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Protein
Submitted name:

Acetyl-CoA carboxylase

Gene

Acacb

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

biotinSAAS annotation

GO - Molecular functioni

  • acetyl-CoA carboxylase activity Source: RGD
  • ATP binding Source: RGD
  • biotin binding Source: RGD
  • biotin carboxylase activity Source: InterPro
  • metal ion binding Source: InterPro

GO - Biological processi

  • acetyl-CoA metabolic process Source: RGD
  • fatty acid biosynthetic process Source: InterPro
  • response to drug Source: RGD
  • response to organic cyclic compound Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

LigaseSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, BiotinSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Acetyl-CoA carboxylaseImported
Gene namesi
Name:AcacbImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi620500. Acacb.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: RGD
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiO70151.

PTM databases

iPTMnetiO70151.
PhosphoSiteiO70151.

Expressioni

Gene expression databases

GenevisibleiO70151. RN.

Structurei

3D structure databases

ProteinModelPortaliO70151.
SMRiO70151. Positions 235-755, 881-973.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini255 – 757503Biotin carboxylationInterPro annotationAdd
BLAST
Domaini414 – 605192ATP-graspInterPro annotationAdd
BLAST
Domaini884 – 95875Lipoyl-bindingInterPro annotationAdd
BLAST
Domaini1806 – 1987182CarboxyltransferaseInterPro annotationAdd
BLAST
Domaini1988 – 2303316COA_CT_CTERInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains ATP-grasp domain.SAAS annotation
Contains biotin carboxylation domain.SAAS annotation
Contains biotinyl-binding domain.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000214115.
HOVERGENiHBG005371.
KOiK01946.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.226.10. 3 hits.
InterProiIPR013537. AcCoA_COase_cen.
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005481. BC-like_N.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR000089. Biotin_lipoyl.
IPR000022. Carboxyl_trans.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR029045. ClpP/crotonase-like_dom.
IPR011763. COA_CT_C.
IPR011762. COA_CT_N.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF08326. ACC_central. 1 hit.
PF02785. Biotin_carb_C. 1 hit.
PF00289. Biotin_carb_N. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF01039. Carboxyl_trans. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
[Graphical view]
SMARTiSM00878. Biotin_carb_C. 1 hit.
[Graphical view]
SUPFAMiSSF51230. SSF51230. 1 hit.
SSF51246. SSF51246. 1 hit.
SSF52096. SSF52096. 2 hits.
SSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
PS50989. COA_CT_CTER. 1 hit.
PS50980. COA_CT_NTER. 1 hit.
PS00866. CPSASE_1. 1 hit.
PS00867. CPSASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70151-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLLLFLTYL VFSCLTISWL KIWGKMTDSR PLSNSKVDAS LLPSKEESFA
60 70 80 90 100
SDQSEEHGDC SCPLTTPDQE ELASHGGPVD ASQQRNSVPT SHQKPPRNPL
110 120 130 140 150
SSNDTCSSPE LQTNGVAAPG SEVPEANGLP FPARPQTQRT GSPTREDKKQ
160 170 180 190 200
APIKRQLMTS FILGSLDDNS SDEDPSSNSF QTSSRKGSRD SLGTCSQEAA
210 220 230 240 250
LNTADPESHT PTMRPSMSGL HLVKRGREHK KLDLHRDFTV ASPAEFVTRF
260 270 280 290 300
GGNRVIETVL IANNGIAAVK WMRSIRRWAY EMFRNERAIR FVVMVTPEDL
