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O70167 (P3C2G_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
Short name=PI3K-C2-gamma
Short name=PtdIns-3-kinase C2 subunit gamma
EC=2.7.1.154
Alternative name(s):
Phosphoinositide 3-kinase-C2-gamma
Gene names
Name:Pik3c2g
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length1506 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis. Ref.1 Ref.2

Catalytic activity

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate.

Subcellular location

Membrane; Peripheral membrane protein Ref.1.

Tissue specificity

Expressed predominantly in liver. Also found in kidney, lung and lymphoid tissue. Down-regulated in BeF3 cells expressing the BCR-ABL oncogene p185. Ref.1 Ref.2

Sequence similarities

Belongs to the PI3/PI4-kinase family.

Contains 1 C2 domain.

Contains 1 C2 PI3K-type domain.

Contains 1 PI3K-RBD domain.

Contains 1 PI3K/PI4K domain.

Contains 1 PIK helical domain.

Contains 1 PX (phox homology) domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O70167-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O70167-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-853: Missing.
     854-855: YW → MG

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15061506Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
PRO_0000088800

Regions

Domain285 – 37187PI3K-RBD
Domain541 – 689149C2 PI3K-type
Domain704 – 880177PIK helical
Domain977 – 1241265PI3K/PI4K
Domain1260 – 1372113PX
Domain1403 – 150098C2

Natural variations

Alternative sequence1 – 853853Missing in isoform 2.
VSP_004706
Alternative sequence854 – 8552YW → MG in isoform 2.
VSP_004707

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 2D802A2B5449B672

FASTA1,506171,580
        10         20         30         40         50         60 
MAYSWQTEPN RTEPQEDGSD TQQFHHTNQH LSSRQVRLGF DQLVEEINNK TPLSESEKEE 

        70         80         90        100        110        120 
DTYFVPDAPN LGSKWPSIYE THPRYFSEFT SQSPDSSQLR FGKLSAIGFN PAVLPTHQLI 

       130        140        150        160        170        180 
HEGASWRNPS GKYHGIEYPR FDALPPSSTG QGECNPQGQS GTKHHNYCGE HEGNLPHHHS 

       190        200        210        220        230        240 
SYSIDSIPNR EKRRSGDVNL VEPSLEFSKD SFLPRTSENV SVESTEPIGC PIEIVEVPQG 

       250        260        270        280        290        300 
SNKNLASFCN KVKKIRESYH ASDINSNSGK IWAITTAYPS RLFADTKFRV KISIDNSAQL 

       310        320        330        340        350        360 
LLLMPHANYL VKDLIAEILL LCANEPLSPK EYLLSVCGSE EFLQMDHSLG SHKIFQKNKS 

       370        380        390        400        410        420 
VIQLHLQKNR DTPGKLSRKS EDDHSPFHLN QLLEFTHIWK ISRQCLSTVM KKYNLHVEHL 

       430        440        450        460        470        480 
LKPQKDMEEK HLSSMVSGNQ HTSQPHVNNV LEEVKNICSV LGCIETKQVS DAVKELNLIL 

       490        500        510        520        530        540 
QRPSQNFHQN SETSKKGFIE RVTAELSRSI YQLIDVYCSS FCTDFQPVHT PGGVSHVHAG 

       550        560        570        580        590        600 
LQSHLSFTVC SLHNVPETWA HSYKAFSFSC WLTYAGKKLC QVKSCRPLPV TKSFSLLVNW 

       610        620        630        640        650        660 
NEIINFPLEI KSLPRESMLV IKLFGIDSAT HSTNLLAWTC LPLFPRQESV LGSRLFSVTL 

       670        680        690        700        710        720 
QSEPPIEMIA PGVWDGSQPS PLTLQIDFPD AGWEYLKPES EENRTDHEEP PRECLKHIAK 

       730        740        750        760        770        780 
LSQKKSPLLL SEEKRRYLWF YRLYCNNENS SLPLVLGSAP GWDEETVSEM HAILRRWTFS 

       790        800        810        820        830        840 
HPWEALGLLT SRFPDQDIRE VAVQQLDTLL TDELLDCLPQ LVQAVKFEWN LESPLVELLP 

       850        860        870        880        890        900 
RRPLQSIRVA HCLYWLLRDA QGEAYFKSWY QELLAALQFC AGEALNEELS KEQKLVKLLG 

       910        920        930        940        950        960 
DIGEKVKSAS DPQRKDVLKK EIGSLEEFFK DIKTCHLPLN PALCIKGIDR DACSYFTSNA 

       970        980        990       1000       1010       1020 
SPLKITFINA NPMGKNISVI FKAGDDLRQD MLALQIIQVM DNAWLQEGLD MQMITYGCLS 

