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Protein

Methionine aminopeptidase

Gene

map

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotation

Cofactori

Co2+UniRule annotation, Zn2+UniRule annotation, Mn2+UniRule annotation, Fe2+UniRule annotationNote: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei83 – 831SubstrateUniRule annotation
Metal bindingi100 – 1001Divalent metal cation 1UniRule annotation
Metal bindingi111 – 1111Divalent metal cation 1UniRule annotation
Metal bindingi111 – 1111Divalent metal cation 2; catalyticUniRule annotation
Metal bindingi174 – 1741Divalent metal cation 2; catalytic; via tele nitrogenUniRule annotation
Binding sitei181 – 1811SubstrateUniRule annotation
Metal bindingi207 – 2071Divalent metal cation 2; catalyticUniRule annotation
Metal bindingi239 – 2391Divalent metal cation 1UniRule annotation
Metal bindingi239 – 2391Divalent metal cation 2; catalyticUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

AminopeptidaseUniRule annotationImported, Hydrolase, Protease

Keywords - Ligandi

Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine aminopeptidaseUniRule annotation (EC:3.4.11.18UniRule annotation)
Short name:
MAPUniRule annotation
Short name:
MetAPUniRule annotation
Alternative name(s):
Peptidase MUniRule annotation
Gene namesi
Name:mapUniRule annotation
Ordered Locus Names:SCO6409Imported
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)Imported
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi100226.SCO6409.

Structurei

3D structure databases

ProteinModelPortaliO69937.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 246235Peptidase_M24InterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiENOG4105CA1. Bacteria.
COG0024. LUCA.
HOGENOMiHOG000030426.
InParanoidiO69937.
KOiK01265.
OMAiEPMLIAD.
OrthoDBiEOG6MWNDS.
PhylomeDBiO69937.

Family and domain databases

Gene3Di3.90.230.10. 1 hit.
HAMAPiMF_01974. MetAP_1.
InterProiIPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002467. Pept_M24A_MAP1.
[Graphical view]
PfamiPF00557. Peptidase_M24. 1 hit.
[Graphical view]
PRINTSiPR00599. MAPEPTIDASE.
SUPFAMiSSF55920. SSF55920. 1 hit.
TIGRFAMsiTIGR00500. met_pdase_I. 1 hit.

Sequencei

Sequence statusi: Complete.

O69937-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVELKTDTSI DAMHAAGQVV ARALTAVRQA ADVGVSLLEL DAVAHEVLRE
60 70 80 90 100
AGAGSPFLGY RPSFAPTPFP GVICASVNDA IVHGIPDGYR LRDGDLVSID
110 120 130 140 150
CGALLDGWAG DSALSFVVGT PRPADVTLIE TAERALEAGI AAAVVGNRIG
160 170 180 190 200
DIAHAIGTVC RSAGYGIMED FGGHGIGRHM HEDPGVPNEG RPGRGLPLRH
210 220 230 240 250
GMVLAIEPML TAGGRDDYHA APDGWTLRTN DGSRAAHVEH TVAITDGGPR

VLTSRDGL
Length:258
Mass (Da):26,714
Last modified:August 1, 1998 - v1
Checksum:i09C5F7A267DC65F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939127 Genomic DNA. Translation: CAA19620.1.
PIRiT34903.
RefSeqiNP_630496.1. NC_003888.3.
WP_003972570.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAA19620; CAA19620; CAA19620.
GeneIDi1101848.
KEGGisco:SCO6409.
PATRICi23742725. VBIStrCoe124346_6509.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939127 Genomic DNA. Translation: CAA19620.1.
PIRiT34903.
RefSeqiNP_630496.1. NC_003888.3.
WP_003972570.1. NC_003888.3.

3D structure databases

ProteinModelPortaliO69937.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO6409.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAA19620; CAA19620; CAA19620.
GeneIDi1101848.
KEGGisco:SCO6409.
PATRICi23742725. VBIStrCoe124346_6509.

Phylogenomic databases

eggNOGiENOG4105CA1. Bacteria.
COG0024. LUCA.
HOGENOMiHOG000030426.
InParanoidiO69937.
KOiK01265.
OMAiEPMLIAD.
OrthoDBiEOG6MWNDS.
PhylomeDBiO69937.

Family and domain databases

Gene3Di3.90.230.10. 1 hit.
HAMAPiMF_01974. MetAP_1.
InterProiIPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002467. Pept_M24A_MAP1.
[Graphical view]
PfamiPF00557. Peptidase_M24. 1 hit.
[Graphical view]
PRINTSiPR00599. MAPEPTIDASE.
SUPFAMiSSF55920. SSF55920. 1 hit.
TIGRFAMsiTIGR00500. met_pdase_I. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145Imported.

Entry informationi

Entry nameiO69937_STRCO
AccessioniPrimary (citable) accession number: O69937
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: July 6, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.