Bile salt export pump - Rattus norvegicus (Rat)

Contribute

Send feedback

Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot O70127 (ABCBB_RAT)

Last modified October 13, 2009. Version 78. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data |

Customize display

text xml rdf/xml gff fasta

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein names

Recommended name:
    Bile salt export pump
Alternative name(s):
    ATP-binding cassette sub-family B member 11
    Sister of P-glycoprotein

Gene names

Name:	Abcb11
Synonyms:	Bsep, Spgp

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Hide | Top

Protein attributes

Sequence length	1321 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

Hide | Top

General annotation (Comments)

Function	Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Expressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ.
Domain	Multifunctional polypeptide with two homologous halves, each containing an hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain.
Sequence similarities	Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. [View classification] Contains 2 ABC transmembrane type-1 domains. Contains 2 ABC transporter domains.

Hide | Top

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Repeat Transmembrane
Ligand	ATP-binding Nucleotide-binding
PTM	Glycoprotein Phosphoprotein
Gene Ontology (GO)
Biological process	canalicular bile acid transport Ref.1 Inferred from direct assay. Source: RGD drug export Inferred from direct assay. Source: RGD response to oxidative stress Inferred from expression pattern. Source: RGD
Cellular component	Golgi membrane Inferred from direct assay. Source: RGD apical plasma membrane Inferred from direct assay. Source: RGD integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of substances Inferred from electronic annotation. Source: InterPro canalicular bile acid transmembrane transporter activity Ref.1 Inferred from direct assay. Source: RGD drug transporter activity Inferred from direct assay. Source: RGD protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Hide | Top

Binary interactions

With	Entry	#Exp.	IntAct	Notes
HAX1	O00165	1	EBI-930036,EBI-357001	From a different organism.
Hax1	Q7TSE9	3	EBI-930036,EBI-930005

Hide | Top

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1321

1321

Bile salt export pump

PRO_0000093299

Regions

Topological domain

1 – 62

Cytoplasmic Potential

Transmembrane

63 – 83

Potential

Topological domain

84 – 147

Extracellular Potential

Transmembrane

148 – 168

Potential

Topological domain

169 – 215

Cytoplasmic Potential

Transmembrane

216 – 236

Potential

Topological domain

237 – 240

Extracellular Potential

Transmembrane

241 – 261

Potential

Topological domain

262 – 319

Cytoplasmic Potential

Transmembrane

320 – 340

Potential

Topological domain

341 – 353

Extracellular Potential

Transmembrane

354 – 374

Potential

Topological domain

375 – 755

381

Cytoplasmic Potential

Transmembrane

756 – 776

Potential

Topological domain

777 – 794

Extracellular Potential

Transmembrane

795 – 815

Potential

Topological domain

816 – 869

Cytoplasmic Potential

Transmembrane

870 – 890

Potential

Transmembrane

891 – 911

Potential

Topological domain

912 – 979

Cytoplasmic Potential

Transmembrane

980 – 1000

Potential

Topological domain

1001 – 1011

Extracellular Potential

Transmembrane

1012 – 1032

Potential

Topological domain

1033 – 1321

289

Cytoplasmic Potential

Domain

62 – 385

324

ABC transmembrane type-1 1

Domain

420 – 656

237

ABC transporter 1

Domain

755 – 1043

289

ABC transmembrane type-1 2

Domain

1078 – 1316

239

ABC transporter 2

Nucleotide binding

455 – 462

ATP 1 Potential

Nucleotide binding

1113 – 1120

ATP 2 Potential

Amino acid modifications

Modified residue

692

Phosphoserine By similarity

Modified residue

696

Phosphoserine By similarity

Modified residue

703

Phosphoserine By similarity

Glycosylation

109

N-linked (GlcNAc...) Potential

Glycosylation

116

N-linked (GlcNAc...) Potential

Glycosylation

122

N-linked (GlcNAc...) Potential

Glycosylation

125

N-linked (GlcNAc...) Potential

Hide | Top

Sequences

Sequence

Length

Mass (Da)

Tools

O70127-1 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 5443F4EF7B9FB1F6
Show »

FASTA

1,321

146,258

        10         20         30         40         50         60 
MSDSVILRSV KKFGEENHAF ESDGSHNNDK KSRLQDKMKE GDIRVGFFEL FRFSSSKDIW 

        70         80         90        100        110        120 
LMLMGGVCAL LHGMAQPGIL IIFGIMTDIF IKYDIERQEL EIPGKACVNN TIVWINSSFH 

       130        140        150        160        170        180 
QNMTNGTVCG LVDIESEMIK FSGIYAGVGM TVLILGYFQI RLWVITGARQ IRRMRKIYFR 

       190        200        210        220        230        240 
RIMRMEIGWF DCTSVGELNS RFADDIEKIN DAIADQLAHF LQRMSTAMCG LLLGFYRGWK 

       250        260        270        280        290        300 
LTLVILAVSP LIGIGAAVIG LSIAKFTELE LKAYAKAGSI ADEVLSSIRT VAAFGGENKE 

