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Protein

cAMP-dependent protein kinase inhibitor gamma

Gene

Pkig

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.By similarity

GO - Molecular functioni

  • cAMP-dependent protein kinase inhibitor activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protein kinase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-dependent protein kinase inhibitor gamma
Short name:
PKI-gamma
Gene namesi
Name:Pkig
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1343086. Pkig.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001545431 – 76cAMP-dependent protein kinase inhibitor gammaAdd BLAST76

Proteomic databases

PaxDbiO70139.
PRIDEiO70139.

PTM databases

PhosphoSitePlusiO70139.

Expressioni

Gene expression databases

BgeeiENSMUSG00000035268.
CleanExiMM_PKIG.
ExpressionAtlasiO70139. baseline and differential.
GenevisibleiO70139. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000068344.

Structurei

3D structure databases

ProteinModelPortaliO70139.
SMRiO70139.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PKI family.Curated

Phylogenomic databases

eggNOGiENOG410J1ME. Eukaryota.
ENOG410ZDGT. LUCA.
GeneTreeiENSGT00390000002707.
HOGENOMiHOG000059641.
HOVERGENiHBG104492.
InParanoidiO70139.
OMAiEANTPDK.
OrthoDBiEOG091G13WE.
PhylomeDBiO70139.
TreeFamiTF330809.

Family and domain databases

InterProiIPR004171. cAMP_dep_PKI.
[Graphical view]
PfamiPF02827. PKI. 1 hit.
[Graphical view]
PIRSFiPIRSF001667. PKI. 1 hit.
ProDomiPD010366. cAMP_dep_PKI. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

O70139-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMEVESSYSD FISCDRTGRR NAVPDIQGDS EAVSVRKLAG DMGELALEGA
60 70
EGQAEGSTPD KEASSQPESS DANTSS
Length:76
Mass (Da):7,943
Last modified:August 1, 1998 - v1
Checksum:i965F577D80C8DE59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U97170 mRNA. Translation: AAC09065.1.
BC026550 mRNA. Translation: AAH26550.1.
CCDSiCCDS17014.1.
RefSeqiNP_001034479.1. NM_001039390.2.
NP_001034480.1. NM_001039391.2.
NP_001157525.1. NM_001164053.1.
NP_001157527.1. NM_001164055.1.
NP_035236.1. NM_011106.2.
XP_006498989.1. XM_006498926.3.
XP_006498990.1. XM_006498927.1.
UniGeneiMm.10091.

Genome annotation databases

EnsembliENSMUST00000064703; ENSMUSP00000068344; ENSMUSG00000035268.
ENSMUST00000099105; ENSMUSP00000096704; ENSMUSG00000035268.
ENSMUST00000109400; ENSMUSP00000105027; ENSMUSG00000035268.
ENSMUST00000126182; ENSMUSP00000120145; ENSMUSG00000035268.
ENSMUST00000164399; ENSMUSP00000126223; ENSMUSG00000035268.
GeneIDi18769.
KEGGimmu:18769.
UCSCiuc008nth.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U97170 mRNA. Translation: AAC09065.1.
BC026550 mRNA. Translation: AAH26550.1.
CCDSiCCDS17014.1.
RefSeqiNP_001034479.1. NM_001039390.2.
NP_001034480.1. NM_001039391.2.
NP_001157525.1. NM_001164053.1.
NP_001157527.1. NM_001164055.1.
NP_035236.1. NM_011106.2.
XP_006498989.1. XM_006498926.3.
XP_006498990.1. XM_006498927.1.
UniGeneiMm.10091.

3D structure databases

ProteinModelPortaliO70139.
SMRiO70139.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000068344.

PTM databases

PhosphoSitePlusiO70139.

Proteomic databases

PaxDbiO70139.
PRIDEiO70139.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064703; ENSMUSP00000068344; ENSMUSG00000035268.
ENSMUST00000099105; ENSMUSP00000096704; ENSMUSG00000035268.
ENSMUST00000109400; ENSMUSP00000105027; ENSMUSG00000035268.
ENSMUST00000126182; ENSMUSP00000120145; ENSMUSG00000035268.
ENSMUST00000164399; ENSMUSP00000126223; ENSMUSG00000035268.
GeneIDi18769.
KEGGimmu:18769.
UCSCiuc008nth.2. mouse.

Organism-specific databases

CTDi11142.
MGIiMGI:1343086. Pkig.

Phylogenomic databases

eggNOGiENOG410J1ME. Eukaryota.
ENOG410ZDGT. LUCA.
GeneTreeiENSGT00390000002707.
HOGENOMiHOG000059641.
HOVERGENiHBG104492.
InParanoidiO70139.
OMAiEANTPDK.
OrthoDBiEOG091G13WE.
PhylomeDBiO70139.
TreeFamiTF330809.

Miscellaneous databases

ChiTaRSiPkig. mouse.
PROiO70139.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035268.
CleanExiMM_PKIG.
ExpressionAtlasiO70139. baseline and differential.
GenevisibleiO70139. MM.

Family and domain databases

InterProiIPR004171. cAMP_dep_PKI.
[Graphical view]
PfamiPF02827. PKI. 1 hit.
[Graphical view]
PIRSFiPIRSF001667. PKI. 1 hit.
ProDomiPD010366. cAMP_dep_PKI. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiIPKG_MOUSE
AccessioniPrimary (citable) accession number: O70139
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.