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O70127

- ABCBB_RAT

UniProt

O70127 - ABCBB_RAT

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Protein

Bile salt export pump

Gene
Abcb11, Bsep, Spgp
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi455 – 4628ATP 1 Reviewed prediction
Nucleotide bindingi1113 – 11208ATP 2 Reviewed prediction

GO - Molecular functioni

  1. ATPase activity, coupled to transmembrane movement of substances Source: RefGenome
  2. ATP binding Source: UniProtKB-KW
  3. canalicular bile acid transmembrane transporter activity Source: RGD
  4. drug transmembrane transporter activity Source: RGD
  5. protein binding Source: IntAct

GO - Biological processi

  1. canalicular bile acid transport Source: RGD
  2. drug export Source: RGD
  3. drug transmembrane transport Source: GOC
  4. response to drug Source: RGD
  5. response to estrogen Source: RGD
  6. response to oxidative stress Source: RGD
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Bile salt export pump
Alternative name(s):
ATP-binding cassette sub-family B member 11
Sister of P-glycoprotein
Gene namesi
Name:Abcb11
Synonyms:Bsep, Spgp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi619930. Abcb11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6262Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei63 – 8321Helical; Reviewed predictionAdd
BLAST
Topological domaini84 – 14764Extracellular Reviewed predictionAdd
BLAST
Transmembranei148 – 16821Helical; Reviewed predictionAdd
BLAST
Topological domaini169 – 21547Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei216 – 23621Helical; Reviewed predictionAdd
BLAST
Topological domaini237 – 2404Extracellular Reviewed prediction
Transmembranei241 – 26121Helical; Reviewed predictionAdd
BLAST
Topological domaini262 – 31958Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei320 – 34021Helical; Reviewed predictionAdd
BLAST
Topological domaini341 – 35313Extracellular Reviewed predictionAdd
BLAST
Transmembranei354 – 37421Helical; Reviewed predictionAdd
BLAST
Topological domaini375 – 755381Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei756 – 77621Helical; Reviewed predictionAdd
BLAST
Topological domaini777 – 79418Extracellular Reviewed predictionAdd
BLAST
Transmembranei795 – 81521Helical; Reviewed predictionAdd
BLAST
Topological domaini816 – 86954Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei870 – 89021Helical; Reviewed predictionAdd
BLAST
Transmembranei891 – 91121Helical; Reviewed predictionAdd
BLAST
Topological domaini912 – 97968Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei980 – 100021Helical; Reviewed predictionAdd
BLAST
Topological domaini1001 – 101111Extracellular Reviewed predictionAdd
BLAST
Transmembranei1012 – 103221Helical; Reviewed predictionAdd
BLAST
Topological domaini1033 – 1321289Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: RGD
  2. Golgi apparatus Source: RGD
  3. Golgi membrane Source: RGD
  4. integral component of membrane Source: RefGenome
  5. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13211321Bile salt export pumpPRO_0000093299Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi109 – 1091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi116 – 1161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi122 – 1221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi125 – 1251N-linked (GlcNAc...) Reviewed prediction
Modified residuei692 – 6921Phosphoserine By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiO70127.

PTM databases

PhosphoSiteiO70127.

Expressioni

Tissue specificityi

Expressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ.

Gene expression databases

GenevestigatoriO70127.

Interactioni

Subunit structurei

Interacts with HAX1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Hax1Q7TSE95EBI-930036,EBI-930005

Protein-protein interaction databases

BioGridi249756. 1 interaction.
IntActiO70127. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliO70127.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini62 – 385324ABC transmembrane type-1 1Add
BLAST
Domaini420 – 656237ABC transporter 1Add
BLAST
Domaini755 – 1043289ABC transmembrane type-1 2Add
BLAST
Domaini1078 – 1316239ABC transporter 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni651 – 67424Interaction with HAX1Add
BLAST

Domaini

Multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain.

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG080809.
KOiK05664.
PhylomeDBiO70127.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 3 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70127-1 [UniParc]FASTAAdd to Basket

