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Protein

HTH-type transcriptional regulator NmtR

Gene

nmtR

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Represses transcription of ctpJ/nmtA, by binding to its promoter region.1 Publication

Enzyme regulationi

Binding to DNA is inhibited by nickel and, to some extent, cobalt ions.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi91Nickel1
Metal bindingi93Nickel1
Metal bindingi104Nickel1
Metal bindingi107Nickel1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi49 – 72H-T-H motifPROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

  • regulation of fatty acid metabolic process Source: MTBBASE
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Nickel

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-8034-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator NmtR
Gene namesi
Name:nmtR
Ordered Locus Names:Rv3744
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv3744.

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi51D → A: Does not affect activity and regulation by metal ions. 1 Publication1
Mutagenesisi91D → A: No change in activity. Lack of regulation by metal ions. 1 Publication1
Mutagenesisi93H → R: No change in activity. Lack of regulation by metal ions. 1 Publication1
Mutagenesisi104H → R: No change in activity. Lack of regulation by metal ions. 1 Publication1
Mutagenesisi107H → R: No change in activity. Lack of regulation by metal ions. 1 Publication1
Mutagenesisi109H → R: No change in activity. Lack of regulation by metal ions. 1 Publication1
Mutagenesisi114D → A: Does not affect activity and regulation by metal ions. 1 Publication1
Mutagenesisi116H → R: No change in activity. Lack of regulation by metal ions. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004191791 – 120HTH-type transcriptional regulator NmtRAdd BLAST120

Proteomic databases

PaxDbiO69711.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi83332.Rv3744.

Structurei

3D structure databases

ProteinModelPortaliO69711.
SMRiO69711.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 109HTH arsR-typePROSITE-ProRule annotationAdd BLAST95

Sequence similaritiesi

Contains 1 HTH arsR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG41066UM. Bacteria.
ENOG41124TA. LUCA.
HOGENOMiHOG000144506.
InParanoidiO69711.
OMAiMIHHTRH.
PhylomeDBiO69711.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001845. HTH_ArsR_DNA-bd_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01022. HTH_5. 1 hit.
[Graphical view]
PRINTSiPR00778. HTHARSR.
SMARTiSM00418. HTH_ARSR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50987. HTH_ARSR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O69711-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHGVEGRNR PSAPLDSQAA AQVASTLQAL ATPSRLMILT QLRNGPLPVT
60 70 80 90 100
DLAEAIGMEQ SAVSHQLRVL RNLGLVVGDR AGRSIVYSLY DTHVAQLLDE
110 120
AIYHSEHLHL GLSDRHPSAG
Length:120
Mass (Da):12,836
Last modified:July 5, 2004 - v3
Checksum:iEC9D7491B06A61E5
GO

Mass spectrometryi

Molecular mass is 12699.7 Da from positions 2 - 120. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP46571.1.
PIRiA70799.
RefSeqiNP_218261.1. NC_000962.3.
WP_003901716.1. NZ_KK339374.1.

Genome annotation databases

EnsemblBacteriaiCCP46571; CCP46571; Rv3744.
GeneIDi885418.
KEGGimtu:Rv3744.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP46571.1.
PIRiA70799.
RefSeqiNP_218261.1. NC_000962.3.
WP_003901716.1. NZ_KK339374.1.

3D structure databases

ProteinModelPortaliO69711.
SMRiO69711.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv3744.

Proteomic databases

PaxDbiO69711.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP46571; CCP46571; Rv3744.
GeneIDi885418.
KEGGimtu:Rv3744.

Organism-specific databases

TubercuListiRv3744.

Phylogenomic databases

eggNOGiENOG41066UM. Bacteria.
ENOG41124TA. LUCA.
HOGENOMiHOG000144506.
InParanoidiO69711.
OMAiMIHHTRH.
PhylomeDBiO69711.

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-8034-MONOMER.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001845. HTH_ArsR_DNA-bd_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01022. HTH_5. 1 hit.
[Graphical view]
PRINTSiPR00778. HTHARSR.
SMARTiSM00418. HTH_ARSR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50987. HTH_ARSR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNMTR_MYCTU
AccessioniPrimary (citable) accession number: O69711
Secondary accession number(s): L0TGE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2012
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.