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Protein

SHC-transforming protein 2

Gene

Shc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-167044. Signalling to RAS.
R-RNO-4420097. VEGFA-VEGFR2 Pathway.
R-RNO-5673001. RAF/MAP kinase cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
SHC-transforming protein 2
Alternative name(s):
Protein Sck
SH2 domain protein C2
Src homology 2 domain-containing-transforming protein C2
Gene namesi
Name:Shc2
Synonyms:Sck
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1307137. Shc2.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003422641 – 573SHC-transforming protein 2Add BLAST573

Post-translational modificationi

Phosphorylated on tyrosine by the Trk receptors.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO70142.
PRIDEiO70142.

PTM databases

iPTMnetiO70142.
PhosphoSitePlusiO70142.

Expressioni

Gene expression databases

BgeeiENSRNOG00000008030.
GenevisibleiO70142. RN.

Interactioni

Subunit structurei

Interacts with the Trk receptors in a phosphotyrosine-dependent manner and MEGF12. Once activated, binds to GRB2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010714.

Structurei

3D structure databases

ProteinModelPortaliO70142.
SMRiO70142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini125 – 307PIDPROSITE-ProRule annotationAdd BLAST183
Domaini478 – 569SH2PROSITE-ProRule annotationAdd BLAST92

Domaini

The PID domain mediates binding to the TrkA receptor.By similarity

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG3697. Eukaryota.
ENOG410XTJN. LUCA.
GeneTreeiENSGT00390000018860.
HOGENOMiHOG000231974.
HOVERGENiHBG050121.
InParanoidiO70142.
KOiK17447.
OMAiPRMPQWK.
OrthoDBiEOG091G04DC.
PhylomeDBiO70142.
TreeFamiTF315807.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR011993. PH_dom-like.
IPR006019. PID_Shc-like.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
IPR029591. SHC2.
PANTHERiPTHR10337:SF14. PTHR10337:SF14. 1 hit.
PfamiView protein in Pfam
PF00640. PID. 1 hit.
PF00017. SH2. 1 hit.
PRINTSiPR00401. SH2DOMAIN.
PR00629. SHCPIDOMAIN.
SMARTiView protein in SMART
SM00462. PTB. 1 hit.
SM00252. SH2. 1 hit.
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiView protein in PROSITE
PS01179. PID. 1 hit.
PS50001. SH2. 1 hit.

Sequencei

Sequence statusi: Complete.

O70142-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQGPGGRAA PEPEAPTTFC ALLPRMPQWK FAAPGSFLGR GPAAARVAGA
60 70 80 90 100
AEAQPEPGVP ALAAVLGACE PRCAAPCPLP ALGRCRGSGS RGARGTPDVA
110 120 130 140 150
DEWVRKGGFI HKPAHGWLHP DARVLGPGVS YIVRYMGCIE VLRSMRSLDF
160 170 180 190 200
NTRTQVTREA INRLHEAVPG VRGSWKKKAP NKALASILGK SNLRFAGMSI
210 220 230 240 250
SVNISVDGLN LSVPATRQII ANHHMQSISF ASGGDTDMTD YVAYVAKDPI
260 270 280 290 300
NQRACHILEC CEGLAQSVIS TVGQAFELRF KQYLHSPPKA VVPPERLTGL
310 320 330 340 350
EESAWGDGEV TADHDYYNSI PGKEPPLGGL VDSRLAVTQP CALTTLGGLG
360 370 380 390 400
QGLSPAWRDV RGLPWDMGPS GAVPPGDGYV QADARGPHDY EEHLYVNTQG
410 420 430 440 450
LDALELEDTS ETPLQPEDSP KKDLFDMRPF EDALKLHECS VAAGITAASL
460 470 480 490 500
PLEDQWPSPP TRRAPIAPTE EQLRQEPWYH GRMSRRAAEK LLRADGDFLV
510 520 530 540 550
RDSITNPGQY VLTGMHAGQP KHLLLVDPEG VVRTKDVLFE SISHLIDYHL
560 570
KNGLPIVAAE SELHLRGVVS REP
Length:573
Mass (Da):61,770
Last modified:July 1, 2008 - v2
Checksum:iF81449473CB4F7AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03055985 Genomic DNA. No translation available.
AABR03059160 Genomic DNA. No translation available.
AB001452 mRNA. Translation: BAA28173.1.
RefSeqiNP_001101535.1. NM_001108065.1.
UniGeneiRn.120041.

Genome annotation databases

EnsembliENSRNOT00000010714; ENSRNOP00000010714; ENSRNOG00000008030.
GeneIDi314612.
KEGGirno:314612.
UCSCiRGD:1307137. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03055985 Genomic DNA. No translation available.
AABR03059160 Genomic DNA. No translation available.
AB001452 mRNA. Translation: BAA28173.1.
RefSeqiNP_001101535.1. NM_001108065.1.
UniGeneiRn.120041.

3D structure databases

ProteinModelPortaliO70142.
SMRiO70142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010714.

PTM databases

iPTMnetiO70142.
PhosphoSitePlusiO70142.

Proteomic databases

PaxDbiO70142.
PRIDEiO70142.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010714; ENSRNOP00000010714; ENSRNOG00000008030.
GeneIDi314612.
KEGGirno:314612.
UCSCiRGD:1307137. rat.

Organism-specific databases

CTDi25759.
RGDi1307137. Shc2.

Phylogenomic databases

eggNOGiKOG3697. Eukaryota.
ENOG410XTJN. LUCA.
GeneTreeiENSGT00390000018860.
HOGENOMiHOG000231974.
HOVERGENiHBG050121.
InParanoidiO70142.
KOiK17447.
OMAiPRMPQWK.
OrthoDBiEOG091G04DC.
PhylomeDBiO70142.
TreeFamiTF315807.

Enzyme and pathway databases

ReactomeiR-RNO-167044. Signalling to RAS.
R-RNO-4420097. VEGFA-VEGFR2 Pathway.
R-RNO-5673001. RAF/MAP kinase cascade.

Miscellaneous databases

PROiPR:O70142.

Gene expression databases

BgeeiENSRNOG00000008030.
GenevisibleiO70142. RN.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR011993. PH_dom-like.
IPR006019. PID_Shc-like.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
IPR029591. SHC2.
PANTHERiPTHR10337:SF14. PTHR10337:SF14. 1 hit.
PfamiView protein in Pfam
PF00640. PID. 1 hit.
PF00017. SH2. 1 hit.
PRINTSiPR00401. SH2DOMAIN.
PR00629. SHCPIDOMAIN.
SMARTiView protein in SMART
SM00462. PTB. 1 hit.
SM00252. SH2. 1 hit.
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiView protein in PROSITE
PS01179. PID. 1 hit.
PS50001. SH2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSHC2_RAT
AccessioniPrimary (citable) accession number: O70142
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 1, 2008
Last modified: May 10, 2017
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.