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O70143 (SHC3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
SHC-transforming protein 3
Alternative name(s):
Neuronal Shc
Short name=N-Shc
SHC-transforming protein C
Src homology 2 domain-containing-transforming protein C3
Short name=SH2 domain protein C3
Gene names
Name:Shc3
Synonyms:Nshc, Shcc
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length594 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons By similarity.

Subunit structure

Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors By similarity.

Tissue specificity

Predominantly expressed in the adult brain, in the hippocampus. Ref.1

Post-translational modification

Tyrosine phosphorylated By similarity.

Sequence similarities

Contains 1 PID domain.

Contains 1 SH2 domain.

Ontologies

Keywords
   Coding sequence diversityAlternative initiation
   DomainSH2 domain
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processintracellular signal transduction

Traceable author statement PubMed 12882334. Source: RGD

   Cellular_componentcytosol

Traceable author statement. Source: Reactome

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionphosphotyrosine binding

Traceable author statement PubMed 12882334. Source: RGD

receptor binding

Traceable author statement PubMed 12882334. Source: RGD

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative initiation. [Align] [Select]
Isoform p66 (identifier: O70143-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform p52 (identifier: O70143-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-120: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 594594SHC-transforming protein 3
PRO_0000022342

Regions

Domain149 – 334186PID
Domain499 – 59092SH2
Region335 – 498164CH1

Natural variations

Alternative sequence1 – 120120Missing in isoform p52.
VSP_018793

Sequences

Sequence LengthMass (Da)Tools
Isoform p66 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 6AC6531CA30DA514

FASTA59464,100
        10         20         30         40         50         60 
MLPRTKYNRF RNDSVTSVDD LLHSLSVSGS GGKVSAEPAA SPYLVSGEAL RKAPDDGPGS 

        70         80         90        100        110        120 
LGHLLHKVSH LKLSSSGLRG LSSAARERAG ARLSGSCSAP SLAAPDGGSA TPGSRAPAAS 

       130        140        150        160        170        180 
MSATRKSRAS DEPLPRPPRG APHASDQVLG SGVTYVVKYL GCIEVLRSMR SLDFSTRTQV 

       190        200        210        220        230        240 
TREAISRVCE AVPGAKGAFK KRKPPSKMLS SILGKSNLQF AGMSISLTIS TASLNLRTPD 

       250        260        270        280        290        300 
SKQIISNHHM RSISFASGGD PDTTDYVAYV AKDPVNRRAC HILECCDGLA QDVIGSIGQA 

       310        320        330        340        350        360 
FELRFKQYLQ CPSKIPALQD RMQSLDEPWT EEEGDGPDHP YYNSVPNKMP PPGGFLDARL 

       370        380        390        400        410        420 
KARPHAPDAA QFSGKEQTYY QGRHLGDAFG EDWQRAPTRQ GSLDIYSTPE GKAHMVPVGE 

       430        440        450        460        470        480 
TPTYVNTQPV PPQVWPAATS STESSPRKDL FDMKPFEDAL RNQPLGPVLS KAASVECISP 

       490        500        510        520        530        540 
VTPRAPDAKM LEELNAEPWY QGEMSRKEAE ALLQEDGDFL VRKSTTNPGS FVLTGMHNGQ 

       550        560        570        580        590 
AKHLLLVDPE GTVRTKDRVF DSISHLITYH LESSLPIVSA GSELCLRQPV ERKP

« Hide

Isoform p52 [UniParc].

Checksum: AA0F15263DD65825
Show »

FASTA47452,083

References

[1]"N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling."
Nakamura T., Muraoka S., Sanokawa R., Mori N.
J. Biol. Chem. 273:6960-6967(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS P52 AND P66), TISSUE SPECIFICITY.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB001453 mRNA. Translation: BAA28174.1.
AB001453 mRNA. Translation: BAA28175.1.
IPIIPI00324794.
IPI00760119.
UniGeneRn.210551.

3D structure databases

ProteinModelPortalO70143.
SMRO70143. Positions 136-310, 492-593.
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-2517226.
STRING10116.ENSRNOP00000019442.

PTM databases

PhosphoSiteO70143.

Proteomic databases

PaxDbO70143.
PRIDEO70143.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

RGD69348. Shc3.

Phylogenomic databases

eggNOGNOG315087.
HOGENOMHOG000231974.
HOVERGENHBG050121.
InParanoidO70143.
OrthoDBEOG4SF960.

Enzyme and pathway databases

ReactomeREACT_111984. Signal Transduction.

Gene expression databases

GenevestigatorO70143.
GermOnlineENSRNOG00000014366. Rattus norvegicus.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProIPR011993. PH_like_dom.
IPR006019. PID_domain.
IPR006020. PTyr_interaction_dom.
IPR000980. SH2.
[Graphical view]
PfamPF00640. PID. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
PR00629. SHCPIDOMAIN.
SMARTSM00462. PTB. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
PROSITEPS01179. PID. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSHC3_RAT
AccessionPrimary (citable) accession number: O70143
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: August 1, 1998
Last modified: April 3, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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