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Protein

Bile salt export pump

Gene

Abcb11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi455 – 462ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1113 – 1120ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • canalicular bile acid transport Source: RGD
  • drug export Source: RGD
  • response to drug Source: RGD
  • response to estrogen Source: RGD
  • response to oxidative stress Source: RGD
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Chemistry databases

SwissLipidsiSLP:000001598.

Names & Taxonomyi

Protein namesi
Recommended name:
Bile salt export pump
Alternative name(s):
ATP-binding cassette sub-family B member 11
Sister of P-glycoprotein
Gene namesi
Name:Abcb11
Synonyms:Bsep, Spgp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619930. Abcb11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 62CytoplasmicSequence analysisAdd BLAST62
Transmembranei63 – 83HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini84 – 147ExtracellularSequence analysisAdd BLAST64
Transmembranei148 – 168HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini169 – 215CytoplasmicSequence analysisAdd BLAST47
Transmembranei216 – 236HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini237 – 240ExtracellularSequence analysis4
Transmembranei241 – 261HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini262 – 319CytoplasmicSequence analysisAdd BLAST58
Transmembranei320 – 340HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini341 – 353ExtracellularSequence analysisAdd BLAST13
Transmembranei354 – 374HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini375 – 755CytoplasmicSequence analysisAdd BLAST381
Transmembranei756 – 776HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini777 – 794ExtracellularSequence analysisAdd BLAST18
Transmembranei795 – 815HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini816 – 869CytoplasmicSequence analysisAdd BLAST54
Transmembranei870 – 890HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei891 – 911HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini912 – 979CytoplasmicSequence analysisAdd BLAST68
Transmembranei980 – 1000HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini1001 – 1011ExtracellularSequence analysisAdd BLAST11
Transmembranei1012 – 1032HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini1033 – 1321CytoplasmicSequence analysisAdd BLAST289

GO - Cellular componenti

  • apical plasma membrane Source: RGD
  • Golgi apparatus Source: RGD
  • Golgi membrane Source: RGD
  • integral component of membrane Source: GO_Central
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2073674.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000932991 – 1321Bile salt export pumpAdd BLAST1321

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi109N-linked (GlcNAc...)Sequence analysis1
Glycosylationi116N-linked (GlcNAc...)Sequence analysis1
Glycosylationi122N-linked (GlcNAc...)Sequence analysis1
Glycosylationi125N-linked (GlcNAc...)Sequence analysis1
Modified residuei586PhosphothreonineBy similarity1
Modified residuei587PhosphoserineBy similarity1
Modified residuei692PhosphoserineBy similarity1
Modified residuei703PhosphoserineCombined sources1
Modified residuei706PhosphoserineCombined sources1
Modified residuei1321PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO70127.
PRIDEiO70127.

PTM databases

iPTMnetiO70127.
PhosphoSitePlusiO70127.

Expressioni

Tissue specificityi

Expressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ.

Interactioni

Subunit structurei

Interacts with HAX1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Hax1Q7TSE95EBI-930036,EBI-930005

Protein-protein interaction databases

BioGridi249756. 1 interactor.
IntActiO70127. 2 interactors.
STRINGi10116.ENSRNOP00000064279.

Chemistry databases

BindingDBiO70127.

Structurei

3D structure databases

ProteinModelPortaliO70127.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 385ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST324
Domaini420 – 656ABC transporter 1PROSITE-ProRule annotationAdd BLAST237
Domaini755 – 1043ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST289
Domaini1078 – 1316ABC transporter 2PROSITE-ProRule annotationAdd BLAST239

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni651 – 674Interaction with HAX11 PublicationAdd BLAST24

Domaini

Multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain.

