Reviewed, UniProtKB/Swiss-Prot O69783 (DAPB2_RHIME)

Names and origin

Protein names

Recommended name:
    Dihydrodipicolinate reductase
      Short name=DHPR
    EC=1.3.1.26

Gene names

Name:

dapB

Encoded on

Plasmid pRmeGR4b

Organism

Rhizobium meliloti (Sinorhizobium meliloti)

Taxonomic identifier

382 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Sinorhizobium/Ensifer group › Sinorhizobium

Protein attributes

Sequence length	242 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2,3,4,5-tetrahydrodipicolinate + NAD(P)(+) = 2,3-dihydrodipicolinate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; tetrahydrodipicolinate from L-aspartate: step 4/4.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.
Sequence caution	The sequence CAA10958.1 differs from that shown. Reason: Frameshift at several positions.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Plasmid
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›242	›242	Dihydrodipicolinate reductase		PRO_0000141477
Experimental info
	Non-terminal residue	242	1

Sequences

	Sequence		Length	Mass (Da)
	O69783-1 [UniParc]. Last modified May 30, 2000. Version 2. Checksum: 31C962599F153CC5	FASTA	242	24,880
	10 20 30 40 50 60 MSQMRLVVVG AAGRMGRTLI KAIAENPGCM LSGAVERPGS AAVGQDAGFV AGMASCGVLV 70 80 90 100 110 120 TDEPGSAFAE ADGVLDFTTP DATAEYSSLA AQVGIVHVVG TTGMEPVHFS KLVRAARTIP 130 140 150 160 170 180 VVQSGNMSLG VNILAALVQK VAAILDKEWD IEVLEMHHRM KVDAPSGAAL LLGEAAASGR 190 200 210 220 230 240 QTILSDHYVA GRDGYTGCRT VGTIGFAPCA GXVVGDHKVV FAGAGXRIEL SHIAEDRSLF AQ

References

[1]

"Characterization of the Sinorhizobium meliloti genes encoding a functional dihydrodipicolinate synthase (dapA) and dihydrodipicolinate reductase (dapB)." Garcia-Rodriguez F.M., Zekri S., Toro N. Arch. Microbiol. 173:438-444(2000) [PubMed: 10896225] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: GR4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ222715 Genomic DNA. Translation: CAA10958.1. Frameshift.
3D structure databases
HSSP	HSSP built from PDB template 1DRW based on UniProtKB P04036.
ModBase	Search...
Family and domain databases
HAMAP	MF_00102. [Tree]
InterPro	IPR000846. DapB. IPR011770. DapB_bac/pln. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
ProDom	PD004105. DapB. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00036. dapB. 1 hit.
PROSITE	PS01298. DAPB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB2_RHIME

Accession

Primary (citable) accession number: O69783

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 30, 2000
Last modified:	November 25, 2008
This is version 54 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)