« Hide

MSDSVILRSV KKFGEENHAF ESDGSHNNDK KSRLQDKMKE GDIRVGFFEL     50
FRFSSSKDIW LMLMGGVCAL LHGMAQPGIL IIFGIMTDIF IKYDIERQEL 100
EIPGKACVNN TIVWINSSFH QNMTNGTVCG LVDIESEMIK FSGIYAGVGM 150
TVLILGYFQI RLWVITGARQ IRRMRKIYFR RIMRMEIGWF DCTSVGELNS 200
RFADDIEKIN DAIADQLAHF LQRMSTAMCG LLLGFYRGWK LTLVILAVSP 250
LIGIGAAVIG LSIAKFTELE LKAYAKAGSI ADEVLSSIRT VAAFGGENKE 300
VERYEKNLVF AQRWGIWKGM VMGFFTGYMW CLIFFCYALA FWYGSTLVLD 350
EEEYTPGTLV QIFLCVILAA MNIGHASSCL EIFSTGCSAA TNIFQTIDRQ 400
PVIDCMSGDG YKLDRIKGEI EFHNVTFHYP SRPDVKILDN LSMVIKPGET 450
TALVGSSGAG KSTALQLIQR FYDPCEGMVT LDGHDIRSLN IRWLRDQIGI 500
VEQEPVLFST TIAENIRFGR EDATMEDIVQ AAKDANAYNF IMALPQQFDT 550
LVGEGGGQMS GGQKQRVAIA RALIRNPKIL LLDMATSALD NESEARVQEA 600
LNKIQHGHTI ISVAHRLSTV RAADVIIGFE HGVAVERGTH EELLERKGVY 650
FMLVTLQSQG DNAHKETSIM GKDATEGGTL ERTFSRGSYR DSLRASIRQR 700
SKSQLSLLTH DPPLAVADHK SSYKDSKDND VLVEEVEPAP VRRILKYNIP 750
EWHYILVGSL SAAINGAVTP IYSLLFSQLL GTFSLLDKEQ QRSEIHSMCL 800
FFVILGCVSI FTQFLQGYTF AKSGELLTKR LRKFGFKAML GQDIGWFDDL 850
RNNPGVLTTR LATDASQVQG ATGSQVGMMV NSFTNIIAAL LIAFFFSWKL 900
SLIITIFFPF LALSGAVQTK MLTGFASQDK QALEKAGQIT SEALSNIRTV 950
AGIGVEGRFI KAFEVELQTS YKTAVRKANI YGLCFAFSQG IAFLANSAAY 1000
RYGGYLIAYE GLGFSHVFRV VSSVALSATA VGRTFSYTPS YAKAKISAAR 1050
FFQLLDRKPP INVYSEAGEK WDNFQGKIDF IDCKFTYPSR PDIQVLNGLS 1100
VSVNPGQTLA FVGSSGCGKS TSIQLLERFY DPDQGTVMID GHDSKKVNIQ 1150
FLRSNIGIVS QEPVLFDCSI MDNIKYGDNT KEISVERAIA AAKQAQLHDF 1200
VMSLPEKYET NVGIQGSQLS RGEKQRIAIA RAIVRDPKIL LLDEATSALD 1250
TESEKTVQTA LDKAREGRTC IVIAHRLSTI QNSDIIAVVS QGVVIEKGTH 1300
EKLMAQKGAY YKLVITGAPI S 1321
Length:1,321
Mass (Da):146,258
Last modified:August 1, 1998 - v1
Checksum:i5443F4EF7B9FB1F6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U69487 mRNA. Translation: AAC40084.1.
PIRiT42842.
RefSeqiNP_113948.1. NM_031760.1.
UniGeneiRn.14539.

Genome annotation databases

GeneIDi83569.
KEGGirno:83569.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U69487 mRNA. Translation: AAC40084.1 .
PIRi T42842.
RefSeqi NP_113948.1. NM_031760.1.
UniGenei Rn.14539.

3D structure databases

ProteinModelPortali O70127.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 249756. 1 interaction.
IntActi O70127. 2 interactions.

Chemistry

BindingDBi O70127.
ChEMBLi CHEMBL2073674.

PTM databases

PhosphoSitei O70127.

Proteomic databases

PRIDEi O70127.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 83569.
KEGGi rno:83569.

Organism-specific databases

CTDi 8647.
RGDi 619930. Abcb11.

Phylogenomic databases

HOVERGENi HBG080809.
KOi K05664.
PhylomeDBi O70127.

Miscellaneous databases

NextBioi 616061.
PROi O70127.

Gene expression databases

Genevestigatori O70127.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 3 hits.
PROSITEi PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver."
    Gerloff T., Stieger B., Hagenbuch B., Madon J., Landmann L., Roth J., Hofmann A.F., Meier P.J.
    J. Biol. Chem. 273:10046-10050(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.
  2. "Identification of HAX-1 as a protein that binds bile salt export protein and regulates its abundance in the apical membrane of Madin-Darby canine kidney cells."
    Ortiz D.F., Moseley J., Calderon G., Swift A.L., Li S., Arias I.M.
    J. Biol. Chem. 279:32761-32770(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HAX1.

Entry informationi

Entry nameiABCBB_RAT
AccessioniPrimary (citable) accession number: O70127
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: August 1, 1998
Last modified: September 3, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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