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Protein

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma

Gene

Pik3c2g

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis.2 Publications

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate.

GO - Molecular functioni

GO - Biological processi

  • cell migration Source: GO_Central
  • chemotaxis Source: UniProtKB
  • phosphatidylinositol 3-kinase signaling Source: GO_Central
  • viral RNA genome replication Source: MGI

Keywordsi

Molecular functionKinase, Transferase
Biological processChemotaxis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.137 3474
2.7.1.154 3474

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma (EC:2.7.1.154)
Short name:
PI3K-C2-gamma
Short name:
PtdIns-3-kinase C2 subunit gamma
Alternative name(s):
Phosphoinositide 3-kinase-C2-gamma
Gene namesi
Name:Pik3c2g
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:1203730 Pik3c2g

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000888001 – 1506Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gammaAdd BLAST1506

Proteomic databases

PaxDbiO70167
PRIDEiO70167

PTM databases

iPTMnetiO70167
PhosphoSitePlusiO70167

Expressioni

Tissue specificityi

Expressed predominantly in liver. Also found in kidney, lung and lymphoid tissue. Down-regulated in BeF3 cells expressing the BCR-ABL oncogene p185.2 Publications

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000107499

Structurei

3D structure databases

ProteinModelPortaliO70167
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini285 – 371PI3K-RBDPROSITE-ProRule annotationAdd BLAST87
Domaini541 – 689C2 PI3K-typePROSITE-ProRule annotationAdd BLAST149
Domaini704 – 880PIK helicalPROSITE-ProRule annotationAdd BLAST177
Domaini977 – 1241PI3K/PI4KPROSITE-ProRule annotationAdd BLAST265
Domaini1260 – 1372PXPROSITE-ProRule annotationAdd BLAST113
Domaini1403 – 1500C2Add BLAST98

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0905 Eukaryota
COG5032 LUCA
HOGENOMiHOG000185857
HOVERGENiHBG053398
InParanoidiO70167
PhylomeDBiO70167

