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Protein

SHC-transforming protein 3

Gene

Shc3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity).By similarity

GO - Molecular functioni

  • phosphotyrosine binding Source: RGD
  • protein kinase binding Source: GO_Central
  • receptor binding Source: RGD
  • receptor tyrosine kinase binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_312904. p38MAPK events.
REACT_316581. Signalling to RAS.

Names & Taxonomyi

Protein namesi
Recommended name:
SHC-transforming protein 3
Alternative name(s):
Neuronal Shc
Short name:
N-Shc
SHC-transforming protein C
Src homology 2 domain-containing-transforming protein C3
Short name:
SH2 domain protein C3
Gene namesi
Name:Shc3
Synonyms:Nshc, Shcc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi69348. Shc3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 594594SHC-transforming protein 3PRO_0000022342Add
BLAST

Post-translational modificationi

Tyrosine phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO70143.
PRIDEiO70143.

PTM databases

PhosphoSiteiO70143.

Expressioni

Tissue specificityi

Predominantly expressed in the adult brain, in the hippocampus.1 Publication

Interactioni

Subunit structurei

Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors (By similarity).By similarity

Protein-protein interaction databases

IntActiO70143. 2 interactions.
MINTiMINT-2517226.
STRINGi10116.ENSRNOP00000019442.

Structurei

3D structure databases

ProteinModelPortaliO70143.
SMRiO70143. Positions 136-310, 492-593.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini149 – 334186PIDPROSITE-ProRule annotationAdd
BLAST
Domaini499 – 59092SH2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni335 – 498164CH1Add
BLAST

Sequence similaritiesi

Contains 1 PID domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiNOG315087.
HOGENOMiHOG000231974.
HOVERGENiHBG050121.
InParanoidiO70143.
PhylomeDBiO70143.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011993. PH_like_dom.
IPR006019. PID_Shc-like.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
IPR029593. Shc3/ShcC/N-Shc.
[Graphical view]
PANTHERiPTHR10337:SF4. PTHR10337:SF4. 1 hit.
PfamiPF00640. PID. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00629. SHCPIDOMAIN.
SMARTiSM00462. PTB. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS01179. PID. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform p66 (identifier: O70143-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLPRTKYNRF RNDSVTSVDD LLHSLSVSGS GGKVSAEPAA SPYLVSGEAL
60 70 80 90 100
RKAPDDGPGS LGHLLHKVSH LKLSSSGLRG LSSAARERAG ARLSGSCSAP
110 120 130 140 150
SLAAPDGGSA TPGSRAPAAS MSATRKSRAS DEPLPRPPRG APHASDQVLG
160 170 180 190 200
SGVTYVVKYL GCIEVLRSMR SLDFSTRTQV TREAISRVCE AVPGAKGAFK
210 220 230 240 250
KRKPPSKMLS SILGKSNLQF AGMSISLTIS TASLNLRTPD SKQIISNHHM
260 270 280 290 300
RSISFASGGD PDTTDYVAYV AKDPVNRRAC HILECCDGLA QDVIGSIGQA
310 320 330 340 350
FELRFKQYLQ CPSKIPALQD RMQSLDEPWT EEEGDGPDHP YYNSVPNKMP
360 370 380 390 400
PPGGFLDARL KARPHAPDAA QFSGKEQTYY QGRHLGDAFG EDWQRAPTRQ
410 420 430 440 450
GSLDIYSTPE GKAHMVPVGE TPTYVNTQPV PPQVWPAATS STESSPRKDL
460 470 480 490 500
FDMKPFEDAL RNQPLGPVLS KAASVECISP VTPRAPDAKM LEELNAEPWY
510 520 530 540 550
QGEMSRKEAE ALLQEDGDFL VRKSTTNPGS FVLTGMHNGQ AKHLLLVDPE
560 570 580 590
GTVRTKDRVF DSISHLITYH LESSLPIVSA GSELCLRQPV ERKP
Length:594
Mass (Da):64,100
Last modified:August 1, 1998 - v1
Checksum:i6AC6531CA30DA514
GO
Isoform p52 (identifier: O70143-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-120: Missing.

Show »
Length:474
Mass (Da):52,083
Checksum:iAA0F15263DD65825
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 120120Missing in isoform p52. 1 PublicationVSP_018793Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001453 mRNA. Translation: BAA28174.1.
AB001453 mRNA. Translation: BAA28175.1.
UniGeneiRn.210551.

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001453 mRNA. Translation: BAA28174.1.
AB001453 mRNA. Translation: BAA28175.1.
UniGeneiRn.210551.

3D structure databases

ProteinModelPortaliO70143.
SMRiO70143. Positions 136-310, 492-593.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO70143. 2 interactions.
MINTiMINT-2517226.
STRINGi10116.ENSRNOP00000019442.

PTM databases

PhosphoSiteiO70143.

Proteomic databases

PaxDbiO70143.
PRIDEiO70143.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi69348. Shc3.

Phylogenomic databases

eggNOGiNOG315087.
HOGENOMiHOG000231974.
HOVERGENiHBG050121.
InParanoidiO70143.
PhylomeDBiO70143.

Enzyme and pathway databases

ReactomeiREACT_312904. p38MAPK events.
REACT_316581. Signalling to RAS.

Miscellaneous databases

PROiO70143.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011993. PH_like_dom.
IPR006019. PID_Shc-like.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
IPR029593. Shc3/ShcC/N-Shc.
[Graphical view]
PANTHERiPTHR10337:SF4. PTHR10337:SF4. 1 hit.
PfamiPF00640. PID. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00629. SHCPIDOMAIN.
SMARTiSM00462. PTB. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS01179. PID. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling."
    Nakamura T., Muraoka S., Sanokawa R., Mori N.
    J. Biol. Chem. 273:6960-6967(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS P52 AND P66), TISSUE SPECIFICITY.
    Tissue: Brain.

Entry informationi

Entry nameiSHC3_RAT
AccessioniPrimary (citable) accession number: O70143
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: August 1, 1998
Last modified: June 24, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.