70167.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084939.

Structurei

3D structure databases

ProteinModelPortaliO70167.
SMRiO70167. Positions 579-1223, 1262-1368, 1390-1501.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini285 – 37187PI3K-RBDPROSITE-ProRule annotationAdd
BLAST
Domaini541 – 689149C2 PI3K-typePROSITE-ProRule annotationAdd
BLAST
Domaini704 – 880177PIK helicalPROSITE-ProRule annotationAdd
BLAST
Domaini977 – 1241265PI3K/PI4KPROSITE-ProRule annotationAdd
BLAST
Domaini1260 – 1372113PXPROSITE-ProRule annotationAdd
BLAST
Domaini1403 – 150098C2Add
BLAST

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotation
Contains 1 C2 domain.Curated
Contains 1 C2 PI3K-type domain.PROSITE-ProRule annotation
Contains 1 PI3K-RBD domain.PROSITE-ProRule annotation
Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation
Contains 1 PIK helical domain.PROSITE-ProRule annotation
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5032.
HOGENOMiHOG000185857.
HOVERGENiHBG053398.
InParanoidiO70167.
KOiK00923.
PhylomeDBiO70167.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 2 hits.
3.30.1520.10. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR001683. Phox.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF00613. PI3Ka. 1 hit.
PF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00142. PI3K_C2. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
SM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 2 hits.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
PS50195. PX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O70167-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAYSWQTEPN RTEPQEDGSD TQQFHHTNQH LSSRQVRLGF DQLVEEINNK
60 70 80 90 100
TPLSESEKEE DTYFVPDAPN LGSKWPSIYE THPRYFSEFT SQSPDSSQLR
110 120 130 140 150
FGKLSAIGFN PAVLPTHQLI HEGASWRNPS GKYHGIEYPR FDALPPSSTG
160 170 180 190 200
QGECNPQGQS GTKHHNYCGE HEGNLPHHHS SYSIDSIPNR EKRRSGDVNL
210 220 230 240 250
VEPSLEFSKD SFLPRTSENV SVESTEPIGC PIEIVEVPQG SNKNLASFCN
260 270 280 290 300
KVKKIRESYH ASDINSNSGK IWAITTAYPS RLFADTKFRV KISIDNSAQL
310 320 330 340 350
LLLMPHANYL VKDLIAEILL LCANEPLSPK EYLLSVCGSE EFLQMDHSLG
360 370 380 390 400
SHKIFQKNKS VIQLHLQKNR DTPGKLSRKS EDDHSPFHLN QLLEFTHIWK
410 420 430 440 450
ISRQCLSTVM KKYNLHVEHL LKPQKDMEEK HLSSMVSGNQ HTSQPHVNNV
460 470 480 490 500
LEEVKNICSV LGCIETKQVS DAVKELNLIL QRPSQNFHQN SETSKKGFIE
510 520 530 540 550
RVTAELSRSI YQLIDVYCSS FCTDFQPVHT PGGVSHVHAG LQSHLSFTVC
560 570 580 590 600
SLHNVPETWA HSYKAFSFSC WLTYAGKKLC QVKSCRPLPV TKSFSLLVNW
610 620 630 640 650
NEIINFPLEI KSLPRESMLV IKLFGIDSAT HSTNLLAWTC LPLFPRQESV
660 670 680 690 700
LGSRLFSVTL QSEPPIEMIA PGVWDGSQPS PLTLQIDFPD AGWEYLKPES
710 720 730 740 750
EENRTDHEEP PRECLKHIAK LSQKKSPLLL SEEKRRYLWF YRLYCNNENS
760 770 780 790 800
SLPLVLGSAP GWDEETVSEM HAILRRWTFS HPWEALGLLT SRFPDQDIRE
810 820 830 840 850
VAVQQLDTLL TDELLDCLPQ LVQAVKFEWN LESPLVELLP RRPLQSIRVA
860 870 880 890 900
HCLYWLLRDA QGEAYFKSWY QELLAALQFC AGEALNEELS KEQKLVKLLG
910 920 930 940 950
DIGEKVKSAS DPQRKDVLKK EIGSLEEFFK DIKTCHLPLN PALCIKGIDR
960 970 980 990 1000
DACSYFTSNA SPLKITFINA NPMGKNISVI FKAGDDLRQD MLALQIIQVM
1010 1020 1030 1040 1050
DNAWLQEGLD MQMITYGCLS TGRAQGFIEM VPDAVTLAKI HLHSGLIGPL
1060 1070 1080 1090 1100
KENTIKKWFS QHNHLKEDYE KALRNFFYSC AGWCVVTFIL GVCDRHNDNI
1110 1120 1130 1140 1150
MLTKSGHMFH IDFGKFLGHA QTFGGIKRDR APFIFTSEME YFITEGGKNI
1160 1170 1180 1190 1200
QHFQDFVELC CRAYNIVRKH SQLILSLLEM MLHAGLPELR GIEDLKYVHN
1210 1220 1230 1240 1250
NLRPQDTDLE ATSHFTKKIK ESLECFPVKL NNLIHTLAQM PALSLAKPAP
1260 1270 1280 1290 1300
QTLLQESCIL NKTRTIQRVT ILGFSKTHSN LYLMEVTCSD NRRSLTKKSF
1310 1320 1330 1340 1350
EQFYRLHSQM QKQFSSLALP EFPHWWHLPF TDSDHKRIRD LSHYVEQVLR
1360 1370 1380 1390 1400
GSYEVANSDC VLSFFLSEHI QPTLEDSPFV DPGENSLDKS PKVQLLMTYE
1410 1420 1430 1440 1450
DSRLTILVKH LKNIHLPDGS VPSAHVEIYL LPHPSEVRRK KTKCVPKCTD
1460 1470 1480 1490 1500
PTYNEIVVYD EVLGLQGHVL MLIVKSKTVF VGAVNIQLCS VPLNEEKWYP

