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Protein

Ficolin-1

Gene

Fcn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8. Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi270CalciumBy similarity1
Metal bindingi272CalciumBy similarity1
Sitei308Mediates specificity for sialic acidsBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processImmunity, Innate immunity
LigandCalcium, Lectin, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ficolin-1
Alternative name(s):
Collagen/fibrinogen domain-containing protein 1
Ficolin-A
Ficolin-alpha
M-ficolin
Gene namesi
Name:Fcn1
Synonyms:Fcna
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1340905 Fcna

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 171 PublicationAdd BLAST17
ChainiPRO_000000913718 – 334Ficolin-1Add BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi119 ↔ 147PROSITE-ProRule annotation
Disulfide bondi126 ↔ 154PROSITE-ProRule annotation
Glycosylationi261N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi278 ↔ 291PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO70165
PeptideAtlasiO70165
PRIDEiO70165

PTM databases

iPTMnetiO70165
PhosphoSitePlusiO70165

Expressioni

Tissue specificityi

Highly expressed in liver and spleen.

Gene expression databases

BgeeiENSMUSG00000026938
CleanExiMM_FCNA
ExpressionAtlasiO70165 baseline and differential
GenevisibleiO70165 MM

Interactioni

Subunit structurei

Homotrimer. Interacts with elastin/ELN. Interacts (via Fibrinogen C-terminal domain) with FFAR2. Interacts with CRP; may regulate monocyte activation by FCN1.By similarity

Protein-protein interaction databases

BioGridi199622, 2 interactors
STRINGi10090.ENSMUSP00000028307

Structurei

3D structure databases

ProteinModelPortaliO70165
SMRiO70165
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 88Collagen-likeAdd BLAST39
Domaini117 – 334Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST218

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni123 – 162A domain; contributes to trimerizationBy similarityAdd BLAST40
Regioni163 – 251B domain; contributes to trimerizationBy similarityAdd BLAST89
Regioni290 – 292Carbohydrate-bindingBy similarity3
Regioni325 – 334P domainBy similarity10

Domaini

The fibrinogen C-terminal domain mediates calcium-dependent binding to carbohydrates and tethering to the cell surface in monocytes and granulocytes. The domain undergoes a conformational switch at pH under 6.2, and looses its carbohydrate-binding ability.By similarity

Sequence similaritiesi

Belongs to the ficolin lectin family.Curated

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00830000128240
HOGENOMiHOG000037127
HOVERGENiHBG001644
InParanoidiO70165
KOiK10104
OMAiTGNCAVM
OrthoDBiEOG091G03M1
PhylomeDBiO70165
TreeFamiTF329953

Family and domain databases

CDDicd00087 FReD, 1 hit
Gene3Di3.90.215.10, 1 hit
4.10.530.10, 1 hit
InterProiView protein in InterPro
IPR008160 Collagen
IPR036056 Fibrinogen-like_C
IPR014716 Fibrinogen_a/b/g_C_1
IPR014715 Fibrinogen_a/b/g_C_2
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS
PfamiView protein in Pfam
PF01391 Collagen, 1 hit
PF00147 Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186 FBG, 1 hit
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70165-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQWPTLWAFS GLLCLCPSQA LGQERGACPD VKVVGLGAQD KVVVIQSCPG
60 70 80 90 100
FPGPPGPKGE PGSPAGRGER GFQGSPGKMG PAGSKGEPGT MGPPGVKGEK
110 120 130 140 150
GDTGAAPSLG EKELGDTLCQ RGPRSCKDLL TRGIFLTGWY TIHLPDCRPL
160 170 180 190 200
TVLCDMDVDG GGWTVFQRRV DGSIDFFRDW DSYKRGFGNL GTEFWLGNDY
210 220 230 240 250
LHLLTANGNQ ELRVDLQDFQ GKGSYAKYSS FQVSEEQEKY KLTLGQFLEG
260 270 280 290 300
TAGDSLTKHN NMSFTTHDQD NDANSMNCAA LFHGAWWYHN CHQSNLNGRY
310 320 330
LSGSHESYAD GINWGTGQGH HYSYKVAEMK IRAS
Length:334
Mass (Da):36,298
Last modified:August 1, 1998 - v1
Checksum:i9D30C05036AA04B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007813 mRNA Translation: BAA25126.1
BC019180 mRNA Translation: AAH19180.1
CCDSiCCDS15785.1
PIRiJC5980
RefSeqiNP_032021.1, NM_007995.3
XP_006497736.1, XM_006497673.3
XP_011237318.1, XM_011239016.2
UniGeneiMm.10510

Genome annotation databases

EnsembliENSMUST00000028307; ENSMUSP00000028307; ENSMUSG00000026938
GeneIDi14133
KEGGimmu:14133
UCSCiuc008isz.1 mouse

Similar proteinsi

Entry informationi

Entry nameiFCN1_MOUSE
AccessioniPrimary (citable) accession number: O70165
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: August 1, 1998
Last modified: March 28, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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