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O70156

- OLR1_RAT

UniProt

O70156 - OLR1_RAT

Protein

Oxidized low-density lipoprotein receptor 1

Gene

Olr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.2 Publications

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. low-density lipoprotein receptor activity Source: RGD
    3. receptor activity Source: RGD

    GO - Biological processi

    1. cell death Source: RGD
    2. immune system process Source: UniProtKB-KW
    3. inflammatory response Source: RGD
    4. leukocyte cell-cell adhesion Source: RGD
    5. lipoprotein metabolic process Source: RGD
    6. receptor-mediated endocytosis Source: GOC
    7. response to hydrogen peroxide Source: RGD

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Cell adhesion, Immunity, Inflammatory response

    Keywords - Ligandi

    Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oxidized low-density lipoprotein receptor 1
    Short name:
    Ox-LDL receptor 1
    Alternative name(s):
    Lectin-like oxidized LDL receptor 1
    Short name:
    LOX-1
    Short name:
    Lectin-like oxLDL receptor 1
    Lectin-type oxidized LDL receptor 1
    Cleaved into the following chain:
    Gene namesi
    Name:Olr1
    Synonyms:Lox1, Oldlr1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi620515. Olr1.

    Subcellular locationi

    Cell membrane By similarity; Lipid-anchor By similarity. Cell membrane By similarity; Single-pass type II membrane protein By similarity. Membrane raft By similarity. Secreted By similarity
    Note: A secreted form also exists. Localization to membrane rafts requires palmitoylation By similarity.By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane raft Source: UniProtKB-SubCell
    4. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 364Oxidized low-density lipoprotein receptor 1, soluble formPRO_0000017452
    Chaini1 – 364364Oxidized low-density lipoprotein receptor 1PRO_0000017451Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi35 – 351S-palmitoyl cysteineBy similarity
    Lipidationi45 – 451S-palmitoyl cysteineBy similarity
    Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi92 – 921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi235 ↔ 246PROSITE-ProRule annotation
    Disulfide bondi262 ↔ 354PROSITE-ProRule annotation
    Disulfide bondi333 ↔ 346PROSITE-ProRule annotation

    Post-translational modificationi

    N-glycosylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiO70156.

    Expressioni

    Tissue specificityi

    Predominantly expressed in lung and at lower level in kidney. Expressed in macrophages but not in vascular smooth muscle cells.1 Publication

    Inductioni

    By hypertension. Up-regulated by shear stress, lipopolysaccharide and TNF-alpha in cultured vascular endothelial cells.2 Publications

    Gene expression databases

    GenevestigatoriO70156.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked. May form a hexamer composed of 3 homodimers. Interacts with HSP70 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000011196.

    Structurei

    3D structure databases

    ProteinModelPortaliO70156.
    SMRiO70156. Positions 227-360.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3131CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini55 – 364310ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei32 – 5423Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati96 – 141461Add
    BLAST
    Repeati142 – 187462Add
    BLAST
    Repeati188 – 233463Add
    BLAST
    Domaini242 – 355114C-type lectinPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni55 – 242188NeckAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili83 – 233151Sequence AnalysisAdd
    BLAST

    Domaini

    The cytoplasmic region is required for subcellular sorting on the cell surface.By similarity
    The C-type lectin domain mediates the recognition and binding of oxLDL.By similarity
    The Neck region contains 3 internal repeats that are only found in rodents.

    Sequence similaritiesi

    Contains 1 C-type lectin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat, Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG242244.
    GeneTreeiENSGT00700000104266.
    HOGENOMiHOG000220927.
    HOVERGENiHBG056863.
    InParanoidiO70156.
    KOiK08763.
    OMAiSICQKKA.
    OrthoDBiEOG747PJT.
    PhylomeDBiO70156.
    TreeFamiTF336674.