       310        320        330        340        350        360 
VERYEKNLVF AQRWGIWKGM VMGFFTGYMW CLIFFCYALA FWYGSTLVLD EEEYTPGTLV 

       370        380        390        400        410        420 
QIFLCVILAA MNIGHASSCL EIFSTGCSAA TNIFQTIDRQ PVIDCMSGDG YKLDRIKGEI 

       430        440        450        460        470        480 
EFHNVTFHYP SRPDVKILDN LSMVIKPGET TALVGSSGAG KSTALQLIQR FYDPCEGMVT 

       490        500        510        520        530        540 
LDGHDIRSLN IRWLRDQIGI VEQEPVLFST TIAENIRFGR EDATMEDIVQ AAKDANAYNF 

       550        560        570        580        590        600 
IMALPQQFDT LVGEGGGQMS GGQKQRVAIA RALIRNPKIL LLDMATSALD NESEARVQEA 

       610        620        630        640        650        660 
LNKIQHGHTI ISVAHRLSTV RAADVIIGFE HGVAVERGTH EELLERKGVY FMLVTLQSQG 

       670        680        690        700        710        720 
DNAHKETSIM GKDATEGGTL ERTFSRGSYR DSLRASIRQR SKSQLSLLTH DPPLAVADHK 

       730        740        750        760        770        780 
SSYKDSKDND VLVEEVEPAP VRRILKYNIP EWHYILVGSL SAAINGAVTP IYSLLFSQLL 

       790        800        810        820        830        840 
GTFSLLDKEQ QRSEIHSMCL FFVILGCVSI FTQFLQGYTF AKSGELLTKR LRKFGFKAML 

       850        860        870        880        890        900 
GQDIGWFDDL RNNPGVLTTR LATDASQVQG ATGSQVGMMV NSFTNIIAAL LIAFFFSWKL 

       910        920        930        940        950        960 
SLIITIFFPF LALSGAVQTK MLTGFASQDK QALEKAGQIT SEALSNIRTV AGIGVEGRFI 

       970        980        990       1000       1010       1020 
KAFEVELQTS YKTAVRKANI YGLCFAFSQG IAFLANSAAY RYGGYLIAYE GLGFSHVFRV 

      1030       1040       1050       1060       1070       1080 
VSSVALSATA VGRTFSYTPS YAKAKISAAR FFQLLDRKPP INVYSEAGEK WDNFQGKIDF 

      1090       1100       1110       1120       1130       1140 
IDCKFTYPSR PDIQVLNGLS VSVNPGQTLA FVGSSGCGKS TSIQLLERFY DPDQGTVMID 

      1150       1160       1170       1180       1190       1200 
GHDSKKVNIQ FLRSNIGIVS QEPVLFDCSI MDNIKYGDNT KEISVERAIA AAKQAQLHDF 

      1210       1220       1230       1240       1250       1260 
VMSLPEKYET NVGIQGSQLS RGEKQRIAIA RAIVRDPKIL LLDEATSALD TESEKTVQTA 

      1270       1280       1290       1300       1310       1320 
LDKAREGRTC IVIAHRLSTI QNSDIIAVVS QGVVIEKGTH EKLMAQKGAY YKLVITGAPI 


S

« Hide

Hide | Top

References

[1]	"The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver." Gerloff T., Stieger B., Hagenbuch B., Madon J., Landmann L., Roth J., Hofmann A.F., Meier P.J. J. Biol. Chem. 273:10046-10050(1998) [PubMed: 9545351] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Liver.
+	Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases
	U69487 mRNA. Translation: AAC40084.1.
IPI	IPI00195615.
PIR	T42842.
RefSeq	NP_113948.1.
UniGene	Rn.14539
3D structure databases
HSSP	HSSP built from PDB template 1MT0 based on UniProtKB P08716.
ModBase	Search...
Protein-protein interaction databases
IntAct	O70127. 2 interactions.
PTM databases
PhosphoSite	O70127.
Proteomic databases
PRIDE	O70127.
Genome annotation databases
GeneID	83569.
KEGG	rno:83569.
Organism-specific databases
CTD	83569.
RGD	619930. Abcb11.
Phylogenomic databases
HOVERGEN	O70127.
Gene expression databases
Genevestigator	O70127.
Family and domain databases
InterPro	IPR001140. ABC_TM_transpt. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR003593. ATPase_AAA+_core. [Graphical view]
Pfam	PF00664. ABC_membrane. 2 hits. PF00005. ABC_tran. 2 hits. [Graphical view]
ProDom	PD000006. ABC_transporter. 2 hits. [Graphical view] [Entries sharing at least one domain]
SMART	SM00382. AAA. 2 hits. [Graphical view]
PROSITE	PS50929. ABC_TM1F. 2 hits. PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	616061.

Hide | Top

Entry information

Entry name

ABCBB_RAT

Accession

Primary (citable) accession number: O70127

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
Last sequence update:	August 1, 1998
Last modified:	October 13, 2009
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Hide | Top

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents