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O69773 (AMPC_PROST) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-lactamase

EC=3.5.2.6
Alternative name(s):
Cephalosporinase
Gene names
Name:ampC
OrganismProvidencia stuartii
Taxonomic identifier588 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProvidencia

Protein attributes

Sequence length384 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Subcellular location

Periplasm By similarity.

Sequence similarities

Belongs to the class-C beta-lactamase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   Cellular componentPeriplasm
   DomainSignal
   Molecular functionHydrolase
Gene Ontology (GO)
   Biological_processantibiotic catabolic process

Inferred from electronic annotation. Source: InterPro

response to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentouter membrane-bounded periplasmic space

Inferred from electronic annotation. Source: InterPro

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 384355Beta-lactamase
PRO_0000016962

Regions

Region337 – 3393Substrate binding By similarity

Sites

Active site871Acyl-ester intermediate By similarity
Active site1721Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
O69773 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 8CCCAC7F9B1377E9

FASTA38443,366
        10         20         30         40         50         60 
MDNSMKNIFR QGRLFIALSL AMTSISAFAL TQQEVDDIIK PLMKQEQIPG MSVAISVNGK 

        70         80         90        100        110        120 
QAIYHYGVQS KQTQIPVSDR TLYEIGSLSK TFTATLATYA QIQGKLDFSQ SVSHYLPELK 

       130        140        150        160        170        180 
GSAFDNVSVM NLATHTSGLS LFVPSDIKTN DQLMAYYQKW LPDNEVGQYR SYSNLGVGLL 

       190        200        210        220        230        240 
GIVTAKQLNM PFSQAMEKLM LPSLGLKHTY IHVPKSQEKY YAQGYNKQNQ PVRLNLEILG 

       250        260        270        280        290        300 
PEAYGLKSNA KDLIRYLEIN MQSIKVAKTW QEAIENTHTG VYLTDSFVQD MMWESYPWPV 

       310        320        330        340        350        360 
SLSQLLQGNR DDMALKPQKV ELIKPAMAPE VRAYYNKTGS SNGFATYAIF IPEEKIAIVM 

       370        380 
LSNKWIPIPQ RITATYQLLE KIER 

« Hide

References

[1]"Cloning and sequencing of ampC and ampR genes from Providencia stuartii."
Koeck J.L., Basmaciogullari S., Parzy D., Barnaud G., Teyssou R., Buisson Y., Philippon A., Arlet G.J.
Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: VDG 96.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y17315 Genomic DNA. Translation: CAA76739.1.

3D structure databases

ProteinModelPortalO69773.
ModBaseSearch...
MobiDBSearch...

Chemistry

ChEMBLCHEMBL5895.

Protein family/group databases

MEROPSS12.006.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR001586. Beta-lactam_class-C_AS.
[Graphical view]
PfamPF00144. Beta-lactamase. 1 hit.
[Graphical view]
SUPFAMSSF56601. SSF56601. 1 hit.
PROSITEPS00336. BETA_LACTAMASE_C. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAMPC_PROST
AccessionPrimary (citable) accession number: O69773
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: December 11, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families