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Protein

Protein FEV

Gene

Fev

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Functions as a transcriptional regulator. May function as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi47 – 127ETSPROSITE-ProRule annotationAdd BLAST81

GO - Molecular functioni

  • double-stranded DNA binding Source: RGD
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: NTNU_SB
  • transcription factor activity, sequence-specific DNA binding Source: RGD

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FEV
Alternative name(s):
PC12 ETS domain-containing transcription factor 1
Short name:
PC12 ETS factor 1
Short name:
Pet-1
Gene namesi
Name:Fev
Synonyms:Pet1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628860. Fev.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003442061 – 237Protein FEVAdd BLAST237

Proteomic databases

PaxDbiO70132.

PTM databases

PhosphoSitePlusiO70132.

Expressioni

Tissue specificityi

Specifically expressed in central serotonergic neurons. Also expressed in adrenal gland and to a lower extent in small intestine and eye.2 Publications

Developmental stagei

Earliest expression is detected at E12.5 in the developing brain in regions corresponding to the future rostral and caudal serotonergic neuron clusters.1 Publication

Gene expression databases

GenevisibleiO70132. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024190.

Structurei

3D structure databases

ProteinModelPortaliO70132.
SMRiO70132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni129 – 237May mediate active transcriptional repressionBy similarityAdd BLAST109

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi132 – 209Ala-richAdd BLAST78

Sequence similaritiesi

Belongs to the ETS family.Curated

Phylogenomic databases

eggNOGiKOG3806. Eukaryota.
ENOG410Z0ZF. LUCA.
HOGENOMiHOG000234879.
HOVERGENiHBG095796.
InParanoidiO70132.
KOiK09437.
OrthoDBiEOG091G0HJF.
PhylomeDBiO70132.
TreeFamiTF316214.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR000418. Ets_dom.
IPR036388. WH-like_DNA-bd_sf.
IPR036390. WH_DNA-bd_sf.
PfamiView protein in Pfam
PF00178. Ets. 1 hit.
PRINTSiPR00454. ETSDOMAIN.
SMARTiView protein in SMART
SM00413. ETS. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.

Sequencei

Sequence statusi: Complete.

O70132-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQSGTSQPL LINMYLPDPV GDGLFKEGKS PSWGPLSPAV QKGSGQIQLW
60 70 80 90 100
QFLLELLADR ANAGCIAWEG GHGEFKLTDP DEVARRWGER KSKPNMNYDK
110 120 130 140 150
LSRALRYYYD KNIMSKVHGK RYAYRFDFQG LAQACQPPPA HAHAAAAAAA
160 170 180 190 200
AAAAAQDGAL YKLPAGLAPL PFPGLSKLNL MAASAGVAPA GFSYWPGPNA
210 220 230
TAAAAATAAL YPTPGLQPPP GPFGAVAAAS HLGGHYH
Length:237
Mass (Da):24,991
Last modified:July 22, 2008 - v2
Checksum:iE82F76640038BA3A
GO

Sequence cautioni

The sequence AAC12859 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91679 mRNA. Translation: AAC12859.1. Sequence problems.
RefSeqiNP_653354.2. NM_144753.2.
UniGeneiRn.83616.

Genome annotation databases

GeneIDi246271.
KEGGirno:246271.
UCSCiRGD:628860. rat.

Similar proteinsi

Entry informationi

Entry nameiFEV_RAT
AccessioniPrimary (citable) accession number: O70132
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: November 22, 2017
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families