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Protein

DNA topoisomerase (ATP-hydrolyzing)

Gene

SCO5822

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

ATP-dependent breakage, passage and rejoining of double-stranded DNA.SAAS annotation

Cofactori

Mg2+SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, TopoisomeraseSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA topoisomerase (ATP-hydrolyzing)SAAS annotation (EC:5.99.1.3SAAS annotation)
Gene namesi
Ordered Locus Names:SCO5822Imported
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)Imported
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiO69998.

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO5822.

Structurei

3D structure databases

ProteinModelPortaliO69998.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini480 – 594115ToprimInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains Toprim domain.SAAS annotation

Phylogenomic databases

eggNOGiENOG4105C7D. Bacteria.
COG0187. LUCA.
HOGENOMiHOG000075154.
InParanoidiO69998.
KOiK02470.
OMAiQSKNIRY.
OrthoDBiEOG6P334W.
PhylomeDBiO69998.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.565.10. 1 hit.
3.40.50.670. 1 hit.
InterProiIPR002288. DNA_gyrase_B_C.
IPR003594. HATPase_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR001241. Topo_IIA.
IPR013760. Topo_IIA-like_dom.
IPR013506. Topo_IIA_bsu_dom2.
IPR013759. Topo_IIA_cen_dom.
IPR018522. TopoIIA_CS.
IPR006171. Toprim_domain.
[Graphical view]
PfamiPF00204. DNA_gyraseB. 1 hit.
PF00986. DNA_gyraseB_C. 1 hit.
PF02518. HATPase_c. 1 hit.
PF01751. Toprim. 1 hit.
[Graphical view]
PRINTSiPR00418. TPI2FAMILY.
SMARTiSM00387. HATPase_c. 1 hit.
SM00433. TOP2c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
SSF56719. SSF56719. 1 hit.
PROSITEiPS00177. TOPOISOMERASE_II. 1 hit.
PS50880. TOPRIM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O69998-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAETSVPST ALLAGADRDG SNYTARHLLV LEGLEAVRKR PGMYIGSTDS
60 70 80 90 100
RGLMHCLWEI IDNSVDEALG GYCDHIEVIL HDDASVEVRD NGRGIPVDVE
110 120 130 140 150
PKTGLSGVEV VMTKLHAGGK FGGGAYAASG GLHGVGASVV NALSARLDIE
160 170 180 190 200
VDLGGHTHAI SFRRGVPGTF AKAGPDAKFE AGSGLRKVKK VPKSRRGTRV
210 220 230 240 250
RYWADRQIFL KDAKLSLDNL HQRARQTAFL VPGLTIVVRD EFGLGDGGSK
260 270 280 290 300
GEESFRFDGG ISEFCEFLAG DRPVCDVLRF SGQGSFKETV PVLDEDGQMT
310 320 330 340 350
PSEVTRDLGV DVALRWGTGY DTTVRSFVNI IATPKGGTHV AGFEQAVAKT
360 370 380 390 400
MNEVLRTKKM LRVAEDDIVK DDALEGLTAV VTVRLAEPQF EGQTKEVLGT
410 420 430 440 450
SAARRIVNNV ISRELKAFLT STKRDAAQQA RVVMEKAVAA ARTRIAARQH
460 470 480 490 500
KDAQRRKTAL ESSSLPAKLA DCRSDDVDRS ELFIVEGDSA LGTAKLARNS
510 520 530 540 550
EFQALLPIRG KILNVQKSSV TDMLKNAECG AIIQVIGAGS GRTFDIDAAR
560 570 580 590 600
YGKIIMMTDA DVDGSHIRTL LLTLFHRYMR PMVEAGRVFA AVPPLHRIEL
610 620 630 640 650
VQPKKGQDKY VYTYSDRELR DKLMEFQSKN IRYKDSIQRY KGLGEMDADQ
660 670 680 690 700
LAETTMDPRR RTLRRINLTD LDSAEQVFDL LMGNDVAPRK EFISSSAATL

DRSRIDA
Length:707
Mass (Da):77,270
Last modified:August 1, 1998 - v1
Checksum:i1A5427EB8EFB6661
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939125 Genomic DNA. Translation: CAA18520.1.
PIRiT35196.
RefSeqiNP_629945.1. NC_003888.3.
WP_003973199.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAA18520; CAA18520; CAA18520.
GeneIDi1101264.
KEGGisco:SCO5822.
PATRICi23741544. VBIStrCoe124346_5919.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939125 Genomic DNA. Translation: CAA18520.1.
PIRiT35196.
RefSeqiNP_629945.1. NC_003888.3.
WP_003973199.1. NC_003888.3.

3D structure databases

ProteinModelPortaliO69998.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO5822.

Proteomic databases

PRIDEiO69998.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAA18520; CAA18520; CAA18520.
GeneIDi1101264.
KEGGisco:SCO5822.
PATRICi23741544. VBIStrCoe124346_5919.

Phylogenomic databases

eggNOGiENOG4105C7D. Bacteria.
COG0187. LUCA.
HOGENOMiHOG000075154.
InParanoidiO69998.
KOiK02470.
OMAiQSKNIRY.
OrthoDBiEOG6P334W.
PhylomeDBiO69998.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.565.10. 1 hit.
3.40.50.670. 1 hit.
InterProiIPR002288. DNA_gyrase_B_C.
IPR003594. HATPase_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR001241. Topo_IIA.
IPR013760. Topo_IIA-like_dom.
IPR013506. Topo_IIA_bsu_dom2.
IPR013759. Topo_IIA_cen_dom.
IPR018522. TopoIIA_CS.
IPR006171. Toprim_domain.
[Graphical view]
PfamiPF00204. DNA_gyraseB. 1 hit.
PF00986. DNA_gyraseB_C. 1 hit.
PF02518. HATPase_c. 1 hit.
PF01751. Toprim. 1 hit.
[Graphical view]
PRINTSiPR00418. TPI2FAMILY.
SMARTiSM00387. HATPase_c. 1 hit.
SM00433. TOP2c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
SSF56719. SSF56719. 1 hit.
PROSITEiPS00177. TOPOISOMERASE_II. 1 hit.
PS50880. TOPRIM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145Imported.

Entry informationi

Entry nameiO69998_STRCO
AccessioniPrimary (citable) accession number: O69998
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: July 6, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.