Penicillin-binding protein 1b - Streptococcus pneumoniae

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Unreviewed, UniProtKB/TrEMBL O70038 (O70038_STRPN)

Last modified June 16, 2009. Version 47. History...

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Names and origin · Protein attributes · Ontologies · Sequences · References · Cross-references · Entry information

Names and origin

Protein names

Submitted name:
Penicillin-binding protein 1b EMBL CAA05302.1

Gene names

Name:

pbp1b EMBL CAA05302.1

Organism

Streptococcus pneumoniae EMBL CAA05302.1

Taxonomic identifier

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	821 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation Spearmint SPM001264 Peptidoglycan synthesis Spearmint SPM001264
Gene Ontology (GO)
Biological process	peptidoglycan biosynthetic process Inferred from electronic annotation. Source: InterPro regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	peptidoglycan-based cell wall Inferred from electronic annotation. Source: InterPro
Molecular function	catalytic activity Inferred from electronic annotation. Source: InterPro penicillin binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

Sequence

Length

Mass (Da)

Tools

O70038-1 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: DA94560B4B8BD3AB
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821

89,481

        10         20         30         40         50         60 
MQNQLNELKR KMLEFFQQKQ KNKKSARPGK KGSSTKKSKT LDKSAIFPAI LLSIKALFNL 

        70         80         90        100        110        120 
LFVLGFLGGM LGAGIALGYG VALFDKVRVP QTEELVNQVK DISSISEITY SDGTVIASIE 

       130        140        150        160        170        180 
SDLLRTSISS EQISENLKKA IIATEDEHFK EHKGVVPKAV IRATLGKFVG LGSSSGGSTL 

       190        200        210        220        230        240 
TQQLIKQQVV GDAPTLARKA AEIVDALALE RAMNKDEILT TYLNVAPFGR NNKGQNIAGA 

       250        260        270        280        290        300 
RQAAEGIFGV DASQLTVPQA AFLAGLPQSP ITYSPYENTG ELKSDEDLEI GLRRAKAVLY 

       310        320        330        340        350        360 
SMYRTGALSK DEYSQYKDYD LKQDFLPSGT VTGISRDYLY FTTLAEAQER MYDYLAQRDN 

       370        380        390        400        410        420 
VSAKELKNEA TQKFYRDLAA KEIENGGYKI TTTIDQKIHS AMQSAVADYG YLLDDGTGRV 

       430        440        450        460        470        480 
EVGNVLMDNQ TGAILGFVGG RNYQENQNNH AFDTKRSPAS TTKPLLAYGI AIDQGLMGSE 

       490        500        510        520        530        540 
TILSNYPTNF ANGNPIMYAN SKGTGMMTLG EALNYSWNIP AYWTYRMLRE NGVDVKGYME 

       550        560        570        580        590        600 
KMGYEIPEYG IESLPMGGGI EVTVAQHTNG YQTLANNGVY HQKHVISKIE AADGRVVYEY 

       610        620        630        640        650        660 
QDKPVQVYSK ATATIMQGLL REVLSSRVTT TFKSNLTSLN PTLANADWIG KTGTTNQDEN 

       670        680        690        700        710        720 
MWLMLSTPRL TLGGWIGHDD NHSLSRRAGY SNNSNYMAHL VNAIQQASPS IWGNERFALD 

       730        740        750        760        770        780 
PSVVKSEVLK STGQKPGKVS VEGKEVEVTG STVTSYWANK SGAPATSYRF AIGGSDADYQ 

       790        800        810        820 
NAWSSIVGSL PTPSSSSSSS SSSSDSSNSS TTRPSSSRAR R

References

[1]	"Acquisition of five high-Mr penicillin-binding protein variants during transfer of high-level beta-lactam resistance from Streptococcus mitis to Streptococcus pneumoniae." Hakenbeck R., Konig A., Kern I., van der Linden M., Keck W., Billot-Klein D., Legrand R., Schoot B., Gutmann L. J. Bacteriol. 180:1831-1840(1998) [PubMed: 9537382] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: R6 EMBL CAA05302.1.
[2]	"Complete sequences of six penicillin-binding protein genes from 40 Streptococcus pneumoniae clinical isolates collected in Japan." Sanbongi Y., Ida T., Ishikawa M., Osaki Y., Kataoka H., Suzuki T., Kondo K., Ohsawa F., Yonezawa M. Antimicrob. Agents Chemother. 48:2244-2250(2004) [PubMed: 15155228] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: SP00079 EMBL BAD00807.1 and SP00077 EMBL BAD00805.1.
[3]	"Gene disruption studies of penicillin-binding proteins 1a, 1b, and 2a in Streptococcus pneumoniae." Hoskins J., Matsushima P., Mullen D.L., Tang J., Zhao G., Meier T.I., Nicas T.I., Jaskunas S.R. J. Bacteriol. 181:6552-6555(1999) [PubMed: 10515951] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: R6 EMBL AAF04736.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases

AF101781 Genomic DNA. Translation: AAF04736.1.
AB119817 Genomic DNA. Translation: BAD00805.1.
AB119819 Genomic DNA. Translation: BAD00807.1.
AJ002291 Genomic DNA. Translation: CAA05302.1.

PIR

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2BG1	X-ray	1.90	A	101-791	[»]
2FFF	X-ray	2.23	B	337-789	[»]
2JCH	X-ray	2.40	A	74-791	[»]
2JCI	X-ray	2.50	A/B	74-791	[»]

ModBase

Protein family/group databases

CAZy

GT51. Glycosyltransferase Family 51.

Family and domain databases

InterPro

IPR001264. Glyco_trans_51.
IPR001460. PCN-bd_Tpept.
[Graphical view]

Pfam

PF00912. Transgly. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]

ProDom

PD001895. Glyco_trans_51. 1 hit.
[Graphical view] [Entries sharing at least one domain]

ProtoNet

Entry information

Entry name

O70038_STRPN

Accession

Primary (citable) accession number: O70038

Entry history

Integrated into UniProtKB/TrEMBL:	August 1, 1998
Last sequence update:	August 1, 1998
Last modified:	June 16, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names and origin · Protein attributes · Ontologies · Sequences · References · Cross-references · Entry information