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Protein

Protein FEV

Gene

Fev

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Functions as a transcriptional regulator. May function as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi47 – 127ETSPROSITE-ProRule annotationAdd BLAST81

GO - Molecular functioni

  • DNA binding transcription factor activity Source: RGD
  • double-stranded DNA binding Source: RGD
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
  • transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FEV
Alternative name(s):
PC12 ETS domain-containing transcription factor 1
Short name:
PC12 ETS factor 1
Short name:
Pet-1
Gene namesi
Name:Fev
Synonyms:Pet1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628860 Fev

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003442061 – 237Protein FEVAdd BLAST237

Proteomic databases

PaxDbiO70132

PTM databases

PhosphoSitePlusiO70132

Expressioni

Tissue specificityi

Specifically expressed in central serotonergic neurons. Also expressed in adrenal gland and to a lower extent in small intestine and eye.2 Publications

Developmental stagei

Earliest expression is detected at E12.5 in the developing brain in regions corresponding to the future rostral and caudal serotonergic neuron clusters.1 Publication

Gene expression databases

GenevisibleiO70132 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024190

Structurei

3D structure databases

ProteinModelPortaliO70132
SMRiO70132
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni129 – 237May mediate active transcriptional repressionBy similarityAdd BLAST109

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi132 – 209Ala-richAdd BLAST78

Sequence similaritiesi

Belongs to the ETS family.Curated

Phylogenomic databases

eggNOGiKOG3806 Eukaryota
ENOG410Z0ZF LUCA
HOGENOMiHOG000234879
HOVERGENiHBG095796
InParanoidiO70132
KOiK09437
OrthoDBiEOG091G0HJF
PhylomeDBiO70132
TreeFamiTF316214

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit

Sequencei

Sequence statusi: Complete.

O70132-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQSGTSQPL LINMYLPDPV GDGLFKEGKS PSWGPLSPAV QKGSGQIQLW
60 70 80 90 100
QFLLELLADR ANAGCIAWEG GHGEFKLTDP DEVARRWGER KSKPNMNYDK
110 120 130 140 150
LSRALRYYYD KNIMSKVHGK RYAYRFDFQG LAQACQPPPA HAHAAAAAAA
160 170 180 190 200
AAAAAQDGAL YKLPAGLAPL PFPGLSKLNL MAASAGVAPA GFSYWPGPNA
210 220 230
TAAAAATAAL YPTPGLQPPP GPFGAVAAAS HLGGHYH
Length:237
Mass (Da):24,991
Last modified:July 22, 2008 - v2
Checksum:iE82F76640038BA3A
GO

Sequence cautioni

The sequence AAC12859 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91679 mRNA Translation: AAC12859.1 Sequence problems.
RefSeqiNP_653354.2, NM_144753.2
UniGeneiRn.83616

Genome annotation databases

GeneIDi246271
KEGGirno:246271
UCSCiRGD:628860 rat

Similar proteinsi

Entry informationi

Entry nameiFEV_RAT
AccessioniPrimary (citable) accession number: O70132
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: May 23, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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