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Protein

HTH-type transcriptional activator AmpR

Gene

ampR

Organism
Providencia stuartii
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This protein is a positive regulator of gene expression of beta-lactamase (AmpC).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi26 – 4520H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional activator AmpR
Gene namesi
Name:ampR
OrganismiProvidencia stuartii
Taxonomic identifieri588 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProvidencia

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292HTH-type transcriptional activator AmpRPRO_0000105588Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi471874.PROSTU_00251.

Structurei

3D structure databases

ProteinModelPortaliO69772.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 6658HTH lysR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH lysR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105ETT. Bacteria.
ENOG410XS6G. LUCA.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005119. LysR_subst-bd.
IPR000847. Tscrpt_reg_HTH_LysR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00126. HTH_1. 1 hit.
PF03466. LysR_substrate. 1 hit.
[Graphical view]
PRINTSiPR00039. HTHLYSR.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50931. HTH_LYSR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O69772-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGNYRHRLP LNALRAFEAS ARHLSFTRAG LELNVTQAAV SQQVRLLEEQ
60 70 80 90 100
LGLELFIRLP RGLALTDEGL ALLPVLSRSF DQIESLLQQF EDGHYHEVLS
110 120 130 140 150
VSVVGTFAVG WLLPRLPAFA ALYPYIDLRI MTHNNVVNLA AEGVDFAIRF
160 170 180 190 200
GEGLWPLAEN TALFSAAHTV LCSEKVANKL THPLDLKDHS LMRSYRKDEW
210 220 230 240 250
EKWQIAAELE PWRVKGPIFD SSRLMVEAAL LTDGVALAPS CMFEHELSAG
260 270 280 290
TLVQPFDISV TLGGYWLSRL KSRPTTPAMA IFRHWLLAEV QK
Length:292
Mass (Da):32,742
Last modified:August 1, 1998 - v1
Checksum:i9B2CEFF667E112F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17315 Genomic DNA. Translation: CAA76738.1.
RefSeqiWP_014657004.1. NZ_LNHS01000070.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17315 Genomic DNA. Translation: CAA76738.1.
RefSeqiWP_014657004.1. NZ_LNHS01000070.1.

3D structure databases

ProteinModelPortaliO69772.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi471874.PROSTU_00251.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105ETT. Bacteria.
ENOG410XS6G. LUCA.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005119. LysR_subst-bd.
IPR000847. Tscrpt_reg_HTH_LysR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00126. HTH_1. 1 hit.
PF03466. LysR_substrate. 1 hit.
[Graphical view]
PRINTSiPR00039. HTHLYSR.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50931. HTH_LYSR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and sequencing of ampC and ampR genes from Providencia stuartii."
    Koeck J.L., Basmaciogullari S., Parzy D., Barnaud G., Teyssou R., Buisson Y., Philippon A., Arlet G.J.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: VDG 96.

Entry informationi

Entry nameiAMPR_PROST
AccessioniPrimary (citable) accession number: O69772
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: May 11, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.