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Protein

Homeobox protein aristaless-like 3

Gene

Alx3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional regulator with a possible role in patterning of mesoderm during development.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi153 – 212HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • embryonic cranial skeleton morphogenesis Source: InterPro
  • embryonic forelimb morphogenesis Source: MGI
  • embryonic hindlimb morphogenesis Source: MGI
  • embryonic skeletal system morphogenesis Source: MGI
  • pattern specification process Source: MGI
  • regulation of apoptotic process Source: MGI
  • regulation of transcription, DNA-templated Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein aristaless-like 3
Alternative name(s):
Proline-rich transcription factor ALX3
Gene namesi
Name:Alx3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1277097. Alx3.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488131 – 343Homeobox protein aristaless-like 3Add BLAST343

Proteomic databases

PaxDbiO70137.
PRIDEiO70137.

PTM databases

PhosphoSitePlusiO70137.

Expressioni

Tissue specificityi

Predominantly in neural crest-derived mesenchyme and in lateral plate mesoderm. Prominent expression in frontonasal head mesenchyme and in the first and second pharyngeal arches and some of their derivatives. High expression is also seen in the tail and in many derivatives of the lateral plate mesoderm including the limbs, the body wall, and the genital tubercle.

Developmental stagei

Expressed in embryos from 8 days of gestation onward.

Gene expression databases

BgeeiENSMUSG00000014603.
CleanExiMM_ALX3.
ExpressionAtlasiO70137. baseline and differential.
GenevisibleiO70137. MM.

Interactioni

Protein-protein interaction databases

BioGridi198080. 1 interactor.
STRINGi10090.ENSMUSP00000014747.

Structurei

3D structure databases

ProteinModelPortaliO70137.
SMRiO70137.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the paired homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
GeneTreeiENSGT00760000118958.
HOGENOMiHOG000231518.
HOVERGENiHBG004213.
InParanoidiO70137.
KOiK09323.
OMAiSIHGFPP.
OrthoDBiEOG09040G1Y.
PhylomeDBiO70137.
TreeFamiTF350743.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiView protein in InterPro
IPR033211. ALX3.
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
PANTHERiPTHR24329:SF471. PTHR24329:SF471. 1 hit.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O70137-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPERCAPFS VGPAAGPYAA AGDEAPGPQG TPDAAPHLHP APPRGPRLSR
60 70 80 90 100
FPACGPLEPY LPEPAKPPAK YLQDLGPGPV LNGGHFYEGS AEAEEKASKA
110 120 130 140 150
ASFPQLPVDC RGGPRDGPSN VQASPGPCLA SLSVPLSPGL PDSMELAKTK
160 170 180 190 200
SKKRRNRTTF STFQLEELEK VFQKTHYPDV YAREQLALRT DLTEARVQVW
210 220 230 240 250
FQNRRAKWRK RERYGKMQEG RNPFTTAYDI SVLPRTDSHP QLQNSLWPSP
260 270 280 290 300
GSGSPGGPCL MSPEGIPSPC MSPYSHSHGN VAGFMGVPAS PAAHPGIYSI
310 320 330 340
HGFPPALGGH SFEPSPDGDY KSPSLVSLRM KPKEPPGLLN WTT
Length:343
Mass (Da):36,851
Last modified:August 1, 1998 - v1
Checksum:i87900BF977FACD2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96109 mRNA. Translation: AAC15094.1.
CCDSiCCDS17739.1.
RefSeqiNP_031467.1. NM_007441.3.
UniGeneiMm.10112.

Genome annotation databases

EnsembliENSMUST00000014747; ENSMUSP00000014747; ENSMUSG00000014603.
GeneIDi11694.
KEGGimmu:11694.
UCSCiuc008qxf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96109 mRNA. Translation: AAC15094.1.
CCDSiCCDS17739.1.
RefSeqiNP_031467.1. NM_007441.3.
UniGeneiMm.10112.

3D structure databases

ProteinModelPortaliO70137.
SMRiO70137.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198080. 1 interactor.
STRINGi10090.ENSMUSP00000014747.

PTM databases

PhosphoSitePlusiO70137.

Proteomic databases

PaxDbiO70137.
PRIDEiO70137.

Protocols and materials databases

DNASUi11694.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000014747; ENSMUSP00000014747; ENSMUSG00000014603.
GeneIDi11694.
KEGGimmu:11694.
UCSCiuc008qxf.2. mouse.

Organism-specific databases

CTDi257.
MGIiMGI:1277097. Alx3.

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
GeneTreeiENSGT00760000118958.
HOGENOMiHOG000231518.
HOVERGENiHBG004213.
InParanoidiO70137.
KOiK09323.
OMAiSIHGFPP.
OrthoDBiEOG09040G1Y.
PhylomeDBiO70137.
TreeFamiTF350743.

Miscellaneous databases

PROiO70137.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000014603.
CleanExiMM_ALX3.
ExpressionAtlasiO70137. baseline and differential.
GenevisibleiO70137. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiView protein in InterPro
IPR033211. ALX3.
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
PANTHERiPTHR24329:SF471. PTHR24329:SF471. 1 hit.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiALX3_MOUSE
AccessioniPrimary (citable) accession number: O70137
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 1, 1998
Last modified: February 15, 2017
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.