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O69773

- AMPC_PROST

UniProt

O69773 - AMPC_PROST

Protein

Beta-lactamase

Gene

ampC

Organism
Providencia stuartii
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    • Comment

    Functioni

    This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei87 – 871Acyl-ester intermediatePROSITE-ProRule annotation
    Active sitei172 – 1721Proton acceptorBy similarity

    GO - Molecular functioni

    1. beta-lactamase activity Source: UniProtKB-EC

    GO - Biological processi

    1. antibiotic catabolic process Source: InterPro
    2. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance

    Protein family/group databases

    MEROPSiS12.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-lactamase (EC:3.5.2.6)
    Alternative name(s):
    Cephalosporinase
    Gene namesi
    Name:ampC
    OrganismiProvidencia stuartii
    Taxonomic identifieri588 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProvidencia

    Subcellular locationi

    Periplasm By similarity

    GO - Cellular componenti

    1. outer membrane-bounded periplasmic space Source: InterPro

    Keywords - Cellular componenti

    Periplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 384355Beta-lactamasePRO_0000016962Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliO69773.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni337 – 3393Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the class-C beta-lactamase family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR001466. Beta-lactam-related.
    IPR012338. Beta-lactam/transpept-like.
    IPR001586. Beta-lactam_class-C_AS.
    [Graphical view]
    PfamiPF00144. Beta-lactamase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56601. SSF56601. 1 hit.
    PROSITEiPS00336. BETA_LACTAMASE_C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O69773-1 [UniParc]FASTAAdd to Basket

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    MDNSMKNIFR QGRLFIALSL AMTSISAFAL TQQEVDDIIK PLMKQEQIPG    50
    MSVAISVNGK QAIYHYGVQS KQTQIPVSDR TLYEIGSLSK TFTATLATYA 100
    QIQGKLDFSQ SVSHYLPELK GSAFDNVSVM NLATHTSGLS LFVPSDIKTN 150
    DQLMAYYQKW LPDNEVGQYR SYSNLGVGLL GIVTAKQLNM PFSQAMEKLM 200
    LPSLGLKHTY IHVPKSQEKY YAQGYNKQNQ PVRLNLEILG PEAYGLKSNA 250
    KDLIRYLEIN MQSIKVAKTW QEAIENTHTG VYLTDSFVQD MMWESYPWPV 300
    SLSQLLQGNR DDMALKPQKV ELIKPAMAPE VRAYYNKTGS SNGFATYAIF 350
    IPEEKIAIVM LSNKWIPIPQ RITATYQLLE KIER 384
    Length:384
    Mass (Da):43,366
    Last modified:August 1, 1998 - v1
    Checksum:i8CCCAC7F9B1377E9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y17315 Genomic DNA. Translation: CAA76739.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y17315 Genomic DNA. Translation: CAA76739.1 .

    3D structure databases

    ProteinModelPortali O69773.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    ChEMBLi CHEMBL5895.

    Protein family/group databases

    MEROPSi S12.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR001466. Beta-lactam-related.
    IPR012338. Beta-lactam/transpept-like.
    IPR001586. Beta-lactam_class-C_AS.
    [Graphical view ]
    Pfami PF00144. Beta-lactamase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56601. SSF56601. 1 hit.
    PROSITEi PS00336. BETA_LACTAMASE_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of ampC and ampR genes from Providencia stuartii."
      Koeck J.L., Basmaciogullari S., Parzy D., Barnaud G., Teyssou R., Buisson Y., Philippon A., Arlet G.J.
      Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: VDG 96.

    Entry informationi

    Entry nameiAMPC_PROST
    AccessioniPrimary (citable) accession number: O69773
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3