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Protein

Oxidized low-density lipoprotein receptor 1

Gene

Olr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.2 Publications

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB-KW
  • low-density lipoprotein receptor activity Source: RGD
  • receptor activity Source: RGD

GO - Biological processi

  • cell death Source: RGD
  • immune system process Source: UniProtKB-KW
  • inflammatory response Source: RGD
  • leukocyte cell-cell adhesion Source: RGD
  • lipoprotein metabolic process Source: RGD
  • response to hydrogen peroxide Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion, Immunity, Inflammatory response

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Oxidized low-density lipoprotein receptor 1
Short name:
Ox-LDL receptor 1
Alternative name(s):
Lectin-like oxidized LDL receptor 1
Short name:
LOX-1
Short name:
Lectin-like oxLDL receptor 1
Lectin-type oxidized LDL receptor 1
Cleaved into the following chain:
Gene namesi
Name:Olr1
Synonyms:Lox1, Oldlr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620515. Olr1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 31CytoplasmicSequence analysisAdd BLAST31
Transmembranei32 – 54Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST23
Topological domaini55 – 364ExtracellularSequence analysisAdd BLAST310

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000017452? – 364Oxidized low-density lipoprotein receptor 1, soluble form
ChainiPRO_00000174511 – 364Oxidized low-density lipoprotein receptor 1Add BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi35S-palmitoyl cysteineBy similarity1
Lipidationi45S-palmitoyl cysteineBy similarity1
Glycosylationi72N-linked (GlcNAc...)Sequence analysis1
Glycosylationi92N-linked (GlcNAc...)Sequence analysis1
Glycosylationi138N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi235 ↔ 246PROSITE-ProRule annotation
Disulfide bondi262 ↔ 354PROSITE-ProRule annotation
Disulfide bondi333 ↔ 346PROSITE-ProRule annotation

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO70156.
PRIDEiO70156.

Expressioni

Tissue specificityi

Predominantly expressed in lung and at lower level in kidney. Expressed in macrophages but not in vascular smooth muscle cells.1 Publication

Inductioni

By hypertension. Up-regulated by shear stress, lipopolysaccharide and TNF-alpha in cultured vascular endothelial cells.2 Publications

Gene expression databases

BgeeiENSRNOG00000008375.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. May form a hexamer composed of 3 homodimers. Interacts with HSP70 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011196.

Structurei

3D structure databases

ProteinModelPortaliO70156.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati96 – 1411Add BLAST46
Repeati142 – 1872Add BLAST46
Repeati188 – 2333Add BLAST46
Domaini242 – 355C-type lectinPROSITE-ProRule annotationAdd BLAST114

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni55 – 242NeckAdd BLAST188

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili83 – 233Sequence analysisAdd BLAST151

Domaini

The cytoplasmic region is required for subcellular sorting on the cell surface.By similarity
The C-type lectin domain mediates the recognition and binding of oxLDL.By similarity
The Neck region contains 3 internal repeats that are only found in rodents.

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
HOGENOMiHOG000220927.
HOVERGENiHBG056863.
InParanoidiO70156.
KOiK08763.
PhylomeDBiO70156.
TreeFamiTF336674.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70156-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFDDKMKPV NGQPDQKSCG KKPKGLHLLS STWWCPAAVT LAILCLVLSV
60 70 80 90 100
TLIVQQTQLL QVSDLLKQYQ ANLTQQDHIL EGQMSAQKKA ENASQESKRE
110 120 130 140 150
LKEQIDTLTW KLNEKSKEQE KLLQQNQNLQ EALQRAVNAS EESKWELKEQ
160 170 180 190 200
IDILNWKLNG ISKEQKELLQ QNQNLQEALQ KAEKYSEESQ RELKEQIDTL
210 220 230 240 250
SWKLNEKSKE QEELLQQNQN LQEALQRAAN SSGPCPQDWI WHKENCYLFH
260 270 280 290 300
GPFNWEKSRE NCLSLDAQLL QISTTDDLNF VLQATSHSTS PFWMGLHRKN
310 320 330 340 350
PNHPWLWENG SPLSFQFFRT RGVSLQMYSS GTCAYIQGGV VFAENCILTA
360
FSICQKKANL LLTQ
Length:364
Mass (Da):41,890
Last modified:August 1, 1998 - v1
Checksum:i0AD2839C07206E09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005900 mRNA. Translation: BAA25785.1.
AB018104 Genomic DNA. Translation: BAA35123.1.
BC097290 mRNA. Translation: AAH97290.1.
RefSeqiNP_579840.2. NM_133306.2.
UniGeneiRn.87449.

Genome annotation databases

GeneIDi140914.
KEGGirno:140914.
UCSCiRGD:620515. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005900 mRNA. Translation: BAA25785.1.
AB018104 Genomic DNA. Translation: BAA35123.1.
BC097290 mRNA. Translation: AAH97290.1.
RefSeqiNP_579840.2. NM_133306.2.
UniGeneiRn.87449.

3D structure databases

ProteinModelPortaliO70156.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011196.

Proteomic databases

PaxDbiO70156.
PRIDEiO70156.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi140914.
KEGGirno:140914.
UCSCiRGD:620515. rat.

Organism-specific databases

CTDi4973.
RGDi620515. Olr1.

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
HOGENOMiHOG000220927.
HOVERGENiHBG056863.
InParanoidiO70156.
KOiK08763.
PhylomeDBiO70156.
TreeFamiTF336674.

Miscellaneous databases

PROiO70156.

Gene expression databases

BgeeiENSRNOG00000008375.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOLR1_RAT
AccessioniPrimary (citable) accession number: O70156
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.