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Protein

Probable transcriptional regulatory protein TcrX

Gene

tcrX

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Member of the two-component regulatory system TcrY/TcrX.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi135 – 232OmpR/PhoB-typePROSITE-ProRule annotationAdd BLAST98

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation, Two-component regulatory system

Names & Taxonomyi

Protein namesi
Recommended name:
Probable transcriptional regulatory protein TcrX
Gene namesi
Name:tcrX
Ordered Locus Names:Rv3765c
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv3765c.

Subcellular locationi

O69730:

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Cells lacking TcrX and TcrY show an increase in virulence in mouse model of infection, with significantly shorter survival times.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004122011 – 234Probable transcriptional regulatory protein TcrXAdd BLAST234

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei594-aspartylphosphatePROSITE-ProRule annotation1

Post-translational modificationi

Phosphorylated by TcrY.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO69730.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv3765c.

Structurei

3D structure databases

ProteinModelPortaliO69730.
SMRiO69730.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 124Response regulatoryPROSITE-ProRule annotationAdd BLAST115

Phylogenomic databases

eggNOGiENOG4105CK6. Bacteria.
COG0745. LUCA.
HOGENOMiHOG000034815.
InParanoidiO69730.
KOiK02483.
OMAiMGDSNII.
PhylomeDBiO69730.

Family and domain databases

CDDicd00156. REC. 1 hit.
cd00383. trans_reg_C. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR011006. CheY-like_superfamily.
IPR001867. OmpR/PhoB-type_DNA-bd.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR036388. WH-like_DNA-bd_sf.
PfamiView protein in Pfam
PF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
SMARTiView protein in SMART
SM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiView protein in PROSITE
PS51755. OMPR_PHOB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

O69730-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRADGQPVT VLVVDDEPVL AEMVSMALRY EGWNITTAGD GSSAIAAARR
60 70 80 90 100
QRPDVVVLDV MLPDMSGLDV LHKLRSENPG LPVLLLTAKD AVEDRIAGLT
110 120 130 140 150
AGGDDYVTKP FSIEEVVLRL RALLRRTGVT TVDSGAQLVV GDLVLDEDSH
160 170 180 190 200
EVMRAGEPVS LTSTEFELLR FMMHNSKRVL SKAQILDRVW SYDFGGRSNI
210 220 230
VELYISYLRK KIDNGREPMI HTLRGAGYVL KPAR
Length:234
Mass (Da):25,844
Last modified:July 5, 2004 - v3
Checksum:i4595223F8B0F9604
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti81L → P in CAA67749 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99370 Genomic DNA. Translation: CAA67749.1.
AL123456 Genomic DNA. Translation: CCP46592.1.
PIRiF70801.
RefSeqiNP_218282.1. NC_000962.3.
WP_003420552.1. NZ_KK339374.1.

Genome annotation databases

EnsemblBacteriaiCCP46592; CCP46592; Rv3765c.
GeneIDi886100.
KEGGimtu:Rv3765c.

Similar proteinsi

Entry informationi

Entry nameiTCRX_MYCTU
AccessioniPrimary (citable) accession number: O69730
Secondary accession number(s): L0TF65, Q50808
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 130 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names