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Protein

C5a anaphylatoxin chemotactic receptor 1

Gene

C5AR1

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:9576615). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (By similarity). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
C5a anaphylatoxin chemotactic receptor 1
Alternative name(s):
C5a anaphylatoxin chemotactic receptor
Short name:
C5a-R
Short name:
C5aR
CD_antigen: CD88
Gene namesi
Name:C5AR1
Synonyms:C5R1
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32ExtracellularSequence analysisAdd BLAST32
Transmembranei33 – 55Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini56 – 66CytoplasmicSequence analysisAdd BLAST11
Transmembranei67 – 89Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini90 – 105ExtracellularSequence analysisAdd BLAST16
Transmembranei106 – 127Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini128 – 148CytoplasmicSequence analysisAdd BLAST21
Transmembranei149 – 169Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini170 – 195ExtracellularSequence analysisAdd BLAST26
Transmembranei196 – 221Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini222 – 237CytoplasmicSequence analysisAdd BLAST16
Transmembranei238 – 260Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini261 – 277ExtracellularSequence analysisAdd BLAST17
Transmembranei278 – 298Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini299 – 345CytoplasmicSequence analysisAdd BLAST47

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2861

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692071 – 345C5a anaphylatoxin chemotactic receptor 1Add BLAST345

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9SulfotyrosineBy similarity1
Modified residuei11SulfotyrosineBy similarity1
Glycosylationi12N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi104 ↔ 183PROSITE-ProRule annotation
Modified residuei309PhosphoserineBy similarity1
Modified residuei312PhosphoserineBy similarity1
Modified residuei322PhosphoserineBy similarity1
Modified residuei329PhosphoserineBy similarity1
Modified residuei333PhosphoserineBy similarity1

Post-translational modificationi

Sulfation plays a critical role in the association of C5aR with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small peptide agonist.By similarity
Phosphorylated on serine residues in response to C5a binding, resulting in internalization of the receptor and short-term desensitization to C5a.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation

Expressioni

Tissue specificityi

Expressed strongly in macrophages and spleen. Weak expression detected in lung, liver, brain, heart and kidney.1 Publication

Interactioni

Subunit structurei

Homodimer. May also form higher-order oligomers. Interacts (when phosphorylated) with ARRB1 and ARRB2; the interaction is associated with internalization of C5aR.By similarity

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000020216

Structurei

3D structure databases

ProteinModelPortaliO70129
SMRiO70129
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF0K Eukaryota
ENOG410Y9HH LUCA
HOGENOMiHOG000234122
HOVERGENiHBG107547
InParanoidiO70129

Family and domain databases

InterProiView protein in InterPro
IPR001274 Anaphtx_C5AR1/C5AR2
IPR002234 Anphylx_rcpt
IPR000826 Formyl_rcpt-rel
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24225 PTHR24225, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01104 ANPHYLATOXNR
PR00426 C5ANPHYLTXNR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O70129-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMVTVSYDYD YNSTFLPDGF VDNYVERLSF GDLVAVVIMV VVFLVGVPGN
60 70 80 90 100
ALVVWVTACE ARRHINAIWF LNLAAADLLS CLALPILLVS TVHLNHWYFG
110 120 130 140 150
DTACKVLPSL ILLNMYTSIL LLATISADRL LLVLSPIWCQ RFRGGCLAWT
160 170 180 190 200
ACGLAWVLAL LLSSPSFLYR RTHNEHFSFK VYCVTDYGRD ISKERAVALV
210 220 230 240 250
RLLVGFIVPL ITLTACYTFL LLRTWSRKAT RSAKTVKVVV AVVSSFFVFW
260 270 280 290 300
LPYQVTGILL AWHSPNSATY RNTKALDAVC VAFAYINCCI NPIIYVVAGH
310 320 330 340
GFQGRLLKSL PSVLRNVLTE ESLDKRHQSF ARSTVDTMPQ KSESV
Length:345
Mass (Da):38,592
Last modified:August 1, 1998 - v1
Checksum:iBE40459F1450404A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U86103 mRNA Translation: AAC40074.1
RefSeqiNP_001166393.1, NM_001172922.1

Genome annotation databases

GeneIDi100135489

Similar proteinsi

Entry informationi

Entry nameiC5AR1_CAVPO
AccessioniPrimary (citable) accession number: O70129
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: April 25, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health