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O70127

- ABCBB_RAT

UniProt

O70127 - ABCBB_RAT

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Protein

Bile salt export pump

Gene

Abcb11

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi455 – 4628ATP 1PROSITE-ProRule annotation
Nucleotide bindingi1113 – 11208ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. ATPase activity, coupled to transmembrane movement of substances Source: RefGenome
  2. ATP binding Source: UniProtKB-KW
  3. canalicular bile acid transmembrane transporter activity Source: RGD
  4. drug transmembrane transporter activity Source: RGD

GO - Biological processi

  1. canalicular bile acid transport Source: RGD
  2. drug export Source: RGD
  3. drug transmembrane transport Source: GOC
  4. response to drug Source: RGD
  5. response to estrogen Source: RGD
  6. response to oxidative stress Source: RGD
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Bile salt export pump
Alternative name(s):
ATP-binding cassette sub-family B member 11
Sister of P-glycoprotein
Gene namesi
Name:Abcb11
Synonyms:Bsep, Spgp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi619930. Abcb11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6262CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei63 – 8321HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini84 – 14764ExtracellularSequence AnalysisAdd
BLAST
Transmembranei148 – 16821HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini169 – 21547CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei216 – 23621HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini237 – 2404ExtracellularSequence Analysis
Transmembranei241 – 26121HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini262 – 31958CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei320 – 34021HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini341 – 35313ExtracellularSequence AnalysisAdd
BLAST
Transmembranei354 – 37421HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini375 – 755381CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei756 – 77621HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini777 – 79418ExtracellularSequence AnalysisAdd
BLAST
Transmembranei795 – 81521HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini816 – 86954CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei870 – 89021HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei891 – 91121HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini912 – 97968CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei980 – 100021HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini1001 – 101111ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1012 – 103221HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini1033 – 1321289CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: RGD
  2. Golgi apparatus Source: RGD
  3. Golgi membrane Source: RGD
  4. integral component of membrane Source: RefGenome
  5. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13211321Bile salt export pumpPRO_0000093299Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence Analysis
Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi122 – 1221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence Analysis
Modified residuei692 – 6921PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiO70127.

PTM databases

PhosphoSiteiO70127.

Expressioni

Tissue specificityi

Expressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ.

Gene expression databases

GenevestigatoriO70127.

Interactioni

Subunit structurei

Interacts with HAX1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Hax1Q7TSE95EBI-930036,EBI-930005

Protein-protein interaction databases

BioGridi249756. 1 interaction.
IntActiO70127. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliO70127.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini62 – 385324ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini420 – 656237ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini755 – 1043289ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini1078 – 1316239ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni651 – 67424Interaction with HAX1Add
BLAST

Domaini

Multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain.