LGNSII
Length:1,506
Mass (Da):171,580
Last modified:August 1, 1998 - v1
Checksum:i2D802A2B5449B672
GO
Isoform 2 (identifier: O70167-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-853: Missing.
     854-855: YW → MG

Show »
Length:653
Mass (Da):74,421
Checksum:iC984DA330E8BF6F4
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 853853Missing in isoform 2. CuratedVSP_004706Add
BLAST
Alternative sequencei854 – 8552YW → MG in isoform 2. CuratedVSP_004707

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB008791 mRNA. Translation: BAA25427.1.
AB008792 mRNA. Translation: BAA25428.1.
PIRiJC5985.
RefSeqiNP_997566.1. NM_207683.2. [O70167-1]
UniGeneiMm.333471.
Mm.391538.

Genome annotation databases

GeneIDi18705.
KEGGimmu:18705.
UCSCiuc029wch.1. mouse. [O70167-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB008791 mRNA. Translation: BAA25427.1 .
AB008792 mRNA. Translation: BAA25428.1 .
PIRi JC5985.
RefSeqi NP_997566.1. NM_207683.2. [O70167-1 ]
UniGenei Mm.333471.
Mm.391538.

3D structure databases

ProteinModelPortali O70167.
SMRi O70167. Positions 579-1223, 1262-1368, 1390-1501.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000084939.

PTM databases

PhosphoSitei O70167.

Proteomic databases

PaxDbi O70167.
PRIDEi O70167.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 18705.
KEGGi mmu:18705.
UCSCi uc029wch.1. mouse. [O70167-1 ]

Organism-specific databases

CTDi 5288.
MGIi MGI:1203730. Pik3c2g.

Phylogenomic databases

eggNOGi COG5032.
HOGENOMi HOG000185857.
HOVERGENi HBG053398.
InParanoidi O70167.
KOi K00923.
PhylomeDBi O70167.

Enzyme and pathway databases

BRENDAi 2.7.1.137. 3474.

Miscellaneous databases

NextBioi 294763.
PROi O70167.
SOURCEi Search...

Gene expression databases

Genevestigatori O70167.

Family and domain databases

Gene3Di 1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 2 hits.
3.30.1520.10. 1 hit.
InterProi IPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR001683. Phox.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
PANTHERi PTHR10048. PTHR10048. 1 hit.
Pfami PF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF00613. PI3Ka. 1 hit.
PF00787. PX. 1 hit.
[Graphical view ]
SMARTi SM00239. C2. 1 hit.
SM00142. PI3K_C2. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
SM00312. PX. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 2 hits.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEi PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
PS50195. PX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of a novel class II phosphoinositide 3-kinase containing C2 domain."
    Misawa H., Ohtsubo M., Copeland N.G., Gilbert D.J., Jenkins N.A., Yoshimura A.
    Biochem. Biophys. Res. Commun. 244:531-539(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
    Tissue: Liver and Lymphoid tissue.
  2. "Inhibition of class II phosphoinositide 3-kinase gamma expression by p185(Bcr-Abl) contributes to impaired chemotaxis and aberrant homing of leukemic cells."
    Yu W., Sun X., Tang H., Tao Y., Dai Z.
    Leuk. Lymphoma 51:1098-1107(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiP3C2G_MOUSE
AccessioniPrimary (citable) accession number: O70167
Secondary accession number(s): O70168
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3