310 320 330 340 350
KANAEYYKMA DPVLPVPGGP NNNNYANVEL IIDIAKRIPV QAVWAGWGHA
360 370 380 390 400
SENPKLPELL CKHGIAFLGP RVRPMLGLGD RLSSTIVAQT LQIPTLPWSG
410 420 430 440 450
SGLTVEWTED SQHQGKCISV TEDVYEQGCV RDVDEGLQAA EKVGFPLMIK
460 470 480 490 500
ASEGGGGKGI RQAESAEDFP CFFRQVQSEI PGSPIFLMKL AQNARHLEVQ
510 520 530 540 550
VLADQYGNAV SLFGRDCSIQ RRHQKIIEEA PANIAAPAVF EFMEQCAVLL
560 570 580 590 600
AKTVVYVSAG TVGYLYSQDG SFHFLELNPR LQVEHPCTEM IADVNLPAAQ
610 620 630 640 650
LQIAMGVPLH RLKDIRLLYG ESPWGVTPVS FETPLSPPIA RGHVIAARIT
660 670 680 690 700
SENPDEAFKP SSGTVQELNF RSNKNVWGYF SVAAAGGLHE FPISQFGHCF
710 720 730 740 750
SWGENQEEAI SNMVVALKEL SIRGDFRTTV EYLVNLLETE SLQNNDIDTG
760 770 780 790 800
WLDHLIAQRV QAEKPDIMLG VVFGALNVAD AMFRTCITEF LHSLERGQVL
810 820 830 840 850
PADSLLNIVD VELIYGGIKY VLKVARQSLT MFVLIMNGCH IEIDAHRPND
860 870 880 890 900
GGLLLSYNGS SYTTYMKEEV DSYRITIGNK TCVFEKENDP TVLRSPSAGK
910 920 930 940 950
LMQYTVEDGQ HVEVGSSYAE MEVMKMIMTL NVQESGRVNY IKRPGAVLEA
960 970 980 990 1000
GCVVAKLELD DPSKVHAAQP FTGELPAQQT LPILGERLHQ VFHSVLENLT
1010 1020 1030 1040 1050
NVMNGYCLPE PFFSMKLKDW VEKPMMTLRH PSLPLLELQE IMTSVADRIP
1060 1070 1080 1090 1100
VPVEKAVRRV FAQDASNITS VLCQFPSQQI ATILDCHAAT LQRKVDREAF
1110 1120 1130 1140 1150
FMNTQSIVQL IQRYRSGTRG IMKAVVLDLL RRYLNVEHHF QQAHYDKCVI
1160 1170 1180 1190 1200
NLREQFKADM TRVLDCIFSH SQVAKKNQLV TMLIDELCGP DPTLSEELTS
1210 1220 1230 1240 1250
ILKELTQLSR SEHCKVALRA RQVLIASHLP SYELRHNQVE SSSCQPLTCN
1260 1270 1280 1290 1300
GHQFCPENLK KLILSETTIF DVLPTFFYHA NKVVCMASLE VYVRRGYIAY
1310 1320 1330 1340 1350
ELNSLQHREL PDGTCVVEFQ FMLPSSHPNR MAMPINVSDP DLLRHSKELF
1360 1370 1380 1390 1400
MDSGFSPLCH QRMGAMVAFR RFEEFTRNFD EVISCFANVP TDTPLFSKAC
1410 1420 1430 1440 1450
TSLYSEEDSK SLQEEPIHIL NVAIQCADHM EDERLVPVFR AFVQSKKHIL
1460 1470 1480 1490 1500
VDYGLRRITF LIAQEKEFPK FFTFRARDEF AEDRIYRHLE PGLAFQLELS
1510 1520 1530 1540 1550
RMRNFDLTAV PCANHKMHLY LGAAKVKEGL EVTDHRFFIR AIIRHSDLIT
1560 1570 1580 1590 1600
KEASFEYLQN EGERLLLEAM DELEVAFNNT SVRTDCNHIF LNFVAHVIMD
1610 1620 1630 1640 1650
PLKIEESVRA MVMRYGSRLW KLRVLQAQVK INIRQTTSDC AVPIRLFITN
1660 1670 1680 1690 1700
ESGYYLDISL YKEVTDSRSG NIMFHSFGNK QGSLHGMLIN TPYVTKDLLQ
1710 1720 1730 1740 1750
AKRFQAQSLG TTYVYDFPEM FRQALFKLWG SPEKYGPDIL TYTELVLDSQ
1760 1770 1780 1790 1800
GQLVEMNRLP GCNEVGMVVF KMRFKTPEYP EGRDTIVIGN DITFQIGSFG
1810 1820 1830 1840 1850
IGEDFLYLRA SEMARTEGIP QIYLAANSGA VLGLSEEIKQ IFQVAWVDPE
1860 1870 1880 1890 1900
DPYKGFRYLY LYLTPQDYTQ ISSQNSVHCK HIEDEGESGI IVDVIGKDSS
1910 1920 1930 1940 1950
LGVENLRGSG MIAGEASLAY EKNVTISMVD CRAIGIGAYL VRLGQRVIQV
1960 1970 1980 1990 2000
ENSHIILTGA GALNKVLGRE VYTSNNQLGG VQIMHTNGVS HVTVPDDFEG
2010 2020 2030 2040 2050
VCTILEWLSY IPKDNQSPVP IITPSDPIDR EIEFTPTKAP YDPRWLLAGR
2060 2070 2080 2090 2100
PHPTLKGTWQ SGFFDHGSFK EIMAPWDQTV VTGRARLGGI PVGVIAVETR
2110 2120 2130 2140 2150
SVEVAVPAHP ANLDSEAKII QQAGQVWFPD SAFKTAQVIR DFNQEHLLLM
2160 2170 2180 2190 2200
IFANWRGFSG GMKDMSEQML KFGAYIVDSL RLSKQPVLIY IPPGAELRGG
2210 2220 2230 2240 2250
SWVVLDSSIN PLCIEMYADK ESRGGVLEPE GTVEIKFRKK DLVKTIRRID
2260 2270 2280 2290 2300
PVCKKLLEPA GDTQLPDKDR KELESQLKAR EDLLLPIYHQ VAVQFADLHD
2310 2320 2330 2340 2350
TPGHMLKKGI ISDVLEWKTT RTYFYWRLRR LLLEAQVKQE ILRASPELSH
2360 2370 2380 2390 2400
EHTQSMLRRW FVETEGAVKA YLWDSNQVVV QWLEQHWSAR DNLRSTIREN
2410 2420 2430 2440 2450
LNYLKRDSVL KTIQSLVQEH PEATMGLCGY LSQHLTPAEQ MQVVQLLSTT

