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O69773

- AMPC_PROST

UniProt

O69773 - AMPC_PROST

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Protein

Beta-lactamase

Gene

ampC

Organism
Providencia stuartii
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei87 – 871Acyl-ester intermediatePROSITE-ProRule annotation
Active sitei172 – 1721Proton acceptorBy similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase (EC:3.5.2.6)
Alternative name(s):
Cephalosporinase
Gene namesi
Name:ampC
OrganismiProvidencia stuartii
Taxonomic identifieri588 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProvidencia

Subcellular locationi

Periplasm By similarity

GO - Cellular componenti

  1. outer membrane-bounded periplasmic space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Chaini30 – 384355Beta-lactamasePRO_0000016962Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO69773.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni337 – 3393Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the class-C beta-lactamase family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR001586. Beta-lactam_class-C_AS.
[Graphical view]
PfamiPF00144. Beta-lactamase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00336. BETA_LACTAMASE_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O69773-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDNSMKNIFR QGRLFIALSL AMTSISAFAL TQQEVDDIIK PLMKQEQIPG
60 70 80 90 100
MSVAISVNGK QAIYHYGVQS KQTQIPVSDR TLYEIGSLSK TFTATLATYA
110 120 130 140 150
QIQGKLDFSQ SVSHYLPELK GSAFDNVSVM NLATHTSGLS LFVPSDIKTN
160 170 180 190 200
DQLMAYYQKW LPDNEVGQYR SYSNLGVGLL GIVTAKQLNM PFSQAMEKLM
210 220 230 240 250
LPSLGLKHTY IHVPKSQEKY YAQGYNKQNQ PVRLNLEILG PEAYGLKSNA
260 270 280 290 300
KDLIRYLEIN MQSIKVAKTW QEAIENTHTG VYLTDSFVQD MMWESYPWPV
310 320 330 340 350
SLSQLLQGNR DDMALKPQKV ELIKPAMAPE VRAYYNKTGS SNGFATYAIF
360 370 380
IPEEKIAIVM LSNKWIPIPQ RITATYQLLE KIER
Length:384
Mass (Da):43,366
Last modified:August 1, 1998 - v1
Checksum:i8CCCAC7F9B1377E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17315 Genomic DNA. Translation: CAA76739.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17315 Genomic DNA. Translation: CAA76739.1 .

3D structure databases

ProteinModelPortali O69773.
ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL5895.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR001586. Beta-lactam_class-C_AS.
[Graphical view ]
Pfami PF00144. Beta-lactamase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00336. BETA_LACTAMASE_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and sequencing of ampC and ampR genes from Providencia stuartii."
    Koeck J.L., Basmaciogullari S., Parzy D., Barnaud G., Teyssou R., Buisson Y., Philippon A., Arlet G.J.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: VDG 96.

Entry informationi

Entry nameiAMPC_PROST
AccessioniPrimary (citable) accession number: O69773
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3