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O70156

- OLR1_RAT

UniProt

O70156 - OLR1_RAT

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Protein
Oxidized low-density lipoprotein receptor 1
Gene
Olr1, Lox1, Oldlr1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.2 Publications

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. low-density lipoprotein receptor activity Source: RGD
  3. receptor activity Source: RGD

GO - Biological processi

  1. cell death Source: RGD
  2. immune system process Source: UniProtKB-KW
  3. inflammatory response Source: RGD
  4. leukocyte cell-cell adhesion Source: RGD
  5. lipoprotein metabolic process Source: RGD
  6. receptor-mediated endocytosis Source: GOC
  7. response to hydrogen peroxide Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion, Immunity, Inflammatory response

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Oxidized low-density lipoprotein receptor 1
Short name:
Ox-LDL receptor 1
Alternative name(s):
Lectin-like oxidized LDL receptor 1
Short name:
LOX-1
Short name:
Lectin-like oxLDL receptor 1
Lectin-type oxidized LDL receptor 1
Cleaved into the following chain:
Gene namesi
Name:Olr1
Synonyms:Lox1, Oldlr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi620515. Olr1.

Subcellular locationi

Cell membrane; Lipid-anchor By similarity. Cell membrane; Single-pass type II membrane protein By similarity. Membrane raft By similarity. Secreted By similarity
Note: A secreted form also exists. Localization to membrane rafts requires palmitoylation By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3131Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei32 – 5423Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini55 – 364310Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane raft Source: UniProtKB-SubCell
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 364Oxidized low-density lipoprotein receptor 1, soluble formPRO_0000017452
Chaini1 – 364364Oxidized low-density lipoprotein receptor 1
PRO_0000017451Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi35 – 351S-palmitoyl cysteine By similarity
Lipidationi45 – 451S-palmitoyl cysteine By similarity
Glycosylationi72 – 721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi92 – 921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi138 – 1381N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi235 ↔ 246 By similarity
Disulfide bondi262 ↔ 354 By similarity
Disulfide bondi333 ↔ 346 By similarity

Post-translational modificationi

N-glycosylated By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiO70156.

Expressioni

Tissue specificityi

Predominantly expressed in lung and at lower level in kidney. Expressed in macrophages but not in vascular smooth muscle cells.1 Publication

Inductioni

By hypertension. Up-regulated by shear stress, lipopolysaccharide and TNF-alpha in cultured vascular endothelial cells.2 Publications

Gene expression databases

GenevestigatoriO70156.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. May form a hexamer composed of 3 homodimers. Interacts with HSP70 By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011196.

Structurei

3D structure databases

ProteinModelPortaliO70156.
SMRiO70156. Positions 227-360.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati96 – 141461
Add
BLAST
Repeati142 – 187462
Add
BLAST
Repeati188 – 233463
Add
BLAST
Domaini242 – 355114C-type lectin
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni55 – 242188Neck
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili83 – 233151 Reviewed prediction
Add
BLAST

Domaini

The cytoplasmic region is required for subcellular sorting on the cell surface By similarity.
The C-type lectin domain mediates the recognition and binding of oxLDL By similarity.
The Neck region contains 3 internal repeats that are only found in rodents.

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG242244.
GeneTreeiENSGT00700000104266.
HOGENOMiHOG000220927.
HOVERGENiHBG056863.
InParanoidiO70156.
KOiK08763.
OMAiSICQKKA.
OrthoDBiEOG747PJT.
PhylomeDBiO70156.
TreeFamiTF336674.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70156-1 [UniParc]FASTAAdd to Basket

« Hide

MAFDDKMKPV NGQPDQKSCG KKPKGLHLLS STWWCPAAVT LAILCLVLSV    50
TLIVQQTQLL QVSDLLKQYQ ANLTQQDHIL EGQMSAQKKA ENASQESKRE 100
LKEQIDTLTW KLNEKSKEQE KLLQQNQNLQ EALQRAVNAS EESKWELKEQ 150
IDILNWKLNG ISKEQKELLQ QNQNLQEALQ KAEKYSEESQ RELKEQIDTL 200
SWKLNEKSKE QEELLQQNQN LQEALQRAAN SSGPCPQDWI WHKENCYLFH 250
GPFNWEKSRE NCLSLDAQLL QISTTDDLNF VLQATSHSTS PFWMGLHRKN 300
PNHPWLWENG SPLSFQFFRT RGVSLQMYSS GTCAYIQGGV VFAENCILTA 350
FSICQKKANL LLTQ 364
Length:364
Mass (Da):41,890
Last modified:August 1, 1998 - v1
Checksum:i0AD2839C07206E09
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB005900 mRNA. Translation: BAA25785.1.
AB018104 Genomic DNA. Translation: BAA35123.1.
BC097290 mRNA. Translation: AAH97290.1.
RefSeqiNP_579840.2. NM_133306.2.
UniGeneiRn.87449.

Genome annotation databases

EnsembliENSRNOT00000011196; ENSRNOP00000011196; ENSRNOG00000008375.
GeneIDi140914.
KEGGirno:140914.
UCSCiRGD:620515. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB005900 mRNA. Translation: BAA25785.1 .
AB018104 Genomic DNA. Translation: BAA35123.1 .
BC097290 mRNA. Translation: AAH97290.1 .
RefSeqi NP_579840.2. NM_133306.2.
UniGenei Rn.87449.

3D structure databases

ProteinModelPortali O70156.
SMRi O70156. Positions 227-360.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000011196.

Proteomic databases

PRIDEi O70156.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000011196 ; ENSRNOP00000011196 ; ENSRNOG00000008375 .
GeneIDi 140914.
KEGGi rno:140914.
UCSCi RGD:620515. rat.

Organism-specific databases

CTDi 4973.
RGDi 620515. Olr1.

Phylogenomic databases

eggNOGi NOG242244.
GeneTreei ENSGT00700000104266.
HOGENOMi HOG000220927.
HOVERGENi HBG056863.
InParanoidi O70156.
KOi K08763.
OMAi SICQKKA.
OrthoDBi EOG747PJT.
PhylomeDBi O70156.
TreeFami TF336674.

Miscellaneous databases

NextBioi 620753.
PROi O70156.

Gene expression databases

Genevestigatori O70156.

Family and domain databases

Gene3Di 3.10.100.10. 1 hit.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view ]
Pfami PF00059. Lectin_C. 1 hit.
[Graphical view ]
SMARTi SM00034. CLECT. 1 hit.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 1 hit.
PROSITEi PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Unique repetitive sequence and unexpected regulation of expression of rat endothelial receptor for oxidized low-density lipoprotein (LOX-1)."
    Nagase M., Hirose S., Fujita T.
    Biochem. J. 330:1417-1422(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
    Strain: SHR.
    Tissue: Kidney.
  2. "Genomic organization and regulation of expression of the lectin-like oxidized low-density lipoprotein receptor (LOX-1) gene."
    Nagase M., Abe J., Takahashi K., Ando J., Hirose S., Fujita T.
    J. Biol. Chem. 273:33702-33707(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION.
    Strain: Sprague-Dawley.
    Tissue: Liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  4. "Lectin-like oxidized LDL receptor-1 is a cell-adhesion molecule involved in endotoxin-induced inflammation."
    Honjo M., Nakamura K., Yamashiro K., Kiryu J., Tanihara H., McEvoy L.M., Honda Y., Butcher E.C., Masaki T., Sawamura T.
    Proc. Natl. Acad. Sci. U.S.A. 100:1274-1279(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiOLR1_RAT
AccessioniPrimary (citable) accession number: O70156
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 1, 1998
Last modified: April 16, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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