Reviewed, UniProtKB/Swiss-Prot O70137 (ALX3_MOUSE)

Names and origin

Protein names

Recommended name:
    Homeobox protein aristaless-like 3
Alternative name(s):
    Proline-rich transcription factor ALX3

Gene names

Name:

Alx3

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Transcriptional regulator with a possible role in patterning of mesoderm during development.
Subcellular location	Nucleus By similarity.
Tissue specificity	Predominantly in neural crest-derived mesenchyme and in lateral plate mesoderm. Prominent expression in frontonasal head mesenchyme and in the first and second pharyngeal arches and some of their derivatives. High expression is also seen in the tail and in many derivatives of the lateral plate mesoderm including the limbs, the body wall, and the genital tubercle.
Developmental stage	Expressed in embryos from 8 days of gestation onward.
Sequence similarities	Belongs to the paired homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	embryonic forelimb morphogenesis Inferred from genetic interaction. Source: MGI embryonic hindlimb morphogenesis Inferred from genetic interaction. Source: MGI embryonic skeletal system morphogenesis Inferred from genetic interaction. Source: MGI pattern specification process Inferred from genetic interaction. Source: MGI regulation of apoptosis Inferred from genetic interaction. Source: MGI regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	Homeobox protein aristaless-like 3		PRO_0000048813
Regions
	DNA binding	153 – 212	60	Homeobox

Sequences

	Sequence		Length	Mass (Da)
	O70137-1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 87900BF977FACD2D	FASTA	343	36,851
	10 20 30 40 50 60 MDPERCAPFS VGPAAGPYAA AGDEAPGPQG TPDAAPHLHP APPRGPRLSR FPACGPLEPY 70 80 90 100 110 120 LPEPAKPPAK YLQDLGPGPV LNGGHFYEGS AEAEEKASKA ASFPQLPVDC RGGPRDGPSN 130 140 150 160 170 180 VQASPGPCLA SLSVPLSPGL PDSMELAKTK SKKRRNRTTF STFQLEELEK VFQKTHYPDV 190 200 210 220 230 240 YAREQLALRT DLTEARVQVW FQNRRAKWRK RERYGKMQEG RNPFTTAYDI SVLPRTDSHP 250 260 270 280 290 300 QLQNSLWPSP GSGSPGGPCL MSPEGIPSPC MSPYSHSHGN VAGFMGVPAS PAAHPGIYSI 310 320 330 340 HGFPPALGGH SFEPSPDGDY KSPSLVSLRM KPKEPPGLLN WTT

References

[1]	"Mouse Alx3: an aristaless-like homeobox gene expressed during embryogenesis in ectomesenchyme and lateral plate mesoderm." ten Berge D., Brouwer A., el Bahi S., Guenet J.-L., Robert B., Meijlink F. Dev. Biol. 199:11-25(1998) [PubMed: 9676189] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: NIH Swiss.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U96109 mRNA. Translation: AAC15094.1.
IPI	IPI00115634.
RefSeq	NP_031467.1.
UniGene	Mm.10112
3D structure databases
SMR	O70137. Positions 152-211.
ModBase	Search...
Protein-protein interaction databases
STRING	O70137.
Proteomic databases
PRIDE	O70137.
Genome annotation databases
Ensembl	ENSMUST00000014747; ENSMUSP00000014747; ENSMUSG00000014603; Mus musculus. [Genome view]
GeneID	11694.
KEGG	mmu:11694.
UCSC	uc008qxf.1. mouse.
Organism-specific databases
CTD	11694.
MGI	MGI:1277097. Alx3.
Phylogenomic databases
eggNOG	roNOG05132.
HOGENOM	HBG126173.
HOVERGEN	O70137.
InParanoid	O70137.
OMA	PRDGPSN.
OrthoDB	EOG9K0T70.
PhylomeDB	O70137.
Gene expression databases
ArrayExpress	O70137.
Bgee	O70137.
CleanEx	MM_ALX3.
Genevestigator	O70137.
GermOnline	ENSMUSG00000014603. Mus musculus.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	279353.
SOURCE	Search...

Entry information

Entry name

ALX3_MOUSE

Accession

Primary (citable) accession number: O70137

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	August 1, 1998
Last modified:	January 19, 2010
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)