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Protein

cAMP-dependent protein kinase inhibitor gamma

Gene

Pkig

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.By similarity

GO - Molecular functioni

  • cAMP-dependent protein kinase inhibitor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionProtein kinase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-dependent protein kinase inhibitor gamma
Short name:
PKI-gamma
Gene namesi
Name:Pkig
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1343086. Pkig.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001545431 – 76cAMP-dependent protein kinase inhibitor gammaAdd BLAST76

Proteomic databases

PaxDbiO70139.
PRIDEiO70139.

PTM databases

PhosphoSitePlusiO70139.

Expressioni

Gene expression databases

BgeeiENSMUSG00000035268.
CleanExiMM_PKIG.
ExpressionAtlasiO70139. baseline and differential.
GenevisibleiO70139. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000068344.

Structurei

3D structure databases

SMRiO70139.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PKI family.Curated

Phylogenomic databases

eggNOGiENOG410J1ME. Eukaryota.
ENOG410ZDGT. LUCA.
GeneTreeiENSGT00390000002707.
HOGENOMiHOG000059641.
HOVERGENiHBG104492.
InParanoidiO70139.
OMAiEANTPDK.
OrthoDBiEOG091G13WE.
PhylomeDBiO70139.
TreeFamiTF330809.

Family and domain databases

InterProiView protein in InterPro
IPR004171. cAMP_dep_PKI.
PfamiView protein in Pfam
PF02827. PKI. 1 hit.
PIRSFiPIRSF001667. PKI. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010366. cAMP_dep_PKI. 1 hit.

Sequencei

Sequence statusi: Complete.

O70139-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMEVESSYSD FISCDRTGRR NAVPDIQGDS EAVSVRKLAG DMGELALEGA
60 70
EGQAEGSTPD KEASSQPESS DANTSS
Length:76
Mass (Da):7,943
Last modified:August 1, 1998 - v1
Checksum:i965F577D80C8DE59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U97170 mRNA. Translation: AAC09065.1.
BC026550 mRNA. Translation: AAH26550.1.
CCDSiCCDS17014.1.
RefSeqiNP_001034479.1. NM_001039390.2.
NP_001034480.1. NM_001039391.2.
NP_001157525.1. NM_001164053.1.
NP_001157527.1. NM_001164055.1.
NP_035236.1. NM_011106.2.
XP_006498989.1. XM_006498926.3.
XP_006498990.1. XM_006498927.1.
UniGeneiMm.10091.

Genome annotation databases

EnsembliENSMUST00000064703; ENSMUSP00000068344; ENSMUSG00000035268.
ENSMUST00000099105; ENSMUSP00000096704; ENSMUSG00000035268.
ENSMUST00000109400; ENSMUSP00000105027; ENSMUSG00000035268.
ENSMUST00000126182; ENSMUSP00000120145; ENSMUSG00000035268.
ENSMUST00000164399; ENSMUSP00000126223; ENSMUSG00000035268.
GeneIDi18769.
KEGGimmu:18769.
UCSCiuc008nth.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U97170 mRNA. Translation: AAC09065.1.
BC026550 mRNA. Translation: AAH26550.1.
CCDSiCCDS17014.1.
RefSeqiNP_001034479.1. NM_001039390.2.
NP_001034480.1. NM_001039391.2.
NP_001157525.1. NM_001164053.1.
NP_001157527.1. NM_001164055.1.
NP_035236.1. NM_011106.2.
XP_006498989.1. XM_006498926.3.
XP_006498990.1. XM_006498927.1.
UniGeneiMm.10091.

3D structure databases

SMRiO70139.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000068344.

PTM databases

PhosphoSitePlusiO70139.

Proteomic databases

PaxDbiO70139.
PRIDEiO70139.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064703; ENSMUSP00000068344; ENSMUSG00000035268.
ENSMUST00000099105; ENSMUSP00000096704; ENSMUSG00000035268.
ENSMUST00000109400; ENSMUSP00000105027; ENSMUSG00000035268.
ENSMUST00000126182; ENSMUSP00000120145; ENSMUSG00000035268.
ENSMUST00000164399; ENSMUSP00000126223; ENSMUSG00000035268.
GeneIDi18769.
KEGGimmu:18769.
UCSCiuc008nth.2. mouse.

Organism-specific databases

CTDi11142.
MGIiMGI:1343086. Pkig.

Phylogenomic databases

eggNOGiENOG410J1ME. Eukaryota.
ENOG410ZDGT. LUCA.
GeneTreeiENSGT00390000002707.
HOGENOMiHOG000059641.
HOVERGENiHBG104492.
InParanoidiO70139.
OMAiEANTPDK.
OrthoDBiEOG091G13WE.
PhylomeDBiO70139.
TreeFamiTF330809.

Miscellaneous databases

ChiTaRSiPkig. mouse.
PROiPR:O70139.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035268.
CleanExiMM_PKIG.
ExpressionAtlasiO70139. baseline and differential.
GenevisibleiO70139. MM.

Family and domain databases

InterProiView protein in InterPro
IPR004171. cAMP_dep_PKI.
PfamiView protein in Pfam
PF02827. PKI. 1 hit.
PIRSFiPIRSF001667. PKI. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010366. cAMP_dep_PKI. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIPKG_MOUSE
AccessioniPrimary (citable) accession number: O70139
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: May 10, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.