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O70142

- SHC2_RAT

UniProt

O70142 - SHC2_RAT

Protein

SHC-transforming protein 2

Gene

Shc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 2 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons By similarity.By similarity

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SHC-transforming protein 2
    Alternative name(s):
    Protein Sck
    SH2 domain protein C2
    Src homology 2 domain-containing-transforming protein C2
    Gene namesi
    Name:Shc2
    Synonyms:Sck
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi1307137. Shc2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 573573SHC-transforming protein 2PRO_0000342264Add
    BLAST

    Post-translational modificationi

    Phosphorylated on tyrosine by the Trk receptors.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiO70142.
    PRIDEiO70142.

    PTM databases

    PhosphoSiteiO70142.

    Expressioni

    Gene expression databases

    GenevestigatoriO70142.

    Interactioni

    Subunit structurei

    Interacts with the Trk receptors in a phosphotyrosine-dependent manner and MEGF12. Once activated, binds to GRB2 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000010714.

    Structurei

    3D structure databases

    ProteinModelPortaliO70142.
    SMRiO70142. Positions 82-284, 471-572.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini125 – 307183PIDPROSITE-ProRule annotationAdd
    BLAST
    Domaini478 – 56992SH2PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The PID domain mediates binding to the TrkA receptor.By similarity

    Sequence similaritiesi

    Contains 1 PID domain.PROSITE-ProRule annotation
    Contains 1 SH2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain

    Phylogenomic databases

    eggNOGiNOG315087.
    GeneTreeiENSGT00390000018860.
    HOGENOMiHOG000231974.
    HOVERGENiHBG050121.
    KOiK17447.
    OMAiGACEPRC.
    OrthoDBiEOG7MD4QK.
    PhylomeDBiO70142.
    TreeFamiTF315807.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    3.30.505.10. 1 hit.
    InterProiIPR011993. PH_like_dom.
    IPR006019. PID_Shc-like.
    IPR006020. PTB/PI_dom.
    IPR000980. SH2.
    [Graphical view]
    PfamiPF00640. PID. 1 hit.
    PF00017. SH2. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    PR00629. SHCPIDOMAIN.
    SMARTiSM00462. PTB. 1 hit.
    SM00252. SH2. 1 hit.
    [Graphical view]
    SUPFAMiSSF55550. SSF55550. 1 hit.
    PROSITEiPS01179. PID. 1 hit.
    PS50001. SH2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O70142-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTQGPGGRAA PEPEAPTTFC ALLPRMPQWK FAAPGSFLGR GPAAARVAGA    50
    AEAQPEPGVP ALAAVLGACE PRCAAPCPLP ALGRCRGSGS RGARGTPDVA 100
    DEWVRKGGFI HKPAHGWLHP DARVLGPGVS YIVRYMGCIE VLRSMRSLDF 150
    NTRTQVTREA INRLHEAVPG VRGSWKKKAP NKALASILGK SNLRFAGMSI 200
    SVNISVDGLN LSVPATRQII ANHHMQSISF ASGGDTDMTD YVAYVAKDPI 250
    NQRACHILEC CEGLAQSVIS TVGQAFELRF KQYLHSPPKA VVPPERLTGL 300
    EESAWGDGEV TADHDYYNSI PGKEPPLGGL VDSRLAVTQP CALTTLGGLG 350
    QGLSPAWRDV RGLPWDMGPS GAVPPGDGYV QADARGPHDY EEHLYVNTQG 400
    LDALELEDTS ETPLQPEDSP KKDLFDMRPF EDALKLHECS VAAGITAASL 450
    PLEDQWPSPP TRRAPIAPTE EQLRQEPWYH GRMSRRAAEK LLRADGDFLV 500
    RDSITNPGQY VLTGMHAGQP KHLLLVDPEG VVRTKDVLFE SISHLIDYHL 550
    KNGLPIVAAE SELHLRGVVS REP 573
    Length:573
    Mass (Da):61,770
    Last modified:July 1, 2008 - v2
    Checksum:iF81449473CB4F7AB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR03055985 Genomic DNA. No translation available.
    AABR03059160 Genomic DNA. No translation available.
    AB001452 mRNA. Translation: BAA28173.1.
    RefSeqiNP_001101535.1. NM_001108065.1.
    UniGeneiRn.120041.

    Genome annotation databases

    EnsembliENSRNOT00000010714; ENSRNOP00000010714; ENSRNOG00000008030.
    GeneIDi314612.
    KEGGirno:314612.
    UCSCiRGD:1307137. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR03055985 Genomic DNA. No translation available.
    AABR03059160 Genomic DNA. No translation available.
    AB001452 mRNA. Translation: BAA28173.1 .
    RefSeqi NP_001101535.1. NM_001108065.1.
    UniGenei Rn.120041.

    3D structure databases

    ProteinModelPortali O70142.
    SMRi O70142. Positions 82-284, 471-572.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000010714.

    PTM databases

    PhosphoSitei O70142.

    Proteomic databases

    PaxDbi O70142.
    PRIDEi O70142.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000010714 ; ENSRNOP00000010714 ; ENSRNOG00000008030 .
    GeneIDi 314612.
    KEGGi rno:314612.
    UCSCi RGD:1307137. rat.

    Organism-specific databases

    CTDi 25759.
    RGDi 1307137. Shc2.

    Phylogenomic databases

    eggNOGi NOG315087.
    GeneTreei ENSGT00390000018860.
    HOGENOMi HOG000231974.
    HOVERGENi HBG050121.
    KOi K17447.
    OMAi GACEPRC.
    OrthoDBi EOG7MD4QK.
    PhylomeDBi O70142.
    TreeFami TF315807.

    Miscellaneous databases

    NextBioi 667898.

    Gene expression databases

    Genevestigatori O70142.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    3.30.505.10. 1 hit.
    InterProi IPR011993. PH_like_dom.
    IPR006019. PID_Shc-like.
    IPR006020. PTB/PI_dom.
    IPR000980. SH2.
    [Graphical view ]
    Pfami PF00640. PID. 1 hit.
    PF00017. SH2. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    PR00629. SHCPIDOMAIN.
    SMARTi SM00462. PTB. 1 hit.
    SM00252. SH2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55550. SSF55550. 1 hit.
    PROSITEi PS01179. PID. 1 hit.
    PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown Norway.
    2. "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling."
      Nakamura T., Muraoka S., Sanokawa R., Mori N.
      J. Biol. Chem. 273:6960-6967(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 97-573.

    Entry informationi

    Entry nameiSHC2_RAT
    AccessioniPrimary (citable) accession number: O70142
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 76 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3