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Protein

Gamma-glutamyl-hercynylcysteine sulfoxide hydrolase

Gene

egtC

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine.By similarity

Catalytic activityi

Gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide + H2O = S-(hercyn-2-yl)-L-cysteine S-oxide + L-glutamate.By similarity

Pathwayi: ergothioneine biosynthesis

This protein is involved in the pathway ergothioneine biosynthesis, which is part of Amino-acid biosynthesis.By similarity
View all proteins of this organism that are known to be involved in the pathway ergothioneine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21NucleophilePROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciMTBRV:RV3702C-MONOMER.
UniPathwayiUPA01014.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamyl-hercynylcysteine sulfoxide hydrolase (EC:3.5.1.118By similarity)
Alternative name(s):
Gamma-glutamyl hercynylcysteine S-oxide hydrolase
Gene namesi
Name:egtC
Ordered Locus Names:Rv3702c
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv3702c.

Subcellular locationi

GO - Cellular componenti

  • plasma membrane Source: MTBBASE
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 233233Gamma-glutamyl-hercynylcysteine sulfoxide hydrolasePRO_0000413650Add
BLAST

Proteomic databases

PaxDbiO69670.

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv3702c.

Structurei

3D structure databases

ProteinModelPortaliO69670.
SMRiO69670. Positions 3-226.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 233232Glutamine amidotransferase type-2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.PROSITE-ProRule annotation

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiENOG4108V75. Bacteria.
COG0121. LUCA.
HOGENOMiHOG000256686.
InParanoidiO69670.
KOiK07008.
OMAiNADGWGA.
OrthoDBiEOG6KT2N8.
PhylomeDBiO69670.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_02036. EgtC.
InterProiIPR017808. EgtC.
IPR032889. EgtC_Actinobacteria.
IPR017932. GATase_2_dom.
IPR029055. Ntn_hydrolases_N.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR03442. TIGR03442. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O69670-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCRHLGWLGA QVAVSSLVLD PPQGLRVQSY APRRQKHGLM NADGWGVGFF
60 70 80 90 100
DGAIPRRWRS PAPLWGDTSF HSVAPALRSH CILAAVRSAT VGMPIEVSAT
110 120 130 140 150
PPFTDGHWLL AHNGVVDRAV LPAGPAAESV CDSAILAATI FAHGLDALGD
160 170 180 190 200
TIVKVGAADP NARLNILAAN GSRLIATTWG DTLSILRRAD GVVLASEPYD
210 220 230
DDSGWGDVPD RHLVEVTQKG VTLTALDRAK GPR
Length:233
Mass (Da):24,627
Last modified:August 1, 1998 - v1
Checksum:iF4371315DA610B63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP46527.1.
PIRiG70793.
RefSeqiNP_218219.1. NC_000962.3.
WP_003419806.1. NZ_KK339374.1.

Genome annotation databases

EnsemblBacteriaiCCP46527; CCP46527; Rv3702c.
GeneIDi885224.
KEGGimtu:Rv3702c.
PATRICi18156838. VBIMycTub87468_4126.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP46527.1.
PIRiG70793.
RefSeqiNP_218219.1. NC_000962.3.
WP_003419806.1. NZ_KK339374.1.

3D structure databases

ProteinModelPortaliO69670.
SMRiO69670. Positions 3-226.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv3702c.

Proteomic databases

PaxDbiO69670.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP46527; CCP46527; Rv3702c.
GeneIDi885224.
KEGGimtu:Rv3702c.
PATRICi18156838. VBIMycTub87468_4126.

Organism-specific databases

TubercuListiRv3702c.

Phylogenomic databases

eggNOGiENOG4108V75. Bacteria.
COG0121. LUCA.
HOGENOMiHOG000256686.
InParanoidiO69670.
KOiK07008.
OMAiNADGWGA.
OrthoDBiEOG6KT2N8.
PhylomeDBiO69670.

Enzyme and pathway databases

UniPathwayiUPA01014.
BioCyciMTBRV:RV3702C-MONOMER.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_02036. EgtC.
InterProiIPR017808. EgtC.
IPR032889. EgtC_Actinobacteria.
IPR017932. GATase_2_dom.
IPR029055. Ntn_hydrolases_N.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR03442. TIGR03442. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25618 / H37Rv.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ATCC 25618 / H37Rv.

Entry informationi

Entry nameiEGTC_MYCTU
AccessioniPrimary (citable) accession number: O69670
Secondary accession number(s): L0TF00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: August 1, 1998
Last modified: April 13, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.