Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O70143

- SHC3_RAT

UniProt

O70143 - SHC3_RAT

Protein

SHC-transforming protein 3

Gene

Shc3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons By similarity.By similarity

    GO - Molecular functioni

    1. phosphotyrosine binding Source: RGD
    2. receptor binding Source: RGD

    GO - Biological processi

    1. intracellular signal transduction Source: RGD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SHC-transforming protein 3
    Alternative name(s):
    Neuronal Shc
    Short name:
    N-Shc
    SHC-transforming protein C
    Src homology 2 domain-containing-transforming protein C3
    Short name:
    SH2 domain protein C3
    Gene namesi
    Name:Shc3
    Synonyms:Nshc, Shcc
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi69348. Shc3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. plasma membrane Source: Reactome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 594594SHC-transforming protein 3PRO_0000022342Add
    BLAST

    Post-translational modificationi

    Tyrosine phosphorylated.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiO70143.
    PRIDEiO70143.

    PTM databases

    PhosphoSiteiO70143.

    Expressioni

    Tissue specificityi

    Predominantly expressed in the adult brain, in the hippocampus.1 Publication

    Gene expression databases

    GenevestigatoriO70143.

    Interactioni

    Subunit structurei

    Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors By similarity.By similarity

    Protein-protein interaction databases

    IntActiO70143. 2 interactions.
    MINTiMINT-2517226.
    STRINGi10116.ENSRNOP00000019442.

    Structurei

    3D structure databases

    ProteinModelPortaliO70143.
    SMRiO70143. Positions 136-310, 492-593.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini149 – 334186PIDPROSITE-ProRule annotationAdd
    BLAST
    Domaini499 – 59092SH2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni335 – 498164CH1Add
    BLAST

    Sequence similaritiesi

    Contains 1 PID domain.PROSITE-ProRule annotation
    Contains 1 SH2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain

    Phylogenomic databases

    eggNOGiNOG315087.
    HOGENOMiHOG000231974.
    HOVERGENiHBG050121.
    InParanoidiO70143.
    PhylomeDBiO70143.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    3.30.505.10. 1 hit.
    InterProiIPR011993. PH_like_dom.
    IPR006019. PID_Shc-like.
    IPR006020. PTB/PI_dom.
    IPR000980. SH2.
    [Graphical view]
    PfamiPF00640. PID. 1 hit.
    PF00017. SH2. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    PR00629. SHCPIDOMAIN.
    SMARTiSM00462. PTB. 1 hit.
    SM00252. SH2. 1 hit.
    [Graphical view]
    SUPFAMiSSF55550. SSF55550. 1 hit.
    PROSITEiPS01179. PID. 1 hit.
    PS50001. SH2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative initiation. Align

    Isoform p66 (identifier: O70143-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLPRTKYNRF RNDSVTSVDD LLHSLSVSGS GGKVSAEPAA SPYLVSGEAL    50
    RKAPDDGPGS LGHLLHKVSH LKLSSSGLRG LSSAARERAG ARLSGSCSAP 100
    SLAAPDGGSA TPGSRAPAAS MSATRKSRAS DEPLPRPPRG APHASDQVLG 150
    SGVTYVVKYL GCIEVLRSMR SLDFSTRTQV TREAISRVCE AVPGAKGAFK 200
    KRKPPSKMLS SILGKSNLQF AGMSISLTIS TASLNLRTPD SKQIISNHHM 250
    RSISFASGGD PDTTDYVAYV AKDPVNRRAC HILECCDGLA QDVIGSIGQA 300
    FELRFKQYLQ CPSKIPALQD RMQSLDEPWT EEEGDGPDHP YYNSVPNKMP 350
    PPGGFLDARL KARPHAPDAA QFSGKEQTYY QGRHLGDAFG EDWQRAPTRQ 400
    GSLDIYSTPE GKAHMVPVGE TPTYVNTQPV PPQVWPAATS STESSPRKDL 450
    FDMKPFEDAL RNQPLGPVLS KAASVECISP VTPRAPDAKM LEELNAEPWY 500
    QGEMSRKEAE ALLQEDGDFL VRKSTTNPGS FVLTGMHNGQ AKHLLLVDPE 550
    GTVRTKDRVF DSISHLITYH LESSLPIVSA GSELCLRQPV ERKP 594
    Length:594
    Mass (Da):64,100
    Last modified:August 1, 1998 - v1
    Checksum:i6AC6531CA30DA514
    GO
    Isoform p52 (identifier: O70143-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-120: Missing.

    Show »
    Length:474
    Mass (Da):52,083
    Checksum:iAA0F15263DD65825
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 120120Missing in isoform p52. 1 PublicationVSP_018793Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB001453 mRNA. Translation: BAA28174.1.
    AB001453 mRNA. Translation: BAA28175.1.
    UniGeneiRn.210551.

    Keywords - Coding sequence diversityi

    Alternative initiation

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB001453 mRNA. Translation: BAA28174.1 .
    AB001453 mRNA. Translation: BAA28175.1 .
    UniGenei Rn.210551.

    3D structure databases

    ProteinModelPortali O70143.
    SMRi O70143. Positions 136-310, 492-593.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O70143. 2 interactions.
    MINTi MINT-2517226.
    STRINGi 10116.ENSRNOP00000019442.

    PTM databases

    PhosphoSitei O70143.

    Proteomic databases

    PaxDbi O70143.
    PRIDEi O70143.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    RGDi 69348. Shc3.

    Phylogenomic databases

    eggNOGi NOG315087.
    HOGENOMi HOG000231974.
    HOVERGENi HBG050121.
    InParanoidi O70143.
    PhylomeDBi O70143.

    Miscellaneous databases

    PROi O70143.

    Gene expression databases

    Genevestigatori O70143.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    3.30.505.10. 1 hit.
    InterProi IPR011993. PH_like_dom.
    IPR006019. PID_Shc-like.
    IPR006020. PTB/PI_dom.
    IPR000980. SH2.
    [Graphical view ]
    Pfami PF00640. PID. 1 hit.
    PF00017. SH2. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    PR00629. SHCPIDOMAIN.
    SMARTi SM00462. PTB. 1 hit.
    SM00252. SH2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55550. SSF55550. 1 hit.
    PROSITEi PS01179. PID. 1 hit.
    PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling."
      Nakamura T., Muraoka S., Sanokawa R., Mori N.
      J. Biol. Chem. 273:6960-6967(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS P52 AND P66), TISSUE SPECIFICITY.
      Tissue: Brain.

    Entry informationi

    Entry nameiSHC3_RAT
    AccessioniPrimary (citable) accession number: O70143
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2004
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3