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0055. Eukaryota.
COG1132. LUCA.
HOVERGENiHBG080809.
InParanoidiO70127.
KOiK05664.
PhylomeDBiO70127.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030278. BSEP.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24221:SF165. PTHR24221:SF165. 1 hit.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 3 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70127-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDSVILRSV KKFGEENHAF ESDGSHNNDK KSRLQDKMKE GDIRVGFFEL
60 70 80 90 100
FRFSSSKDIW LMLMGGVCAL LHGMAQPGIL IIFGIMTDIF IKYDIERQEL
110 120 130 140 150
EIPGKACVNN TIVWINSSFH QNMTNGTVCG LVDIESEMIK FSGIYAGVGM
160 170 180 190 200
TVLILGYFQI RLWVITGARQ IRRMRKIYFR RIMRMEIGWF DCTSVGELNS
210 220 230 240 250
RFADDIEKIN DAIADQLAHF LQRMSTAMCG LLLGFYRGWK LTLVILAVSP
260 270 280 290 300
LIGIGAAVIG LSIAKFTELE LKAYAKAGSI ADEVLSSIRT VAAFGGENKE
310 320 330 340 350
VERYEKNLVF AQRWGIWKGM VMGFFTGYMW CLIFFCYALA FWYGSTLVLD
360 370 380 390 400
EEEYTPGTLV QIFLCVILAA MNIGHASSCL EIFSTGCSAA TNIFQTIDRQ
410 420 430 440 450
PVIDCMSGDG YKLDRIKGEI EFHNVTFHYP SRPDVKILDN LSMVIKPGET
460 470 480 490 500
TALVGSSGAG KSTALQLIQR FYDPCEGMVT LDGHDIRSLN IRWLRDQIGI
510 520 530 540 550
VEQEPVLFST TIAENIRFGR EDATMEDIVQ AAKDANAYNF IMALPQQFDT
560 570 580 590 600
LVGEGGGQMS GGQKQRVAIA RALIRNPKIL LLDMATSALD NESEARVQEA
610 620 630 640 650
LNKIQHGHTI ISVAHRLSTV RAADVIIGFE HGVAVERGTH EELLERKGVY
660 670 680 690 700
FMLVTLQSQG DNAHKETSIM GKDATEGGTL ERTFSRGSYR DSLRASIRQR
710 720 730 740 750
SKSQLSLLTH DPPLAVADHK SSYKDSKDND VLVEEVEPAP VRRILKYNIP
760 770 780 790 800
EWHYILVGSL SAAINGAVTP IYSLLFSQLL GTFSLLDKEQ QRSEIHSMCL
810 820 830 840 850
FFVILGCVSI FTQFLQGYTF AKSGELLTKR LRKFGFKAML GQDIGWFDDL
860 870 880 890 900
RNNPGVLTTR LATDASQVQG ATGSQVGMMV NSFTNIIAAL LIAFFFSWKL
910 920 930 940 950
SLIITIFFPF LALSGAVQTK MLTGFASQDK QALEKAGQIT SEALSNIRTV
960 970 980 990 1000
AGIGVEGRFI KAFEVELQTS YKTAVRKANI YGLCFAFSQG IAFLANSAAY
1010 1020 1030 1040 1050
RYGGYLIAYE GLGFSHVFRV VSSVALSATA VGRTFSYTPS YAKAKISAAR
1060 1070 1080 1090 1100
FFQLLDRKPP INVYSEAGEK WDNFQGKIDF IDCKFTYPSR PDIQVLNGLS
1110 1120 1130 1140 1150
VSVNPGQTLA FVGSSGCGKS TSIQLLERFY DPDQGTVMID GHDSKKVNIQ
1160 1170 1180 1190 1200
FLRSNIGIVS QEPVLFDCSI MDNIKYGDNT KEISVERAIA AAKQAQLHDF
1210 1220 1230 1240 1250
VMSLPEKYET NVGIQGSQLS RGEKQRIAIA RAIVRDPKIL LLDEATSALD
1260 1270 1280 1290 1300
TESEKTVQTA LDKAREGRTC IVIAHRLSTI QNSDIIAVVS QGVVIEKGTH
1310 1320
EKLMAQKGAY YKLVITGAPI S
Length:1,321
Mass (Da):146,258
Last modified:August 1, 1998 - v1
Checksum:i5443F4EF7B9FB1F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69487 mRNA. Translation: AAC40084.1.
PIRiT42842.
RefSeqiNP_113948.1. NM_031760.1.
UniGeneiRn.14539.

Genome annotation databases

GeneIDi83569.
KEGGirno:83569.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69487 mRNA. Translation: AAC40084.1.
PIRiT42842.
RefSeqiNP_113948.1. NM_031760.1.
UniGeneiRn.14539.

3D structure databases

ProteinModelPortaliO70127.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249756. 1 interactor.
IntActiO70127. 2 interactors.
STRINGi10116.ENSRNOP00000064279.

Chemistry databases

BindingDBiO70127.
ChEMBLiCHEMBL2073674.
SwissLipidsiSLP:000001598.

PTM databases

iPTMnetiO70127.
PhosphoSitePlusiO70127.

Proteomic databases

PaxDbiO70127.
PRIDEiO70127.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi83569.
KEGGirno:83569.

Organism-specific databases

CTDi8647.
RGDi619930. Abcb11.

Phylogenomic databases

eggNOGiKOG0055. Eukaryota.
COG1132. LUCA.
HOVERGENiHBG080809.
InParanoidiO70127.
KOiK05664.
PhylomeDBiO70127.

Miscellaneous databases

PROiO70127.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030278. BSEP.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24221:SF165. PTHR24221:SF165. 1 hit.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 3 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiABCBB_RAT
AccessioniPrimary (citable) accession number: O70127
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.