Family and domain databases

CDDicd05177 PI3Kc_C2_gamma, 1 hit
Gene3Di1.10.1070.11, 1 hit
2.60.40.150, 2 hits
3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011009 Kinase-like_dom_sf
IPR001683 Phox
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR037707 PI3K-C2-gamma_dom
IPR002420 PI3K_C2_dom
IPR000341 PI3K_Ras-bd_dom
IPR015433 PI_Kinase
IPR001263 PInositide-3_kin_accessory_dom
IPR036871 PX_dom_sf
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR10048 PTHR10048, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF00454 PI3_PI4_kinase, 1 hit
PF00792 PI3K_C2, 1 hit
PF00613 PI3Ka, 1 hit
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00142 PI3K_C2, 1 hit
SM00145 PI3Ka, 1 hit
SM00146 PI3Kc, 1 hit
SM00312 PX, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF54236 SSF54236, 1 hit
SSF56112 SSF56112, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51547 PI3K_C2, 1 hit
PS51546 PI3K_RBD, 1 hit
PS51545 PIK_HELICAL, 1 hit
PS50195 PX, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O70167-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAYSWQTEPN RTEPQEDGSD TQQFHHTNQH LSSRQVRLGF DQLVEEINNK
60 70 80 90 100
TPLSESEKEE DTYFVPDAPN LGSKWPSIYE THPRYFSEFT SQSPDSSQLR
110 120 130 140 150
FGKLSAIGFN PAVLPTHQLI HEGASWRNPS GKYHGIEYPR FDALPPSSTG
160 170 180 190 200
QGECNPQGQS GTKHHNYCGE HEGNLPHHHS SYSIDSIPNR EKRRSGDVNL
210 220 230 240 250
VEPSLEFSKD SFLPRTSENV SVESTEPIGC PIEIVEVPQG SNKNLASFCN
260 270 280 290 300
KVKKIRESYH ASDINSNSGK IWAITTAYPS RLFADTKFRV KISIDNSAQL
310 320 330 340 350
LLLMPHANYL VKDLIAEILL LCANEPLSPK EYLLSVCGSE EFLQMDHSLG
360 370 380 390 400
SHKIFQKNKS VIQLHLQKNR DTPGKLSRKS EDDHSPFHLN QLLEFTHIWK
410 420 430 440 450
ISRQCLSTVM KKYNLHVEHL LKPQKDMEEK HLSSMVSGNQ HTSQPHVNNV
460 470 480 490 500
LEEVKNICSV LGCIETKQVS DAVKELNLIL QRPSQNFHQN SETSKKGFIE
510 520 530 540 550
RVTAELSRSI YQLIDVYCSS FCTDFQPVHT PGGVSHVHAG LQSHLSFTVC
560 570 580 590 600
SLHNVPETWA HSYKAFSFSC WLTYAGKKLC QVKSCRPLPV TKSFSLLVNW
610 620 630 640 650
NEIINFPLEI KSLPRESMLV IKLFGIDSAT HSTNLLAWTC LPLFPRQESV
660 670 680 690 700
LGSRLFSVTL QSEPPIEMIA PGVWDGSQPS PLTLQIDFPD AGWEYLKPES
710 720 730 740 750
EENRTDHEEP PRECLKHIAK LSQKKSPLLL SEEKRRYLWF YRLYCNNENS
760 770 780 790 800
SLPLVLGSAP GWDEETVSEM HAILRRWTFS HPWEALGLLT SRFPDQDIRE
810 820 830 840 850
VAVQQLDTLL TDELLDCLPQ LVQAVKFEWN LESPLVELLP RRPLQSIRVA
860 870 880 890 900
HCLYWLLRDA QGEAYFKSWY QELLAALQFC AGEALNEELS KEQKLVKLLG
910 920 930 940 950
DIGEKVKSAS DPQRKDVLKK EIGSLEEFFK DIKTCHLPLN PALCIKGIDR
960 970 980 990 1000
DACSYFTSNA SPLKITFINA NPMGKNISVI FKAGDDLRQD MLALQIIQVM
1010 1020 1030 1040 1050
DNAWLQEGLD MQMITYGCLS TGRAQGFIEM VPDAVTLAKI HLHSGLIGPL
1060 1070 1080 1090 1100
KENTIKKWFS QHNHLKEDYE KALRNFFYSC AGWCVVTFIL GVCDRHNDNI
1110 1120 1130 1140 1150
MLTKSGHMFH IDFGKFLGHA QTFGGIKRDR APFIFTSEME YFITEGGKNI
1160 1170 1180 1190 1200
QHFQDFVELC CRAYNIVRKH SQLILSLLEM MLHAGLPELR GIEDLKYVHN
1210 1220 1230 1240 1250
NLRPQDTDLE ATSHFTKKIK ESLECFPVKL NNLIHTLAQM PALSLAKPAP
1260 1270 1280 1290 1300
QTLLQESCIL NKTRTIQRVT ILGFSKTHSN LYLMEVTCSD NRRSLTKKSF
1310 1320 1330 1340 1350
EQFYRLHSQM QKQFSSLALP EFPHWWHLPF TDSDHKRIRD LSHYVEQVLR
1360 1370 1380 1390 1400
GSYEVANSDC VLSFFLSEHI QPTLEDSPFV DPGENSLDKS PKVQLLMTYE
1410 1420 1430 1440 1450
DSRLTILVKH LKNIHLPDGS VPSAHVEIYL LPHPSEVRRK KTKCVPKCTD
1460 1470 1480 1490 1500
PTYNEIVVYD EVLGLQGHVL MLIVKSKTVF VGAVNIQLCS VPLNEEKWYP

LGNSII
Length:1,506
Mass (Da):171,580
Last modified:August 1, 1998 - v1
Checksum:i2D802A2B5449B672
GO
Isoform 2 (identifier: O70167-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-853: Missing.
     854-855: YW → MG

Show »
Length:653
Mass (Da):74,421
Checksum:iC984DA330E8BF6F4
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0047061 – 853Missing in isoform 2. CuratedAdd BLAST853
Alternative sequenceiVSP_004707854 – 855YW → MG in isoform 2. Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008791 mRNA Translation: BAA25427.1
AB008792 mRNA Translation: BAA25428.1
CCDSiCCDS80630.1 [O70167-2]
PIRiJC5985
RefSeqiNP_997566.1, NM_207683.2
UniGeneiMm.333471
Mm.391538

Genome annotation databases

GeneIDi18705
UCSCiuc029wch.1 mouse [O70167-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiP3C2G_MOUSE
AccessioniPrimary (citable) accession number: O70167
Secondary accession number(s): O70168
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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