    Family and domain databases

    Gene3Di3.10.100.10. 1 hit.
    InterProiIPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    [Graphical view]
    PfamiPF00059. Lectin_C. 1 hit.
    [Graphical view]
    SMARTiSM00034. CLECT. 1 hit.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 1 hit.
    PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O70156-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFDDKMKPV NGQPDQKSCG KKPKGLHLLS STWWCPAAVT LAILCLVLSV    50
    TLIVQQTQLL QVSDLLKQYQ ANLTQQDHIL EGQMSAQKKA ENASQESKRE 100
    LKEQIDTLTW KLNEKSKEQE KLLQQNQNLQ EALQRAVNAS EESKWELKEQ 150
    IDILNWKLNG ISKEQKELLQ QNQNLQEALQ KAEKYSEESQ RELKEQIDTL 200
    SWKLNEKSKE QEELLQQNQN LQEALQRAAN SSGPCPQDWI WHKENCYLFH 250
    GPFNWEKSRE NCLSLDAQLL QISTTDDLNF VLQATSHSTS PFWMGLHRKN 300
    PNHPWLWENG SPLSFQFFRT RGVSLQMYSS GTCAYIQGGV VFAENCILTA 350
    FSICQKKANL LLTQ 364
    Length:364
    Mass (Da):41,890
    Last modified:August 1, 1998 - v1
    Checksum:i0AD2839C07206E09
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB005900 mRNA. Translation: BAA25785.1.
    AB018104 Genomic DNA. Translation: BAA35123.1.
    BC097290 mRNA. Translation: AAH97290.1.
    RefSeqiNP_579840.2. NM_133306.2.
    UniGeneiRn.87449.

    Genome annotation databases

    EnsembliENSRNOT00000011196; ENSRNOP00000011196; ENSRNOG00000008375.
    GeneIDi140914.
    KEGGirno:140914.
    UCSCiRGD:620515. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB005900 mRNA. Translation: BAA25785.1 .
    AB018104 Genomic DNA. Translation: BAA35123.1 .
    BC097290 mRNA. Translation: AAH97290.1 .
    RefSeqi NP_579840.2. NM_133306.2.
    UniGenei Rn.87449.

    3D structure databases

    ProteinModelPortali O70156.
    SMRi O70156. Positions 227-360.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000011196.

    Proteomic databases

    PRIDEi O70156.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000011196 ; ENSRNOP00000011196 ; ENSRNOG00000008375 .
    GeneIDi 140914.
    KEGGi rno:140914.
    UCSCi RGD:620515. rat.

    Organism-specific databases

    CTDi 4973.
    RGDi 620515. Olr1.

    Phylogenomic databases

    eggNOGi NOG242244.
    GeneTreei ENSGT00700000104266.
    HOGENOMi HOG000220927.
    HOVERGENi HBG056863.
    InParanoidi O70156.
    KOi K08763.
    OMAi SICQKKA.
    OrthoDBi EOG747PJT.
    PhylomeDBi O70156.
    TreeFami TF336674.

    Miscellaneous databases

    NextBioi 620753.
    PROi O70156.

    Gene expression databases

    Genevestigatori O70156.

    Family and domain databases

    Gene3Di 3.10.100.10. 1 hit.
    InterProi IPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    [Graphical view ]
    Pfami PF00059. Lectin_C. 1 hit.
    [Graphical view ]
    SMARTi SM00034. CLECT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 1 hit.
    PROSITEi PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Unique repetitive sequence and unexpected regulation of expression of rat endothelial receptor for oxidized low-density lipoprotein (LOX-1)."
      Nagase M., Hirose S., Fujita T.
      Biochem. J. 330:1417-1422(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
      Strain: SHR.
      Tissue: Kidney.
    2. "Genomic organization and regulation of expression of the lectin-like oxidized low-density lipoprotein receptor (LOX-1) gene."
      Nagase M., Abe J., Takahashi K., Ando J., Hirose S., Fujita T.
      J. Biol. Chem. 273:33702-33707(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION.
      Strain: Sprague-Dawley.
      Tissue: Liver.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    4. "Lectin-like oxidized LDL receptor-1 is a cell-adhesion molecule involved in endotoxin-induced inflammation."
      Honjo M., Nakamura K., Yamashiro K., Kiryu J., Tanihara H., McEvoy L.M., Honda Y., Butcher E.C., Masaki T., Sawamura T.
      Proc. Natl. Acad. Sci. U.S.A. 100:1274-1279(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiOLR1_RAT
    AccessioniPrimary (citable) accession number: O70156
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2005
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3