ESPASH
Length:2,456
Mass (Da):276,100
Last modified:August 1, 1998 - v1
Checksum:iC1D41AF0BEA38863
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004329 mRNA. Translation: BAA25799.1.
RefSeqiNP_446374.1. NM_053922.1.
UniGeneiRn.162151.

Genome annotation databases

GeneIDi116719.
KEGGirno:116719.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004329 mRNA. Translation: BAA25799.1.
RefSeqiNP_446374.1. NM_053922.1.
UniGeneiRn.162151.

3D structure databases

ProteinModelPortaliO70151.
SMRiO70151. Positions 235-755, 881-973.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiO70151.
PhosphoSiteiO70151.

Proteomic databases

PRIDEiO70151.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi116719.
KEGGirno:116719.

Organism-specific databases

CTDi32.
RGDi620500. Acacb.

Phylogenomic databases

HOGENOMiHOG000214115.
HOVERGENiHBG005371.
KOiK01946.

Gene expression databases

GenevisibleiO70151. RN.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.226.10. 3 hits.
InterProiIPR013537. AcCoA_COase_cen.
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005481. BC-like_N.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR000089. Biotin_lipoyl.
IPR000022. Carboxyl_trans.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR029045. ClpP/crotonase-like_dom.
IPR011763. COA_CT_C.
IPR011762. COA_CT_N.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF08326. ACC_central. 1 hit.
PF02785. Biotin_carb_C. 1 hit.
PF00289. Biotin_carb_N. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF01039. Carboxyl_trans. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
[Graphical view]
SMARTiSM00878. Biotin_carb_C. 1 hit.
[Graphical view]
SUPFAMiSSF51230. SSF51230. 1 hit.
SSF51246. SSF51246. 1 hit.
SSF52096. SSF52096. 2 hits.
SSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
PS50989. COA_CT_CTER. 1 hit.
PS50980. COA_CT_NTER. 1 hit.
PS00866. CPSASE_1. 1 hit.
PS00867. CPSASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation and characterization of cDNA encoding rat heart type acetyl-CoA carboxylase."
    Abe K., Shinohara Y., Terada H.
    Biochim. Biophys. Acta 1398:347-352(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: WistarImported.

Entry informationi

Entry nameiO70151_RAT
AccessioniPrimary (citable) accession number: O70151
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: July 6, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.