Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O70167

- P3C2G_MOUSE

UniProt

O70167 - P3C2G_MOUSE

Protein

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma

Gene

Pik3c2g

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis.2 Publications

    Catalytic activityi

    ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate.

    GO - Molecular functioni

    1. 1-phosphatidylinositol-3-kinase activity Source: RefGenome
    2. 1-phosphatidylinositol-4-phosphate 3-kinase activity Source: RefGenome
    3. ATP binding Source: UniProtKB-KW
    4. phosphatidylinositol binding Source: InterPro

    GO - Biological processi

    1. chemotaxis Source: UniProtKB
    2. phosphatidylinositol-3-phosphate biosynthetic process Source: GOC
    3. phosphatidylinositol-mediated signaling Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Chemotaxis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.1.137. 3474.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma (EC:2.7.1.154)
    Short name:
    PI3K-C2-gamma
    Short name:
    PtdIns-3-kinase C2 subunit gamma
    Alternative name(s):
    Phosphoinositide 3-kinase-C2-gamma
    Gene namesi
    Name:Pik3c2g
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1203730. Pik3c2g.

    Subcellular locationi

    Membrane 1 Publication; Peripheral membrane protein 1 Publication

    GO - Cellular componenti

    1. phosphatidylinositol 3-kinase complex Source: RefGenome
    2. plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15061506Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gammaPRO_0000088800Add
    BLAST

    Proteomic databases

    PaxDbiO70167.
    PRIDEiO70167.

    PTM databases

    PhosphoSiteiO70167.

    Expressioni

    Tissue specificityi

    Expressed predominantly in liver. Also found in kidney, lung and lymphoid tissue. Down-regulated in BeF3 cells expressing the BCR-ABL oncogene p185.2 Publications

    Gene expression databases

    GenevestigatoriO70167.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000084939.

    Structurei

    3D structure databases

    ProteinModelPortaliO70167.
    SMRiO70167. Positions 579-1223, 1262-1368, 1390-1501.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini285 – 37187PI3K-RBDPROSITE-ProRule annotationAdd
    BLAST
    Domaini541 – 689149C2 PI3K-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini704 – 880177PIK helicalPROSITE-ProRule annotationAdd
    BLAST
    Domaini977 – 1241265PI3K/PI4KPROSITE-ProRule annotationAdd
    BLAST
    Domaini1260 – 1372113PXPROSITE-ProRule annotationAdd
    BLAST
    Domaini1403 – 150098C2Add
    BLAST

    Sequence similaritiesi

    Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotation
    Contains 1 C2 domain.Curated
    Contains 1 C2 PI3K-type domain.PROSITE-ProRule annotation
    Contains 1 PI3K-RBD domain.PROSITE-ProRule annotation
    Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation
    Contains 1 PIK helical domain.PROSITE-ProRule annotation
    Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5032.
    HOGENOMiHOG000185857.
    HOVERGENiHBG053398.
    KOiK00923.
    PhylomeDBiO70167.

    Family and domain databases

    Gene3Di1.10.1070.11. 1 hit.
    1.25.40.70. 1 hit.
    2.60.40.150. 2 hits.
    3.30.1520.10. 1 hit.
    InterProiIPR016024. ARM-type_fold.
    IPR000008. C2_dom.
    IPR011009. Kinase-like_dom.
    IPR001683. Phox.
    IPR000403. PI3/4_kinase_cat_dom.
    IPR018936. PI3/4_kinase_CS.
    IPR002420. PI3K_C2_dom.
    IPR000341. PI3K_Ras-bd_dom.
    IPR015433. PI_Kinase.
    IPR001263. PInositide-3_kin_accessory_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PANTHERiPTHR10048. PTHR10048. 1 hit.
    PfamiPF00454. PI3_PI4_kinase. 1 hit.
    PF00792. PI3K_C2. 1 hit.
    PF00613. PI3Ka. 1 hit.
    PF00787. PX. 1 hit.
    [Graphical view]
    SMARTiSM00239. C2. 1 hit.
    SM00142. PI3K_C2. 1 hit.
    SM00144. PI3K_rbd. 1 hit.
    SM00145. PI3Ka. 1 hit.
    SM00146. PI3Kc. 1 hit.
    SM00312. PX. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    SSF49562. SSF49562. 2 hits.
    SSF54236. SSF54236. 1 hit.
    SSF56112. SSF56112. 1 hit.
    SSF64268. SSF64268. 1 hit.
    PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
    PS00916. PI3_4_KINASE_2. 1 hit.
    PS50290. PI3_4_KINASE_3. 1 hit.
    PS51547. PI3K_C2. 1 hit.
    PS51546. PI3K_RBD. 1 hit.
    PS51545. PIK_HELICAL. 1 hit.
    PS50195. PX. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O70167-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAYSWQTEPN RTEPQEDGSD TQQFHHTNQH LSSRQVRLGF DQLVEEINNK     50
    TPLSESEKEE DTYFVPDAPN LGSKWPSIYE THPRYFSEFT SQSPDSSQLR 100
    FGKLSAIGFN PAVLPTHQLI HEGASWRNPS GKYHGIEYPR FDALPPSSTG 150
    QGECNPQGQS GTKHHNYCGE HEGNLPHHHS SYSIDSIPNR EKRRSGDVNL 200
    VEPSLEFSKD SFLPRTSENV SVESTEPIGC PIEIVEVPQG SNKNLASFCN 250
    KVKKIRESYH ASDINSNSGK IWAITTAYPS RLFADTKFRV KISIDNSAQL 300
    LLLMPHANYL VKDLIAEILL LCANEPLSPK EYLLSVCGSE EFLQMDHSLG 350
    SHKIFQKNKS VIQLHLQKNR DTPGKLSRKS EDDHSPFHLN QLLEFTHIWK 400
    ISRQCLSTVM KKYNLHVEHL LKPQKDMEEK HLSSMVSGNQ HTSQPHVNNV 450
    LEEVKNICSV LGCIETKQVS DAVKELNLIL QRPSQNFHQN SETSKKGFIE 500
    RVTAELSRSI YQLIDVYCSS FCTDFQPVHT PGGVSHVHAG LQSHLSFTVC 550
    SLHNVPETWA HSYKAFSFSC WLTYAGKKLC QVKSCRPLPV TKSFSLLVNW 600
    NEIINFPLEI KSLPRESMLV IKLFGIDSAT HSTNLLAWTC LPLFPRQESV 650
    LGSRLFSVTL QSEPPIEMIA PGVWDGSQPS PLTLQIDFPD AGWEYLKPES 700
    EENRTDHEEP PRECLKHIAK LSQKKSPLLL SEEKRRYLWF YRLYCNNENS 750
    SLPLVLGSAP GWDEETVSEM HAILRRWTFS HPWEALGLLT SRFPDQDIRE 800
    VAVQQLDTLL TDELLDCLPQ LVQAVKFEWN LESPLVELLP RRPLQSIRVA 850
    HCLYWLLRDA QGEAYFKSWY QELLAALQFC AGEALNEELS KEQKLVKLLG 900
    DIGEKVKSAS DPQRKDVLKK EIGSLEEFFK DIKTCHLPLN PALCIKGIDR 950
    DACSYFTSNA SPLKITFINA NPMGKNISVI FKAGDDLRQD MLALQIIQVM 1000
    DNAWLQEGLD MQMITYGCLS TGRAQGFIEM VPDAVTLAKI HLHSGLIGPL 1050
    KENTIKKWFS QHNHLKEDYE KALRNFFYSC AGWCVVTFIL GVCDRHNDNI 1100
    MLTKSGHMFH IDFGKFLGHA QTFGGIKRDR APFIFTSEME YFITEGGKNI 1150
    QHFQDFVELC CRAYNIVRKH SQLILSLLEM MLHAGLPELR GIEDLKYVHN 1200
    NLRPQDTDLE ATSHFTKKIK ESLECFPVKL NNLIHTLAQM PALSLAKPAP 1250
    QTLLQESCIL NKTRTIQRVT ILGFSKTHSN LYLMEVTCSD NRRSLTKKSF 1300
    EQFYRLHSQM QKQFSSLALP EFPHWWHLPF TDSDHKRIRD LSHYVEQVLR 1350
    GSYEVANSDC VLSFFLSEHI QPTLEDSPFV DPGENSLDKS PKVQLLMTYE 1400
    DSRLTILVKH LKNIHLPDGS VPSAHVEIYL LPHPSEVRRK KTKCVPKCTD 1450
    PTYNEIVVYD EVLGLQGHVL MLIVKSKTVF VGAVNIQLCS VPLNEEKWYP 1500
    LGNSII 1506
    Length:1,506
    Mass (Da):171,580
    Last modified:August 1, 1998 - v1
    Checksum:i2D802A2B5449B672
    GO
    Isoform 2 (identifier: O70167-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-853: Missing.
         854-855: YW → MG

    Show »
    Length:653
    Mass (Da):74,421
    Checksum:iC984DA330E8BF6F4
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 853853Missing in isoform 2. CuratedVSP_004706Add
    BLAST
    Alternative sequencei854 – 8552YW → MG in isoform 2. CuratedVSP_004707

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB008791 mRNA. Translation: BAA25427.1.
    AB008792 mRNA. Translation: BAA25428.1.
    PIRiJC5985.
    RefSeqiNP_997566.1. NM_207683.2. [O70167-1]
    UniGeneiMm.333471.
    Mm.391538.

    Genome annotation databases

    GeneIDi18705.
    KEGGimmu:18705.
    UCSCiuc029wch.1. mouse. [O70167-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB008791 mRNA. Translation: BAA25427.1 .
    AB008792 mRNA. Translation: BAA25428.1 .
    PIRi JC5985.
    RefSeqi NP_997566.1. NM_207683.2. [O70167-1 ]
    UniGenei Mm.333471.
    Mm.391538.

    3D structure databases

    ProteinModelPortali O70167.
    SMRi O70167. Positions 579-1223, 1262-1368, 1390-1501.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000084939.

    PTM databases

    PhosphoSitei O70167.

    Proteomic databases

    PaxDbi O70167.
    PRIDEi O70167.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 18705.
    KEGGi mmu:18705.
    UCSCi uc029wch.1. mouse. [O70167-1 ]

    Organism-specific databases

    CTDi 5288.
    MGIi MGI:1203730. Pik3c2g.

    Phylogenomic databases

    eggNOGi COG5032.
    HOGENOMi HOG000185857.
    HOVERGENi HBG053398.
    KOi K00923.
    PhylomeDBi O70167.

    Enzyme and pathway databases

    BRENDAi 2.7.1.137. 3474.

    Miscellaneous databases

    NextBioi 294763.
    PROi O70167.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori O70167.

    Family and domain databases

    Gene3Di 1.10.1070.11. 1 hit.
    1.25.40.70. 1 hit.
    2.60.40.150. 2 hits.
    3.30.1520.10. 1 hit.
    InterProi IPR016024. ARM-type_fold.
    IPR000008. C2_dom.
    IPR011009. Kinase-like_dom.
    IPR001683. Phox.
    IPR000403. PI3/4_kinase_cat_dom.
    IPR018936. PI3/4_kinase_CS.
    IPR002420. PI3K_C2_dom.
    IPR000341. PI3K_Ras-bd_dom.
    IPR015433. PI_Kinase.
    IPR001263. PInositide-3_kin_accessory_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    PANTHERi PTHR10048. PTHR10048. 1 hit.
    Pfami PF00454. PI3_PI4_kinase. 1 hit.
    PF00792. PI3K_C2. 1 hit.
    PF00613. PI3Ka. 1 hit.
    PF00787. PX. 1 hit.
    [Graphical view ]
    SMARTi SM00239. C2. 1 hit.
    SM00142. PI3K_C2. 1 hit.
    SM00144. PI3K_rbd. 1 hit.
    SM00145. PI3Ka. 1 hit.
    SM00146. PI3Kc. 1 hit.
    SM00312. PX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    SSF49562. SSF49562. 2 hits.
    SSF54236. SSF54236. 1 hit.
    SSF56112. SSF56112. 1 hit.
    SSF64268. SSF64268. 1 hit.
    PROSITEi PS00915. PI3_4_KINASE_1. 1 hit.
    PS00916. PI3_4_KINASE_2. 1 hit.
    PS50290. PI3_4_KINASE_3. 1 hit.
    PS51547. PI3K_C2. 1 hit.
    PS51546. PI3K_RBD. 1 hit.
    PS51545. PIK_HELICAL. 1 hit.
    PS50195. PX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a novel class II phosphoinositide 3-kinase containing C2 domain."
      Misawa H., Ohtsubo M., Copeland N.G., Gilbert D.J., Jenkins N.A., Yoshimura A.
      Biochem. Biophys. Res. Commun. 244:531-539(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
      Tissue: Liver and Lymphoid tissue.
    2. "Inhibition of class II phosphoinositide 3-kinase gamma expression by p185(Bcr-Abl) contributes to impaired chemotaxis and aberrant homing of leukemic cells."
      Yu W., Sun X., Tang H., Tao Y., Dai Z.
      Leuk. Lymphoma 51:1098-1107(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiP3C2G_MOUSE
    AccessioniPrimary (citable) accession number: O70167
    Secondary accession number(s): O70168
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 126 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3