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O70142

- SHC2_RAT

UniProt

O70142 - SHC2_RAT

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Protein

SHC-transforming protein 2

Gene

Shc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity).By similarity

GO - Biological processi

  1. activation of MAPK activity Source: InterPro
  2. intracellular signal transduction Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
SHC-transforming protein 2
Alternative name(s):
Protein Sck
SH2 domain protein C2
Src homology 2 domain-containing-transforming protein C2
Gene namesi
Name:Shc2
Synonyms:Sck
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi1307137. Shc2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 573573SHC-transforming protein 2PRO_0000342264Add
BLAST

Post-translational modificationi

Phosphorylated on tyrosine by the Trk receptors.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO70142.
PRIDEiO70142.

PTM databases

PhosphoSiteiO70142.

Expressioni

Gene expression databases

GenevestigatoriO70142.

Interactioni

Subunit structurei

Interacts with the Trk receptors in a phosphotyrosine-dependent manner and MEGF12. Once activated, binds to GRB2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010714.

Structurei

3D structure databases

ProteinModelPortaliO70142.
SMRiO70142. Positions 82-284, 471-572.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini125 – 307183PIDPROSITE-ProRule annotationAdd
BLAST
Domaini478 – 56992SH2PROSITE-ProRule annotationAdd
BLAST

Domaini

The PID domain mediates binding to the TrkA receptor.By similarity

Sequence similaritiesi

Contains 1 PID domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiNOG315087.
GeneTreeiENSGT00390000018860.
HOGENOMiHOG000231974.
HOVERGENiHBG050121.
InParanoidiO70142.
KOiK17447.
OMAiGACEPRC.
OrthoDBiEOG7MD4QK.
PhylomeDBiO70142.
TreeFamiTF315807.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011993. PH_like_dom.
IPR006019. PID_Shc-like.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
IPR029591. SHC2.
[Graphical view]
PANTHERiPTHR10337:SF5. PTHR10337:SF5. 1 hit.
PfamiPF00640. PID. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00629. SHCPIDOMAIN.
SMARTiSM00462. PTB. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS01179. PID. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70142-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQGPGGRAA PEPEAPTTFC ALLPRMPQWK FAAPGSFLGR GPAAARVAGA
60 70 80 90 100
AEAQPEPGVP ALAAVLGACE PRCAAPCPLP ALGRCRGSGS RGARGTPDVA
110 120 130 140 150
DEWVRKGGFI HKPAHGWLHP DARVLGPGVS YIVRYMGCIE VLRSMRSLDF
160 170 180 190 200
NTRTQVTREA INRLHEAVPG VRGSWKKKAP NKALASILGK SNLRFAGMSI
210 220 230 240 250
SVNISVDGLN LSVPATRQII ANHHMQSISF ASGGDTDMTD YVAYVAKDPI
260 270 280 290 300
NQRACHILEC CEGLAQSVIS TVGQAFELRF KQYLHSPPKA VVPPERLTGL
310 320 330 340 350
EESAWGDGEV TADHDYYNSI PGKEPPLGGL VDSRLAVTQP CALTTLGGLG
360 370 380 390 400
QGLSPAWRDV RGLPWDMGPS GAVPPGDGYV QADARGPHDY EEHLYVNTQG
410 420 430 440 450
LDALELEDTS ETPLQPEDSP KKDLFDMRPF EDALKLHECS VAAGITAASL
460 470 480 490 500
PLEDQWPSPP TRRAPIAPTE EQLRQEPWYH GRMSRRAAEK LLRADGDFLV
510 520 530 540 550
RDSITNPGQY VLTGMHAGQP KHLLLVDPEG VVRTKDVLFE SISHLIDYHL
560 570
KNGLPIVAAE SELHLRGVVS REP
Length:573
Mass (Da):61,770
Last modified:July 1, 2008 - v2
Checksum:iF81449473CB4F7AB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR03055985 Genomic DNA. No translation available.
AABR03059160 Genomic DNA. No translation available.
AB001452 mRNA. Translation: BAA28173.1.
RefSeqiNP_001101535.1. NM_001108065.1.
UniGeneiRn.120041.

Genome annotation databases

EnsembliENSRNOT00000010714; ENSRNOP00000010714; ENSRNOG00000008030.
GeneIDi314612.
KEGGirno:314612.
UCSCiRGD:1307137. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR03055985 Genomic DNA. No translation available.
AABR03059160 Genomic DNA. No translation available.
AB001452 mRNA. Translation: BAA28173.1 .
RefSeqi NP_001101535.1. NM_001108065.1.
UniGenei Rn.120041.

3D structure databases

ProteinModelPortali O70142.
SMRi O70142. Positions 82-284, 471-572.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000010714.

PTM databases

PhosphoSitei O70142.

Proteomic databases

PaxDbi O70142.
PRIDEi O70142.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000010714 ; ENSRNOP00000010714 ; ENSRNOG00000008030 .
GeneIDi 314612.
KEGGi rno:314612.
UCSCi RGD:1307137. rat.

Organism-specific databases

CTDi 25759.
RGDi 1307137. Shc2.

Phylogenomic databases

eggNOGi NOG315087.
GeneTreei ENSGT00390000018860.
HOGENOMi HOG000231974.
HOVERGENi HBG050121.
InParanoidi O70142.
KOi K17447.
OMAi GACEPRC.
OrthoDBi EOG7MD4QK.
PhylomeDBi O70142.
TreeFami TF315807.

Miscellaneous databases

NextBioi 667898.

Gene expression databases

Genevestigatori O70142.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProi IPR011993. PH_like_dom.
IPR006019. PID_Shc-like.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
IPR029591. SHC2.
[Graphical view ]
PANTHERi PTHR10337:SF5. PTHR10337:SF5. 1 hit.
Pfami PF00640. PID. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
PR00629. SHCPIDOMAIN.
SMARTi SM00462. PTB. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view ]
SUPFAMi SSF55550. SSF55550. 1 hit.
PROSITEi PS01179. PID. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling."
    Nakamura T., Muraoka S., Sanokawa R., Mori N.
    J. Biol. Chem. 273:6960-6967(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 97-573.

Entry informationi

Entry nameiSHC2_RAT
AccessioniPrimary (citable) accession number: O70142
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 1, 2008
Last modified: October 29, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3