O70038 (O70038_STRPN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Penicillin-binding protein 1B EMBL BAD00805.1

Submitted name:
Penicillin-binding protein 1b EMBL CAA05302.1

Gene names

Name:

pbp1b EMBL CAA05302.1

Organism

Streptococcus pneumoniae EMBL CAA05302.1

Taxonomic identifier

1313 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	821 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation SAAS SAAS001264 Peptidoglycan synthesis SAAS SAAS001264
Technical term	3D-structure PDB 2JE5 PDB 2BG1 PDB 2JCH PDB 2FFF
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	peptidoglycan-based cell wall Inferred from electronic annotation. Source: InterPro
Molecular function	catalytic activity Inferred from electronic annotation. Source: InterPro penicillin binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O70038 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: DA94560B4B8BD3AB	FASTA	821	89,481
	10 20 30 40 50 60 MQNQLNELKR KMLEFFQQKQ KNKKSARPGK KGSSTKKSKT LDKSAIFPAI LLSIKALFNL 70 80 90 100 110 120 LFVLGFLGGM LGAGIALGYG VALFDKVRVP QTEELVNQVK DISSISEITY SDGTVIASIE 130 140 150 160 170 180 SDLLRTSISS EQISENLKKA IIATEDEHFK EHKGVVPKAV IRATLGKFVG LGSSSGGSTL 190 200 210 220 230 240 TQQLIKQQVV GDAPTLARKA AEIVDALALE RAMNKDEILT TYLNVAPFGR NNKGQNIAGA 250 260 270 280 290 300 RQAAEGIFGV DASQLTVPQA AFLAGLPQSP ITYSPYENTG ELKSDEDLEI GLRRAKAVLY 310 320 330 340 350 360 SMYRTGALSK DEYSQYKDYD LKQDFLPSGT VTGISRDYLY FTTLAEAQER MYDYLAQRDN 370 380 390 400 410 420 VSAKELKNEA TQKFYRDLAA KEIENGGYKI TTTIDQKIHS AMQSAVADYG YLLDDGTGRV 430 440 450 460 470 480 EVGNVLMDNQ TGAILGFVGG RNYQENQNNH AFDTKRSPAS TTKPLLAYGI AIDQGLMGSE 490 500 510 520 530 540 TILSNYPTNF ANGNPIMYAN SKGTGMMTLG EALNYSWNIP AYWTYRMLRE NGVDVKGYME 550 560 570 580 590 600 KMGYEIPEYG IESLPMGGGI EVTVAQHTNG YQTLANNGVY HQKHVISKIE AADGRVVYEY 610 620 630 640 650 660 QDKPVQVYSK ATATIMQGLL REVLSSRVTT TFKSNLTSLN PTLANADWIG KTGTTNQDEN 670 680 690 700 710 720 MWLMLSTPRL TLGGWIGHDD NHSLSRRAGY SNNSNYMAHL VNAIQQASPS IWGNERFALD 730 740 750 760 770 780 PSVVKSEVLK STGQKPGKVS VEGKEVEVTG STVTSYWANK SGAPATSYRF AIGGSDADYQ 790 800 810 820 NAWSSIVGSL PTPSSSSSSS SSSSDSSNSS TTRPSSSRAR R

References

[1]	"Complete sequences of six penicillin-binding protein genes from 40 Streptococcus pneumoniae clinical isolates collected in Japan." Sanbongi Y., Ida T., Ishikawa M., Osaki Y., Kataoka H., Suzuki T., Kondo K., Ohsawa F., Yonezawa M. Antimicrob. Agents Chemother. 48:2244-2250(2004) [PubMed: 15155228] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: SP00077 EMBL BAD00805.1 and SP00079 EMBL BAD00807.1.
[2]	"Acquisition of five high-Mr penicillin-binding protein variants during transfer of high-level beta-lactam resistance from Streptococcus mitis to Streptococcus pneumoniae." Hakenbeck R., Konig A., Kern I., van der Linden M., Keck W., Billot-Klein D., Legrand R., Schoot B., Gutmann L. J. Bacteriol. 180:1831-1840(1998) [PubMed: 9537382] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: R6 EMBL CAA05302.1.
[3]	"Gene disruption studies of penicillin-binding proteins 1a, 1b, and 2a in Streptococcus pneumoniae." Hoskins J., Matsushima P., Mullen D.L., Tang J., Zhao G., Meier T.I., Nicas T.I., Jaskunas S.R. J. Bacteriol. 181:6552-6555(1999) [PubMed: 10515951] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: R6 EMBL AAF04736.1.
[4]	"Active site restructuring regulates ligand recognition in class A penicillin-binding proteins." Macheboeuf P., Di Guilmi A.M., Job V., Vernet T., Dideberg O., Dessen A. Proc. Natl. Acad. Sci. U.S.A. 102:577-582(2005) [PubMed: 15637155] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 101-791.
[5]	"Structural analysis of an "open" form of PBP1B from Streptococcus pneumoniae." Lovering A.L., De Castro L., Lim D., Strynadka N.C. Protein Sci. 15:1701-1709(2006) [PubMed: 16751607] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.23 ANGSTROMS) OF 337-789.
[6]	"Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins." Macheboeuf P., Fischer D.S., Brown T., Zervosen A., Luxen A., Joris B., Dessen A., Schofield C.J. Nat. Chem. Biol. 3:565-569(2007) [PubMed: 17676039] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 74-791.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF101781 Genomic DNA. Translation: AAF04736.1.
AB119817 Genomic DNA. Translation: BAD00805.1.
AB119819 Genomic DNA. Translation: BAD00807.1.
AJ002291 Genomic DNA. Translation: CAA05302.1.

PIR

B99110.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2BG1	X-ray	1.90	A	101-791	[»]
2FFF	X-ray	2.23	B	337-789	[»]
2JCH	X-ray	2.40	A	74-791	[»]
2JE5	X-ray	2.60	A/B	74-791	[»]

ProteinModelPortal

O70038.

SMR

O70038. Positions 337-789.

ModBase

Search...

Protein family/group databases

CAZy

GT51. Glycosyltransferase Family 51.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

InterPro

IPR012338. Beta-lactam/transpept-like.
IPR001264. Glyco_trans_51.
IPR001460. PCN-bd_Tpept.
[Graphical view]

Gene3D

G3DSA:3.40.710.10. G3DSA:3.40.710.10. 1 hit.

Pfam

PF00912. Transgly. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]

SUPFAM

SSF56601. PBP_transp_fold. 1 hit.

ProtoNet

Search...

Entry information

Entry name

O70038_STRPN

Accession

Primary (citable) accession number: O70038

Entry history

Integrated into UniProtKB/TrEMBL:	August 1, 1998
Last sequence update:	August 1, 1998
Last modified:	January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)