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG080809.
InParanoidiO70127.
KOiK05664.
PhylomeDBiO70127.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 3 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70127-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDSVILRSV KKFGEENHAF ESDGSHNNDK KSRLQDKMKE GDIRVGFFEL
60 70 80 90 100
FRFSSSKDIW LMLMGGVCAL LHGMAQPGIL IIFGIMTDIF IKYDIERQEL
110 120 130 140 150
EIPGKACVNN TIVWINSSFH QNMTNGTVCG LVDIESEMIK FSGIYAGVGM
160 170 180 190 200
TVLILGYFQI RLWVITGARQ IRRMRKIYFR RIMRMEIGWF DCTSVGELNS
210 220 230 240 250
RFADDIEKIN DAIADQLAHF LQRMSTAMCG LLLGFYRGWK LTLVILAVSP
260 270 280 290 300
LIGIGAAVIG LSIAKFTELE LKAYAKAGSI ADEVLSSIRT VAAFGGENKE
310 320 330 340 350
VERYEKNLVF AQRWGIWKGM VMGFFTGYMW CLIFFCYALA FWYGSTLVLD
360 370 380 390 400
EEEYTPGTLV QIFLCVILAA MNIGHASSCL EIFSTGCSAA TNIFQTIDRQ
410 420 430 440 450
PVIDCMSGDG YKLDRIKGEI EFHNVTFHYP SRPDVKILDN LSMVIKPGET
460 470 480 490 500
TALVGSSGAG KSTALQLIQR FYDPCEGMVT LDGHDIRSLN IRWLRDQIGI
510 520 530 540 550
VEQEPVLFST TIAENIRFGR EDATMEDIVQ AAKDANAYNF IMALPQQFDT
560 570 580 590 600
LVGEGGGQMS GGQKQRVAIA RALIRNPKIL LLDMATSALD NESEARVQEA
610 620 630 640 650
LNKIQHGHTI ISVAHRLSTV RAADVIIGFE HGVAVERGTH EELLERKGVY
660 670 680 690 700
FMLVTLQSQG DNAHKETSIM GKDATEGGTL ERTFSRGSYR DSLRASIRQR
710 720 730 740 750
SKSQLSLLTH DPPLAVADHK SSYKDSKDND VLVEEVEPAP VRRILKYNIP
760 770 780 790 800
EWHYILVGSL SAAINGAVTP IYSLLFSQLL GTFSLLDKEQ QRSEIHSMCL
810 820 830 840 850
FFVILGCVSI FTQFLQGYTF AKSGELLTKR LRKFGFKAML GQDIGWFDDL
860 870 880 890 900
RNNPGVLTTR LATDASQVQG ATGSQVGMMV NSFTNIIAAL LIAFFFSWKL
910 920 930 940 950
SLIITIFFPF LALSGAVQTK MLTGFASQDK QALEKAGQIT SEALSNIRTV
960 970 980 990 1000
AGIGVEGRFI KAFEVELQTS YKTAVRKANI YGLCFAFSQG IAFLANSAAY
1010 1020 1030 1040 1050
RYGGYLIAYE GLGFSHVFRV VSSVALSATA VGRTFSYTPS YAKAKISAAR
1060 1070 1080 1090 1100
FFQLLDRKPP INVYSEAGEK WDNFQGKIDF IDCKFTYPSR PDIQVLNGLS
1110 1120 1130 1140 1150
VSVNPGQTLA FVGSSGCGKS TSIQLLERFY DPDQGTVMID GHDSKKVNIQ
1160 1170 1180 1190 1200
FLRSNIGIVS QEPVLFDCSI MDNIKYGDNT KEISVERAIA AAKQAQLHDF
1210 1220 1230 1240 1250
VMSLPEKYET NVGIQGSQLS RGEKQRIAIA RAIVRDPKIL LLDEATSALD
1260 1270 1280 1290 1300
TESEKTVQTA LDKAREGRTC IVIAHRLSTI QNSDIIAVVS QGVVIEKGTH
1310 1320
EKLMAQKGAY YKLVITGAPI S
Length:1,321
Mass (Da):146,258
Last modified:August 1, 1998 - v1
Checksum:i5443F4EF7B9FB1F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69487 mRNA. Translation: AAC40084.1.
PIRiT42842.
RefSeqiNP_113948.1. NM_031760.1.
UniGeneiRn.14539.

Genome annotation databases

GeneIDi83569.
KEGGirno:83569.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69487 mRNA. Translation: AAC40084.1 .
PIRi T42842.
RefSeqi NP_113948.1. NM_031760.1.
UniGenei Rn.14539.

3D structure databases

ProteinModelPortali O70127.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 249756. 1 interaction.
IntActi O70127. 2 interactions.

Chemistry

BindingDBi O70127.
ChEMBLi CHEMBL2073674.

PTM databases

PhosphoSitei O70127.

Proteomic databases

PRIDEi O70127.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 83569.
KEGGi rno:83569.

Organism-specific databases

CTDi 8647.
RGDi 619930. Abcb11.

Phylogenomic databases

HOVERGENi HBG080809.
InParanoidi O70127.
KOi K05664.
PhylomeDBi O70127.

Miscellaneous databases

NextBioi 616061.
PROi O70127.

Gene expression databases

Genevestigatori O70127.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 3 hits.
PROSITEi PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver."
    Gerloff T., Stieger B., Hagenbuch B., Madon J., Landmann L., Roth J., Hofmann A.F., Meier P.J.
    J. Biol. Chem. 273:10046-10050(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.
  2. "Identification of HAX-1 as a protein that binds bile salt export protein and regulates its abundance in the apical membrane of Madin-Darby canine kidney cells."
    Ortiz D.F., Moseley J., Calderon G., Swift A.L., Li S., Arias I.M.
    J. Biol. Chem. 279:32761-32770(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HAX1.

Entry informationi

Entry nameiABCBB_RAT
AccessioniPrimary (citable) accession number: O70127
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3