      1030       1040       1050       1060       1070       1080 
TGRAQGFIEM VPDAVTLAKI HLHSGLIGPL KENTIKKWFS QHNHLKEDYE KALRNFFYSC 

      1090       1100       1110       1120       1130       1140 
AGWCVVTFIL GVCDRHNDNI MLTKSGHMFH IDFGKFLGHA QTFGGIKRDR APFIFTSEME 

      1150       1160       1170       1180       1190       1200 
YFITEGGKNI QHFQDFVELC CRAYNIVRKH SQLILSLLEM MLHAGLPELR GIEDLKYVHN 

      1210       1220       1230       1240       1250       1260 
NLRPQDTDLE ATSHFTKKIK ESLECFPVKL NNLIHTLAQM PALSLAKPAP QTLLQESCIL 

      1270       1280       1290       1300       1310       1320 
NKTRTIQRVT ILGFSKTHSN LYLMEVTCSD NRRSLTKKSF EQFYRLHSQM QKQFSSLALP 

      1330       1340       1350       1360       1370       1380 
EFPHWWHLPF TDSDHKRIRD LSHYVEQVLR GSYEVANSDC VLSFFLSEHI QPTLEDSPFV 

      1390       1400       1410       1420       1430       1440 
DPGENSLDKS PKVQLLMTYE DSRLTILVKH LKNIHLPDGS VPSAHVEIYL LPHPSEVRRK 

      1450       1460       1470       1480       1490       1500 
KTKCVPKCTD PTYNEIVVYD EVLGLQGHVL MLIVKSKTVF VGAVNIQLCS VPLNEEKWYP 


LGNSII

« Hide

Isoform 2 [UniParc].

Checksum: C984DA330E8BF6F4
Show »

FASTA65374,421

References

[1]"Cloning and characterization of a novel class II phosphoinositide 3-kinase containing C2 domain."
Misawa H., Ohtsubo M., Copeland N.G., Gilbert D.J., Jenkins N.A., Yoshimura A.
Biochem. Biophys. Res. Commun. 244:531-539(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
Tissue: Liver and Lymphoid tissue.
[2]"Inhibition of class II phosphoinositide 3-kinase gamma expression by p185(Bcr-Abl) contributes to impaired chemotaxis and aberrant homing of leukemic cells."
Yu W., Sun X., Tang H., Tao Y., Dai Z.
Leuk. Lymphoma 51:1098-1107(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB008791 mRNA. Translation: BAA25427.1.
AB008792 mRNA. Translation: BAA25428.1.
IPIIPI00115695.
IPI00229886.
PIRJC5985.
RefSeqNP_035214.2. NM_011084.2.
NP_997566.1. NM_207683.2.
UniGeneMm.333471.
Mm.391538.

3D structure databases

ProteinModelPortalO70167.
SMRO70167. Positions 579-1223, 1262-1368, 1390-1501.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000084939.

PTM databases

PhosphoSiteO70167.

Proteomic databases

PaxDbO70167.
PRIDEO70167.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID18705.
KEGGmmu:18705.
UCSCuc009ent.1. mouse.
uc009enx.1. mouse.

Organism-specific databases

CTD5288.
MGIMGI:1203730. Pik3c2g.

Phylogenomic databases

eggNOGCOG5032.
HOGENOMHOG000185857.
HOVERGENHBG053398.
KOK00923.

Enzyme and pathway databases

BRENDA2.7.1.137. 3474.

Gene expression databases

GenevestigatorO70167.

Family and domain databases

Gene3D1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
3.30.1520.10. 1 hit.
InterProIPR016024. ARM-type_fold.
IPR000008. C2_Ca-dep.
IPR008973. C2_Ca/lipid-bd_dom_CaLB.
IPR011009. Kinase-like_dom.
IPR001683. Phox.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
[Graphical view]
PANTHERPTHR10048. PTHR10048. 1 hit.
PfamPF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF00613. PI3Ka. 1 hit.
PF00787. PX. 1 hit.
[Graphical view]
SMARTSM00239. C2. 1 hit.
SM00142. PI3K_C2. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
SM00312. PX. 1 hit.
[Graphical view]
SUPFAMSSF48371. ARM-type_fold. 1 hit.
SSF49562. C2_CaLB. 2 hits.
SSF56112. Kinase_like. 1 hit.
SSF64268. PX. 1 hit.
PROSITEPS50004. C2. False negative.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
PS50195. PX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio294763.
SOURCESearch...

Entry information

Entry nameP3C2G_MOUSE
AccessionPrimary (citable) accession number: O70167
Secondary accession number(s): O70168
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 1, 1998
Last modified: May 1, 2013
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents