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Protein

Stathmin-3

Gene

Stmn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Exhibits microtubule-destabilizing activity, which is antagonized by STAT3.1 Publication

GO - Molecular functioni

  • protein domain specific binding Source: HGNC

GO - Biological processi

  • cytoplasmic microtubule organization Source: HGNC
  • negative regulation of Rac protein signal transduction Source: HGNC
  • neuron projection development Source: HGNC
  • regulation of cytoskeleton organization Source: HGNC
  • regulation of GTPase activity Source: HGNC
  • regulation of microtubule polymerization or depolymerization Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Stathmin-3
Alternative name(s):
Hippocampus abundant transcript 3
SCG10-like protein
SCG10-related protein HiAT3
Gene namesi
Name:Stmn3
Synonyms:Sclip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1277137. Stmn3.

Subcellular locationi

GO - Cellular componenti

  • axon Source: UniProtKB-SubCell
  • cytoplasm Source: HGNC
  • Golgi apparatus Source: UniProtKB-SubCell
  • growth cone Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 180180Stathmin-3PRO_0000182403Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi22 – 221S-palmitoyl cysteineBy similarity
Lipidationi24 – 241S-palmitoyl cysteineBy similarity
Modified residuei50 – 501PhosphoserineCombined sources
Modified residuei60 – 601PhosphoserineCombined sources
Modified residuei65 – 651PhosphoserineCombined sources
Modified residuei68 – 681PhosphoserineCombined sources
Modified residuei72 – 721PhosphoserineCombined sources
Modified residuei73 – 731PhosphoserineCombined sources
Modified residuei81 – 811PhosphoserineBy similarity

Post-translational modificationi

N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15 (By similarity).By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiO70166.
PRIDEiO70166.

PTM databases

iPTMnetiO70166.
PhosphoSiteiO70166.

Expressioni

Tissue specificityi

Neuron specific.

Gene expression databases

BgeeiO70166.
CleanExiMM_STMN3.
ExpressionAtlasiO70166. baseline and differential.
GenevisibleiO70166. MM.

Interactioni

Subunit structurei

Interacts with STAT3.1 Publication

GO - Molecular functioni

  • protein domain specific binding Source: HGNC

Protein-protein interaction databases

BioGridi203096. 1 interaction.
IntActiO70166. 1 interaction.
STRINGi10090.ENSMUSP00000099334.

Structurei

3D structure databases

ProteinModelPortaliO70166.
SMRiO70166. Positions 40-173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 180143SLDPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili75 – 179105Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the stathmin family.Curated
Contains 1 SLD (stathmin-like) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEAZ. Eukaryota.
ENOG4111H1E. LUCA.
HOGENOMiHOG000013197.
HOVERGENiHBG054037.
InParanoidiO70166.
OMAiAEEKLNH.
OrthoDBiEOG744TBN.
PhylomeDBiO70166.
TreeFamiTF326935.

Family and domain databases

InterProiIPR028835. Stathmin-3.
IPR030514. Stathmin_CS.
IPR000956. Stathmin_fam.
[Graphical view]
PANTHERiPTHR10104. PTHR10104. 1 hit.
PTHR10104:SF17. PTHR10104:SF17. 1 hit.
PfamiPF00836. Stathmin. 1 hit.
[Graphical view]
PIRSFiPIRSF002285. Stathmin. 1 hit.
PRINTSiPR00345. STATHMIN.
SUPFAMiSSF101494. SSF101494. 1 hit.
PROSITEiPS00563. STATHMIN_1. 1 hit.
PS01041. STATHMIN_2. 1 hit.
PS51663. STATHMIN_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70166-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTVSAYKE KMKELSVLSL ICSCFYSQPH PNTIYQYGDM EVKQLDKRAS
60 70 80 90 100
GQSFEVILKS PSDLSPESPV LSSPPKRKDA SLEELQKRLE AAEERRKTQE
110 120 130 140 150
AQVLKQLAER REHEREVLHK ALEENNNFSR LAEEKLNYKM ELSKEIREAH
160 170 180
LAALRERLRE KELHAAEVRR NKEQREEMSG
Length:180
Mass (Da):20,954
Last modified:August 1, 1998 - v1
Checksum:iA7C0D35A6A684765
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007912 mRNA. Translation: BAA28629.1.
AF069708 mRNA. Translation: AAC21575.1.
BC057017 mRNA. Translation: AAH57017.1.
CCDSiCCDS17207.1.
RefSeqiNP_033159.1. NM_009133.3.
UniGeneiMm.2319.
Mm.447659.

Genome annotation databases

EnsembliENSMUST00000103045; ENSMUSP00000099334; ENSMUSG00000027581.
GeneIDi20262.
KEGGimmu:20262.
UCSCiuc008olt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007912 mRNA. Translation: BAA28629.1.
AF069708 mRNA. Translation: AAC21575.1.
BC057017 mRNA. Translation: AAH57017.1.
CCDSiCCDS17207.1.
RefSeqiNP_033159.1. NM_009133.3.
UniGeneiMm.2319.
Mm.447659.

3D structure databases

ProteinModelPortaliO70166.
SMRiO70166. Positions 40-173.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203096. 1 interaction.
IntActiO70166. 1 interaction.
STRINGi10090.ENSMUSP00000099334.

PTM databases

iPTMnetiO70166.
PhosphoSiteiO70166.

Proteomic databases

PaxDbiO70166.
PRIDEiO70166.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000103045; ENSMUSP00000099334; ENSMUSG00000027581.
GeneIDi20262.
KEGGimmu:20262.
UCSCiuc008olt.1. mouse.

Organism-specific databases

CTDi50861.
MGIiMGI:1277137. Stmn3.

Phylogenomic databases

eggNOGiENOG410IEAZ. Eukaryota.
ENOG4111H1E. LUCA.
HOGENOMiHOG000013197.
HOVERGENiHBG054037.
InParanoidiO70166.
OMAiAEEKLNH.
OrthoDBiEOG744TBN.
PhylomeDBiO70166.
TreeFamiTF326935.

Miscellaneous databases

ChiTaRSiStmn3. mouse.
NextBioi297927.
PROiO70166.
SOURCEiSearch...

Gene expression databases

BgeeiO70166.
CleanExiMM_STMN3.
ExpressionAtlasiO70166. baseline and differential.
GenevisibleiO70166. MM.

Family and domain databases

InterProiIPR028835. Stathmin-3.
IPR030514. Stathmin_CS.
IPR000956. Stathmin_fam.
[Graphical view]
PANTHERiPTHR10104. PTHR10104. 1 hit.
PTHR10104:SF17. PTHR10104:SF17. 1 hit.
PfamiPF00836. Stathmin. 1 hit.
[Graphical view]
PIRSFiPIRSF002285. Stathmin. 1 hit.
PRINTSiPR00345. STATHMIN.
SUPFAMiSSF101494. SSF101494. 1 hit.
PROSITEiPS00563. STATHMIN_1. 1 hit.
PS01041. STATHMIN_2. 1 hit.
PS51663. STATHMIN_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel SCG10-related gene uniquely expressed in the nervous system."
    Matsuo N., Kawamoto S., Matsubara K., Okubo K.
    Gene 215:477-481(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Hippocampus.
  2. "SCLIP: a novel SCG10-like protein of the stathmin family expressed in the nervous system."
    Ozon S., Byk T., Sobel A.
    J. Neurochem. 70:2386-2396(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-65 AND SER-68, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  5. "Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin."
    Ng D.C., Lin B.H., Lim C.P., Huang G., Zhang T., Poli V., Cao X.
    J. Cell Biol. 172:245-257(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH STAT3.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50; SER-60; SER-65; SER-68; SER-72 AND SER-73, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiSTMN3_MOUSE
AccessioniPrimary (citable) accession number: O70166
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: August 1, 1998
Last modified: May 11, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.